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Acupain (Tramadol)

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Acupain is a centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Acupain is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine.

Other names for this medication:
Adamon, Antram, Arodol, Combitram, Contramal, Decotram, Dolfre, Domadol, Esgiypyrin, Ivydol, Jpdol, Kamadol, Lagesic, Neutram, Paxmax, Radol, Ramadol, Rybix, Ryzolt, Stemadol, Traceta, Tramalex, Tramatas, Tramataur, Tramazac, Tramazol, Tramest, Tramot, Tranzat, Trazac, Trectadol, Tryme, Ultracon, Ultrax, Unidol, Urgendol, Veeradol

Similar Products:
Cleocin, Lasix, Levothroid, Xalatan, Lopid, Zyloprim, Combivent, Fosamax

Also known as: Tramadol


{name} (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

{name} is used to treat moderate to severe pain in adults.

The extended-release form of tramadol ({name} ER) is for around-the-clock treatment of pain. {name} ER is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Acupain ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Acupain ER.

Never share Acupain ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Acupain ER.

Acupain ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Acupain ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Acupain ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Acupain ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Acupain ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep your medicine container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how Acupain ER will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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Why do sulfate-reducing bacteria outcompete methanogenic bacteria for substrates?. Discussion of the methods for establishing embryonic stem cell lines from 129/ter. By extending an auxiliary method to distributed dynamic systems, the partial synchronization of two turbulent orbits in the present study can be categorized in the domain of generalized synchronization of spatiotemporal dynamics. A High-Throughput Screening Platform of Microbial Natural Products for the Discovery of Molecules with Antibiofilm Properties against Salmonella. It is certain that there are causes, still unrecognized, which have an effect on the pathways and direction of malignant tumor spread.


To quantify the accuracy of our patient positioning, we examined the weekly portal films of 46 women treated with IM-WPRT at our institution. G40-labelled cells were detected in the side scatter (90 degrees) channel and fluorescent cells in the red and green fluorescence channels, respectively. Using a contrast probe technique, we showed that in noise, contrast increments are more easily seen at the end of the trajectory than at the beginning. Promotive, neutral, and inhibitory bacteria in the community would synergistically determine the effects. Overall, these results suggest that the phenotypes of c-CA-treated plants are the consequence of a local change in auxin accumulation, induced by the inhibition of auxin efflux. Here, we had analyzed the relationship between the transthyretin levels during the acute phase and Functional Independence Measure in stroke patients undergoing convalescent rehabilitation. Analgesic and antiemetic use and incidence of retching, vomiting and other complaints were also recorded. Overall, these data suggest that whisker trimming, producing depression of thalamocortical responses, prevents elimination of aberrant synapses during a critical developmental period before 4 weeks in the mouse barrel cortex. Measurements that showed little difference included magnitude and activation threshold of a calcium-dependent outward current (IJ) and magnitude, activation threshold, voltage dependence, and inactivation time course of A current (IA).

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Our previous observations showed alterations of oral cavity status among hemodialyzed patients and kidney allograft recipients as well as differences in the prevalence and composition of microorganisms occurring in the mouths of patients. It also takes part in DNA functions such as replication, recombination, and repair. The model, which agrees well with the experiment, indicates that the tension difference between the two leaflets is governed by the different adsorptions of counterions at the two membrane surfaces, rather than by the direct contribution of the electric double layers to the membrane tension. In the preceding paper a theory has been developed for the X-ray diffraction pattern from a lipid bilayer coated with protein molecules. While some studies suggest that fiber can increase stool weight and bowel transit time in acutely ill patients, there is less information in stable patients receiving chronic enteral nutritional support. Here we illustrate a motile, elongate plasmodium that undergoes coordinated undulatory locomotion, revealing remarkable convergence to a functional worm at the cellular level. Effectiveness of ursodeoxycholic acid in cholesterosis of the gallbladder.

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Clinical trial of hepatitis B vaccine in a simplified immunization programme. alpha-Melanocyte-stimulating hormone (alpha-MSH) is implicated in pigmentation, central nervous system and immune system functions, growth, mitogenesis, and melanoma. Improved synthesis of glycine, taurine and sulfate conjugated bile acids as reference compounds and internal standards for ESI-MS/MS urinary profiling of inborn errors of bile acid synthesis. Deletion of upstream sequences or even the TATA box does not influence significantly the degree of transcriptional initiation or pausing. Further studies of histone phosphorylation in the presence of inhibitors of DNA synthesis.

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Gene silencing with RNA interference: a novel tool for the study of physiology and pathophysiology of adrenal cortex. Although species composition was fairly constant, the distribution of individuals among species changed greatly.In contrast to the ideas of Thorson, adult dispersal was shown to be a significant factor in the establishment of benthic populations with larval settlement being more significant in maintenance of the populations.The community is viewed as a system in which species composition is determined primarily by the physical attributes of the area, and the density dominance of any species is dampened by the vagaries of adult dispersal and larval settlement. However, as achieving and maintaining weight loss is difficult, alternative strategies are needed. To discuss the clinical and neuroradiological profile of pediatric patients with acute disseminated encephalomyelitis (ADEM). This article is part of a Special Issue entitled: Genetic and epigenetic control of heart failure - edited by Jun Ren and Megan Yingmei Zhang. To determine in vitro the loss of integrity caused on photocatalytic anatase coated implant surfaces by clinical instrumentation through changes in surface topography and loss of functionality.

