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Aplatin (Clopidogrel)

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Aplatin is an antiplatelet medicine, or blood thinner. It works by preventing cells called platelets from sticking together and helps to prevent your blood from clotting inside veins and arteries. This helps the blood flow freely around your body thereby preventing a heart attack or stroke (or deep vein thrombosis or pulmonary embolism).

Other names for this medication:
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Also known as: Clopidogrel


{name} (clopidogrel) prevents platelets in your blood from sticking together to form an unwanted blood clot that could block an artery.

{name} is used to lower your risk of having a stroke, blood clot, or serious heart problem after you've had a heart attack, severe chest pain (angina), or circulation problems.


Usual Adult Dose for Acute Coronary Syndrome:

Unstable Angina (UA)/Non-ST-Elevation Myocardial Infarction (NSTEMI): -Loading dose: 300 mg orally once -Maintenance dose: 75 mg orally once a day -Duration of therapy: Optimal duration unknown. ST-Elevation Myocardial Infarction (STEMI): -Loading dose: 300 mg orally once (OPTIONAL) -Maintenance dose: 75 mg orally once a day, with or without thrombolytics -Duration of therapy: Optimal duration unknown. Comments: -Administer this drug in combination with aspirin 75 mg to 325 mg orally once a day. -The benefit of this drug for patients who undergo primary percutaneous coronary intervention is unknown. Uses: Prevention of atherothrombotic events in patients with non-ST-segment elevation acute coronary syndrome (UA, NSTEMI, those who are to be managed medically, those who are to be managed with coronary revascularization) and STEMI.

Usual Adult Dose for Ischemic Stroke:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Myocardial Infarction:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Peripheral Arterial Disease:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Detailed Aplatin dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause excessive bleeding.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aplatin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid alcohol. It can increase your risk of stomach bleeding.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

If you also take aspirin: Ask a doctor or pharmacist before using medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to aspirin (such as salicylates, ibuprofen, ketoprofen, or naproxen). Taking these products together can increase your risk of bleeding.

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In this report we show that almitrine interferes with the binding of basic fibroblast growth factor and vasculotropin/vascular endothelial growth factor to their receptors present on vascular endothelial cells, smooth muscle cells or retinal pigment epithelium. BMMC consistently yielded a greater number of DCs than PBMC, and there were fewer macrophages than DC from both compartments. We believe that systematic elimination of lactose from the diets of these patients is erroneous. Obstetric care: Supply and demand care in three valleys of the western High Atlas region of Morocco (Anougal, Azgour and Imnane). This report presents the surgical management of a patient with a mandible fracture after inferior alveolar nerve transposition with concurrent placement of two endosseous implants. Very little is known about the pathophysiology of somatization disorder. False detection of Plasmodium falciparum sporozoites in Anopheles marshallii group mosquitoes. Alterations in pharmacologic receptor activity by dithiothreitol.

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The decay of the charge-transfer excited state occurs exponentially with a time constant of approximately 280 fs and is modulated by well visible oscillations. CD images were then acquired on FFDM for kVp values from 23-35 for a molybdenum-molybdenum (Mo-Mo), 23-40 for a molybdenum-rhodium (Mo-Rh), and 25-49 for a rhodium-rhodium (Rh-Rh) target-filter under the constraint of matching the AGD from screen-film for each breast thickness (2, 4, 6, and 8 cm). Hepatocellular carcinoma (HCC) is a malignancy with high incidence worldwide. Characterisation of senescence-induced changes in light harvesting complex II and photosystem I complex of thylakoids of Cucumis sativus cotyledons: age induced association of LHCII with photosystem I. Screening for LVSD among high-risk patients is feasible and has substantial yield, even among patients without prior MI. Repair and deletion frequencies of the linearized plasmids were measured after transformation of E. Drinking in the monkey evoked by nicotine or angiotensin II microinjected in hypothalamic and mesencephalic sites. Ryegrass staggers (RGS) is a metabolic disease of herbivores, caused by the ingestion of perennial ryegrass (Lolium perenne L.) containing a fungal endophyte (Neotyphodium lolii) which produces a tremorgenic toxin, lolitrem B.

