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Alendronate is used to prevent and treat certain types of bone loss (osteoporosis) in adults. Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases as you age, after menopause, or if you are taking corticosteroid medications (such as prednisone) for a long time.

Other names for this medication:
Alant, Alendix, Alendronate, Alenost, Bifosa, Denfos, Osteofos, Ostogee, Poronil, Ralenost, Restofos, Zophost

Similar Products:
Cytoxan, Rhinocort, Bactrim, Starlix, Microzide, Avodart, Feldene, Protonix, Zyvox


Generic Alendronate is a drug which helps to fight with postmenopausal osteoporosis, steroid-induced osteoporosis, Pagets disease of bone. Generic Alendronate is a medicine which belongs to the group of medicines called bisphosphonates. Alendronate is also known as Alendronic acid, Alendronate sodium, Ostofos. Generic Alendronate works by preventing bone breakdown and increasing bone density (thickness). Generic name of Generic Alendronate is Alendronate. Brand name of Generic Alendronate is Alendronate.


Generic Alendronate should be taken orally. It is recommended to take Generic Alendronate in liquid form once a week in the morning without food. It is recommended to take Generic Alendronate in tablets of 5-mg and 10-mg once a day in the morning without food. It is recommended to take Generic Alendronate in tablets of 30-mg and 70-mg once a week in the morning without food. It is recommended to take Generic Alendronate in tablets of 40-mg once a day in the morning for six months to treat Paget's disease of bone. If you want to achieve most effective results do not stop taking Generic Alendronate suddenly.


Drink a full glass of milk and seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Do not make yourself vomit and do not lie down.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alendronate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Alendronate Plus D if you have low levels of calcium in your blood (hypocalcemia), or a problem with the movement of muscles in your esophagus.

Do not take a Alendronate Plus D tablet if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious problems in the stomach or esophagus (the tube that connects your mouth and stomach). You will need to stay upright for at least 30 minutes after taking Alendronate Plus D.

To make sure Alendronate Plus D is safe for you, tell your doctor if you have:

low blood calcium (hypocalcemia); a cancer such as sarcoidosis, leukemia, lymphoma; a vitamin D deficiency; kidney disease; or an ulcer in your stomach or esophagus.

In rare cases, this medicine may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use Alendronate Plus D, the more likely you are to develop this condition.

Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre existing dental problem.

Talk with your doctor about the risks and benefits of using this medication.

It is not known whether Alendronate Plus D will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether alendronate and cholecalciferol passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

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Shortly after inhibition of protein synthesis by pactamycin administration to re-fed mice, the number of transcribing RNA polymerase I molecules in liver nuclei decreases to the basal level found in nuclei from protein-depleted mice, while in the latter, protein synthesis inhibition has no effect. Two types of intracortical inhibition were assessed by paired-pulse transcranial magnetic stimulation (TMS). Using barium depletion semiempirical relations developed by Palluel and Shroff, it is estimated that 25,000 h of operation remained in the discharge insert at the conclusion of the test. The spectrum of biological systems which makes use of the signal transducers and activators of transcription (STAT) paradigm extends beyond the interferon system in which it was first discovered to include many other cytokines and agonists. Here we report on conjugated polymer fibers with tailored internal molecular order, leading to a significant enhancement of the emission quantum yield. Intraoperative and postoperative pathologic studies were performed at the Institute of Endocrinology and Metabolism, Kyiv. We report a case of Churg Strauss Syndrome (CSS), presenting as septic shock with acute onset of fever and multiple organ failure including pulmonary involvement with severe hypoxemia, hypotension requiring vasoactive support and acute renal failure.

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Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. The recent experience has allowed to test this plan, to precise and correct some of its features. The quality of the images is adequate for detailed cross-sectional evaluation of various corneal pathologies. These data revealed that only the beta-chain of haptoglobin is involved in receptor recognition. Movement related cortical source for elbow flexion in patients with branchial plexus injury after intercostal-musculocutaneous nerve crossing.

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Statistical analysis confirmed that these organizations did not reflect random distributions. The results suggest that HAb impregnated with a chemotherapeutic agent using a simple vacuum system may serve as a valuable new method of administering local chemotherapy, primarily when used as a strut graft for bone defects. Following steroid injection and radial cuts performed either under jet anesthesia or mask ventilation with brief periods of apnea, a small endotracheal tube may be passed beyond the narrowing to permit adjacent balloon dilation with the airway secured. Although the preservation of their genetic expression across animal phyla suggests that MTs may play an important physiological role, MT-I, II knock out (KO) mice survive to adulthood. Isolation and phylogeny of endogenous retrovirus sequences belonging to the HERV-W family in primates. Distraction osteogenesis is a new and reliable technique for lengthening of hard and soft tissue in cranio-maxillofacial surgery. Other known extracellular proteins, such as fibronectin and collagen, did not share common antigenic determinants with sarcolectins. A study was conducted to assess subjective reports of intoxication during the ascending phase of the plasma ethanol curve. Aortic PWV is a powerful independent predictor of mortality in both diabetes and GTT population samples. Butyrate, naturally produced by anaerobic fermentation of diet-fiber, is the major nutrient of colonocytes and also an important regulator of colonic epithelium renewal and physiology.

