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Aspitrate

Aspitrate is a nitrate. It reduces the workload of the heart. As a result, the heart muscle does not need as much blood and oxygen supply. Use it as advised by your doctor or check the label for directions before use. Aspitrate is to be taken empty stomach.

Other names for this medication:
Aspitrate, Dilatrate, Ecosmin, Ismorin, Ismotic, Isoditrate, Isoloprin, Isordil, Isosorbide, Monit, Monoket, Monosprin, Nitren, Nitrofix, Nitroprin, Solosprin, Vasoprin

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Also known as: Isosorbide

Description

Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). It does not work fast enough to relieve the pain of an angina attack that has already started.

Isosorbide mononitrate belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. When used regularly on a long-term basis, this helps prevent angina attacks from occurring.

This medicine is available only with your doctor's prescription.

Dosage

Usual Adult Dose for Angina Pectoris Prophylaxis:

EXTENDED RELEASE: 30 to 60 mg orally once a day in the morning Maximum dose: 240 mg orally once a day in the morning Comments: -Swallow whole (do not crush or chew) with half-glass of fluid. -Start at low end of dosing range for elderly patients. Use: Prevention of angina pectoris due to coronary artery disease; onset of action is not sufficiently rapid to be useful in aborting an acute anginal episode.

Usual Adult Dose for Angina Pectoris:

EXTENDED RELEASE: 30 to 60 mg orally once a day in the morning Maximum dose: 240 mg orally once a day in the morning Comments: -Swallow whole (do not crush or chew) with half-glass of fluid. -Start at low end of dosing range for elderly patients. Use: Prevention of angina pectoris due to coronary artery disease; onset of action is not sufficiently rapid to be useful in aborting an acute anginal episode.

Detailed Aspitrate dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of isosorbide mononitrate can be fatal.

Overdose symptoms may include a severe throbbing headache, fever, confusion, severe dizziness, fast or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cold or clammy skin, fainting, and seizure (convulsions).

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Isosorbide mononitrate dosage information

Side effects

The most common side effects associated with Aspitrate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Aspitrate if:

you are allergic to isosorbide mononitrate, isosorbide dinitrate, or nitroglycerin; or you have early signs of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating).

You should not take erectile dysfunction medicine (Viagra, Cialis, Levitra, Stendra, Staxyn, sildenafil, avanafil, tadalafil, vardenafil) while you are taking Aspitrate. Taking these medicines together can cause a sudden and serious decrease in blood pressure.

To make sure Aspitrate is safe for you, tell your doctor if you have:

congestive heart failure; kidney disease; or low blood pressure.

It is not known whether Aspitrate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether isosorbide mononitrate passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

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Photodegradation of triazine herbicides in aqueous solutions and natural waters. It has been noted that this problem is neglected and that physicians should inquire about medication sharing. The proposed nomogram may assist in evaluating outcome from the two markers of bone turnover. Leu-DOX was more effective than free DOX in inhibiting xenograft growth. The artery-vein contrast in two-dimensional projection MRA was managed by manually selecting specific templates for the matched filters. The study aims to review the increasing trends of wearable devices and need of multimodal recognition for continuous or discontinuous monitoring of human activity, biological signals such as Electroencephalogram (EEG), Electrooculogram (EOG), Electromyogram (EMG), Electrocardiogram (ECG) and parameters along with other symptoms. Comparative trial of shampoos for treatment of head infestation. Experimentally, these conditions are stated as intensive variables--pH and other chemical potentials--as though small solutes were infinite resources that come at an externally varied free energy cost. albicans was found to be the most important inducer of IgG antibodies, since the IgG level against P. At what age should a one-time only colonoscopy for screening of colorectal cancer be performed?.

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For example, the dopamine hypothesis states that schizophrenia is the result of dopaminergic hyperactivity. Tyramine as an independent transmitter and a precursor of octopamine in the locust central nervous system: an immunocytochemical study. However, mean values for BMI, insulin, HOMA IR, HOMA beta-cell, triglyceride (TG), homocysteine, and baPWV were significantly higher in the SLE patients with hyperinsulinemia when compared with those SLE controls. Common forms of metabolic and cardiovascular diseases involve the interplay of numerous genes as well as important environmental factors. cumana plastid genome was investigated using a long-distance PCR strategy in order to determine their localization.

