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Agulan (Aceclofenac)
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Agulan

Agulan is an angiotensin-converting enzyme (ACE) inhibitor (ACEI). It exerts a protective effect in DR by decreasing VEGF-to-PEDF ratio (downregulating VEGF and upregulating PEDF). The lowering of VEGF-to-PEDF ratio is significantly correlated with the relief of the vascular damage and was a result of reduced mitochondrial ROS production by increasing uncoupling protein 2 (UCP-2).

Other names for this medication:
Aceclofenac, Acertil, Acerycal, Agulan, Aldoc, Armix, Asyntilsan, Bionoliprel, Biprel, Bipreterax, Cardipen, Coveram, Coverene, Coverex, Covinace, Domanion, Dorover, Indapril, Inopil, Midopril, Noliprel, Pendoril, Pendrex, Percarnil, Perindal, Perindan, Perindo, Perindox, Prestance, Prestarium, Preterax, Prexanil, Prexum, Prindace, Procaptan, Provinace, Reaptan, Stopress, Teraxans, Vectoryl, Vidotin

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Also known as: Aceclofenac

Description

Agulan is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking ACE, an enzyme involved in narrowing blood vessels and causing sodium and fluid retention by the kidneys. This causes blood vessels to relax, allowing blood to flow more freely and at a lower pressure, and increasing the heart's ability to pump blood in some types of heart failure. Agulan is also known as Coversyl, Perindopril, Acertil, Armix, Coverene, Coverex, Coversum, Prestarium, Prexanil, Prexum, Procaptan. Generic name of Agulan is Perindopril. Brand name of Agulan is Agulan.

Dosage

Usual Adult Dose for Coronary Artery Disease:

Initial dose: 4 mg orally once a day for 2 weeks, then increase to maintenance dose as tolerated. Maintenance dose: 8 mg orally once a day Use: Treatment of patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or nonfatal myocardial infarction.

Usual Adult Dose for Hypertension:

Initial dose: 4 mg orally once a day Maintenance dose: 4 to 8 mg orally per day in 1 or 2 divided doses Maximum dose: 16 mg/day Comments: In patients treated with a diuretic, consider reducing the diuretic dose prior to starting this drug.

Usual Geriatric Dose for Coronary Artery Disease:

Greater than 70 Years: Initial dose: -Week 1: 2 mg orally once a day -Week 2: 4 mg orally once a day, then increase to maintenance dose as tolerated. Maintenance dose: 8 mg orally once a day Use: Treatment of patients with stable coronary artery disease to reduce the risk of cardiovascular mortality or nonfatal myocardial infarction.

Usual Geriatric Dose for Hypertension:

Initial dose: 4 mg orally per day in 1 or 2 divided doses Comments: Experience with doses above 8 mg is limited; administer with careful blood pressure monitoring and dose titration.

Detailed Agulan dosage information

Overdose

If you overdose Agulan and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Agulan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Agulan if you are allergic to perindopril or if:

you have hereditary angioedema; you recently took a heart medicine called sacubitril; or you are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, quinapril, ramipril, or trandolapril.

Do not take Agulan within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use Agulan together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking Agulan with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

kidney disease (or if you are on dialysis); liver disease; heart disease or congestive heart failure; diabetes; or a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis.

Do not use if you are pregnant, and tell your doctor right away if you become pregnant. Perindopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

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Why yeast cells can undergo apoptosis: death in times of peace, love, and war. Impact of antimicrobial gauze on bacterial colonies in wounds that require packing. This unusual enlarged editing property was studied in a model of a primitive editing system containing a composite minihelix carrying the triple leucine, isoleucine, and valine identity mimicking the primitive tRNA precursor. From a biomechanical perspective, the long-term success of an interbody cage fusion depends on effective load transfer. In this work, we study in detail Xenopus Iro (Xiro) function in primary neurogenesis. Juvenile law and the viable fetus: clinical perspectives and legal intervention. Results of long-term D-penicillamine therapy in chronic polyarthritis. Accessions displaying extremely different responses to NaCl were intercrossed, and the phenotypes found in their F(2) progenies suggested that natural variation in NaCl tolerance during germination was under polygenic controls.

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Definitions of dual protection, found mainly in family planning literature, are very narrow. We observed a dose-dependent 10-fold decrease in GJIC induced by UVA in normal human keratinocytes. The aim of our study was to verify if postprocedural transoesophageal echocardiography (TEE) might improve timely detection and management of thrombus formation. Recently, significant progress has been made in understanding the molecular mechanisms underlying these disorders. A recent study on zebrafish has shown that, by rerouting afferents from two eyes into a normally monocular brain structure, a fully functional binocular circuitry can be made to develop spontaneously. The Serotonin Transporter Promoter Variant, Stress, and Attentional Biases in Middle Childhood. Postoperative Venous Thromboembolism in Patients Undergoing Abdominal Surgery for IBD: A Common but Rarely Addressed Problem. Degradation of hard and soft segments of the nanocomposite was evident by infra-red spectroscopy in all conditioned samples. Myocardial NOS3 prevented postcardiac arrest myocardial dysfunction, attenuated end-organ damage, and improved neurologic outcome and survival. The use of a pharmacologic agent for treatment of constipation during pregnancy must be weighed against possible adverse effects.

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Potentially better practices then were integrated into the family-centered care map that was configured in a Web-based format. Media reports may have piqued interest in patient injuries, deaths related to use of restraints. The findings thus suggest that one of the basic defects in acute pancreatitis is the uncontrolled release of enzymes from peripheral acinar cells into the interstitial space which, in turn, presumably by the action of lipase, leads to autodigestive fat necrosis. This was a 12-week multicenter, randomized, double-blind, placebo-controlled study. Future work will be directed towards understanding the extent and specificity with which sex-linked genes and hormones define brain structure and function, and towards elucidating potential interactions between the two mechanisms.

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