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Alendix (Alendronate)

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Alendix is used to prevent and treat certain types of bone loss (osteoporosis) in adults. Osteoporosis causes bones to become thinner and break more easily. This medication works by slowing bone loss. Alendix belongs to a class of drugs called bisphosphonates.

Other names for this medication:
Alant, Alendix, Alendronate, Alenost, Bifosa, Denfos, Osteofos, Ostogee, Poronil, Ralenost, Restofos, Zophost

Similar Products:
Sovaldi, Periactin, Ticlid, Prandin, Catapres, Pamelor, Risperdal

Also known as: Alendronate


{name} (alendronate) is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures.

{name} is used in women to treat or prevent osteoporosis caused by menopause and in men and women to treat osteoporosis caused by taking steroids.

{name} is also used to increase bone mass in men who have osteoporosis, and to treat Paget's disease of bone in men and women.


Take Alendix exactly as prescribed by your doctor. Alendix is taken either once daily or once per week. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take Alendix first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. If you take this medicine only once per week, take it on the same day each week and always first thing in the morning.

Take with a full glass (6 to 8 ounces) of plain water. Do not use coffee, tea, soda, juice, or mineral water. Do not eat or drink anything other than plain water.

Do not crush, chew, or suck on an Alendix tablet. Swallow the tablet whole.

For at least 30 minutes after taking Alendix:

Do not lie down or recline. Do not take any other medicine including vitamins, calcium, or antacids.

Pay special attention to your dental hygiene while taking Alendix. Brush and floss your teeth regularly. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using alendronate.

Alendix is only part of a complete program of treatment that may also include diet changes, exercise, bone mineral density testing, and taking calcium and vitamin supplements. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

Your doctor will determine how long to treat you with this medicine. Alendix is often given for only 3 to 5 years.

Detailed Alendix dosage information


Drink a full glass of milk and seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Do not make yourself vomit and do not lie down.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alendix are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Alendix if you are allergic to alendronate, or if you have:

low levels of calcium in your blood (hypocalcemia); or problems with the muscles in your esophagus (the tube that connects your mouth and stomach).

Do not take Alendix if you cannot sit upright or stand for at least 30 minutes. Alendix can cause serious problems in the stomach or esophagus. You must stay upright for at least 30 minutes after taking this medicine.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

trouble swallowing; problems with your stomach or digestion; low levels of calcium in your blood; a dental problem (you may need a dental exam before you begin taking Alendix); kidney disease; or any condition that makes it hard for your body to absorb nutrients from food (malabsorption).

In rare cases, this medicine may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use Alendix, the more likely you are to develop this condition.

Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.

Alendix has also been reported to cause fractures, or broken bones, in the large bones of the leg. Tell your doctor if you have any leg or groin pain while using Alendix.

Talk with your doctor about the risks and benefits of using this medication.

It is not known whether Alendix will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Stop using the medicine and tell your doctor right away if you become pregnant.

It is not known whether alendronate passes into breast milk or if it could harm a nursing baby. Ask your doctor about any risk.

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The questionnaire incorporated a number of standard scales of psychosocial characteristics as well as questions developed from comments made during focus groups of men with erectile dysfunction and of their female partners. Instead, we argue that delamination of lower continental crust may explain the DUPAL isotopic signature of Indian MORB. The aim of this study was to determine the completeness of ethnicity coding in the Thames Cancer Registry (TCR) database and within the Hospital Episode Statistics (HES) data as held by the London Health Observatory, and to investigate factors associated with ethnicity being recorded. Juvenile bilateral progressive pulmonary dystrophy with malignant development (vanishing lung). The two XSmad4 genes have reciprocal temporal expression patterns in Xenopus embryos and are expressed in varying ratios in adult tissues, suggesting distinct functional roles in vivo. Consequently, new evidence for 19 CAM modalities has emerged between 2000 and 2005. Several studies have investigated inhibition of downstream mediators, including tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta). They differ in the content of serotonin in several brain regions and they respond differently to ethanol. In patients with mixed hyperlipidemia, monotherapy with one of these agents may not be effective and combined treatment may be preferable. Recognizing these aspects can help to improve physician-patient communication.

