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Aptic (Cyproheptadine)
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Aptic

Aptic belongs to a group of medicines called antihistamines. It is used in the treatment of various allergic conditions. It relieves symptoms of inflammation as well as itching, swelling and rashes. It is also used to treat loss of appetite (need for food). It is an effective hunger stimulant.

Other names for this medication:
Actin, Anabol, Apectin, Apeline, Apeplus, Apetamin, Apitol, Apitus, Appetidin, Aptan, Aptic, Aptivin, Becyp, Bonapet, Cadictin, Ciplactic, Ciprohep, Cyper, Cyperton, Cyphoden, Cypratin, Cyprodol, Cyprohemtadin, Cyproheptadine, Cyprorin, Cyprosine, Cyproson, Cypta, Cytodine, Decyp, Dezire, Hepoline, Hypetin, Monic, Neurophas, Normatone, Osactin, Perizor, Prohep, Rarritol, Sycyp, Toractin, Zeeto

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Also known as: Cyproheptadine

Description

Generic Aptic is used to treat fever, nasal inflammation, stuffy nose, red and inflamed eyes, hives, swelling and other symptoms of cold and allergy. Generic Aptic blocks the effects of the naturally occurring chemical histamine in your body. Aptic is also known as Cyproheptadine, Ciplactin, Aptice, Ciproral. Generic name of Generic Aptic is Cyproheptadine. Brand name of Generic Aptic is Aptic.

Dosage

Generic Aptic can be taken in tablets (4mg) and syrup. You should take it by mouth. Take Generic Aptic by mouth with or without food. Measure the syrup form of Generic Aptic with a special dose-measuring spoon or cup. If you want to achieve most effective results do not stop taking Generic Aptic suddenly.

Overdose

If you overdose Generic Aptic and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Aptic overdosage: extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, seizure.

Storage

Store at room temperature between 15 to 30 degrees C (59 to 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aptic are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Aptic if you are allergic to Generic Aptic components. Try to be careful with Generic Aptic if you're pregnant or you plan to have a baby, or you are a nursing mother. Generic Aptic can harm your baby. Do not take cyproheptadine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Be careful in taking Generic Aptic if you have glaucoma or pressure in the eye, stomach ulcer, enlarged prostate, bladder problems, difficulty urinating, hyperthyroidism, hypertension, any problems with heart, asthma. Be careful with taking Generic Aptic if you use anxiety or sleep medicines such as alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), or triazolam (Halcion); anti-depression medications such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), fluoxetine (Prozac), sertraline (Zoloft), or paroxetine (Paxil); any other medications that make you feel drowsy, sleepy, or relaxed. Avoid machine driving while taking Generic Aptic. Avoid alcohol. Do not stop taking Generic Aptic suddenly.

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Inflammatory periodontal disease is one of the most common diseases of mankind. To what extent does visual feedback shape the coordination between our arms?. However, little is known about early treatment processes that facilitate retention in treatment and positive outcomes of PD treatment. A prospective multicenter observational study, matched-pair analysis of 902 patients receiving ceftriaxone or standard therapy (second-generation cephalosporin, broad-spectrum penicillin or a combination of aminopenicillin and beta-lactamase inhibitor) in 75 hospitals yielded 173 pairs matched for definite risk criteria. Iron saturated LF failed to inhibit PHA-induced proliferation, suggesting that the mechanisms of suppression involve the chelating property of LF. Thus, soluble vimentin enables spatial translocation of pErk by importins and dynein in lesioned nerve. The key steps in the submonomer synthesis are the installation of an appropriately protected 2-aminoethyl group on the alpha-nitrogen of an amino acid and its subsequent acylation with a protected nucleobase derivative.

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Life cycle energy and greenhouse gas analysis of a large-scale vertically integrated organic dairy in the United States. Molecular engineering refers to a collection of complex, computer-based methods used to study molecular structures and properties. Four phases (assemblage, conglomeration, cell membrane destruction and decomposition) can be characterized in the process of cell death with increasing decoction dose. The generation of a physical map as an integral part of sequence project management is a problem that present computer systems do not address. CRISPR-Cas9 has quickly become the technology of choice for genome editing due to its simplicity, efficiency and versatility. Environmental interactions were detected for 18 of the main-effect QTLs and 14 of the epistatic interactions. Therefore, two binding sites, one unique to MCR1 and the other shared with MCR2, are involved in MCR1 binding to C3b. In contrast to these acute effects, sPLA(2) from both groups IB and IIA have been shown to induce neuronal cell death via apoptosis. Bacterial superinfections are the most common cause of mortality during influenza epidemics. In this article, we have examined the intracellular behaviour of a Pseudomonas aeruginosa quorum sensing regulator RhlR believed to be important in this process.

