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Aprical (Nifedipine)

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Aprical is used to treat hypertension (high blood pressure) and angina (chest pain). Aprical is in a class of drugs called calcium channel blockers. Aprical relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.

Other names for this medication:
Addos, Afeditab, Aprical, Belnif, Cardules, Chronadalate, Coracten, Coral, Cordafen, Cordalat, Cordipin, Corinfar, Emaberin, Epilat, Farmalat, Fedip, Fenidina, Hypan, Milfadin, Myogard, Nefelid, Nelapine, Nidipine, Nifatenol, Nifcal, Nifecard, Nifecardia, Nifediac, Nifedin, Nifedipina, Nifedipine, Nifedipino, Nifelat, Nifensar, Nifeslow, Nifezzard, Nilol, Nycopin, Ospocard, Sepamit, Tensomax, Vasdalat, Xepalat, Zenusin

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


Aprical should be taken orally with or without food. It is better to take Aprical at the same time every day. Take on an empty stomach. Avoid grapefruit juice during treatment with Aprical. If you want to achieve most effective results do not stop taking Aprical suddenly.


If you overdose Aprical and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Aprical dosage information

Side effects

The most common side effects associated with Aprical are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

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An in vitro assay for evaluation of small-molecule inhibitors of cholesterol absorption. Comparison of psychopathology in the mothers of autistic and mentally retarded children. Arginine kinase: differentiation of gene expression and protein activity in the red imported fire ant, Solenopsis invicta. All suicide attempters were examined concerning seriousness of the attempt, and DSM-IV diagnosis. Carbohydrate-deficient glycoprotein syndrome type IA (phosphomannomutase-deficiency).

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Upon reoperation 4 months after the initial laparotomy, a successful total radical gastrectomy with R2 (partially R3) lymph node dissection was performed. The ileal loop urinary diversion was constructed by pulling the small bowel through the hand port incision. Evaluation of multiple bio-pathological factors in colorectal adenocarcinomas: independent prognostic role of p53 and bcl-2. Global workload scores fell in the midrange of the NASA Task Load Index, with scores on the Frustration subscale increasing linearly over time. During the past decade, endodontics has seen a dramatic shift in the application of periradicular surgery and the role it plays in endodontic treatment. A Clinical Practice Guideline (CPG) to manage acute sickle cell pain offers clinicians a standardized approach for the provision of evidence-based, cost-effective care. Simulations examining multiple ion configurations suggest a two-ion channel. JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration. Specifically, the dual-channel hypothesis predicted that objective and subjective social engagement would enhance positive affect (PA) but be unrelated to depression. To examine the relationship between growth rate of vestibular schwannomas and the expression of various growth factor receptors.

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FDG-PET showed moderate sensitivity and specificity for the detection of locoregional metastases, and reasonable sensitivity and specificity in detection of distant lymphatic and hematogenous metastases. Bioabsorbable interference screws are used in aperture fixation for anatomic fixation of each bundle. However, if the cause of uninterpretability is related to disease status or to the potentially observable test result, then this approach will lead to bias. Polymyalgia rheumatica and temporal arteritis: the endocrine relations and the pathogenesis. We review four major published studies involving animals and humans that may be linked together in a unified hypothesis and justify a comprehensive approach in the treatment of this ever-increasing syndrome. The purpose of this study is to estimate the prevalence of this disorder in people aged 65 and older visiting the primary care physician in 5 health sentinel networks.

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Three months after injection, microscopy of optic nerve sections was performed. Aminoguanidine had no effect on the severity of the pancreatitis. These characteristics make hydroxyurea a good candidate for long-term treatment of HIV infected individuals. Mixture toxicity of the antifouling compound irgarol to the marine phytoplankton species Dunaliella tertiolecta. These compounds were studied by two different analytical approaches: tetramethyl ammonium hydroxide (TMAH) thermochemolysis in combination with gas chromatography-mass spectrometry (GC-MS), and solvent extraction, fractionation by silica column, and identification of the fraction components by GC-MS.

