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Aplenzin (Bupropion)

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Aplenzin is used to treat depression and to prevent depression in patients with seasonal affective disorder (SAD), which is sometimes called winter depression. It is also used as part of a support program to help people stop smoking.

Other names for this medication:
Aplenzin, Budeprion, Bupdep, Bupraset, Bupron, Bupropion, Ession, Nicotex, Smoquit, Unidep, Zyban

Similar Products:
Lioresal, Aceon, Bystolic, Celebrex, Levitra, Combivent

Also known as: Bupropion


{name} SR is an antidepressant used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Too much of this medicine can increase your risk of a seizure.

You may take Aplenzin XL with or without food.

Swallow the extended-release tablet whole and do not crush, chew, or break it.

You should not change your dose or stop using Aplenzin XL suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

If you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the first 2 weeks of treatment. Talk to your doctor if you have trouble quitting after taking Zyban for 7 to 12 weeks.

Your doctor may prescribe a nicotine replacement product (such as patches or gum) to help you stop smoking. Start using the nicotine replacement product on the same day you stop (quit) smoking or using tobacco products.

Some people taking Aplenzin XL (Aplenzin or Zyban) have had high blood pressure that is severe, especially when also using a nicotine replacement product (patch or gum). Your blood pressure may need to be checked before and during treatment with this medicine.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

You may have nicotine withdrawal symptoms when you stop smoking, including: increased appetite, weight gain, trouble sleeping, trouble concentrating, slower heart rate, having the urge to smoke, and feeling anxious, restless, depressed, angry, frustrated, or irritated. These symptoms may occur with or without using medication such as Zyban.

Smoking cessation may also cause new or worsening mental health problems, such as depression.

This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use Aplenzin XL.

Store at room temperature away from moisture, heat, and light.

Detailed Aplenzin XL dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F)away from moisture, light and heat. Do not freeze. Keep foil packaged capsules in their original foil until needed. Throw away any unused medicine after the expiration date. Keep out of reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aplenzin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Aplenzin SR if you are allergic to it, or if you have:

a seizure disorder; an eating disorder such as anorexia or bulimia; or if you have suddenly stopped using alcohol, seizure medication, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others).

Do not use an MAO inhibitor within 14 days before or 14 days after you take Aplenzin SR. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Do not take Aplenzin SR to treat more than one condition at a time. If you take this medicine for depression, do not also take Aplenzin SR to quit smoking.

Aplenzin SR may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

Tell your doctor if you have ever had:

a head injury, seizures, or brain or spinal cord tumor; narrow-angle glaucoma; heart disease, high blood pressure, or a heart attack; diabetes; kidney or liver disease (especially cirrhosis); depression, bipolar disorder, or other mental illness; or if you drink alcohol.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Ask your doctor about taking this medicine if you are pregnant. It is not known whether Aplenzin SR will harm an unborn baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of bupropion on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Aplenzin SR is not approved for use by anyone younger than 18 years old.

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More high-quality worldwide studies performing a multivariate analysis based on larger sample size are urgently required for further verifying and modifying our findings in the future. Individuals with schizophrenia demonstrated intact ToM skills in conversational interactions. In the honey bee vitellogenin is present not only in the hemolymph of fertile queens, but also of infertile nurse workers in colonies. Each of eight patients with bilateral microtia and atresia underwent bilateral reconstruction of the auricles and external auditory canals and were fitted bilateral canal-type hearing aids in the operated ears to replace a bone conduction hearing aid. We have purified two of these proteins, designated MSP fiber proteins (MFPs) 1 and 2 and demonstrated by immunolabeling that both are located in the MSP cytoskeleton in cells and in fibers. Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes. Mitochondria are localized to regions of the cell where ATP consumption is high and are dispersed according to changes in local energy needs.