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Quantitative detection of Moraxella catarrhalis in nasopharyngeal secretions by real-time PCR. The digestive cells are characterized by an apical system of tubules. Distributions of inter-arrival time for individual flowers show standard deviation/mean ratios of 0.44-0.79, a range which is consistent with results obtained for two other plant-pollinator systems. Results are expressed in Lf Hc/ml with reference to a purified tetanus toxoid standard expressed in Lf/ml. The purpose of this report is to illustrate the advantage of minimally invasive approaches in 3 cases of lumbar synovial cysts. We have examined by in situ hybridization the expression patterns of each ebf/coe gene during limb development in mouse and chicken embryos. PCR inhibition by coextraction of humic compounds was minimized in this system, resulting in detection sensitivity of one target DNA copy per reaction well. High-resolution computed tomography in young patients with cystic fibrosis: distribution of abnormalities and correlation with pulmonary function tests.

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Similarly, both thrombin species were able to induce the phosphorylation of platelet 20 KDa and 47KDa proteins. Protocol for determining primary healthcare practice characteristics, models of practice and patient accessibility using an exploratory census survey with linkage to administrative data in Nova Scotia, Canada. These properties of HO-1 suggest anti-atherogenic roles of this enzyme. Plants may experience environmental stress factors operating in nature either simultaneously or in sequence. An enzymatic method for measuring picomole quantities of acetylcholine and choline in CNS tissue. Nucleotide sequences of the coat protein gene of potyviruses infecting Ornithogalum thyrsoides. Studies have demonstrated that oral administration of Celecoxib decreased the incidence of skin and colon tumors.

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To study the expressions of peroxisome proliferator activated receptor alpha (PPAR-alpha) and hypoxia-inducible factor-1alpha (HIF-1alpha) during different hypoxia states in lung cancer cell A549, and to investigate the mechanism of HIF-1alpha induced PPARalpha expression. Videoconferencing is increasingly being accepted as a medium for health-care. A total of 116 hyperthyroidism patients with concomitant LD who received MARS treatment were studied retrospectively. Animal lectins: from initial description to elaborated structural and functional classification. An evaluation of the effects of an Nd:YAG laser on subgingival calculus, dentine and cementum. We performed a candidate gene case-control association study of 2 independent Japanese populations (a total of 3366 adults). We performed a Medline search using specific search terms, then selectively reviewed relevant research relating to physical stimulation of chondrogenic cells in vitro, focusing on cellular responses to the specific load applied. Results indicated that although the spontaneous release of hypothalamic beta-EPLPs was higher by the ANA than by the AA rats, the percentage increase following exposure to various concentrations of ethanol was similar in both lines of rats. Then, the accurate mass of every decomposed material of human liver tissue is correlated to masses of the phantom components.

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Effects of in utero and lactational TCDD exposure on bone development in differentially sensitive rat lines. This dog had disseminated histoplasmosis with multiple organ involvement including the central nervous system (CNS) and eye. Changes in plasma immunoreactive atrial natriuretic peptide in response to saline infusion or to alterations in dietary sodium intake in normal subjects. Investigation of relationship between quality of working life and organizational commitment of nurses in teaching hospitals in Tabriz in 2014. Drugs available in polypharmacy are well elaborated in this article. This limitation could hurt its applicability to important predictive tasks, such as the imputation of TF binding data. It was found that the S(1)/T(1)/T(2) three-surface intersection plays an important role in the photodissociation processes of benzamide. In our laboratory we have developed an indirect ELISA methodology to the diagnosis of aspergillosis in dog, cat, cow, sheep and birds, and dermatophytoses in dog and cat.

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Type II collagen-induced arthritis (CIA) and mice was used as a model to evaluate the effect of etodolac on the arthritic and immunological parameters of the experimental disease. Therefore, thirteen acetogenins, from the roots of Uvaria chamae and Annona senegalensis, were identified. In L-NAME-treated rats, CBF also remained significantly lower than baseline for 30-60 min after reperfusion, and glutamate was higher than in saline-treated rats throughout the experiment. More important we give sufficient conditions on f such that for two arbitrary structures having different numbers of layers there is a finite test set S on which the optimal smaller net performs better. Indigenous medicinal practice in Sri Lanka talks about powerful compounds extracted from native plants for treating venomous snake bites which are hardly documented in literature but are used by the indigenous doctors for thousand years. Both the decalcified tissues and the yolky embryos were dehydrated through an ascending series of isopropanol and embedded in low melting-point paraffin under vacuum. Methionine, a sulfur-containing amino acid, is a key metabolite in plant cells. The pools odds ratio (OR) values of mentality (3.34), smoking (3.04), indoor coal pollution (3.20), indoor cooking oil fume pollution (2.72), family history of lung cancer (2.61), vegetables (0.49), fruits (0.69), BMI (1.57), family history of other tumour (2.97), personal history of respiratory system diseases (2.66), ventilation in kitchen (2.13), coal ever used in life (1.50), and exposure to environmental tobacco smoking (1.42). The efficacy of short- and long-term treatments with Isoprinosine, an immunomodulatory compound, was studied in Echinococcus granulosus cysts developed in NMRI mice intraperitoneally infected with sheep pulmonary cysts. While the cationic glycolipids 1-3 with no headgroup ultram dose spacer unit between the positively charged nitrogen and galactose showed high in vitro gene transfer efficacies in all four cells (lipids 1 and 2 with myristyl and palmityl tails, respectively, being the most efficacious), lipids 4-6 with five-carbon spacer units between the quaternized nitrogen and galactose heads were essentially transfection incompetent.

