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Aptric (Amitriptyline)

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Aptric is used to treat depression. Compared to other antidepressants, it has a higher risk of side effects, such as weight gain and drowsiness. Aptric is a tricyclic antidepressant (TCA). It works on parts of the brain responsible for raising levels of certain chemicals, like serotonin and norepinephrine, to help improve your mood.

Other names for this medication:
Abamax, Amicure, Amidez, Amitone, Amitrip, Amitryn, Amiwel, Amixide, Amize, Amline, Amoten, Amsha, Amtipax, Crypton, Eliwel, Kamitrin, Latilin, Libotryp, Libral, Limbival, Lodep, Maxitrip, Normaline, Relidep, Ristryl, Ronet, Sarotena, Trixide, Tryline, Tryptomec

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Also known as: Amitriptyline


{name} (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

{name} is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Aptric dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amitriptyline can be fatal.

Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aptric are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Aptric if you are allergic to Aptric components. Do not take Aptric if you are pregnant, planning to become pregnant, or are breast-feeding. Be careful with Aptric if you suffer from or have a history of a history of heart attack, stroke, bipolar disorder (manic-depression), schizophrenia or other mental illness, diabetes, overactive thyroid, glaucoma, problems with urination, heart disease, seizures. Be careful with Aptric if you are taking guanethidine (Ismelin), disulfiram (Antabuse), heart rhythm medications such as flecainide (Tambocor), propafenone (Rhythmol), quinidine (Cardioquin, Quinidex, Quinaglute), cimetidine (Tagamet). Avoid alcohol. Be careful! Taking Aptric you can become suicidal. Be careful when you are driving or operating machinery. Be careful with Aptric if you are going to have a surgery. It can be dangerous to stop Aptric taking suddenly.

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Multiplex ligation-dependent probe amplification (MLPA) is a commonly used technique for determining relative DNA sequence dosage (or copy number) in a complex DNA sample. Effects of recombinant human canstatin protein in the treatment of pancreatic cancer. Part of this work was presented at the 15th International Symposium on Microscale Separations and Analysis, HPCE 2002, Stockholm, Sweden, April 2002. Malignant proliferating trichilemmal tumor arising in multiple trichilemmal cysts. Prophylaxis against rheumatic fever recurrences in college students. The markers were automatically tracked across the image sequences, and their three-dimensional coordinates were then calculated. From measurements in Greenland waters carried out since 1962 the transport of radionuclides with the East Greenland Current is calculated and compared with the estimated inputs of 90Sr and 137Cs to the Arctic Ocean. In the present study, we investigated the role of astragaloside IV in the chemoresistance to cisplatin in NSCLC cells. Lumican-null mice are susceptible to aging and isoproterenol-induced myocardial fibrosis. The human DAZ (Deleted in AZoospermia) gene family contains a cluster of DAZ genes on the Y chromosome and a single autosomal homologue, DAZL1 (DAZ-Like) that maps to chromosome 3p24.

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Renal transplantation in Sweden in patients with ileal conduits or continent reservoirs was investigated in order to compare the outcome with regard to graft and patient survival as compared to controls. Terminal fields were found in several structures, for example the lateral geniculate nucleus, nucleus reticularis thalami, subthalamus, zona incerta, substantia nigra, red nucleus, periaqueductal gray, superior colliculus, reticular formation, raphe nuclei, pontine nuclei, trigeminal complex, and ventral horn of the spinal cord. To overcome this variation and produce homogeneously effective red ginseng, we evaluated the antidiabetic effects of probiotic-fermented red ginseng in a mouse model. Microglia can strongly influence the pathologic outcome or response to a stressor due to the release of a plethora of substances, including cytokines, chemokines, and growth factors. Five cDNAs coding for different DHNs were identified and characterized. Biobased Wrinkled Surfaces Induced by Wood Mimetic Skins upon Drying: Effect of Mechanical Properties on Wrinkle Morphology. Dosage of proserine in the investigation of cholinergic reactions of the organism. Sphingoglycolipids with Leb activity, and the co-presence of Lea-, Leb-glycolipids in human tumor tissue.