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All parties within the end-stage renal disease (ESRD) community seek the best value (quality/cost) when receiving, delivering, or paying for ESRD services. The outcome of these patients was compared with the outcome of 53 patients who had ectopic pregnancy without fetal cardiac activity and were being treated only by systemic injection of methotrexate during the same period of time. Dynamical Model of Drug Accumulation in Bacteria: Sensitivity Analysis and Experimentally Testable Predictions. Accuracy was calculated as mean difference between the actual and the calculated rotation, and precision was calculated as the standard deviation of the differences. The data also indicate that masker level plays a role independent of signal level, an effect that could be accounted for by assuming greater internal noise at higher stimulus levels. Prospectively, magnetic alignment can be used to improve specific properties of organogel materials. The p75(NTR) tumor suppressor induces caspase-mediated apoptosis in bladder tumor cells. Two were laser-cut stents (Neuroform and Enterprise) and two were braided from a single nitinol wire (LEO and LVIS stents). The induction potential of different fibric acid derivatives on human drug metabolizing enzymes was evaluated to help assess the role of enzyme induction on pharmacokinetic drug interactions.

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Twenty-four hour patterns of plasma luteinizing hormone and follicle-stimulating hormone in sexual precocity. However, in an increasing number of houses, no indications were found for elevated levels of mould growth. Finally, the clinical relevance of circulating tumour cells is still debatable, although recent published studies show interesting results. Atrial natriuretic factor and renal function during head-out water immersion in conscious dogs. Recently, an aqueous two phase system (ATPS) is emerged as powerful tools for efficient extraction and purification of enzymes due to their versatility, lower cost, process integration capability and easy scale-up.

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Additionally, perioperative epidural analgesia confers physiologic benefits, which may potentially decrease perioperative complications and improve postoperative outcome. Of those, 32 sets were assessed by ten radiologically experienced dentists. Furthermore, our findings may facilitate marker-based breeding efforts aimed at improving fatty acid composition and quality in B. Analysis of the stone revealed a composition of bile pigments and calcium oxalate. Primary hyperparathyroidism has been associated with increased incidence of morbidity and mortality of the cardiovascular system. Dexamethasone alters plasma levels of beta-endorphin and postoperative pain.

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Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia. The other sibs were both prenatally diagnosed with renal disease, polydactyly, and the Dandy-Walker malformation, an unusual central nervous system defect in MS. Similarly, CT scan data did not explain the observed TPD differences in TBI survivors. Increased energetic states at the nanoscale and the energetically favorable configuration of individual copper atoms within silica, identified through EXAFS, are suggested as the cause of nanoparticle disappearance. The effect of age on the discriminative stimulus effects of ethanol and its GABA(A) receptor mediation in cynomolgus monkeys. In recent years, new drugs, and new formulations of old drugs, have been developed that are able to effectively inhibit GH secretion or GH action, and may represent important adjuncts or even alternatives to the traditional approaches of surgery and radiotherapy. Apart from getting new insights into the molecular pathogenesis of HPV-associated cervical carcinogenesis, we anticipate the disclosure of individual markers, a set of markers, or an expression profile of any such marker sets that would be of clinical value as predictors of disease outcome in cervical carcinogenesis. Sub-adult and adult caimans migrated from permanent lagoon refuges to temporary lagoons during the wet season. These results contrast those of Walker (1987) where sex-linked loci of major effect on morph determination were identified in crosses between long-wing and short-wing-selected strains of G. The compressible strain sensor also shows good reliability after long cyclic tests and can be used to detect large strains induced by walking or running motion.

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Fourteen patients with severe respiratory failure and coagulopathy underwent elective percutaneous tracheostomy using Portex percutaneous tracheostomy kit. To fulfil this role, nurses need to be able to assess readiness for change and the factors that enable it and then to intervene in ways that facilitate readiness. Endoscopic pancreatic sphincterotomy however, is still not widespread and carries a significant risk of complications. Regulation of adiponectin in human immunodeficiency virus-infected patients: relationship to body composition and metabolic indices. The effect of grasses on the quality of transmitted radiation and its influence on the growth of white clover Trifolium repens. Nevertheless, pregnancies in such areas are associated with substantial malaria-related morbidity and mortality, particularly among women of low parity. Barrett esophagus: epidemiology, incidence of carcinoma, need for screening. According to the results of this study, within the family Galeodidae, the validity of the genus Galeodopsis is supported, while the validity of the genus Paragaleodes still remains uncertain. The waiting time for heart interventions: trends for percutaneous coronary interventions and cardiothoracic interventions.

