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Alpram (Alprazolam)

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Alprazolam, available under the trade name Xanax, is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder, but also in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpram, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpram is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Alltop, Alparazole, Alpaz, Alprosym, Altin, Altrex, Alwe, Alzac, Alzex, Alzorix, Alzotime, Anilam, Anxicalm, Ateez, Axizox, Berest, Besquil, Betapax, Calmef, Depflu, Depoxit, Endep, Erazol, Exprex, Fludep, Fluzolam, Hiprazole, Mcalm, Mebaspa, Mebrin, Optizole, Pranol, Richpram, Sertamax, Sinaday, Somnirest, Sowel, Tenfree, Unixl, Visram, Zallpam, Zepro, Zolar, Zolin, Zomark

Similar Products:
Abhigra, Imuran, Arcoxia, Imitrex, Astelin

Also known as: Alprazolam


Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


Take Alpram XR exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Alpram XR may be habit-forming and should be used only by the person it was prescribed for. Alpram XR should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Do not crush, chew, or break a Alpram extended-release tablet. Swallow the tablet whole. It is specially made to release alprazolam slowly in the body. Breaking the tablet would cause too much alprazolam to be released at one time.

Contact your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms.

Your symptoms may return when you stop using Alpram XR after using it over a long period of time. You may also have seizures or withdrawal symptoms when you stop using Alpram XR.

Withdrawal symptoms may include blurred vision, trouble concentrating, loss of appetite, diarrhea, muscle twitching, numbness or tingling, or increased sensations.

Do not stop using Alpram XR suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. Do not miss any scheduled visits to your doctor.

Store Alpram XR at room temperature away from moisture, heat, and light. Remove any cotton from the bottle of disintegrating tablets, and keep the bottle tightly closed.

Keep track of how many pills have been used from each new bottle of this medicine. Benzodiazepines are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Detailed Alpram XR dosage information


If you have been prescribed Alpram for medical reasons, the best way to avoid a Alpram overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Alpram consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alpram XR dosage information

Side effects

The most common side effects associated with Alpram are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid drinking alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Grapefruit may interact with alprazolam and lead to unwanted side effects. Avoid the use of grapefruit products.

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Group I mGlu receptors regulate the expression of the neuronal calcium sensor protein VILIP-1 in vitro and in vivo: implications for mGlu receptor-dependent hippocampal plasticity?. Retraction Note to: Evaluation of mRNA expression levels of IL-17A and IL-10 cytokines in cervical cancer. An unknown amino acid was purified from bovine ligament elastin. Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. The patient received radiotherapy, but the general condition deteriorated and died 11 months after tumor detection. Strain-specific brain metallothionein II (MT-II) gene expression, its ethanol responsiveness, and association with ethanol preference in mice.

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The purpose of this study was to identify the facilitators of and barriers to research utilization and to identify research activities and resources needed to promote research among pediatric nurse practitioners. Heart failure (HF) represents a heterogeneous condition characterized by vulnerabilities in the blood, vasculature, and impaired flow dynamics that predispose to both arterial and venous thrombosis. A method of predicting workload and staffing level for radiotherapy treatment planning as plan complexity changes. However, there are numerous reports that adverse effects such as ocular discomfort and headache are associated with these devices. The aim of this study was to determine of influence of 15 strains of lactic acid bacteria on the growth of 7 Salmonella spp. An overview of liquid chromatographic methods, mainly employing fluorescence detection together with sample pre-treatment methods, is presented for the determination of the toxic group of fumonisin mycotoxins in various matrices. MC3T3-E1 cells (pre-osteoblastic cells), human adipose tissue-derived mesenchymal stem cells (HAMSCs), human subcutaneous preadipocytes, and human dermal fibroblasts (HDFs) were each cultured in differentiation medium with or without gadolinium chloride. Influence of older age on survival after radical cystectomy due to urothelial carcinoma of the bladder: survival analysis of a German multi-centre study after curative treatment of urothelial carcinoma of the bladder. Seven populations and five mutant lines of the Andean lupin and four species from the section Albus were screened for their mitochondrial and chloroplast polymorphisms. HIgG adsorption onto the poly(EGDMA-HEMA) sorbents was negligible.

