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Atdol (Tramadol)
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Atdol

Atdol is a centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Atdol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine.

Other names for this medication:
Avdol, Cemadol, Cosdol, Doltel, Euphodol, Gemodol, Ivydol, Lagesic, Madol, Mydol, Neutram, Nictram, Nobligan, Nopidol, Opidol, Ramcet, Standol, Stemadol, Tacil, Tolydol, Topspas, Tragesic, Tramabit, Tramacon, Tramaflam, Tramataur, Tramazac, Tramol, Tramospas, Trandol, Transic, Trofel, Trydol

Similar Products:
Eldepryl, Avana, Lamictal, Robaxin, Alprostadil, Cordarone, Hytrin, Imitrex, Decadron

Also known as: Tramadol

Description

{name} (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

{name} is used to treat moderate to severe pain in adults.

The extended-release form of tramadol ({name} ER) is for around-the-clock treatment of pain. {name} ER is not for use on an as-needed basis for pain.

Dosage

Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Atdol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Atdol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Atdol dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Atdol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how Atdol ER will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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Effects of some inhibitors of phosphodiesterase on neuromuscular transmission. The present study was designed to determine the pathogenic factors responsible for glucose intolerance in CHC patients. Improved patency of collagen-impregnated grafts after in vitro autogenous endothelial cell seeding. The same 10 CpG sites were investigated in non-osseous cell lines and were found fully methylated in ERalpha-negative breast cancer cells (MDA-MB-231) and completely demethylated in ERalpha-positive breast cancer cells (MCF7). Amelioration of postischemic reperfusion injury by antiarrhythmic drugs in isolated perfused rat lung.

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Interaction of the causative agent of lymphogranuloma venereum with macrophages from immune animals in vitro. Brucellar aortic involvement is a rare complication of brucellosis and can occur without concomitant endocarditis. Trehalose was superior to other sugars or conventional cryoprotective agents (e.g. The earthworm Lumbricus rubellus was chosen as representative for organisms mainly taking up metals via the dermal route, and the isopod Porcellio scaber as an organism taking up metals mainly via the alimentary tract. Otitis media (OM) is the most common childhood illness for which medical advice is sought. This article acknowledges the critical purchase on the concept of reflective practice offered by Foucauldian approaches but argues that microsociological and discourse analytic approaches can further illuminate the subject and thus serve as a complement to them. Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications. Anterior Chamber Silicone Oil Removal With an Air-Infusion System and a Silicone Oil Extractor.

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It seems to occur mainly in epithelial cells and has to be examined as special characteristic of this tumor entity in further studies. Therapeutic potential of a tumor-specific, MHC-unrestricted T-cell receptor expressed on effector cells of the innate and the adaptive immune system through bone marrow transduction and immune reconstitution. The physiological role of ascorbate as photosystem II electron donor: protection against photoinactivation in heat-stressed leaves. The implications of these findings are wide-ranging for the practice of threat assessment. Activation in vitro, by 5-iododeoxyuridine, of a latent virus resembling C-type virus in a human sarcoma cell line. Biomass values for individual turtle species are as high as 586 kg/ha. Vandetanib in patients with previously treated RET-rearranged advanced non-small-cell lung cancer (LURET): an open-label, multicentre phase 2 trial.

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We found that polarized CF bronchial and pancreatic epithelia bound P. Neutralizing antibodies to granulocyte macrophage colony-stimulating factor (GM-CSF) dampened the prolonged neutrophil survival observed in TNF-alpha-stimulated A549 conditioned media. To write academic essays to a high standard takes time, practice and skill, but the process can be facilitated by appropriate guidance. In addition to its primary care and mental health care for HIV/AIDS patients, the organization has developed some subspecialties and soon will expand those. A single amino acid difference influences the binding of some antibodies to this domain. The author discusses English terms that often are misused, overused, and abused in both medical writing and everyday language. The kaiser permanente national total joint replacement registry. It was also less stable than the non-oxidized enzyme at an acid pH. Cis-element identification is a prerequisite to understand transcriptional regulation of gene loci.