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Adenovirus-mediated erythropoietin production by airway epithelia is enhanced by apical localization of the coxsackie-adenovirus receptor in vivo. This SEM-based criterion was then validated by cross-classifying the change status (improved, stable, or declined) of 393 follow-up outpatients using the one-SEM criterion and the MCID standard. Mutation of TrkB tyrosine 484, while having no affect on BDNF-inducible PLCgamma and Cbl tyrosine phosphorylation, is essential for the phosphorylation of Shc, the complete activation of extracellular regulated kinase 1/2 (ERK1/2) and the induction of c-fos protein synthesis. In the patients, in-hospital morbidity and mortality with focus on bile leaks and long-term signs of cholangitis and stricture formation were investigated with a median observation period of 42 months. Studies on the normal motility of the carpometacarpal articulation of the thumb and the estimation of traumatic movement restriction and stiffening. These data and the expression pattern suggest that XRnd1 regulates morphogenetic movements by modulating cell adhesion in early embryos. Data show that the outcome of clinical trials of antidepressant drugs are not a function of pre-existing good patient-psychiatrist relationships. Immunohistochemical staining for human involucrin revealed that the transplanted epithelium maintained its human origin, whereas the dermis was infiltrated by numerous mouse fibroblasts and blood vessels. A specific quantitative assay for collagen synthesis by cells seeded in collagen-based biomaterials using sirius red F3B precipitation. In addition, the MWCNT dispersion showed reversible changes with variations in pH.

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She had undergone radical mastectomy and radiotherapy for left breast cancer four years previously. We reviewed the results of 82 consecutive cases of moderate to severe hallux valgus deformities corrected with the Ludloff oblique metaphyseal-diaphyseal osteotomy of the first metatarsal combined with a distal soft-tissue procedure and medial eminence resection. The pulmonary function did not worsen over time in most patients. The slight increase in serum anticholinergicity seen in some elderly patients did not significantly impair cognitive function, even in patients with a preexisting cognitive impairment. Many of the molecules that mediate these interactions are predictably turning out to be large multidomain proteins. PBMCs from patients allergic to house dust mite versus those from healthy donors were stimulated for 48 hours with the related Dermatophagoides pteronyssinus allergen or with a staphylococcal superantigen. (a) The spermatogenic stage specificity for the sensitivity to mutation induction by 20 chemical mutagens is considered. This article highlights that there is a need for an inventory of all the health system research and studies which have been conducted by the Moroccan Ministry of Health and its partners, and that this knowledge base should be made available to the decision-makers, the researchers and even the public. Airborne and surface dust (wipe) samples and samples from flours and baking additives used at the workplace were collected in 5 industrial bakeries and tested in the LFIA for fungal amylase. Higher vertebrates appear to possess six genes encoding a homeodomain of the distal-less type.

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Use of plasminogen activator (urokinase) in treatment of hemorrhage and thromboembolism of the eye. In workplace settings, autonomy is implicated in employee motivation as well as supervisor autonomy support. We created corresponding mutations in PAX6 and PAX6-5a, and evaluated their transcriptional activation and DNA binding properties. Chemotherapy administered in conjunction with osmotic blood-brain barrier modification in patients with brain metastases. Further examinations of gliadin data based on mass spectrometry revealed that quality among wheat varieties could be determined by means of principal component analysis. The effect of high grade prostatic intraepithelial neoplasia on serum total and percentage of free prostate specific antigen levels. Four percent amethocaine gel applied for 30 min prior to the radial arterial puncture, compared with a placebo gel. Our results show that tinzaparin and recombinant TFPI both blocked endothelial tube formation induced by either FGF2 or TF/fVIIa, in a concentration-dependent manner.

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The main factor that contributed to this rise in temperature was an imbalance in the polymer powder : liquid monomer ratio, there was a high incidence of unmixed powder visible in the mixing barrel of some contemporary vacuum mixing devices. Olfactory mucus of these representatives is found to be of great similarity in its glycoprotein composition. Disintegrin-like/cysteine-rich region of ADAM 12 is an active cell adhesion domain. Prevalence is rising more steeply than incidence, due mostly to improved efficiency of treatment -patients are surviving longer. This study demonstrates that detection of disseminated tumor cells in liver samples from patients with UICC stage I-III colorectal cancer has no prognostic influence. The topics discussed in this study include chemical adsorption, addition reaction, cleavage of chemical bonds, etching effect, spin effect, the harpoon mechanism, and the complementary active sites (CAS) mechanism, among others.

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We then present a shape matching scheme based on the features obtained. Each of the seven heavy metals in five geochemical phases correlated positively with OM but, except for Cd, did not correlate with Fe-oxides. Micro-CT was successfully employed to virtually align severed skeletal elements found in different locations, analyse tool marks created during the dismemberment process, and virtually dissect a charred piece of evidence. Blood samples were collected before the operation (laparoscopy, oophrectomy, cystectomy, and/or hysterectomy), and tissue samples of ovarian chocolate cysts were collected during the operation. Traumatic forces applied to the immature knee result in fracture patterns different from those in adults. gcn5 reduced acetylation of histones H3 and H4, mostly on the core promoter regions, whereas hd1 increased acetylation on both core and more upstream promoter regions. Histological examination revealed that the area of the cystic cavity was significantly reduced in the BMSC-SC and SC groups compared with the control rats. Whether cardiac ultrasound and natriuretic peptides provide independent prognostic information is uncertain. The acellular dermal matrix (ADM) allograft is widely used in periodontal surgery.