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Therefore, having the knowledge of the variety of implanted orthopedic devices, their manufacturer, and where to find and how to use identifying numbers in such implants can assist in the identification process when traditional methods are not applicable. There were no differences detected in standard BMD, volumetric BMD, markers of bone metabolism or measures of bone strength between the two groups. Models for metal-protein interaction: copper(II) complexes with some substituted cyclic dipeptides. Eighty-six had partial epilepsy and only 3 had abnormal neurological examinations. In this study, we observed neuroblast differentiation in the somatosensory cortex (SSC) and hippocampal CA1 region (CA1), which is vulnerable to oxidative stress, of the mouse at various early postnatal days (P) 1, 7, 14, and 21 using doublecortin (DCX, a marker for neuroblasts). Because submucosal glands express antibacterial proteins, it has been proposed that they contribute to lung defense. This driving simulator study experimentally tested the effects of peer influence (i.e., risk-accepting compared to risk-averse peer norms reinforced by pressure) on the driving risk behavior (i.e., risky driving behavior and inattention to hazards) of male teenagers.

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For T-cell-mediated DHR, the lymphocyte transformation test and enzyme-linked immunosorbent spot appear to be the most promising. The general species of interest were monitored spectrophotometrically, and the results were treated mathematically to facilitate evaluation of the data. Kindler syndrome (OMIM 173650) is an autosomal recessive condition characterized by skin blistering, skin atrophy, photosensitivity, colonic inflammation and mucosal stenosis. However, irreversible electroporation was completely ignored in cancer therapy. In terrestrial vertebrates, it has been associated with development, remodeling, cell turnover, and tissue repair, all processes involving substantial changes in extracellular matrix (ECM) structure. After both treatments, retrieval of a word list (learned 24 h earlier) containing 10 neutral, 10 negative, and 10 positive words was tested.

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Clonal integration in Fragaria chiloensis differs between populations: ramets from grassland are selfish. These findings suggest that subgingivally delivered doxycycline hyclate produces additional favorable clinical results to periodontal therapy in type 1 DM patients. Abnormalities can be identified successfully by mammary ductoscopy, and intraductal biopsy can be used when the tumor is a polypoid type. These findings suggest that serotonergic and nonserotonergic neurons in the DRN are both heterogeneous with respect to their individual pharmacological and electrophysiological characteristics. To our knowledge, this is the third reported case of chylous ascites after a Nissen fundoplication and the second case after laparoscopic fundoplication. Two had AET localized to the inferolateral orifice of the right atrial appendage, one had AET at the posteroinferior orifice of the left atrial appendage. Excited-state energy-transfer dynamics of self-assembled imine-linked porphyrin dyads. The reference sections of included studies were searched for further trials. SIT4 encodes a type 2A-related protein phosphatase that is required in late G1 for normal G1 cyclin expression and for bud initiation.

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Gender-related differences in lipoprotein-associated cardiovascular risk should be considered in choosing treatment options for patients with diabetes and hyperlipidemia. In addition, FSVM trained with TLSPM can reduce the mean square error (MSE) on seven sentiment rating prediction data sets. Selective angiography of the superior mesenteric artery (SMA) established an arteriovenous malformation (AVM). After successful penetrating keratoplasty in the left eye, despite preventive measures, a peripheral corneal perforation also occurred in the right eye. Here we present a 73-year-old female patient with 3-month history of back pain. The main changes in chemical shift of calmodulin resonances are grouped in six structural regions both in NH2- and COOH-terminal domains. Neurodevelopment changes included improved alertness and recognition of caregivers. Functionally, we revealed that LINC00152 dramatically promoted cell proliferation, metastasis and inhibited apoptosis in vitro. Although colour singletons failed to capture attention, a motion signal, based solely on chromatic information, was able to direct attention in the patient.