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MMS-mutagenized yeast clones were screened for increased sensitivity to ciclopirox olamine. The methods rely on generation of libraries of random nucleotide sequences, selection of molecules possessing the desired property from these libraries, and amplification of the selected molecules. The decreases from baseline observed in tenidap-treated patients were significantly greater than the changes observed in naproxen-treated or placebo patients. Shorter Wait Times for Autism Intervention Is a Win-Win-Win for Kids, Parents, and Taxpayers. Twenty-seven permanent molars with deep carious lesions underwent partial caries removal with the application of CH, RMGIC, or gutta percha (control) and were then sealed for three months. The angioplasty procedure was successfully performed in seven of eight cases (spasm of the left internal mammary artery precluded successful dilatation catheter passage in one case). Ten patients with total and one with partial anomalous pulmonary venous connection were studied by two-dimensional Doppler color flow-mapping echocardiography. Using renal cancer cells, we confirmed that stauprimide inhibits NME2 nuclear localization. In particular, there is a predisposition to develop central nervous system and peripheral nervous system neoplasms. Patients with EPP who develop liver disease usually have a mutation in one ferrochelatase allele that alters enzyme function, together with a polymorphism in the nonmutant allele that causes low gene expression.

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AICRG, Part V: Factors influencing implant stability at placement and their influence on survival of Ankylos implants. This process which is called reconsolidation involves destabilization of the memory after it is reactivated, followed by restabilization. The potential predictive value of MRI and PET-CT in mucinous and nonmucinous rectal cancer to identify patients at high risk of metastatic disease. Clinically distinct presentations of copper deficiency myeloneuropathy and cytopenias in a patient using excessive zinc-containing denture adhesive. A re-evaluation of the effects of lesions of the pontine tegmentum and locus coeruleus on phenomena of paradoxical sleep in the cat. NK1 and NK2 receptors mediate tachykinin and resiniferatoxin-induced bronchospasm in guinea pigs. Long-term survival outcomes in patients with surgically treated oropharyngeal cancer and defined human papilloma virus status. As a strong warning towards uncritical use of the output from a PCA, we employ a newly developed procedure to judge the effective dimensionality of a specific data set. In the present study, we have analyzed the pattern of Trx h expression in developing wheat ( Triticum aestivum L.) seeds. Bone loss is a common feature of periodontitis and osteoporosis.

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However, other proteins including Bcl-2 family members, heat shock proteins, caspase-like decoy, calpains and proteases, and lipid moieties in the form of phosphoinositides also can function as caspase inhibitors. Regulated chromatin domain comprising cluster of co-expressed genes in Drosophila melanogaster. The Renal Treatment Satisfaction Questionnaire (RTSQ): a measure of satisfaction with treatment for chronic kidney failure. The present study was done to confirm this incidence of breakage. The mean age group of students in both the schools was 14 years. Preceptors indicated that PA students had frequent interactions with a wide variety of health professionals and students. Traditional healers and the management of sexually transmitted diseases in Nairobi, Kenya.

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It provides policy-relevant information to balance financial and non-financial incentives for different cadres and profiles of staff. Anhigh-performance liquid chromatography (HPLC)/diode array detector (DAD)/mass spectrometry detection (MSD) with electrospray method was developed in order to detect, confirm and quantify clobazam in the post-mortem samples. Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India. Aglycones, 7-OH-HBOA and HBOA, were isolated together from root extracts of Acanthaceae species. The CrGAP gain-of-function phenotype mimics the loss-of-function phenotypes of both Robo and Rac. Our results indicated that anterior procedures performed solely by our senior orthopedic surgeon had a lower incidence of complications, less blood loss, and shorter operative time than anterior procedures performed by an orthopedic surgeon and a vascular or a general surgeon.

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Five of the mutations greatly reduced or completely eliminated DNA secretion. The distinctive feature of this honey is that it is stored naturally in the pot (cerumen), thus contributing to its beneficial properties, especially in the wound healing process. Effects of inference on dopaminergic prediction errors depend on orbitofrontal processing. Fertility preservation strategies have been developed for many years, and recently diversified thanks to advances in reproductive biology. Effects of enzyme supplementation of a total mixed ration on microbial fermentation in continuous culture, maintained at high and low pH. Initial research and clinical development has focused on anti-pneumococcal applications.