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In a previous paper the flow and free running speed characteristics of dental air turbine handpieces were discussed. In contrast, jnk2(-/-) mice fed a HFD were obese and insulin-resistant, similar to wild-type mice, and had increased liver injury. These include embryonic sexing using polymerase chain reaction, embryonic sexing using fluorescent in situ hybridization, specific diagnosis using restriction enzymes, sequencing and haplotype analysis. In the polar metabolite analysis, the laminaribiose increase after parasitization was conspicuous in Cuscuta, but not in Cassytha. Administration of heparin significantly increases platelet aggregation in response to arachidonic acid, despite adequate inhibition by aspirin administered preoperatively. A total of 30 consecutive patients underwent placement of a ureteral stent with a stainless steel bead attached to its distal end. Revision of a failed patellofemoral arthroplasty to a total knee arthroplasty.

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Diagnosis and occurrence of functional ST-T changes in the electrocardiogram using the Vasalva maneuver. Endothelial cell proliferation may be mediated via the production of endogenous lipoxygenase metabolites. In the absence of p63, the ventral urothelium was neither committed nor differentiated, whereas the dorsal urothelium was both committed and differentiated. On the basis of the state of LPO it became possible to evaluate the extent of bowel failure. Biosynthesis of trichothecenes requires the involvement of at least 15 genes, most of which have been targeted for PCR.

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Safety and efficacy study with various doses of SS-cream in patients with premature ejaculation in a double-blind, randomized, placebo controlled clinical study. Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cells. Nicotine replacement therapy and smoking cessation: what choice for its status?. However, no differences between the two cell types were found regarding the amount of OFR generation. Moreover, interest in PAHs has been mainly due to their genotoxic, teratogenic, mutagenic and carcinogenic property. This study is to elucidate (1) how about the changes of renal endothelial ultrastructures it is in different time of diabetes animals (2) Whether PPARgamma ligand (such as rosiglitazone: ROS) could improve endothelium destruction in diabetes. Although marginal gaps were undetectable even at high magnification, leakage was observed along the gingival margin of almost all of these Class II resin composite restorations.

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Thus we speculate that the functionally altered premotor-reticulospinal tract which normally controls postural adjustment might play an important role in the generation of myoclonic astatic seizures. Activation of the MEK/ERK pathway increases clonogenic radiosensitivity in rat 3Y1 cells. This study examined the incidence and implications of reported chlamydia cases in Los Angeles County residents aged 50 and older. Despite subsequent revisions, the classification remains too complicated to be of utility in clinical practice and epidemiological research. The knowledge trees for the two outcomes, dental fear and behavior management problems, were very different from each other, suggesting that the two phenomena are not equivalent. Moreover, the information already available in the scientific literature on the toxicity of synthetic polyelectrolytes was analyzed. Ultrasound evaluations of internal jugular vein punction techniques in children: the easiest method to reach the target area. Sulfadimethoxine in giant freshwater prawns (Macrobrachium rosenbergii): an attempt to estimate the withdrawal time by a population pharmacokinetic approach. Utilization of metaphosphate for phosphorylation by cell-free extracts of Mycobacterium smegmatis.

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The ECoG recorded frequent spikes in the anterolateral region of the right temporal lobe consistent with the location estimated by dipole analysis. Given the high levels of psychological distress and low levels of identification, education/training was provided for practice staff, enabling them to develop the use of appropriate screening tools. Pretreatment of mice with the angiotensin-converting enzyme (ACE) inhibitor enalapril, but not the anti-hypertensive hydralazine, decreased pulmonary neutrophil recruitment after exposure to LPS. Intraoperative allograft preparation is not a major source of bone allograft contamination during spinal surgery. The study extended these findings by identifying a number of candidate psychological predictors of PTSD reactions such as perceptions of uncontrollability and absence of support. The availability of soluble active recombinant PPV NIa proteinase will be instrumental for the selection of other proteinase inhibitors with increased affinity and specificity for this proteinase. The cerebrospinal fluid pulse pressure (CSFPP) has found application as a measure of intracranial elastance. Patients were classified in the UUA group when they had been admitted to the critical care unit with unstable angina for 7 days with three failed attempts at weaning them off intravenous antianginal medications.