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Several lines of evidence obtained in previous studies suggest that the increased acetylcholine content in the brain homogenate induced by organic solvents such as toluene may be due to a decrease in acetylcholine release from nerve terminals. Among blunt trauma patients with significant pelvic fractures, those 60 years and older have a high likelihood of active retroperitoneal bleeding. Studies on the reuse of waste printed circuit board as an additive for cement mortar. A model is presented in which the voltage oscillation generated by populations of electrically synchronized inferior olivary neurons permits the utilization of sequences of stimuli given at, or faster than, 2 per second. Assembly of this ternary complex may control organ development and prostate cancer metastasis.

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Participants completed self-reports of academic buoyancy, perceived control, test competence, and cognitive test anxiety, that were matched with examination grades in English, science, and mathematics. Methemoglobinemia is a serious medical condition that affects hundreds of infants in the United States each year. Local somatothermal stimulation was brought about by means of application of a heating rod over and above the left median nerve territory (1.5 cm proximal to the palm crease) in male Sprague-Dawley rats. In sentinel lymph node positive samples, 22/27 samples were correctly classified, in comparison to the correct classification of 55/71 sentinel lymph node negative samples. Separation of plasma lipoproteins in self-generated gradients of iodixanol. Genomics and proteomics have enabled the recent recognition of several additional disorders that lead to neonatal death from respiratory disease. Our in vitro study revealed that Tyr promoter-regulated AdRGD exhibited high transgene expression specificity for melanoma cells, and that TERT promoter-regulated AdRGD could induce efficient gene expression in tumor cells, but was relatively quiescent in normal cells.

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Cardiovascular effects of benidipine and amlodipine in isolated tissues and anesthetized dogs. Receptor tyrosine kinases in normal and malignant haematopoiesis. Understanding the precise molecular mechanisms of leukotoxin is critical for the development of more effective prophylactic and therapeutic strategies to control this complex disease. The size, shape, and absorption coefficient of a microalgal cell determines, to a first order approximation, the rate at which light is absorbed by the cell. Control of circadian and episodic variations of adrenal androgens secretion in man. It appears that giant fibre anomalies occur through increased activity stimulated in occasional muscle fibres, perhaps by a structural defect, such as an inadequate amount of sarcoplasmic reticulum, which causes hyper-contractile activity within the fibres and associated compensatory adaptations. Bladder carcinoma producing granulocyte colony-stimulating factor: a case report.

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No failures of the graft were observed and no patient had recurrence of the malignant tumour at 4 year follow-up. Mycobacterium haemophilum is emerging as a pathogen of immunocompromised patients particularly those with AIDS and organ transplants. Compound scores were calculated for memory function, processing capacity/speed, and executive function. Women were significantly more likely to have had a psychiatric hospitalization than men, which may be related to differential use of services by men and women with the worst level of functioning. Prediction of the multimeric assembly of staphylococcal enterotoxin A with cell-surface protein receptors. In vitro studies were carried out on the nature of immunoglobulin synthesis and secretion by peripheral blood mononuclear leukocytes (PBMLs) and on the function of T and B cells from malaria patients. Segment-specific generation of Drosophila Capability neuropeptide neurons by multi-faceted Hox cues. Measurements over time in luminal diameter signalized differences in arterial remodeling mechanisms between patched and stented carotids. The consensus nucleotide sequences were nearly identical among the four viral genomes analysed, although each strain had three to seven positions in the genome with heterogenous non-synonymous nucleotide subpopulations.

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Fermentation,isolation, structural elucidation and biological activities. They comprise an inordinately large percentage of the more difficult and costly cases. Albumin excretion rate (AER) and sodium excretion rate (NaER) in timed daytime (erect) and night-time (supine) urine collections were assessed in 20 insulin-treated diabetics with and in 20 without established autonomic neuropathy, matched for age, sex, duration of diabetes, diabetic control, and systolic blood pressure. Mammary carcinoma with various histopathological patterns and argyrophilic cells. Here we review various aspects of Hedgehog synthesis, secretion, distribution and function in the context of the most common anomaly of the nifedipine er adalat cc 60 mg 24 hr tablet developing forebrain in humans, holoprosencephaly. Then, a Foley balloon urethra-catheter was inserted and attached just inside the anterior chest wall at the top of the cavity for the evacuation of intrathoracic air. Significance of alkaline phosphatase activity for the x-ray and scintigraphic diagnosis of skeletal diseases.