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Furthermore, ROCK protein expression was also significantly lower in CM than EECS as demonstrated by Western blotting. FFAs are known to exert a variety of physiological responses via their G protein-coupled receptors (GPCRs), such as the GPR40 family. In adult animals, the rate of corticosterone metabolism was unaffected by stress, but the administration of phenobarbital raised the rate of metabolism of the corticosterone side chain in the sediment fraction obtained by centrifugation at 10,000 X g. Hepatotoxicity of teucrin A also was increased following pretreatment with the inhibitor of glutathione synthesis buthionine sulfoximine. The levels of alcohol consumption and homicide in Russia are among the highest in the world, and there is mounting evidence that the two are related.

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Macrophage migration inhibitory factor (MIF) is a ubiquitous protein that is found in virtually all cells. The expression of recombinant human bone morphogenetic protein-2 (rhBMP-2) did not show distinct difference comparing with the control, but beta transforming growth factors (TGF-beta) benefited the expression of CNTFs during nerve regeneration. Normal electrical activity is not required for the formation of specific sensory-motor synapses. The masseter SICI was significantly decreased following 10-Hz rTMS, with no significant changes in AMT, MEPs or CSP. The mTOR inhibitor rapamycin has similar inhibitory effects on G(1) cell cycle progression and expression of cyclin D1, CDK4, and Rb phosphorylation. Cellular production of this CC chemokine during toxoplasmosis may be regulated by a PC-PLC-dependent pathway. Women and the practice and teaching of medicine in Bologna in the eighteenth and early nineteenth centuries. The conducting bronchial trees in the lungs display complex self-similar structure.

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Surgical Methods and Experiences of Surgeons did not Significantly Affect the Recovery in Phonation Following Reconstruction of the Recurrent Laryngeal Nerve: Reply. Surprisingly, five of the 24 papers were difficult to read and interpret mostly because of a poor mastery of the English language. Simulation experiments indicate that BiChroM performs well with little to no bias and relatively little variance at a wide range of tree depths when trees have at least 500 taxa. Several compounds from marine organisms have been studied for their potential use in aquaculture. As a result, Ad vectors are continually undergoing refinement to realize their potential for gene therapy application. Nevertheless, clinical successes have been limited because of the redundancy of many cancer-related pathways as well as the high degree of variability in genotype and phenotype among individual tumors.

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Evaluation of interactive online courses for advanced practice nurses. Along these lines, this review covers the metabolism studies of berberine in terms of its metabolic pathways and metabolic organs based on the identified metabolites, and it also covers the pharmacological activities of its active metabolites. The spatial scale of genetic diversity among patches of a host plant could affect the likelihood of pathogen adaptation to the host. This study demonstrates the close connection between T(H)2 cytokines and eosinophil infiltration. Fate of myelinated fibres in the optic nerves in experimental Creutzfeldt-Jakob disease in rodents: an ultrastructural study. In 36 genotyped XLHED patients and 29 control subjects aged 0-57 years, pilocarpine-induced sweat volume, palmar sweat pore density, and palmar skin conductance before and after stimulation were determined. This is possible by inducing heterogeneous nucleation of the crystals on the surface of single walled carbon nanotubes. The purpose of the present investigations was to identify potential key mediators of these pain syndromes by analyzing detailed expression profiles of important chemokines in an experimental SCI paradigm of posttraumatic neuropathic pain in rats.

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Cleavage of the second component of complement by plasma proteases: implications in hereditary C1-inhibitor deficiency. Prevalence of bi-component pore-forming toxin genotypes of Staphylococcus aureus causing skin and soft tissue infections. This population-based study shows that in addition to previously well described risk factors, several others could be associated with intrahepatic cholangiocarcinoma. Prompt recognition of associated popliteal artery disruption and early revascularization is paramount for successful and functional results. Computer reconstructions provided a three-dimensional view of the positions of substance P- and tyrosine hydroxylase-like immunoreactive neurons within the subdivisions of the dorsal motor nucleus of the vagus nerve. Therefor, here it is proposed to use the xenogenic anticarcinogens antibodies for the active immunotherapy of leukemia and other lymphoproliferative neoplasms. When cecal diverticulitis is pre-operatively diagnosed it may be treated medically. After a brief theoretical section, the method is demonstrated on the estimation of the rate and extent of gentamicin bioavailability after intratracheal administration to guinea pigs.