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In addition to contributing to our understanding of the effects of Vmw110 on the cell, our results demonstrate that Vmw110 expression is incompatible with the proliferation of a dividing cell population. Cloning and expression of a cDNA encoding a catalytically active fragment of calf thymus DNA polymerase alpha. Leser-Trelat sign is a rare cutaneous manifestation of internal malignancy that is usually associated with visceral-type adenocarcinoma. Comparing the time course and efficacy of spatial and feature-based attention. We present preliminary results obtained by analyzing data collected from paraspinal muscles during repetitive lift movements, from the first dorsal interosseus during abduction-adduction movements of the index finger, and from knee flexors and extensors during isokinetic exercise. The case is presented of a child in cardiogenic shock in whom oxygen administration exacerbated a systemic to pulmonary shunt that caused a critical deterioration in his cardiovascular status requiring hypoventilation and restoration of baseline hypoxia for reversal. Molecular dynamics of a tetrasaccharide subunit of chondroitin 4-sulfate in water. Fusion-positive tumors have a distinct molecular signature with downstream activation of a number of myogenic and tumorigenic factors. There is a need towards multidisciplinary approaches in order for the provision of improved maternal and reproductive health status and outcomes for this group of disadvantaged women in terms of educational level, residence, fertility rights and access to healthcare services. The purpose of this study was to investigate the feasibility of the local double potential (DP) interval and the change in transisthmus conduction time for predicting complete isthmus block after ablation of the cavotricuspid isthmus.

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It is possible to use existing computerized data, collected in routine health care, in haemovigilance systems for monitoring long-term outcome and disease concordance in blood donors and transfusion recipients. Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Also membrane fouling and reuse potential of membranes were investigated by multiple filtrations. Incidence of end-stage renal disease in overseas-born, compared with Australian-born, non-indigenous Australians. Using this purified and active preparation, the three-dimensional folding of aromatase was revealed by proteomic analysis. First, the surfaces of the carbon nanotubes (CNTs) were coated in situ with mono-dispersed ZnO nanocrystals of about 7 nm by the reaction of zinc acetate and sodium hydroxide.

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Measurement of epsilon-N-trimethyllysine in human blood plasma and urine. The cerebrovascular disease basis of psychiatric syndromes: a model for the power of disease reasoning in psychiatry. Several methods have been proposed to achieve transsphenoidal arachnoid mobilization and chiasmapexy in symptomatic empty sella (primary or secondary empty sella syndrome). Role of chemo(radio)theray prior to surgery for stage IIIa non-small cell lung carcinoma (localized non-resectable tumor). With hard work, perseverance, excellence,compassionate care and support and mentoring, many have contributed to scientific and clinical cardiology in the U.S. We administered the French SISC to a sample of 67 adults older than 15 years, comprising 17 controls and 50 patients with epilepsy (without provoked or isolated seizures). Historical analysis of South Australian nursing curricula shows changes common in Australia as it moved nurse education from hospital to the tertiary sector in the latter part of the twentieth century, to its contemporary shape as collaboration between profession, industry and discipline to produce nurses for the Australian workforce.

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Congenital hypogonadotropic hypogonadism, functional hypogonadotropism or constitutional delay of growth and puberty?. To evaluate the pulmonary function in adulthood after treatment with brace or surgery before maturity. Three populations of model CPGs were evolved, containing three, four, or five neurons. The trans-decalin structure formed by intramolecular Diels-Alder cycloaddition is widely present among bioactive natural products isolated from fungi. Data were collected from 22 adults living in urban and rural areas of a rural western state and included audio taped interviews, clinical and demographic information, and scores from the community form of the Mishel Uncertainty in illness Scale (MUIS-C). Urinary elimination of cortisone and 17-ketosteroids in children. A measure of adequate coverage is of critical importance as the nature of health insurance products evolves. The distribution and unpacking of individual nanocomplexes within cells could thus be unambiguously followed by fluorescence microscopy. Differential intensity sensitivity in the ear with loudness recruitment.

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