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Development of 1-aryl-3-furanyl/thienyl-imidazopyridine templates for inhibitors against hypoxia inducible factor (HIF)-1 transcriptional activity. Abusive experiences and psychiatric morbidity in women primary care attenders. we assessed the incidence, risk factors and outcome of BSI over a 14-year period (2000-2013) in a Swedish county. A 35-year-old ultram dosage man developed leg edema, marked hypoalbuminemia, and proteinuria. White Paper of the Society of Computed Body Tomography and Magnetic Resonance on Dual-Energy CT, Part 4: Abdominal and Pelvic Applications. Analgesic efficacy of ketoprofen in continuous perfusion in refractory pain caused by bone metastases.

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Deep-sea or other high diversity food webs may be investigated using serological methods that are already well-developed for use in terrestrial and shallow-water environments. At the high concentration binding limit Csat of SDS, the above polymers become fully saturated with bound SDS micelles. By contrast, studies indicate that, in females, it is the lack of prenatal testosterone coupled with the organizational effects of pubertal ovarian hormones that may lead to increased binge eating. When the FME was administered from the first day of this instar a supernumerary larval molt occurred in some animals. Equal efficacy of a generic piperacillin/tazobactam formulation trileptal medicine side effects : results of a local screening protocol. This entity has not biological markers and its diagnosis could be done verifying the proposed criteria. Osmoregulation of aldose reductase and sorbitol dehydrogenase in cultivated interstitial cells of rat renal inner medulla.

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Off-pump coronary artery bypass grafting for an 88-year-old man with familial hypercholesterolemia. Diagnosis of bilharziasis was done by stool analysis, or by sigmoidoscopy and rectal snip. Determination of a minimal region of loss of heterozygosity on chromosome 18q21.33 in osteosarcoma. In patients with tachycardia-bradycardia syndrome and permanent pacemakers having these mode switching algorithms, mode switching events are reliable surrogate markers for atrial tachyarrhythmias. The increasing number of detected cases of alveolar echinococcosis (AE) in recent years in Central-Eastern Europe strongly support the need of accurate diagnosis of the disease in patients and its differentiation from cystic echinococcosis. In a factorially designed experiment the factors Mode of Stress (cognitive vs. Docosahexaenoic Acid and Neurodevelopmental Outcomes of Term Infants. Subarachnoid hemorrhage as the initial presentation of dural sinus thrombosis.

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Evidence from two small trials showed that plasma exchange provides significant short-term benefit in about two-thirds of patients with chronic inflammatory demyelinating polyradiculoneuropathy but rapid deterioration may occur afterwards. Given the complexity of many of the conditions, health care input when required should be provided by a multidisciplinary team who have appropriate expertise. Although multiple studies have revealed the role of rottlerin in tumorigenesis, the molecular mechanism of rottlerin-mediated anti-tumor activity has not been fully elucidated. The new era of bioluminescence resonance energy transfer technology. Familial dilated cardiomyopathy (FDCM) is associated with mutations in more than 10 genes, but genes mutation frequencies and associated clinical features remain largely unknown. Proceedings: Influence of postaglandins and oestrus cycle on the spasmodic action of angiotensin II and oxytocin on rat uterus. burttii, demonstrating that Nod factors are strictly necessary for this crack-entry mode, and a noeL mutant was also severely impaired in L. TNM stage (especially the axillary lymph node status)relates to prognosis of breast cancer. Because of the virtually infinite number of mixture-combinations, and the many different targeted organisms, it would be advantageous to have a model for the assessment of mixture effects. We did not see a reduction in the incidence of post-ERCP pancreatitis, but there may be some protective effect of treatment with beta-carotene regarding the severity of disease.

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Surface behaviour and peptide-lipid interactions of the antibiotic peptides, Maculatin and Citropin. Our results confirm that trolamine emulsion significantly reduces the intensity of acute dermatitis following 3D-CRT with weekly cisplatin in HNSCC. It also provides a guide and a helpful resource for further development of resident wellness programs by other disciplines in Canada and internationally. Is brachydactyly type Ballard a variant of brachydactyly type E?. The exact role of proximal and distal nerve transfers in reconstruction strategies of brachial plexus injury remains controversial. Incorporation of radiolabeled leucine into protein to estimate bacterial production in plant litter, sediment, epiphytic biofilms, and water samples.

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