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Aplaket (Ticlopidine)
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Aplaket

Aplaket helps to prevent platelets in your blood from sticking together and forming a blood clot. An unwanted blood clot can occur with certain heart or blood vessel conditions. Aplaket is used to prevent blood clots after a recent heart attack or stroke, and in people who have had a stent placed in the arteries that supply blood to the heart.

Other names for this medication:
Aplaket, Astic, Taispin, Ticlantin, Ticlobest, Ticlogard, Ticlogaurd, Ticlop, Ticlopid, Ticlopidine, Ticlovas, Tikla, Tikleen, Tilkon, Tyklid

Similar Products:
Zudena, Precose, Artane, Actos, Maxalt, Azulfidine

Also known as: Ticlopidine

Description

Ticlopidine is used to lessen the chance of having a stroke. It is given to people who have already had a stroke and to people with certain medical problems that may lead to a stroke. Because ticlopidine can cause serious side effects, especially during the first 3 months of treatment, it is used mostly for people who cannot take aspirin to prevent strokes.

A stroke may occur when blood flow to the brain is interrupted by a blood clot. Ticlopidine reduces the chance that a harmful blood clot will form, by preventing certain cells in the blood from clumping together. This effect of ticlopidine may also increase the chance of serious bleeding in some people.

This medicine is available only with a doctor's prescription.

Dosage

Ticlopidine should be taken with food. This increases the amount of medicine that is absorbed into the body. It may also lessen the chance of stomach upset.

Take this medicine only as directed by your doctor. Ticlopidine will not work properly if you take less of it than directed. Taking more ticlopidine than directed may increase the chance of serious side effects without increasing the helpful effects.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For prevention of strokes: Adults—1 tablet (250 mg) two times a day, with food. Children—It is not likely that ticlopidine would be used to help prevent strokes in children. If a child needs this medicine, however, the dose would have to be determined by the doctor. For prevention of strokes or heart attack following heart stent procedure: Adults—1 tablet (250 mg) two times a day, with food together with your doctor's recommended dose of aspirin for up to 30 days following the procedure Children—It is not likely that ticlopidine would be used to help prevent strokes or heart attack in children. If a child needs this medicine, however, the dose would have to be determined by the doctor

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Aplaket dosage information

Side effects

The most common side effects associated with Aplaket are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Basal cells of the chlorophyte Stigeoclonium dominated communities exposed either to low light or high grazing pressure. The inducing activity of the high-speed supernatant is enhanced under these conditions. It is concluded that the imidazoleacrylic acid antagonists share some interactions in TM-VII of the AT1 receptor with the biphenylimidazole antagonists, but the binding of the imidazoleacrylic acid compounds is uniquely dependent on His256 in TM-VI, possibly through the carboxyphenyl moiety. Functional stenosis due to large shunting volumes in patients with arteriovenous malformations and in the presence of significant collateralization of extracranial obstructive lesions were similarly diagnosed. Long-term reflux control seems to be similar after laparotomy and laparoscopy. In disrupted particles, an envelope was visible but no internal structure could be resolved. Direct sulfonation of methane to methanesulfonic acid with SO2 using Ca coming off the progesterone only pill side effects salts as promoters. Keratosis obturans is a rare condition characterized by the accumulation of desquamated keratin material in the bony portion of the external auditory canal. This technique can be used to compare two mRNA populations and obtain cDNAs representing genes that are either overexpressed or exclusively expressed in one population as compared to another.

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Our objective was to determine the frequency of use of CAM by HIV-positive patients in Thailand. The main associations with infection of cephalhaematomas are instrumental assisted deliveries and sepsis, followed by the use of scalp electrodes, skin abrasions and prolonged rupture of membranes. Microalgae are recognized as a natural source of carotenoids and other beneficial byproducts. In percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy, it is not the speed of intracoronary alcohol injection but the amount of alcohol injected that determines the resultant infarct size. Recently the molecular mechanisms by which mechanical stress increases bone mass and immobilization induces osteopenia have been elucidated. Psilochilus is a poorly studied orchid genus distributed from southern Mexico to south-eastern Brazil. Naive BALB/c mice received an intratracheal injection of ovalbumin (OVA)-pulsed DCs obtained from the bone marrow of wild-type (WT) or CD80/CD86-/- mice and were subsequently challenged with OVA aerosol to address the role of costimulation during sensitization. It is shown zetia 5 mg that the foreseen concentration of general antigenic determinants is observed in S- and SR-zones of LPS represented by O-chains of different length.