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The importance of the five major causes of death was analysed by cause-elimination life tables. Experimentally tractable, pseudo-elastic constitutive law for biomembranes: II. We demonstrate that this modified vector efficiently delivers siRNA into multidrug-resistant human breast and oral cancer cells and suppresses MDR1 gene expression. Vitamin E and the age-related eye disease study supplementation for age-related macular degeneration. A low constitutive level of PXR mRNA was also detected by RT-PCR in the lung of rabbit but not in rat. For progressive diseases such as keratoconus, collagen cross-linking confers the possibility of halting progression and stabilizing the cornea, a benefit that is not observed with any other current treatment. Two review authors independently reviewed titles and abstracts of references retrieved from the searches and selected all potentially relevant studies. The essential advantages of phage-display approaches originate in the incorporation of the protein and genetic components into a single phage particle. In vitro desaturation of 1-14C linoleic acid in Novikoff hepatoma. Two regions of p53 were identified that regulate its binding to GSK3beta.

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Histidase expression during growth in DSM-His medium was significantly altered only in a strain containing the hutC1 mutation. Irrespective of the signal-transducing structures involved, the IL-2-induced proliferative response closely correlates with an increase in p56lck kinase activity along with the tyrosine phosphorylation of a 97-kDa protein. In addition, results from nuclear run-off transcription experiments showed that the two cytokines regulated increasing hHGF gene expression at transcriptional levels rather than a change in mRNA stability. Here we present evidence that CD4 affects the responsiveness of T helper cells by controlling spatial localization of the tyrosine kinase Lck in the synapse. Affinity chromatography of the anterior pituitary D2-dopamine receptor. The resolution obtained is 80 times higher than the laser bandwidth.

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The in situ PnT method provides a very useful tool for pinpointing the precise location of RNA within biological material at the ultrastructural level. rutilus, suggesting that predation does not routinely drive mosquito prey locally extinct in this ecosystem. NSAIDs are safe and effective in the treatment of postoperative pain, and they should be administered to all postoperative surgical patients unless contraindicated. Previous histologic studies in a line of dogs derived from Miniature Poodles with hereditary PDA identified varying degrees of hypoplasia and asymmetry of ductus-specific smooth muscle and the presence of aortalike elastic tissue in the ductus wall sufficient to cause patency. We have developed a general methodology and a general computational tool for the estimation of the value of the distance function and of the error in that estimation, which originates in the experimental uncertainty in the location of the set of points of the studied structure (such as that expressed by the atomic displacement factor in X-ray data analysis). The NER pathway has multiple components including seven xeroderma pigmentosum (XP) proteins (XPA to XPG) and numerous auxiliary factors, including ataxia telangiectasia and Rad3-related (ATR) protein kinase and RCC1 like domain (RLD) and homologous to the E6-AP carboxyl terminus (HECT) domain containing E3 ubiquitin protein ligase 2 (HERC2). Projection neurons responding to the same plant compound did not always arborise in the same glomerulus and some neurons arborising in the same glomerulus responded to different compounds. Phenobarbitone, which is known to inhibit convulsions by potentiating gamma-aminobutyric acid (GABA) activity in the brain, did not inhibit the convulsive action of picrotoxin in L-NAME-posttreated animals. There were 18 cases (including our case) of primary biliary cirrhosis complicated with ulcerative colitis reported in the literature.

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Non-HFE gene mutations may predispose HH patients to iron deposition in the brain. Before the start of therapy, the acute inflammatory macrophage subtype 27E10 was absent or rarely found in 8/13 evaluable biopsies from the osteomyelitis focus, and a further decrease in the expression of these macrophage antigens was observed after treatment. One of the materials often used for fixation in recent years is the EndoButton (Acufex Microsurgical, Mansfield, MA), which provides rapid and secure fixation pictures of norvasc 5mg tabs . Several suggestions are made for future interventions targeted toward college students. Heart weight to body weight ratios were elevated to a similar extent in both T and TP groups. The coordination of sterically hindered bases to metalloporphyrins. Reoperation After Cyst Excision with Hepaticojejunostomy for Choledochal Cysts: Our Experience in 18 Cases. We demonstrate unrepeatered transmission of 8x128Gb/s PDM-QPSK signals over a 515k-m fiber link. We evaluated ten cases: five patients enrolled onto the current trial and five patients enrolled onto a separate phase I SBRT trial for early-stage glottic larynx cancer. Mouse 3-phosphoglycerate dehydrogenase gene: genomic organization, chromosomal localization, and promoter analysis.