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Immunochemical detection of the histone-like bacterial protein Hu in covalently bound DNA-protein complexes, obtained in vitro and in vivo. The cAMP-mediated pathway positively regulates Dfos but negatively regulates Djun. Results indicate the need of diagnostic protocols with standardised instruments and prevention plans to reduce pressure ulcers in the community. Commercial assays can now be adapted to detect salivary anti-hepatitis C virus (HCV) antibodies, increasing the potential of saliva as a non-invasive diagnostic specimen suited to surveillance and epidemiological studies. Tiered disclosure options promote the autonomy and well-being of research subjects.

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Prostate-specific antigen rising in Iranian men in correlation with body mass index, fasting blood sugar and blood lipid profile. Of all skin carcinomas diagnosed histologically in DMBA/TPA-exposed mice, less than one singulair montelukast generic -third had been identified clinically while the mice were alive. The common-capture solid phase is monoclonal anti-fluorescein antibody convalently attached to 6.5 micron-diameter latex particles. MicroRNAs are small approximately 22 nucleotide-long noncoding RNAs capable of controlling gene expression by inhibiting translation. 2-3 d after every insemination, 2 ml blood was collected from helix vein of each rabbit, and stored at -40 degrees C for use. A novel myxomatosis phenotype was observed in European rabbits when infected with the recombinant M-T4 RDEL(-) mutant virus. This vector design appears especially suited to bladder transitional cell carcinoma, because of easy access transurethrally and high rate of local recurrence, and biologically secondary to high proportion of telomerase activity and p53 dysfunction. The arthrodesis as a surgical procedure is commonly used, nevertheless important differences may be stated with regard to the choice of the osteosynthesis or the number of the joints to be fused.

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BMPRII mutations contribute to abnormal mitotic responses to BMP ligands in pulmonary artery smooth muscle cells. The slides were analyzed double-blinded by two observers independently. In this article, dermoscopy, an in vivo technique that allows the clinician to evaluate subsurface structures, is described. In vivo HSV-TK gene transfer and the therapeutic effects of ganciclovir on bladder cancer in mice with HSV-TK gene transfer. Novel methods of controlling GTT as well as medical interventions like ICD need further study. Serratia marcescens ocular strains 93-1399-1 and 94-EI-185-2, and an environmental strain (ATCC 14041) were characterized in vitro in terms of their motility, metabolic profiles, ribotypes, and protease production. A variety of biological processes such as response to stimulus and transcription were found to be enriched among the differentially spliced genes. By increasing cell-matrix anchoring, fibronectin may contribute to protect arterial wall components from the increased mechanical loads associated with hypertension. To identify factors that may support the growth of PCa in bone marrow, expression of receptor and nonreceptor tyrosine kinases by androgen-independent PCa bone marrow metastases was assessed. However, few studies have focused on whether data obtained from the patient and doctor differ.

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Strikingly, with the introduction of ectopic p27Kip via an adenovirus vector, there was a marked growth arrest induced in proliferating cultured satellite cells, despite the presence of a strong mitogenic stimulus. Influence of plant growth regulators ivin and emistim C, and flavonoids daidzein and quercetin on the glutamate dehydrogenase activity of soybean nodule bacteria, with contrasting symbiotic properties, were studied. Factors controlling the microbial ecology of the foot are discussed. Medium-chain triglycerides and n-3 polyunsaturated fatty acid emulsions possess unique physical, chemical, and metabolic properties that make them theoretically myambutol antibiotic advantageous over the conventional long-chain triglycerides. Hepatic fascioliasis resistant to bithionol treatment but responsive to triclabendazole. Placebo and graded doses of the mu-opioid receptor agonist DAMGO (0.5 and 2 mg/kg s.c.) and the kappa-opioid receptor agonist U-50,488H (0.6, 1.25, and 2.5 mg/kg s.c.) were administered to the control mice, winners and losers in two experiments. The Ni tolerance mechanism in PR1 is currently unknown, and traditional mechanisms of Ni resistance do not appear to be present. The material is drawn from public records and interviews conducted with the family of the reported victim and others involved in the matter. This may have serious implications in solid-organ transplant deterioration and chronic rejection. The wild or mutant strains judged by RFLP were identified by clone sequencing.

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Western blot and RIBA-3 showed similar sensitivity to the HCV core and NS5 proteins. The records of 24 girls younger than 6 years who presented with vaginal discharge or bleeding were reviewed retrospectively. For example, blood products have a short shelf life, donation is invasive, the glyburide 2 mg industry is heavily regulated, and safety issues restrict the number of eligible donors. The role of such surveys in ongoing evaluation of clinical practice is emphasised. A variety of chalcones have demonstrated cytotoxic activity toward several cancer cell lines. The effects of dexamethasone (Dex), cycloheximide (CHX) or theophylline on CD62L expression on IFN-gamma-stimulated eosinophils were also studied. Deletion of the adenosine A1 receptor gene does not alter neuronal damage following ischaemia in vivo or in vitro. Numerical simulation were made for two breathing conditions: (a) resting or normal breathing condition and (b) maximal exercise condition. Furthermore the maturation process of the style during the flowering time indicates a mechanism by which the stigma becomes shut off through closure at the terminal aperture of the style. Recently, structure-based drug design has resulted in the discovery of a new class of antiviral agents which specifically target the influenza virus neuraminidase.