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Taken together, our findings reveal a new regulatory mechanism of miR-501-5p and suggest that miR-501-5p might be a potential target in gastric cancer therapy. The opposite effects of IgE and IgG4 were undissociable in the analysis, indicating that these isotypes probably antagonize each other does rulide treat sinus infection in protection. Basal cell carcinoma of the anal margin is about 15-fold less common than squamous cell carcinoma. Our results highlight an astonishing plasticity of mRNA in its ability to adapt to evolutionary constraints, that contrasts with the extreme conservation of the rRNA-binding site. Department of Ophthalmology, Henry Ford Health System, Detroit, Michigan, USA. Phenotypic and genotypic heterogeneity among closely related soil-borne N2 - and N2 O-producing Bacillus isolates harboring the nosZ gene. Gen-17.1A significantly inhibited colon cancer cell growth in vitro and in vivo. During a routine dissection of an adult embalmed male cadaver for educational purpose in the department of anatomy at AIIMS, New Delhi, India, a rare unilateral variation of extensor digitorum longus (EDL) was found which is a muscle of anterior compartment of the leg.

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The distinctive pattern of abnormalities that characterizes fetal alcohol syndrome (FAS) includes: pre- and postnatal growth retardation, cognitive deficit, behavior and language disorders, cerebral malformations (schizencephaly, polymicrogyria, agenesis of the corpus callosum), facial changes (short palpebral fissures, low nasal bridge, anomalies of the auricle, maxillary hypoplasia, cleft lip and palate) and organ anomalies (heart defects clomid cost uk , renal and skeletal malformations). Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation. The current review will consider studies that focused on qualitative data including, but not limited to, designs such as phenomenology, grounded theory, ethnography, action research and feminist research. There is also strong evidence that diabetes causes apoptosis of neural and vascular cells in the retina. Human immunodeficiency virus, although it does not increase in pathogenesis during pregnancy, requires specific attention and management in the context of pregnancy. The late demyelinating changes seen on magnetic resonance imaging of the brain support an immunological basis for the paraneoplastic manifestations of occult neuroblastoma in this child. The aim of the study was to examine the relationship between age, shift work exposure, shift type, and morningness and sleep/health problems in oil rig shift workers. Cross-sectional analysis of the Cervical Spine Research Society Outcomes Study, a longitudinal multicenter cohort study. Improving communication with the older patient: overcoming the physical barrier of a hearing loss.

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Studies on graft survival and posttransplantation complications have often yielded conflicting results. In the latter case, evidence of trade-off between lexical-semantic complexity and sentence length was sought. p175 was identified as alpha 2-macroglobulin by N-terminal amino-acid sequence determination and immunoprecipitation with a specific antibody. The sample type comparison study was performed at 4 different hospitals. The application of metal nanoparticles (NPs) in catalysis has drawn significant research interest, including in their applications to the wastewater treatment. The storage and release of transmitter substances from Helix neurones. The current review examines the cooperation of genetic and endocrine influences from the perspective of behavioral and morphological hypothalamic sexual differentiation, first in adults and then in development. During her pregnancy, she did not experience any symptoms such as vaginal bleeding or abdominal pain. An initial amplification with one primer in excess in order to overproduce one strand of the target, and 2. Prognosis as the basis for selection of the method of treatment of patients with preclinical and clinical stage I cervical cancer.

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Menopausal symptom evaluation scales and psychological questionnaires were administered, and cardiovascular disease markers in blood were analyzed at the beginning and the end of the trial. The genome size (153,429 bp), arrangement, and inverted-repeat (IR)-lacking structure of the B. A micellar electrokinetic chromatographic (MEKC) separation of glutamate (Glu) enantiomers fluorescently tagged with naphthalene-2,3-dicarboxaldehyde (NDA) is described. Body weight was not well correlated with the diagnosis of dementia but was correlated with poor appetite and immobility. Published research and review articles in the English language related to the role of TGF-beta in acute lung injury. Characterization of bovine immortalized luteal endothelial cells: action of cytokines on production and content of arachidonic acid metabolites. We developed four estimation methods that focused on the antibiotic-resistance attributable costs of hospitalization, second-line inpatient antibiotic use, second-line outpatient antibiotic use, and antibiotic stewardship, then summed the estimates across all methods. Hot carriers at metal surfaces can drive nonthermal reactions of adsorbates. Recently, evidence has been put forward that brain death has significant effects on the donor organ quality. The villages were organized in the framework of Primary Health Care.

