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Astic (Ticlopidine)
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Astic

Astic a thienopyridine antiplatelet agent, has been shown to be associated with potentially fatal thrombotic thrombocytopenic purpura (TTP). A similar agent which is now largely replacing Astic for safety reasons, Astic (Plavix), has also been associated with this adverse event, though possibly at a lower rate than Astic.

Other names for this medication:
Aplaket, Astic, Taispin, Ticlantin, Ticlobest, Ticlogard, Ticlogaurd, Ticlop, Ticlopid, Ticlopidine, Ticlovas, Tikla, Tikleen, Tilkon, Tyklid

Similar Products:
Cozaar, Suprax, Cardizem, Kamagra, Provera, Luvox, Sumycin, Robaxin, Levitra, Furadantin

Also known as: Ticlopidine

Description

Ticlopidine is used to lessen the chance of having a stroke. It is given to people who have already had a stroke and to people with certain medical problems that may lead to a stroke. Because ticlopidine can cause serious side effects, especially during the first 3 months of treatment, it is used mostly for people who cannot take aspirin to prevent strokes.

A stroke may occur when blood flow to the brain is interrupted by a blood clot. Ticlopidine reduces the chance that a harmful blood clot will form, by preventing certain cells in the blood from clumping together. This effect of ticlopidine may also increase the chance of serious bleeding in some people.

This medicine is available only with a doctor's prescription.

Dosage

Ticlopidine should be taken with food. This increases the amount of medicine that is absorbed into the body. It may also lessen the chance of stomach upset.

Take this medicine only as directed by your doctor. Ticlopidine will not work properly if you take less of it than directed. Taking more ticlopidine than directed may increase the chance of serious side effects without increasing the helpful effects.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For prevention of strokes: Adults—1 tablet (250 mg) two times a day, with food. Children—It is not likely that ticlopidine would be used to help prevent strokes in children. If a child needs this medicine, however, the dose would have to be determined by the doctor. For prevention of strokes or heart attack following heart stent procedure: Adults—1 tablet (250 mg) two times a day, with food together with your doctor's recommended dose of aspirin for up to 30 days following the procedure Children—It is not likely that ticlopidine would be used to help prevent strokes or heart attack in children. If a child needs this medicine, however, the dose would have to be determined by the doctor

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme dizziness or fainting.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Astic dosage information

Side effects

The most common side effects associated with Astic are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There is no specific information comparing use of ticlopidine in children with use in other age groups.

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Tumoral drug metabolism: perspectives and therapeutic implications. Time-lapse confocal microscopic analysis revealed cotransport of pIgR and MAL in the same endocytic structures. A diterpene as an endogenous signal for the activation of defense responses to infection with tobacco mosaic virus and wounding in tobacco. Treating depression in primary care in low-income women in Santiago, Chile: a randomised controlled trial. The ideal route of delivery has not been determined, but vaginal delivery seems safe and does not directly cause pouch dysfunction. In contrast, no fibroblast growth factor immunoreactivity was detected at the Schwann cell surface at any time point examined.

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The models underpinning CBT are examined for evidence of the influence of developmental psychology, and the outcome literature of CBT techniques is then scrutinized to evaluate the efficacy of these techniques with young children. PFK was used in 25 schizophrenic patients undergoing various surgical procedures from 1995 to 1997. On transforming the data into the logarithms, two negative linear dose-response relationships were obtained. Electrical microstimulation of this region evoked the elbow flexion and shoulder withdrawal that constitute the initial lifting--withdrawal phase of the forepaw placing. Calcium efflux is increased by ionomycin and by A23187 which has been used as a parthenogenetic agent, but not by weak base (NH4Cl). These studies indicated that the site of tumor implantation was an important determinant in the production of plasma VEGF and bFGF levels. Total colectomy is the preferred surgical option in proven slow-transit constipation. The study was conducted in order to investigate whether quantitative EEGs can show postoperative changes in children after open heart surgery. Consumption of statins, the accompanying medication taken, presence of interactions according to the technical details of statins (Spanish Medication Agency, Ministry of Health and Consumption) and social and demographic variables.

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MMP-2 is produced by the corneal fibroblasts in the acute phase after UV-B irradiation. Label-Free Measurements of Tenofovir Diffusion Coefficients in a Microbicide Gel Using Raman Spectroscopy. Four-dimensional computed tomography (4DCT) were acquired at simulation to evaluate the tumor intra-fractional centroid and boundary changes, and Cone-beam Computer Tomography (CBCT) were acquired during each treatment to evaluate the tumor inter-fractional set-up displacement. Homozygous Grm1(crv4/crv4) and, to a lesser extent, heterozygous mice show albuminuria, podocyte foot process effacement, and reduced levels of nephrin and other proteins known to contribute to the maintenance of podocyte cell structure. We set up a three way factorial design with three different levels of sedimentation and terrestrial leaf material. Tying-up some of the hydrogen ions destined for excretion by phosphorus-stimulated ammoniagenesis could reduce the interfering effect of hydrogen ion on kidney calcium reabsorption and provide a mechanism to explain why phosphorus can have a direct positive impact upon tubular calcium reabsorption. No difference in daily solar irradiance was measured across the same elevational gradient. Identification of embolic stroke patterns by diffusion-weighted MRI in clinically defined lacunar stroke syndromes. Risk factors in young adulthood included younger age and prosmoking attitudes.

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