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Acute tolerance to diazepam in mice: pharmacokinetic considerations. The Durham experience: promoting dyslexia and dyspraxia friendly schools. It is shown that increased self-organization is obtained on silicon substrate. In the Chugoku and Kyushu districts, the patients were divided into a combination of ADM and FT, and FT only group. Several other aspects emerged, indicating a pervasive negativity, with non-delusional aspects of the illness being a major concern.

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The statistical properties of this method are completely independent of the size of the grid. Effect of dysthymia on receipt of HAART by minority HIV-infected women. Quantificational evaluation of the rearrangement reaction was carried out by ninhydrin method and mass weighting. Chloroquine treatment of discoid lupus erythematosus and solar eczema. Acetylcholine receptor (AChR) deficiency is a recessively inherited congenital myasthenic syndrome in which fatigable muscle weakness results from impaired neuromuscular transmission caused by reduced AChR numbers. Saturating amounts of PF4 reduce the porosity of the fibrin network 4.4-fold and decrease the values of the elastic what drug class is lanoxin and loss moduli by 31- and 59-fold, respectively. Restoration of host immune defences by tapering of immunosuppressive therapy in transplant patients or correction of granulocytopenia in haematological disease is the cornerstone of modern treatment of aspergillosis in immunocompromised patients. We suggest that the obligatory p50 subunit in IkappaBgamma.NF-kappaB complexes is equivalent to the N-terminal p50 segment in all p105.NF-kappaB complexes. Preliminary locoregional control rates seem to be higher than those reported for treatment with radiation alone. In all three of these examples, the mechanical behavior of some muscle(s) involved in locomotion are altered, although to different degrees and in different ways.

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Fluorodeoxyglucose positron emission tomography (FDG-PET) investigations were performed in addition to the MRI protocol. Indications and clinical aspects of intraoperative radiation therapy. Risk factors explained little variation in early communication trajectories and therefore, based on our findings, this developmental course is more likely to be biologically predetermined. PQQ was unable to block ATP depletion and cell death induced by NO. The SST correlated highly significantly with the whole-body counting method. Untreated slices and microsomes were incubated in vitro for various periods of time in phosphate-buffered media containing various concentrations of MER, IMI/CIL or for comparison cephaloridine (CPH). Granulomatous Pneumocystis carinii pneumonia complicating hematopoietic cell transplantation. NP formation by salting-out and emulsification-diffusion was related to PVAL chain interactions at the droplet interface (e.g., reduction in the interfacial tension, mechanical stabilization, and steric stabilization) and in the bulk solution (hydrodynamic stabilization). Pharmacological and molecular evidence for dopamine D(1) receptor expression by striatal astrocytes in culture. The present study demonstrated that the two chemotherapy methods play an important role in preventing liver metastasis and improving the survival rate, and the intraluminal chemotherapy would be easier and simpler.

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Artemisia vulgaris is a widespread weed in the Mediterranean area and several allergens have been detected in its pollen. A dimeric protein of 114kDa was obtained that showed proper bispecific binding to CD3- and CD19-positive cells and could redirect both pre-stimulated and unstimulated human T cells for lysis of human B lymphoma lines Raji, MEC-1 and Nalm-6. For instance, HSV virions and genomic DNA are recognized by TLR2 and TLR9, respectively. The oesophagus was replaced by an intracorporal tubulated stomach in the posterior mediastinum. To investigate possible functional effects of -1438A/G on either promoter, two different reporter gene assays were used in three cell lines. Ovarian renin gene expression is regulated by follicle-stimulating hormone. During this time, globalization processes, alongside advances in medicine and epidemiology, have altered the way these pandemics are experienced.

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Diagnosis of pulmonary moniliasis with the aid of serum fungistasis. Cardiac involvement in Mulibrey nanism: characterization with magnetic resonance imaging. The movement of the anterior leaflet of the mitral valve has been recorded with an ultrasound echo technique. Numerous scientific reports describe higher expression of Trx and TrxR in some, but not all tumors. Leucyl-, isoleucyl-, and valyl-tRNA synthetases form a subgroup of related aminoacyl-tRNA synthetases that attach similar amino acids to their cognate tRNAs. Normal electroretinogram indices in children and methods ot its registration.

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