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Under fasting conditions, the concentrations of histidine in rabbit liver vary in the range required for activation of fructose bisphosphatase, and the enzyme itself is modified so that it becomes more responsive to histidine. It has been well shown by human and animal studies that mechanical load is an important regulator of skeletal mass and architecture. Skin infiltrates were the dominant clinical sign with conspicuous perivascular aggregations of T, E, Fc gamma lymphocytes, though both patients initially had disseminated disease with mild lymphadenopathy, splenomegaly and, in case 2, also hepatic infiltrations. Serotonin and urocortin 1 in the dorsal raphe and Edinger-Westphal nuclei after early life stress in serotonin transporter knockout rats. Rapid Progression in Early-Stage Primary Glioblastoma Multiforme:A Case Report. Liver parenchymal maintenance and regeneration after injury are physiologically supported by 3 cell compartments: mature liver cells, intra-organ stem cells such as mebeverine maximum dosage cells of the proximal biliary tree and periductal cells, and extra-organ stem cells from the circulation and the bone marrow. Previous reports described verified treatment failure of urogenital gonorrhoea using the internationally recommended first-line drug cefixime, but not with ceftriaxone, the last remaining option for empirical treatment of gonorrhoea. To the best of our knowledge, only seven cases of adrenal alveolar echinococcosis have been reported, all from the Far East.

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Autophagy, a form of lysosomal degradation capable of eliminating dysfunctional proteins and organelles, is a cellular process associated with homeostasis. The drug is indicated for use with other antiretroviral agents in treatment-experienced patients who have evidence of HIV replication despite ongoing antiretroviral treatment. Blood samples were collected on every follow-up visit for PSA measurements. To investigate ownership and perceived utility of written asthma action plans (WAAPs) in general practice. Experiments were designed to investigate hemodynamic parameters in vivo as well as the consequences of CG treatment on the vasoconstriction response to norepinephrine and the vasorelaxant response to ACh ex vivo in isolated aortas and small mesenteric arteries (SMA).

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Using both neuron- and glial-enriched cultures obtained from fetal rat hypothalami we found that addition of beta E2 elicited a significant increase in IGF-I receptor levels in neurons, without affecting its affinity. In the present work, we characterize electrophysiologically a commissural subcortical pathway which is related to binocular interactions in the nucleus of the optic tract (NOT) of the opossum. H-bonding between protein surface polar/charged groups and water is one of the key factors of protein hydration. Conopy architecture of Larrea tridentata (DC.) Cov., a desert shrub: foliage orientation and direct beam radiation interception. Efficacy of pazopanib and sunitinib in advanced axial chordoma: a single reference centre case series. Participants included 195 Head Start children from 32 classrooms representative of a large, urban Head Start program. Serum MGMT methylation predicted response and time to progression in BCNU-treated GBM patients. Twelve patients had elevated serum dehydroepiandrosterone sulfate (DS) levels (high DS group) suggestive of increased adrenal androgen production. To investigate the feasibility of alendronate (ALN) in treating osteoarthritis (OA) by observing the effects of ALN on interleukin 1beta (IL-1beta) induced chondrocytes of rat in vitro.

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As GPCR internalization and trafficking affect receptor signaling and vice versa, we aimed to investigate the molecular mechanism of hY4R desensitization and endocytosis. The published method had erroneous headspace calculations listed and n-butanol could not be recommended as a training odorant because of its irritancy. Phenotypic variation within a species arises from differences in genetic makeup between individuals. The goal was to determine if the HPV16 L1 VLP vaccine protected against HPV16 infection. GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. Few data are available to assist clinicians with decisions regarding long-term use of asthma therapies, including omalizumab. Identification and molecular characterisation of DNA damaging agent induced expression of Plasmodium falciparum cabergoline tablet image recombination protein PfRad51.

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