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Paresthesias, numbness, or upper extremity pains associated with or without headaches and upper back stiffness characterize the T4 syndrome. Mutations of HIV-1 RT gene isolated from patients treated with AZT. The levels of EGR1 expression were examined in relationship to patient characteristics, histology, tumor stage, PTEN expression, and overall and disease-free survival. When male rats were exposed to the scent and view of female rats, pregnenolone again decreased significantly in the olfactory bulb while dehydroepiandrosterone increased significantly in the olfactory bulb and the retina and progesterone decreased significantly in the hypothalamus, amygdala and parietal cortex. Dental stem cells (DSCs) are not only able to differentiate into adipogenic, chondrogenic and osteogenic lineanges, but an increasing amount of research also pointed out their potential applicability in numerous clinical disorders, such as myocardial infarction, neurodegenerative diseases and diabetes. This study demonstrates the usefulness of encapsulated ANP gene transfected cells as a new tool for ANP gene delivery in studying renovascular hypertension and cardiovascular diseases. In experimental peripheral nerve studies, the rat sciatic nerve model is widely used to examine functional outcome following nerve injury and repair. With the knowledge of the eigenvectors, an interpretation of all eigenvalues is possible by a characterization with pseudoquantum numbers that are related to the widely used nomenclature of intermolecular normal motions in aromatic(solvent) clusters. Interferon proved to benefit hairy-cell leukemia patients with active disease, whether or not they had undergone prior splenectomy.

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Bayesian networks have become popular for modeling probabilistic relationships between entities. Benign fibrous histiocytoma is a rare bone tumor that usually presents with localized pain and/or a pathological fracture. The first case, that of a 42-year-old woman, was admitted with a chief complaint of upper abdominal pain. These experimental results suggest that c-Fos immunoreactivity mapping provides a powerful tool for functional investigations on the cellular level after direct electrical stimulation of the cochlear nerve. Against a background of drug resistance and bacterial persistence, recommendations for multidrug therapy and the means to devise rationally based therapy for the future are discussed. A biological sample is homogenized in the reagent and the simultaneous isolation of RNA, DNA and proteins is accomplished in a single step by a liquid-phase separation. The muscarinic agonists oxotremorine (0.3 mg/kg, i.p.) or carbachol (100 microM, infusion) reduced ACh release and reduced the stimulation of ACh release by GAL with a magnitude corresponding to that of oxotremorine or carbachol alone.

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The ITS region of a representative of each morphotype was sequenced. Essential hypertension and cardiovascular-renal-target organ damage is more prevalent in black than white adults in the U.S. Also, the neural cells derived from ADSCs in microgravity condition expressed more MAP-2, GFAP, and synaptophysin protein in comparison to the 1G control. Thus, renalase appears to be the possible new marker of these indications in this special population. Evidence for a functional vasoconstrictor role for ATP in the human cutaneous microvasculature. Severely atrophic comminuted fractures of the mandible often have inadequate bone stock available to allow for adequate rigid fixation and subsequent progression to union.

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Our results suggest that the restriction of EOF after surgery not involving the gastrointestinal tract under spinal anesthesia may not be rational, and that EOF may facilitate recovery of bowel function. To determine the impact of gastro-oesophageal reflux disease (GERD) on the quality of life, to assess changes in the quality of life during treatment with esomeprazole and to define factors that can predict these changes. If added after the 36th hour the same inhibitors give mostly delay or anomalies in regeneration. As a result microbial uptake increased, thereby depleting the plant available pool of N and P, or, for the P-rich Betula extract, depleting soil inorganic N alone, to the extent of reducing plant growth. Bacterial synthesis of truncated forms of the human vitamin D receptor and characterization of anti-receptor monoclonal antibodies. In 2000, the Emergency Medical Services (EMS) Education Agenda for the Future highlighted the need for a single certification agency to provide consistent evaluation of entry level competence for each nationally recognized EMS provider level. Histochemical study of the enzyme activity of the myocardium of sudden death victims with postinfarct cardiosclerosis. There are only few analyses from Germany on the impact of delivery unit size on neonatal outcome. Regulatory agencies suggest that deviations from established guidelines should be assessed on an institutional basis and recommend periodic review by the local IACUC. Results from various papers are hard to compare because of the use of different channel preparations, salt types and concentrations, and electrophysiological techniques (black lipid membrane (BLM) vs.

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The findings highlight the need for routine assessments of language and reading skills, in addition to assessments of speech, in children with a cleft, in order to identify potential problems as early as possible. This review considered all studies that included infants born before 37 weeks of gestational age in any hospital setting. The influence of CPAP on the neurobehavioral performance of patients with obstructive sleep apnea hypopnea syndrome: a systematic review. In this paper we investigate the error threshold for quasispecies with heterogeneous replication accuracy. However, standard immunization approaches frequently fail to provide monoclonal antibodies with the desired specificity. In this study we investigated, for the first time, their possible health effects on loggerhead sea turtles (Caretta caretta). Determination of plasma levels of cardiovascular anti-arrhythmia drugs.