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All the paraclinical test were normal, except the electromyogram, showing a classical pattern of lower motor neuron disease, and the auditory brain stem response with absence of the main components of this evoked response, as expression of VIII cranial nerve damage. The results also show that under some circumstances, nucleotide sequence differences between alleles found within one individual can be distinguished from DNA sequence variation caused by postmortem DNA damage. The target is made of point-diffraction sources that emit two spherical wave fronts, whose interference is monitored by the photodetectors. We therefore aimed to develop an IC/PBS diagnosis method using a cystoscope with a narrow-band imaging (NBI) system that can detect mucosal angiogenic lesions. Three chronic studies using the sternotomy approach were performed. Multiple literacies: Linking the research on bilingualism and biliteracies to the practical.

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Kinetic analysis suggested that colostrum and mature milk regulate superoxide generation by OPMN, thereby modulating the bactericidal activity of these cells in the oral cavity. Preliminary results obtained in elderly subjects with systolic arterial hypertension, support this hypothesis. LPS sialylation had a more profound impact on the amount of alternative-pathway-mediated C3 binding ( approximately 5-fold decrease in fluorescence) when LPS was the main C3 target, as occurred on the more serum-resistant strain. Overall, these results indicate that across the lifespan prospective memory performance follows a similar inverted u-shape function as is well known for retrospective episodic memory. Therefore like other multitendoned muscles of the hand, last-order synaptic inputs to motor neurons supplying the FDS appear to primarily supply subsets of motor neurons innervating specific finger compartments. Some patterns and contextual differences were identified depending upon the gender of care staff. The present study was designed to characterize and evaluate the crystallinity of omeprazole sodium, dehydrated omeprazole sodium (DOMS) and omeprazole free base (OM) using a variety of techniques including thermal analysis (thermogravimetry/derivative thermogravimetry (TG/DTG) and differential scanning calorimetry (DSC)), diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy, scanning electron microscopy (SEM) and X-ray powder diffraction (XRPD). We previously reported a mouse model of bronchial asthma showing eosinophilic inflammation, but not airway hyperresponsiveness (AHR), after prolonged antigen exposure.

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Elastin composition of human skin chronically exposed to the sun. The synthesized MnP had the expected molecular mass (43,000Da) and catalyzed the oxidation of 2,6-dimethoxyphenol (DMP) in the presence of hydrogen peroxide and Mn(II). The purpose of this study was to estimate the regional relative blood volume (rBV) in head and neck tumors, which is useful for tumor staging and tumor biopsy. The clinicopathologic features of 108 patients with thymoma removed surgically were retrospectively reviewed. Superconductivity in the antiperovskite Dirac-metal oxide Sr3-xSnO.

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Conceptual issues in assessing responsibility for actions symptomatic of mental illness. To do so, we suggest, females formed protective relationships with male co-defenders. Neurons, astrocytes, oligodendrocytes and microglial cells all undergo pathological modifications in the onset and progression of ALS. Application of vertebroplasty, neuronavigation and kyphoplasty in the treatment of multiplex osteoporotic vertebral fractures--case report. Analysis of the North American Immune Tolerance Registry (NAITR) 1993-1997: current practice implications. Characterization of sugar binding by the mannose receptor family member, Endo180. CB1 receptor density and CB1 receptor-mediated functional effects in rat hippocampus are decreased by an intracerebroventricularly administered antisense oligodeoxynucleotide. Optimization of a solid-phase extraction method using copolymer sorbents for isolation of phenolic compounds in red wines and quantification by HPLC.

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Role of p14ARF and p15INK4B promoter methylation in patients with lung cancer: a systematic meta-analysis. Data collection automation and total quality management: case studies in the health-service industry. It has been possible to confirm the instability of glucuronide compounds when added to poorly stored equine urine samples. This is neoral dosing the first report indicating that CHM reduces the cytotoxicity induced by PGD2 or delta 12-PGJ2. lactis Supplementation in Gut Microbiota, Immunity, and Metabolism of Infant Rhesus Monkeys. The development of Plasmodium falciparum in experimentally infected Anopheles gambiae (Diptera: Culicidae) under ambient microhabitat temperature in western Kenya. Human immunodeficiency virus nef gene expression affects generation and function of human T cells, but not dendritic cells. Each EC1-4 molecule makes a helical curve allowing some torsional flexibility to the edifice.

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A metal oxide semiconductor field effect transistor (MOSFET) with its inherent high spatial resolution was used for penumbra measurements in a 120 kVp X ray beam. Based on these data, it is concluded that the efficacy of ginseng root extract is not established beyond reasonable doubt for any of these indications. 24 patients with typical angina and normal arteriogram and 30 normal controls were studied with 201Tl SPECT to evaluate uptake and washout. In this paper, we develop a Fourier-domain approach to full-matrix imaging based on the wavenumber algorithm used in synthetic aperture radar and sonar. Three databases were pooled and analyzed to determine which groupings of prognostic factors best predicted overall survival for patients with low-grade gliomas treated with surgery and immediate or delayed radiotherapy. In this study, we show that two entry-mediating envelope gp, gp B (gB) and gp H (gH), display determinants recognized by TLR2.