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All 10 papers reported on human factor issues possibly mediating effects of patient-centered eHealth. Eclampsia, a major cause of maternal and perinatal mortality: a prospective analysis at a tertiary cardizem drug guide care hospital of Peshawar. From 1980 to 1983 the Swiss Group for Clinical Cancer Research (SAKK) performed a randomised phase III trial in patients with small-cell lung cancer with the objective of improving the results of induction chemotherapy and defining the role of consolidating chest irradiation. aureus growth was poor and sed expression was too low to determine. The push towards miniaturized electronics calls for the development of miniaturized energy-storage components that can enable sustained, autonomous operation of electronic devices for applications such as wearable gadgets and wireless sensor networks.

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Chalk and cheese: symptomatic hypocalcaemia during paediatric anti-tuberculous therapy. We found that the identification of the local shape was faster when individual objects reliably co-occurred immediately next to each other as triplets (local regularities, Experiment 1). Many studies have attempted to evaluate the pathophysiology of spinal cord trauma, hypoxia, and variations in the local environment of the spinal cord using a variety of animal models. To identify factors contributing to retention of clinical laboratory practitioners. The authors examined the mortality rate in geriatric patients receiving either haloperidol or atypical antipsychotics. Thus, the finding that a diet rich in antioxidants or drug class of zithromax the elimination of ROS by antioxidant compounds prevents the development of certain cancers provided the setting for subsequent investigation of the tumorigenic actions of reactive oxygen species. However, pitting was observed in different places on the stainless steel surfaces.

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Peripheral-blood mononuclear cell responses to recombinant hepatitis C virus antigens in patients with chronic hepatitis C. All animals underwent angiography, and gross inspection of the anastomotic site was done after excision of the hearts. In all, 31 renal cell carcinomas (RCCs) were examined for expression of the potential tumour suppressor LRIG1 (formerly Lig-1) and the epidermal growth factor receptor (EGFR). We gave Australian native bees, Austroplebia australis, the choice between two white daisies, Chrysanthemum frutescens, one of them occupied by a crab spider. The subsequent decline in cortical porosity is responsible for the continued increase in radial bone density after cessation of growth, referred to as consolidation. This study included 216 randomly selected patients with redundant prepuce or phimosis and 85 normal male controls.

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MRI-guided osseous biopsy is a safe and accurate technique for the diagnosis of pediatric CRMO lesions that are visible on MRI only. Efforts are needed to improve empirical measures of HIV prevalence, incidence, and mortality among children. Antibacterial and antifungal activity of juniper berry oil and its selected components. Scale of assessment of positive symptoms (SAPS) was completed for each subject. Ovariectomized (Ovx) or sham-operated (Cnt) and tetracycline-labelled growing rats were fed either a commercial powdered standard rat diet (Ovx and Cnt) or a high-sucrose diet (Ovxsuc and Cntsuc). Cannabis is an interactive cardiovascular risk factor (additional to tobacco and opioids), shows a prominent dose-response effect and is robust to adjustment. Three-dimensional excitation emission matrix fluorescence spectroscopic characterization of the complexation between mercury (II) and dissolved organic matter. Tissue-type plasminogen activator (tPA) in breast cancer: relationship with clinicopathological parameters and prognostic significance.

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Use of specifically labelled sucrose for the quantitative zithromax dosage kids assay of levansucrase activity. Combining stable insect cell lines with baculovirus-mediated expression for multi-HA influenza VLP production. From pooled serum containing genetically homogeneous transferrin C1, transferrin was purified and separated in three fractions (tri-tri, bi-tri- and bi-bi-antennary transferrin C1), using Concanavalin A-Sepharose. Congenic DA.ACI rat strains localized Eae18 to an approximately 30-Mb large region. Quantitative electroencephalogram examination of effects of risperidone in schizophrenic patients. The model is fitted by maximum likelihood to national HIV-1 and AIDS diagnosis data from 1980 to 2006, estimating parameters on average changes in unsafe sex and time to diagnosis. The residual phase variations are due to fluctuations of the pump power.

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