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A cohort of 13 patients with a final diagnosis of essential hypertension was chosen as the control subjects. Both anxiety sensitivity and pain-related anxiety were significantly and uniquely predictive of post-challenge panic attacks, total post-challenge panic attack symptoms, and intensity of cognitive panic attack symptoms. Deficient activity of glucocerebrosidase in urine from patients with type 1 Gaucher disease. In patients with extraocular disease, there were three partial responses, two cases of stable disease, and one case of progressive disease. The second part is concerned with directional hearing and thus with the ability for angular resolution of insects. We identified all articles of four related publications by searching Chinese and foreign databases from 1997 to 2001. Genetic biomarkers such as isocitrate dehydrogenase 1 (IDH1) mutations, low expression of excitatory amino acid transporter 2 (EAAT2), high xCT expression, overexpression of adenosine kinase (ADK) and low expression of very large G-protein-coupled receptor-1 (VLGR1) are primarily involved in synaptic transmission, whereas BRAF mutations, epidermal growth factor receptor (EGFR) amplification, miR-196b expression and low ki-67 expression are associated with regulation of cell proliferation. Hispanic men presented with higher PSA and higher grade prostate cancer than white men. Interestingly, NRH1 does not require Dishevelled (Xdsh) for the activation of these downstream effectors or translocation of Xdsh to the membrane, suggesting that NRH1 signalling interacts with planar cell polarity signalling downstream of Xdsh.

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Liquid-based cytology allows for standardized and reproducible endometrial preparations, which in turn allows the application of common diagnostic criteria among cytopathologists. Prenatal manifestation and management of a mother and child affected by spondyloperipheral dysplasia with a C-propeptide mutation in COL2A1: case report. The effector immediate-early gene (IEG) arg 3.1, also called arc, encodes a protein interacting with the neuronal cytoskeleton. The purpose of this paper is to create interest in a less well-known but equally useful principle that complements the Three Rs, which was proposed by the American biomathematician Carol M. Detection of DNA adducts at the DNA sequence level by ligation-mediated PCR. Association of a sex-related difference of Strongyloides stercoralis-specific IgG4 antibody titer with the efficacy of treatment of strongyloidiasis.

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A reversed-phase ion-pairing high-performance liquid chromatography (RP-HPIPC) method for the separation of a complex mixture of heparin-derived oligosacchrides has been developed by a stepwise optimization of the mobile phase, in which the concentration of ion-pairing reagent, mobile phase pH, and acetonitrile concentration were varied. Central actions of atrial natriuretic polypeptides in spontaneously hypertensive and normotensive rats. We should pay attention to ischemic complications in clipping because DMCAs are easily deformed. A 4.5-year follow-up retrospective study on the use of epiphysiodesis procedure for juvenile hallux valgus deformity and metatarsus primus adductus deformity shows a good reduction of deformity in nine patients with minimal change in one patient that can be explained due to the timing of the procedure. All four patients had histologic evidence of preservation injury on the initial post-OLT biopsies, but the significance of this finding in relationship to the development of what kind of medication is risperdal NAFLD is unknown. Spikes were irradiated at early meiosis to determine whether acentric fragments carrying subtelomeric heterochromatin were able to behave as neocentromeres. The presence of increased 5alphaR1 in some prostatic malignancies suggests that it is worthwhile to investigate the use of a dual 5alphaR inhibitor to prevent or treat early stage prostate cancer. Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma. Identification of antigens by monoclonal antibody PD4 and its expression in Escherichia coli.