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Fragment methods allow hybrid density functionals to be employed leukeran 2mg dose routinely in chemical shift prediction, and we have recently demonstrated appreciable improvements in the accuracy of the predicted shifts when using the hybrid PBE0 functional instead of generalized gradient approximation (GGA) functionals like PBE. Cough threshold C2 and C5 did not differ between patients with chronic cough due to non-acid or acid reflux, but the values were significantly lower than those for patients with gastro-oesophageal reflux disease without cough and healthy volunteers. To examine the effects of WR1065 on the signalling pathways controlled by p53, isogeneic human colon carcinoma cell lines (HCT116) differing only in the presence or absence of wild-type p53 were used. Determinants of the length of mechanical ventilation in patients with COPD in the intensive care unit. The need to restore the public health base for environmental control. Pattern recognition in gene expression profiling using DNA array: a comparative study of different statistical methods applied to cancer classification.

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The effect of state of health on organ distribution and excretion of systemic plutonium in the Mayak workers. After repeated movements with the shoulder joint fixed we observed a slight and gradual decrease in the activity of pectoralis major relative to movements in which the shoulder was free to rotate. When starved for amino acids, Saccharomyces cerevisiae accumulates uncharged tRNAs to activate its sole eukaryotic initiation factor (eIF) 2alpha kinase GCN2. Both dimerized MLL and exon-duplicated MLL are potent transcriptional activators, suggesting a link between dimerization and partial tandem duplication of DNA binding domains of MLL. Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading. The crystallinity of leucine in the microparticles was found to be correlated with a change in particle morphology, reduction in powder density, and improvement in dispersibility. One month after a single injection of cyclocytidine the early findings described had disappeared. To confirm our findings, we studied adults admitted to another government hospital.

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The level of Smad3 was decreased by co-expression of MITF but not of dominant-negative MITF, which resulted from proteasomal protein degradation. In order to localize the loci more precisely, we generated a series of deletion-subcongenic strains in which OLETF-segments were shortened from either ends. This study tried to determine the feasibility and effectiveness of IONM of the RLN during thoracoscopic esophagectomy in the prone position for esophageal cancer. The Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 3, 2002), MEDLINE (1966 to September 2002), EMBASE (1980 to September 2002), CINAHL (1982 to September 2002), PsychINFO (1967 to September 2002), Applied Science and Technology Plus (1986 to September 2002), Arts and Humanities Index (1991 to September 2002), Biological Abstracts (1969 to September 2002), General Science Plus (1994 to September 2002), Science Citation Index (1992 to September 2002), Social Sciences Citation Index (1991 to September 2002), and Sociofile (1974 to September 2002). Risk assessment in the type 2 diabetic patients must take into account the major risk factors, particularly arterial hypertension which is commonly associated, increasing the risk for macrovascular and microvascular complications. To illustrate how to utilize this stability library, we conducted bacterial toxicity and biocompatibility experiments through the use of one specific set of nanomaterials in the presence and absence of plasmonic irradiation. Diabetic myonecrosis is a reminder that aggressive diabetic control is essential in all patients to avoid end-organ damage. The antifungal protein, unlike its counterpart from green kiwi fruit, did not exert antifungal activity against Botrytis cinerea, but was active against Fusarium oxysporum which was unresponsive to thaumatin-like protein from green kiwi fruit. Using magnetic resonance imaging, we followed up the patient for 33 months after the head trauma. TRAM-deficient mice showed defects in cytokine production in response to the TLR4 ligand, but not to other TLR ligands.

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A high-throughput screening for phosphatases using specific substrates. After accounting for maternal RNA contamination, no published genome-wide data set supports the concept of delayed paternal genome activation in plant embryos. These results indicate that established conspecifics may reduce the survivorship of young ant colonies. High intensity focused ultrasound (HIFU) is a non-invasive therapeutic technique that can thermally ablate tumors. The MR imaging appearance of the most important cartilage transplantation techniques, such as autologous osteochondral transplantation, autologous chondrocyte implantation and matrix-based autologous chondrocyte implantation are described and possible complications of each technique are mentioned. Prospective validation of right ventricular role in primary graft dysfunction after lung transplantation. Polymorphonuclear leukocytes from 115 patients with opisthrochiasis at its different (acute and chronic) stages were studied before and 1-3 days, 1-3 months, and 1-2 years after antihelminthic therapy with bilthricide. Clinical assessment of the structure-activity relationship of anthracyclines and related synthetic derivatives. The anti-microbial effects will also be explored in patients who are not neutropenic but have serious infections which may be benefited by increased stimulation to myeloid cell function. Among differentially expressed proteins, desmoyokin is a marker specific for thymic medulla and is potentially promising immunohistochemical marker in separation of type A and B3 thymomas.