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Treatment outcomes in type A and B alcohol dependence 6 months after serotonergic pharmacotherapy. We demonstrated a slight increase in PGE2-M after CRH injection in a dose that markedly augmented ACTH and cortisol levels. Placental samples were is xanax a schedule 4 drug collected in each patient during the cesarean section. Pathologic diagnosis after incisional biopsy was compatible with aneurysmal bone cyst. Therefore, a systematic review and meta-analytic approach was chosen to examine if probiotic consumption has an effect on psychological symptoms. molecular analyses disclosed loss of heterozygosity at the MEN1 gene locus on chromosome 11q13. Clinical data, including location of tumor, type(s) of treatment, and colonoscopic findings, were collected.

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In spite of this, in the presented case, corneal perforation of the second eye could not be prevented. Countries in Asia need to establish more comprehensive and evidence-based DR screening guidelines to facilitate the execution of robust screening programmes that could help reduce DR-related blindness, improve patient outcomes and reduce healthcare costs. Our objective was to determine whether a yearlong home-based exercise program initiated following UC could be administered to older patients with hip fracture and improve outcomes. The morphogenesis and the heart structure are, to a certain point, independent processes during these stages of development and are due to different factors. HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. For speaking rate, the subjects with TBI had (1) both slow speaking and articulation rates, (2) smaller phonation proportion and larger pause proportion, and (3) larger percentage change in speaking rate and smaller percentage change in articulation rate. Regression of HCV-associated MZL can be achieved with antiviral therapy and the novel generation of direct-acting antiviral agents appears highly effective and safe for the treatment of these lymphoma.

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Here we report important prognostic and functional roles for TTP in human prostate cancer. Comparisons based on both field-caught and lab-reared animals indicated significant, heritable variability in body size among these four populations. Cell-Free Circulating Epigenomic Signatures: Non-Invasive Biomarker for Cardiovascular and Other Age-Related Chronic Diseases. The reduction in barrier function was evaluated with our proposed method, which measured the resistance in the short term. Research on the annual periodicity of carabid beetles in the Cyrenaika (North Africa). H-19 expression in human placenta from the different trimesters of pregnancy remains practically constant. When a 10-gene genomic signature was applied to resected human adenocarcinoma datasets, tumors that were transcriptionally similar to the early progenitors had a significantly worse prognosis than those similar to the late progenitors. Similar effects were observed for in vivo data obtained at the carotid artery bifurcation. In particular, we find a resonance situation for the maximum escape distance as a function of the various frequencies in the system.

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Gender-specific post-stimulus modulation in the alpha band during visual-spatial attention. Psychological assistance provided to patients diagnosed with depression in primary care. Resonance-enhanced multiphoton ionization mass spectrometry using a two-color laser beam generated by stimulated Raman scattering. Cervical Spinal Cord Compression: A Rare Presentation of Hepatocellular Carcinoma. Exercise training improves exercise capacity and quality of life in patients mild to moderate heart failure in the short term. Apoptosis is an essential physiologic process used in almost all tissues to remove damaged or superfluous cells. Oral prednisolone in the acute management of children age 6 to 35 months with viral respiratory infection-induced lower airway disease: a randomized, placebo-controlled trial. This review focuses on the organization and modifications of the acrosomal molecules as well as their compartmentalization within the acrosome. The Bayesian networks, learned from the condensed dataset, identified most of the salient pairwise correlations and some known relationships among several features in the original dataset, confirming the effectiveness of the proposed feature abstraction method. Those with vocal cord dysfunction and asthma report more symptoms on standardized asthma control questionnaires, which can result in increasing amounts of medication if vocal cord dysfunction is not identified and managed appropriately.

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Patients with over 100 counts of factor-VIII antigen-positive cells per 200 x field in the most active areas of neovascularization showed significantly poorer prognosis than those with less than 100 counts. The Escherichia coli DsbA protein is the major oxidative catalyst in the periplasm. There is significant demand among infertility patients for preimplantation sex selection, with a significant portion of this demand coming from patients who do not have any children or have children all of one sex. Time from admission to the stroke unit until initial assessment by doctors and registered nurses. Characteristics of the thalamic ventrobasal relay neurons as a function of conduction velocities of medial lemniscal fibers. A mechanically induced model of intestinal wound healing was developed to study glial-induced epithelial restitution. p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 2.

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