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Structure of acutolysin-C, a haemorrhagic toxin from the venom of Agkistrodon acutus, providing further evidence for the mechanism of the pH-dependent proteolytic reaction of zinc metalloproteinases. Primary cicatricial or scarring alopecias (CA) are a group of inflammatory hair disorders of unknown pathogenesis characterized by the permanent destruction of the hair follicle. Adult intensive care units participating in the Acute Respiratory Distress Syndrome Network trials. Structure and dynamics of DNA-dendrimer complexation: role of counterions, water, and base pair sequence. The children who co-sleep were significantly younger and there was a decrease in the practice with increasing age.

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Typical differentiation inducers that upregulate neuronal and astrocytic markers in sphere cultures, increase the level of ATG mRNAs. Six months postoperatively, global quality of life and pain approximated norm reference values indicating optimal recovery. The promise of myocardial repair--towards a better understanding. Logistic regression analysis showed an association between the vision outcomes of EDTRS letter and BA6 degrees with the change in SRF thickness (R (2): 0.47 and 0.35, respectively). Therefore, the present study was designed to examine the possible difference between the discriminative stimulus effects of TRK-820 and U-50,488H in rats. The synthesis of new tetrahydrobenzo- and benzopsoralen derivatives carrying at position 5 or 8 of the furocoumarin moiety a methoxy, hydroxy, or dimethylaminopropoxy side chain is reported. Here we describe some of the background principles in NO sensors design, methodology and their applications. The survivors show normal hands, feet, cranium and psychomotor development. cornutus larvae caused specific curtailment of mandibles in adults, whereas HDAC3 KD led to hypertrophy.

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Contribution to the pathology of multiplex endochondral dysostosis. Hospitalizations for varicella in the United States, 1988 to 1999. By contrast, we detected integrated proviruses in cells analyzed 32 to 60 days after in vitro transformation. Item response theory analysis of diagnostic criteria for alcohol and cannabis use disorders in adolescents: implications for DSM-V. Hepatic encephalopathy: a review of its pathophysiology and treatment. We found that Vav1 deficiency is sufficient to disrupt DAP10-mediated cytotoxicity, whereas lack of Vav2 and Vav3 profoundly impairs FcRgamma- and DAP12-mediated cytotoxicity. The predilection for prostate cancer screening among healthcare providers declines with increasing patient age but persists for a small proportion of patients.

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Nervous tissue engineering in combination with other therapeutic strategies is an emerging trend for the treatment of different CNS disorders and injuries. We found antibodies to a variety of influenza virus subtypes (H10N7, H4N6, H4N2, H3, and H1) with wide geographic variation in seroprevalence. Distinct cellular factors regulate the c-myb promoter through its E2F element. Matrix proteins versus cytokines in the regulation of osteoblast function and bone formation. This investigation examines the effects of prolonged exposure to microgravity upon lower limb endpoint kinematics. Comparison of the chlorinating agents was performed in terms of the assortment and relative amounts of reaction products.

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With the rise in popularity of alternative or complementary medicine, all physicians will encounter patients using TCHMs. Determinants of plasma potassium levels in diabetic ketoacidosis. We measured VEPs in two monkeys using a dynamic random-dot display in which a stereo-defined checkerboard reversed in depth. The study included 2 health communication interventions-modified delivery of pre-antiretroviral therapy (pre-ART) counseling sessions and SMS reminders-and 3 structural interventions-point-of-care CD4 testing after diagnosis, accelerated ART initiation, and noncash financial incentives. This review discusses recent advances cozaar drug classification in opiate-addiction treatment in the context of three main domains: the use of buprenorphine and buprenorphine/naloxone in an office-based paradigm, psychosocial treatment and the addressing of medical and psychiatric comorbidity, and harm reduction strategies. The soil bacterium Rhizobium lupini H13-3 has complex right-handed flagellar filaments with unusual ridged, grooved surfaces. We derive estimators of the proposed predictive performance measure and study their distributional properties and the corresponding inference procedures.