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In conclusion, TP10 can enhance PEI mediated transfection at relatively low concentrations and may help to develop future gene delivery systems with reduced toxicity. We suggest that aspartic proteases have been evolutionarily selected to possess similar functional motions despite the observed fold variations. Patients with low-PG severe AS and a preserved EF have a worse survival than those with moderate AS, but survived better than those with gradient-matched severe AS. On granulocytes, which do not express CEA, MAb 4/3/17 is specific for NCA-160 (BGP). A neoplastic human salivary intercalated duct cell line, HSG and its derivative HSG-AZA1 cells with a myoepithelial cell phenotype and HSG-AZA3 cells with an acinar cell phenotype, which were induced by treatment of HSG cells with 5-azacytidine, have been used in our laboratory as models for studying mechanisms regulating cytodifferentiation in salivary glands as well as for developing differentiation therapy for salivary gland tumors. Obesity is associated with increased levels of inflammatory mediators. Guidelines from the French evaluation cooperative subgroup of GETTEC. Every year, thousands of individuals around the world suffer from severe lower extremity vascular disorders that are amenable to neither medical nor surgical treatment, and thus amputation is required. The exact conformation of the metal ion interactions allowed us to predict the orientation of the helices, and remodeling of the receptor protein indicated that Glu100 and Ile104 in TM2 and Asp122 and Ile125 in TM3 are directed toward a putative area of activation of the receptor. Based on self-reported prepregnancy body weight, gestational weight gain was categorized as excessive if it was greater than 2009 Institute of Medicine guidelines.

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External application of 10 rig/ml (R)-trichostatin A (TSA), a potent and specific inhibitor of mammalian histone deacetylase, to the embryo of the starfish Asterina pectinifera inhibited development during the early gastrula stage before formation of mesenchyme cells. Subcellular localization and immunoblotting assays indicated that hTLP19 might be secreted out of cell through trans-Golgi network (TGN). Criminally insanes form a special group of mentally ill patients. The organism was added to the digester only once in the first experiment and daily in the other. Estimation of wall stress and left ventricular mass by noninvasive techniques and clinical implications.

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The relationship between ATP and an electrogenic pump in the plasma membrane of Neurospora crassa. One of the mechanisms responsible for the multidrug resistance (MDR) phenotype of cancer cells is overexpression of so-called ATP-dependent drug efflux proteins: the 170-kDa P-glycoprotein (P-gp) encoded by the prilosec dosage 40 mg twice daily MDR1 gene and the 190-kDa multidrug resistance-associated protein 1 encoded by the MRP1 gene. Patients were thereafter followed for a further period of 12 weeks without the study medication. This paper describes and analyses the prolonged efforts - spanning close to two decades - of developing and using EPRs in the large, university-based hospitals in Norway. The intracellularly recovered C73R-UROIIIS protein shows enzymatic activity, paving the way for a new line of therapeutic intervention in CEP patients. Placenta percreta is a complication of pregnancy with significant morbidity and mortality rates. In the present study, the Boyden chamber was modified by the introduction of a filter sandwich that allowed cell migration both upwards and downwards and by the use of a fluid density gradient controlling cell buoyancy and mechanically supporting a movable chemotactic gradient.

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Reciprocal effect of ultraviolet and ionizing radiation on the skin. Second-line weekly paclitaxel in patients with inoperable non-small cell lung cancer who fail combination chemotherapy with cisplatin. A personal view on 50 years of the Japanese Society for Virology. Randomized, controlled trial of trivalent oral poliovirus vaccine (Sabin) starting at birth in Ghana. When this occurs the intravasal fluid is often a thick, white, toothpaste-like material devoid of sperm. Searching for the truly human: standing at the precipice of a post-Christian age. Our interventional studies demonstrate that neither fasting for 48 h, resulting in a low leptin state, nor leptin administration at physiological or pharmacological doses alters serum adiponectin levels. The superfusion prevacid 15 mg tablet system is suitable for the study of hormone synthesis and/or secretion. Bronchial asthma causing symptoms suggestive of angina pectoris.

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