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Troglitazone improves cardiac function in patients with congestive heart failure. We examined whether baseline serum alpha-tocopherol concentrations are associated with total and cause-specific mortality. The calcium deposition on single tenormin dosage range or mixture of the cells did not increase compared with control when cells were incubated in a high concentration of phosphate, cultured in the existence of beta-GP or uremic serum. This in vitro model could be useful to study the resistance of tumors to the effect of natural regulators (i.e. Atopic patch test can be used as a diagnostic tool in characterizing patients with allergen triggered atopic dermatitis. Integrity of renal prostaglandin synthesis is necessary to maintain renal cortical and medullary function in patients with kidney, heart and liver disease. Although these compounds did not influence the activities of prokaryotic DNA polymerases and other DNA metabolic enzymes such as T7 RNA polymerase and deoxyribonuclease I. Estrogen may modulate bone metabolism through binding ER in nuclei and plasma of the osteoblasts.

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In situ hybridization and immunohistochemistry evaluated the retinal distribution of big potassium (BK) channels, and RT-PCR evaluated the expressions of BK channels and m-opsin at 1 week after URD treatment. This study investigated the effects of the administration of 25mg/kg/bodyweight of artemether for a period of 7 days on the trapezoid nuclei and behavioural functions in male Wistar rats. The polyamine synthesis inhibitors alpha-difluoromethylornithine and methylglyoxal-bis(guanylhydrazone) prevented transition into synthetic phenotype as well as initiation of what does omnicef antibiotic treat cell growth. The remaining sites presumably encode tRNAs and other pol III transcripts. Sixteen intensive and nonintensive computer users with either moderate or severe musculoskeletal disorders participated in the study. Successful use of argatroban during the third trimester of pregnancy: case report and review of the literature.

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Exponential-phase glycogen recycling is essential for growth of Mycobacterium smegmatis. In developing countries, infants under 4 years of age are at greatest risk of lower RTIs, whereas in developed countries the severity of infection and rate of mortality are greater aceon in elderly. Cloning and high-level expression of scorpion toxin BmKITa1 in Escherichia coli and insect cells. Crosslinking of the human Fc receptor for IgA (FcalphaRI/CD89) triggers FcR gamma-chain-dependent shedding of soluble CD89. With addition of NaCl, the fluidity in the interior of the vesicle is increased which leads to disassembly of vesicle. Surprisingly, in epidermis, an inhibition of the dose-dependent mutation induction was evident after irradiation above 0.5kJ/m(2) UVB, lowering the increment more than eight-fold, while such suppression was not observed in dermis.

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Neuroprotective effect of afobazole on rats with bilateral local photothrombosis of vessels in the prefrontal cortex. A series of phenylphenalenone type compounds, known to play a role as phytoalexins in plants of the Musaceae family, have been identified for the first time in the leaf fibers of abaca (Musa textilis). We found that chymotrypsin inhibitor, but not captopril, could attenuate the increased angiotensin II generation. The specifics of this distance-enhanced, learner-centered program are described. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.20/issuetoc. To study transcriptional targets of canonical Wnt signaling, we used the conditional Cre/loxP system in mouse to ectopically activate beta-catenin during central nervous system development. The prevalence of classic autism and autism spectrum disorder (ASD) appears to be on the rise, and to date, there remains no clear etiology or cure. Changes over time (Delta) were calculated as the difference between the values before and after catheter intervention for rSO(2).(DeltarSO(2)), SvO(2).(DeltaSvO(2)) and SjO(2).(DeltaSjO(2)). This implicates the EGFR/RSK/YB-1 pathway as an important component of BLBC, providing an important opportunity for therapeutic intervention.

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The kits were assessed using anticoagulated whole-blood samples stored up mobic 15 mg once a day to 10 weeks at 4 degrees C. Integrin-mediated adhesion induces several signaling pathways leading to regulation of gene transcription, control of cell cycle entry and survival from apoptosis. To determine the feasibility and preliminary effectiveness of a novel smartphone-based smoking cessation app designed for socioeconomically disadvantaged smokers. The activity of ASAT could not differentiate any stage of fatty liver. This case-matched study evaluates the outcome of elderly patients in both groups. A modular treatment of molecular traffic through the active site of cholinesterase. A single intravitreal implant of dexamethasone could effectively and stably improve visual acuity and central retinal thickness in some patients with radiation macular edema for 16 months after injection. Participants expressed a need for anticipatory guidance throughout the process.

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