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Statistical analysis of disease association was carried out using the Cochran-Armitage test for trend. This is particularly true for nonessential amino acids such as proline, an amino acid often used in isotopic form to measure collagen synthesis. Antioxidant activities of extracts and metabolites isolated from the fungus Antrodia cinnamomea. The initial pattern of restenosis is the most important predictor of recurrent restenosis or the need for subsequent reintervention. In addition to melanoma, gastric and uterus cancer tissues exhibited higher HSP73 mRNA expression on a matched tumour/normal cDNA array than their normal counterparts which was statistically significant. Because these high-flow lesions may be suboptimally responsive to stereotactic radiosurgery, microsurgical resection, with or without adjunctive endovascular embolization, should be considered as an initial and definitive treatment strategy. Young, elderly, and memory-disordered subjects studied weakly associated word pairs and sentences. We present the clinical and ophthalmological findings in two infants with neonatal Marfan syndrome (nMFS) and primary trabeculodysgenesis (PT).

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Stereotactic anterior cingulate lesions for persistent pain: a report on 68 cases. Although PMA does cause increased expression of cell surface C3b and C3bi receptors, the sequential rise and fall of receptor activity cannot be accounted for by alterations in the number of surface receptors. The present study aims to evaluate a set of oxidative stress biomarkers in the amniotic fluid (AF) of women carrying what are the side effects of the drug actos Down syndrome (DS) fetuses that could prove in vivo the early occurrence of oxidative damage in DS. The H/ACA ribonucleoproteins (RNPs) are known as one of the two major classes of small nucleolar RNPs. Each germ line cell can be identified by the pattern of cell-cell connections which reflect the mitotic history of individual cells in the 16-cell cluster. Direct DOC and nitrate determination in water using dual pathlength and second derivative UV spectrophotometry. In the current study, we show that the murine CD94 gene has two promoters, one of which is upstream of a previously unidentified exon. In contrast, training in relational reasoning improved performance on that task in all age groups, but training benefits were greater for people in late adolescence and adulthood than for people earlier in adolescence.

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Irritable bowel syndrome (IBS) is a common intestinal disorder that includes continuous or recurrent intestinal pain and discomfort and altered bowel habits. Equipment for dynamic, on-line, measurement of morphology and rheology is available, but little used in filamentous fermentations. This study evaluated the shear bond strength of repairs made with a composite (Herculite/Kerr bactrim dosing chart ) when two different surface treatment methods and two new generation bond materials were used. However, cholinergic neurons of the same type have been found to atrophy, hypertrophy or not change at all, according to various reports on different species and genotypes. To evaluate the influence of various factors on the progression of LEA atherosclerosis, the authors estimated overall survival without progression of CLEI.

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The purpose of this study was to understand how phosphorus uptake relates to the phenology of R. All affected rats were descendants of one of two brother-sister breeding pairs established from a single litter in April 2000. Hearts from chimeric LEW rats (with BN DC) were transplanted to untreated BN rats. Impairments in social functioning were highly associated with hemispheric side of damage in adults, but not in children: Specifically, adults with right hemisphere lesions developed social defects much more frequently than adults with left hemisphere lesions, whereas this asymmetry was not ribavirin brand evident in the children. Chromosome regions 17q21 (BRCA1) and 10q23 (PTEN) have been found deleted in colorectal cancer. We studied the kinetics of testosterone metabolism by the constant infusion of 3H-testosterone in six postmenopausal women with breast cancer prior to and during Tamoxifen therapy.

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In a group of 10 patients with SLE, the mean auto-MLR and allo-MLR responses, tested by tritiated thymidine incorporation, were significantly decreased. The implications of these results for endothelial cell IL 1 receptor function are discussed. Nearly all patients infected with HIV experience respiratory infection at some point in the course of their illness. Patients with WLST differ in terms of demographic, arrest, and post-arrest characteristics and treatments from those who did not have WLST. In particular, EphB1 and coreg dose 25 mg EphB3 receptor knockout mice exhibited significantly diminished DPOAE levels as compared to wild-type littermates, indicating that these specific Eph receptors are necessary for normal cochlear function. In the absence of a universally agreed upon framework that integrates physical, social, and cultural aspects of the environment, we used a multidimensional model of access to synthesize the literature. This policy uses a method to determine excess readmission ratios and calculate readmission payment adjustments to hospitals, however, it is unclear whether readmission rates are an effective quality metric.

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