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p21 induction in the LNCaP cell line reached a peak 7.5 h post-irradiation. These findings support the notion that the differential regulation of distinct potassium channel beta subunits, in the developing mouse nervous system, may confer the functional diversity required to mediate both neuronal survival and maturation. Myoglobin-containing carbon-paste enzyme microelectrodes for the biosensing of glucose under oxygen-deficit conditions. Taken together, our data demonstrate that AIP1 functions as an endogenous inhibitor in VEGFR2-mediated adaptive angiogenesis in mice. Effects of dietary protein and energy levels on cow manure excretion and ammonia volatilization. We show the importance of finite particle size in microfluidic asymmetric continuous-flow diffusion arrays, specifically the critical nature of the particle size with respect to the barrier gaps. Organic matter, nitrogen, and lead in deposits correlated positively with the atrazine concentration in groundwater. Fine needle aspiration (FNA) biopsy can be used to reliably classify most conditions involving lymph nodes or, at least, significantly reduce the differential diagnosis. Extensive chromatin remodeling after fertilization is thought to take place to allow a new developmental program to start. Multiple studies have shown that for endocardial defibrillation, biphasic waveforms have a greater efficacy than monophasic waveforms.

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We do not discuss the use of testosterone to induce pubertal development in prepubertal males with hypogonadism. Using an accelerated integration scheme to speed up the calculation of particle size distributions in the latter stages, we find that the recently reported experimental results-some of which are summarized here-can be modeled effectively by the two-stage formation mechanism used previously to model the preparation of uniform gold spheres. Given the importance of trust to population health, it is also important to understand individual and neighborhood predictors of trust among residents panadol medicine use in hindi of low-income and minority communities. Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phospho-regulatory pathways that are crucial for normal growth and development and that often become dysregulated in human disease states such as cancer. The aim of this study is to examine the co-occurrences of low serum ferritin and zinc and anaemia among mothers and their children in two agro-ecological zones of rural Ethiopia.

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A prospective, randomized, multicenter trial to determine whether immunotherapy with a vaccine prepared from vaccinia melanoma cell lysates (VMCL) over a 2-year period after definitive surgery would improve relapse-free survival (RFS) and overall survival (OS) in patients with American Joint Committee on Cancer stage IIB and III melanoma compared with a control group treated only with surgery. Functionally the structural changes may lead to negative consequences during vocal production, such as impaired vocal quality and reduced vocal intensity. The purpose of this study was to establish data points (benchmarks) to incorporate into a pro-forma cost analysis model, comparing film-based and filmless modes of operation. No significant increases in the number of mutant zyrtec dosage chart adults colonies or in structural chromosome aberrations were observed in Chinese hamster V79 cells. The possible pathways for realization of antiviral activity of interferon inducer poly (I).poly(C) have been studied. Our results clearly show that ERp57 must be physically associated with the calnexin cycle to catalyze isomerization reactions with most of its substrates. The use of combined oral contraception in premenopausal women also reduces the risk of endometrial cancer but increases the risk of cervical carcinoma significantly.

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The heavy chain genes were subsequently inserted into the corresponding sites of kappa-PComb3Hss plasmid to generate a combinatorial kappa-Fd-PComb3Hss plasmid. Ring-constrained orvinols as analogs of buprenorphine: differences in opioid activity related to configuration of C(20) hydroxyl group. Ocular disease in children with vertically acquired human immunodeficiency virus infection. Intact IGFBP-1, IGFBP-2 and IGFBP-6 act exclusively as growth inhibitors on IGF-dependent proliferation of growth plate chondrocytes. Healthy dietary patterns consisting of adequate fruits and vegetables and limited alcohol consumption are associated with a delay in CKD progression and improved survival in patients with Stage 3 or 4 CKD. The increase of NK activity which took place during the first 5 days after grafting was concomitant with a hyperplasia of the spleen red pulp. Hypothalamic orexin expression: modulation by blood glucose and feeding. This is hampered by the observation of poor tolerability and side effects. A multistep approach in the cytologic evaluation of liver biopsy samples of dogs with hepatic diseases. Abdominal palpation revealed the presence of a large, hard mass in the lower abdomen, measuring about 20 cm in diameter.

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