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This study examines how systemic biomarkers of endothelial function and nitric oxide metabolism are affected by exercise in dogs. Benign familial proximal amyotrophy with late onset (presentation of a case with dominant hereditary transmission). Mann-Whitney U and Wilcoxon rank tests were used for statistical analyses. Expression of CSF-1, CSF-1R, and GM-CSF mRNA was measured by RT-PCR. An investigation was conducted to study insulin-like growth factor (IGF)-I, IGF-II, insulin, glucagon, leptin, triiodothyronine (T(3)), and thyroxine (T(4)) levels in a chicken population divergently selected for P bioavailability (PBA). Terpenoids, 1, 2 and 3, which selectively inhibit eukaryotic DNA polymerase activities, were isolated from the fruiting body of a basidiomycete, Ganoderma lucidum, and their structures were determined by spectroscopic analyses. PRIMe (, the Platform for RIKEN Metabolomics, is a Web site that has been designed and implemented to support research and analysis workflows ranging from metabolome to transcriptome analysis. In addition, we demonstrate direct writing of complex patterns that exhibit high conductivity upon annealing at sufficiently low temperature ( side effects of zebeta 5 mg 175-210 degrees C) to not damage the transparent plastic substrate such as polyethersulphone (PES).

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Congenital duodenal obstruction: does prenatal diagnosis improve the outcome?. ATA-ACA bypass is anatomically feasible and may be a useful alternative to other revascularization techniques in selected patients. In particular, this tendency was very high in the case of sintered bodies of HAP/PSZ with weight ratios of 1/1.0 and 1/1.5, the shear strength for each reaching 20 MPa 12 months after implantation. We study two challenging systems--zinc metalloenzymes and silicon oxide cages--and demonstrate that electronic embedding shows significant improvement over mechanical embedding. The exams were realized in the period between 1995 and 2003, in is plavix an antiplatelet drug one of three 1.5 Signa GE units (Milwaukee, WI). Amifostine stimulates the formation of hematopoietic bone marrow progenitors from B-cell chronic lymphocytic leukemia.

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Evaluation of the distensibility of the arterial system by the study of the ratio I-A of the carotidogram (experimental and clinical correlations). Not wisely but too well: aging as a cost of neuroendocrine activity. Quantum algorithm for programmed cell death of Caenorhabditis elegans. During danazol treatment, there was a blunted response of E2 to injections of human menopausal gonadotropins. Electrical resection: new concept in management of focal epilepsy. They underwent complete exploration and cleansing of the pericardial cavity. Immunogold was limited to the circumferential microtubule in resting platelets and constricted coils in thrombin-activated cells. There was a similar impairment of function in paired kidneys with and without renal artery stenosis, but occlusion was associated with zithromax liquid dosing chart children significant reduction in function compared to the contralateral kidney.

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A maximum on axis dose of 46 mrad has been measured at 1 m distance from the source. CRT was associated with stabilization of renal function in patients with severe LV dysfunction and improvement in stage 4 and 5 CKD. These variations in GSTM may be due to polymer size and/or structural change within the polymer. New instrumental and laboratory investigations are now available. In this ELISA, the calibration curve showed a strong correlation between the concentration of the synthetic N-myristoyl-biotinylated octapeptide and the absorbance, indicating that this system may be useful for enzyme kinetics studies.

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He was sitting on the lap of the driver and his abdomen was pressed closely between the pregnant driver and the steering wheel. These findings confirm the usefulness of phosphatase inhibition by peroxovanadate as a tool for identifying previously unknown physiological targets for cellular protein tyrosine kinases. Consistent with these results was the finding that no transcriptional induction of Cdk inhibitors such as p21Waf1, p15Ink4b, and p27Kip1 was detected following TGF-beta1 treatment. Computer aided comparative analysis of the binding modes of the adenosine receptor agonists for all known subtypes of adenosine receptors. To evaluate the clinical outcomes of patients with localized retroperitoneal soft tissue sarcoma (STS) treated with complete surgical resection and radiation. These findings do not provide support for the notion that this gene plays a major role in the etiology of RA.