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Epilepsy and intellectual disability are associated with rare variants in the GluN2A and GluN2B (encoded by GRIN2A and GRIN2B) subunits of the N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion periactin 4mg dose channel with essential roles in brain development and function. During alcohol withdrawal, there was a trend toward decreased startle probability and magnitude in HAD2 rats compared with water-treated controls. For example, nurse-cell nuclei of different ploidy classes are present but, contrary to wild-type follicles, the nuclei show no anteroposterior ploidy gradient. Carbon Balance and Contribution of Harvested Wood Products in China Based on the Production Approach of the Intergovernmental Panel on Climate Change. A follow-up could be planned even for solid pseudopapillary tumors but it seems risky to leave untreated big tumors in young patients without a certain diagnosis and with so few studies reported in the literature. It is associated with an important morbi-mortality and a high rate of readmission. Feeding occurred mainly within these aggregations, probably because individuals experienced less disturbance there than when isolated. Properties of a novel thermostable glucoamylase from the hyperthermophilic archaeon Sulfolobus solfataricus in relation to starch processing. Younger patients appeared to develop IRU later than older patients after HAART, suggesting that long-term follow-ups are essential for these patients.

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Therapeutic outcome over eight weeks of treatment assessed across measures of impulsivity, depression/dysphoria, general psychopathology and global functioning showed significant improvement in all spheres. Chinese nutrition educational materials for renal patients: a 2010 update. Determinants of maladaptive behavior of institutionalized mentally retarded individuals. Numerous studies have provided evidence of the economic, community, environmental, and food quality related benefits of CSAs. In chloralose anaesthetized and paralyzed normotensive (Wistar, Wistar--Kyoto) and spontaneously hypertensive rats (SHR), a somatosympathetic reflex in the cervical sympathetic trunk elicited by a single electrical shock to forelimb afferent fibres in the median nerve was recorded. T-wave morphology is determined by more factors than the TD-TR relation alone. Computed tomographic images of membranes in a pulmonary hydatid cyst. In this study, we report that the death of RDM4 and thymocytes induced by oxysterols exhibits the features of apoptosis. Certain diverse lesions and especially, their different intensity, were observed. Psychophysiological investigations suggested a possible effect of scalp DC in humans.

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This implied difference in vocal production may be useful to teachers and clinicians dealing with multiple genres. Value of plasmatic testosterone determination in female hypertrichosis. A genetic algorithm was used to control the photoluminesce-nce (PL) from GaAs(100). The diagnosis was made by echocardiography and cardiac angiography. Surface electromyograms (EMG) of back muscles are often corrupted by electrocardiogram (ECG) signals. Computertomographic characteristics of primary brain tumors in dogs and cats. The resources of the Chinese glyburide metformin max dose traditional medicine mabo in Guizhou Province. Detailed information on these selectivities and mechanistic information on the origins of this regioselectivity will be described in this critical review (95 references).

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Furthermore, our meta-analysis demonstrates a correlation between the magnitude of salt reduction and the magnitude of blood pressure reduction. CCF patients with elevated plasm levels of TNF-alpha showed a severe course of the disease, low IMT, abnormal myocardial contraction and exercise tolerance. Determination of intracellular levels of 6-mercaptopurine metabolites in erythrocytes utilizing capillary electrophoresis with laser-induced fluorescence detection. Depletion of extracellular calcium resulted in a partial block of ethanol-induced apoptosis. For the couple having trouble achieving pregnancy, the options and opportunities for assistance have never been brighter. Daily changes in concentration of pancreatic and serum insulin and of blood glucose during 5 days of treatment of rats with growth hormone, ACTH, cortisol, dexamethasone, and tolbutamide alone and in combinations. Compared with the results of the operations, DUS correctly diagnosed 6 stenoses, while MRA identified 7 correctly and CTA 8. These data suggest that 5HT may play an important role in the normal increase and maintenance of synapses in developing and adult animals. Spacial distribution of photosynthetic capacity and performance in a mountain spruce forest of northern Germany : II. The management of recurrent acute myelogenous leukaemia at a single centre over a fifteen-year period.

