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Alprostadil

Alprostadil injection is used to treat men who have erectile dysfunction (also called sexual impotence). Alprostadil is used alone or with medical tests to help diagnose erectile dysfunction that may be caused by nerve or blood vessel problems in the penis.

Other names for this medication:
Alpostin, Caverject, Edex, Muse, Prostin, Vitaros

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Description

{name} is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. {name} is also used to improve blood flow in newborn babies with heart problems. This medication guide addresses only the adult male use of {name} in erectile disorders.

{name} relaxes blood vessels and muscles in the penis which increases blood flow, causing an erection.

Dosage

Alprostadil is produced in a liquid form and is administered by injecting it directly into the side of the penis. It is important to make sure that you understand how to do this properly. If you are unsure, consult your doctor or healthcare provider. For the purposes of injecting this medication, always choose a less visible blood vessel. After injecting the medication, apply pressure to the affected area with an alcohol swab for about 5 minutes to avoid bruising. The injection must not be administrated close to the surface of the skin, at the top or head of the penis or at the base of the penis near the scrotum or testes. According to the etiology of the erectile dysfunction, the initial dose may vary: - For vasculogenic or psychogenic erectile dysfunction, or for erectile dysfunction of mixed etiology, the starting dose is 2.5mcg. If there is no effect, you may increase the dose to 5mcg, followed by increments of 5–10mcg until the desired result (dose produces an erection for appropriate sexual intercourse and it doesn't last more than 1 hour). If there is still no response to the initial dose, you may give a second dose of 7.5mcg within one hour, followed by increments of 5–10mcg until the desired result is achieved. - For erectile disorders of neurogenic etiology, the recommended dose is 1.25mcg. You may increase the second dose to 2.5mcg, and the third dose to 5mcg, followed by increments of 5mcg until the desired result is achieved. The maximum dose is 60mcg per day. Allow a 24 hour interval between doses. Use Alprostadil only as needed. Do not take a double dose of Alprostadil.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fainting, painful/prolonged erection.

Storage

Store unopened foil pouches in the refrigerator at 36-46 degrees F (2-8 degrees C). If necessary, this product may also be stored at room temperature below 86 degrees F (30 degrees C) for up to 14 days. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to Alprostadil or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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A frequency stabilization technique for diode lasers based on frequency-shifted beams from an acousto-optic modulator. The LRS collects platelet components with significantly lower WBC contamination without adverse effects on the function or in vivo survival of the platelets. We evaluated the impact of hourly and daily stroke onset variations on the pattern of patient hospital referral and on the time interval from stroke onset to hospital admission and brain neuroimaging investigations. At the practical level I conclude that Bodyworlds should use only willed donations or unclaimed bodies for which dignified funerals are not available. These results from a representative sample of untreated middle-aged hypertensives show that: (i) the metabolic syndrome is highly prevalent in this setting and (ii) despite similar ambulatory blood pressure values, patients with metabolic syndrome have a more pronounced cardiac and extracardiac involvement than those without it. After controlling for demographic characteristics, COBRA eligibility raises the probability of health insurance coverage by 0.095, while eligibility for spouse employer insurance increases the likelihood of coverage by 0.318, and eligibility for both increases the likelihood of coverage by 0.341. Pain is one of the most difficult medical problems to diagnose and treat and can be a common symptom of several psychiatric disorders. These findings provide evidence that the mechanism by which testosterone organizes the genitalia involves a role of the arachidonic acid cascade leading to prostaglandins at a critical period of development and that interference with testosterone synthesis or action leads to a teratogenic deficiency of arachidonic acid during this time in the genital anlagen. DNA sequence analysis revealed a complex pattern of point mutations, deletions and insertions in the sodB, cagA and vacA genes, respectively.

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2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated oxidative stress in CYP1A2 knockout (CYP1A2-/-) mice. Prevalence of electrocardiographical signs of right ventricular arrhythmogenic dysplasia. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. Biopsies were scored as having minimal or high levels of TGFbeta. DNA concatemerization has been modified to reduce issues caused by methylation sensitivity and inefficient cloning. Thermodynamic parameters such as the entropy change, enthalpy change and Gibbs free energy change were found to be 1.68 kJ mol(-1)K(-1), 0.46 kJ mol(-1) and -4.38 kJ mol(-1), respectively. The overall level of the profile is shifted (by an equal amount of current units per electrode) until we find the threshold for live speech (new T levels) and the loudness comfort level (new C levels). From November 1996 through December 2004, 30 patients with stage II or III rectal cancer were enrolled. Sequential implicit (picture fragment completion) and explicit (free recall and recognition) memory tasks were performed by two groups of young adults.

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