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Seventy-six percent had attended an endodontic course in the past three years and 85 percent wanted to attend a course. Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection. The CALUX activity pattern of the crude extract and the retention times of 26 polycyclic aromatic compounds (PACs), as determined by RP-HPLC on an octadecylsilica column, suggested that the dioxin-like compounds with the log K(OW) (n-octanol/water partition coefficient) values corresponding to 6.0-7.0 contributed highly to the whole activity. The Grb2 adaptor protein is best known for its role in signaling to the small GTPase p21(ras), mediated through its interaction with the SOS guanine nucleotide exchange factor. Fasting insulin and insulin responses to oral glucose were significantly increased in obese subjects, who also tended to have more dyslipidemia, greater blood pressure, and more visceral fat than lean subjects. Carbon/carbon composites have excellent biocompatibility with human hard tissue and elasticity modulus similar with that of human bones, which endow them great potential applications in substitution for human loaded bones. A contribution to the solution of the problem of the free end prosthesis. Studies of this phenomenon may provide a novel perspective on cancer in women, including in breast, ovarian, and lung cancers. A comparison between open and arthroscopic meniscectomy (medical contribution to cost control).

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The oxidative metabolites of estrogen have been proposed to play an important role in the development of some human cancers. Crude sewage and sewage-contaminated natural waters were analysed for the presence of Salmonella by Most Probable Number Procedures, Direct enrichment in NR10 at 37 degrees C and 43 degrees C was compared with preenrichment in buffered peptone water at these two temperatures, followed by selective enrichment in NR10 at 37 degrees C and 43 degrees C. We hypothesize that the yield of biopsy varies with its indication or suspected diagnosis. The 86-kDa IE2 protein of human cytomegalovirus (HCMV) is an important regulator of viral and host cell gene expression. The previously removed implant and another implant in each tibia were then both removed while recording the removal torque. Here we describe a multifaceted approach including genome mining, transcriptional induction, phytoalexin quantification, protein expression and enzyme purification that led to identification of a S. The recombinant human endostatin had an inhibitory effect on rat AA, which was related to its anti-angiogenesis and inhibition of proinflammatory cytokines.

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Furthermore, coralline hydroxyapatite and direct current electrical stimulation can be used together to increase fusion rates in a rabbit spinal fusion model while avoiding the morbidity associated with harvesting iliac crest bone. Field and laboratory experiments showed that these changes in tail morphology could be induced by chemical and tactile cues from snakes. Given its specificity of activation, optical stimulation may also provide a useful tool in the study of fundamental neuroanatomy and neurophysiological processes. The results suggest a new hypothesis that, in susceptible women, use of oral contraceptives induces production of IL-6, which stimulates production of anti-beta2-glycoprotein I. Dehydrozingerone elicited a concentration-dependent inhibition of PDGF-stimulated VSMC migration, proliferation, collagen synthesis, and PDGF/H2O2 neurontin max dose -stimulated phosphorylation of PDGFR-beta and downstream Akt. Identification and characterization of novel low-density lipoprotein receptor mutations of familial hypercholesterolaemia patients in Taiwan. Low-level exercise echocardiography provides a promising alternative to LDDE for identifying myocardial viability and predicting reversible dysfunction early after AMI.

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This paper examines the optimization process in detail and demonstrates that the commonly used multiresolution local optimization methods can, and do, get trapped in local minima. Effects of prenatal gamma irradiation on the development of the corpus callosum of Swiss mice. Effect of dietary supplementation with fish oil on systolic blood pressure in mild essential hypertension. Branched endovascular stent-graft for suprarenal aortic aneurysm: the future of aortic stent-grafting?. The 1993 National Mortality Followback Survey of 22 957 deaths in the United States, representing 2.2 million people, conducted by the National Center for Health Statistics. Information was obtained with regard to the specific anatomic location of the superior and inferior resection margins, the grade of subglottic stenosis preoperatively, the type of stenting material used postoperatively, and other surgical details specific to each procedure.

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