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Cooperative interactions at M2 muscarinic acetylcholine receptors: structure/activity relationships in stepwise shortened bispyridinium- and bis(ammonio)alkane-type allosteric modulators. These results suggest that anti-IL-9 antibody might represent a potential therapeutic agent for allergen immunotherapy in patients with uncontrolled allergic airway disease. The hormone-induced phosphorylation was rapid and dose-dependent occurring on both phosphoserine and phosphotyrosine residues. Postpartum depression (PPD) is a growing mental health concern in new mothers and fathers. Properties of a cytopathic agent isolated from a patient with subacute sclerosing panencephalitis in zetia medication recall Japan.

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These findings suggest that MMPs may play an important role in matrix accumulation associated with progressive renal scarring in this model. Gentle, fast and effective crystal soaking by acoustic dispensing. The application of breast MRI in staging and screening for breast cancer. Multicopy overexpression of flp-21 transformed wild social animals into solitary feeders. It has been proposed that decreased oral fatty acid sensitivity leads to increased fat intake and thus increased body mass. The highly energetic surface of the nanoparticles is significantly more active than the bulk surface in adsorption of nonpolar halogens (Cl(2), Br(2), and I(2)) and dipole interhalogen molecules (ICl, IBr, and ICl(3)). Clinical and experimental studies on blood histamine levels in topical corticosteroid therapy.

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Comparative study of autologous fat vs hyaluronic acid in correction of the nasolabial folds. Stability of the radiolabeled liposomes was assessed in vitro through incubation with human serum. One decision to be made is what specific research question is to be asked, of the many potential questions that could be asked. The current study uses the DNA vaccination technology, and highly specific Abs to the p28 subunit of IL-27 that were generated by this technology, to delineate its role in the regulation of adjuvant-induced arthritis in Lewis rats. Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis. Role of bristle-coated membrane in the uptake of ferritin by rat macrophages. Development and evaluation of new therapeutic approaches is highly needed. Thirty minutes after extubation, the patient complained of chest discomfort with dyspnea. Biologic behavior and prognostic factors for mast cell tumors of the canine muzzle: 24 cases (1990-2001).

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The gender difference in human hunting, likely a product of both ecological and cultural factors, is mirrored by a similar sex difference among nonhuman primates. To determine CDK and MEN contribution to cytokinesis irrespectively of each other, here we present methods to induce cytokinesis after the inactivation of CDK activity in temperature sensitive mutants of the MEN pathway. The issue of widening patient perspective in outcome assessments was raised at OMERACT 2000 and further activities were initiated at the subsequent American College of Rheumatology meetings. Among them, superoxide dismutases (SOD), glutathione peroxidases (GPx), and catalase (CAT) play a central role. The apparent increase of resolution along the Z-axis offered by confocal microscopy makes this technique suitable for such studies. The use of more aggressive radiation regimens and the addition of cytotoxic chemotherapy to radiotherapy have yielded conflicting results. Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase.

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Drug-induced hypersensitivity syndrome (DIHS) is a severe multi-organ system reaction caused by specific drugs. An algorithm is presented for the calculation of the maximum number of hidden layer decision regions in the MLP input space. An electrophysiological and immunological study of patients with carcinoma of the lung. Recent studies suggest that in contrast to this positive role in osteoclastogenesis, c-Fos expression inhibits differentiation and activation of mononuclear phagocytes. Extensive effort has been directed toward a quantitative evaluation of forces which operate between biomacromolecules since the characterization of such forces is essential to a thorough understanding of fundamental biological processes. Mucous cystadenoma of the appendix: is it safe to remove it by a laparoscopic approach?.

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