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Avana (Avanafil)
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Avana

Avana is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012[1] and by EMA on June 21, 2013. Avana acts by inhibiting a specific phosphodiesterase type 5 enzyme found in various body tissues, primarily in the corpus cavernosum penis.

Other names for this medication:
Avanafil, Spedra, Stendra

Similar Products:
Eriacta, Provigil, Antabuse, Nolvadex, Glucophage, Inderal, Neoral, Plavix, Coreg

Also known as: Avanafil

Description

Avana is FDA-approved anti-impotence drug manufactured by Sunrise Remedies. The active ingredient of Avana is Avanafil, which is classified as PDE5 inhibitor and is aimed to treat male sexual dysfunction. Other well-known agents share a similar mechanism of action as Avanafil: Tadalafil (Cialis), Sildenafil (Viagra) and Vardenafil (Levitra). Once a drug is absorbed into the bloodstream, Avanafil expands muscles in the walls of blood vessels, thereby increases blood flow into the penis and provides a strong erection. The effect of medication starts in 15-30 minutes after taking and can last up to 6 hours, allowing you to choose the most appropriate time for you and your partner. Avanafil helps to achieve an erection when sexual stimulation occurs. Avana doesn't protect you and your partner from sexually transmitted diseases (including HIV) and from pregnancy. Avana is not intended for the treatment in women and children.

Dosage

Take one pill orally with a full glass of water 15-30 minutes before sexual activity. It may be taken with or without food. Start with 50 mg, if you are undergoing stable alpha-blocker therapy or have other health issues. You should not take the medication more than once a day or more than a recommended dose.

Overdose

If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Avana are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Avana if you are allergic to Avana's components. Do not take Avana if you are also using organic nitrates, nitrate drug for chest pain or heart condition (e.g., nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate), nitrates as amyl nitrate or nitrite ("poppers"). Do not take Avana if you take other medication to treat erectile dysfunction, pulmonary arterial hypertension, such as riociguat (Adempas). Do not take Avana in case you are taking erythromycin, medicines called alpha-blockers, ketoconazole, itraconazole (Sporanox or Nizoral), ritonavir (Norvir) or indinavir (Crixivan). Try not to consume alcohol while using Avana, as it can lower your blood pressure, causing dizziness and rapid heart rate (tachycardia). Do not drive or operate machinery while taking the medication. Contact you doctor or health care professional right away if the erection lasts longer than 4 hours or if it becomes painful. Avana does not protect you and your partner from sexually transmitted diseases and pregnancy. Avana can be dangerous for children and women.

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Randomised controlled trial of computer assisted management of hypertension in primary care. We report current parental beliefs about teething and its management in a suburban Australian setting. The approach utilizes spatio-temporal support vector regression (SVR), within which the intrinsic spatio-temporal autocorrelations in fMRI data are reflected. These experiments confirm that ARFI imaging of soft tissue is safe, although thermal response must be monitored when developing ARFI beam sequences for specific tissue types and organsystems. We used a focused laser beam operating in continuous-wave mode for noninvasive optical trapping and manipulation of single yeast cell. Although pathogenic mutations in mtDNA-encoded COX subunits have been described, no mutations in the nDNA-encoded subunits have been uncovered in any mendelian-inherited COX deficiency disorder. Here we show that Suv4-20h1/h2 are mostly absent in mouse embryos before implantation, underscoring a rapid decrease of H4K20me3 from the two-cell stage onward. The M184V mutation is selected by lamivudine (3TC) and emtricitabine (FTC) and is a common mutation in HIV-infected patients.

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Analysis of hindgut microbiota following DES in the ZDF rat elucidated discrete changes in several microbial populations including a reduction in Paraprevotella family members of the Clostridiales order along with an increase in Akkermansia muciniphila and species of the Allobaculum and Bifidobacterium genera. Bt-immunized mice demonstrated an accumulation of neutrophils in the bronchoalveolar lavage fluid, while Dp-immunized mice revealed an intense influx of eosinophils in the airway. Causes of ethnic variation may include differences in the level of acculturation, ethnic beliefs, differences in ideal body images, lack of appreciation of weight management, questionable literacy levels, and/or socioeconomic status. The amino acid could thus be useful in testing endothelium function both in healthy persons and in stroke patients since endothelium dysfunction seems to be an important factor in reperfusion injury. Men were also more optimistic about the health status of the unborn baby. Seven days after the third immunization of normal mice, the spleens of 36 of them were harvested for cytotoxic T lyphocyte (CTL) assays and the others were challenged in the brain with G422 tumor cells. Reversible posterior leukoencephalopathy syndrome (RPLS) is being increasingly described with various etiologies even in the absence of hypertension. Starting from the C-terminal cyclin-binding domain of p21 we have identified the minimal and optimized bioactive (152)HAKRRLIF(159) peptide sequence with respect to CDK protein kinase inhibition where pRb is the substrate. Preliminary ultrastructural analysis indicates that the cyst walls derive from the septum pellucidum rather than the choroid plexus or arachnoid. Accounting for energy and protein reserve changes in predicting diet-allowable milk production in cattle.

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Residual confounding, including surgeon-level heterogeneity, may influence estimates of the effect of immunonutrition. The effect of overjet on the risk of dental injury is less for boys than for girls in the same overjet group. A national survey of practice nurse involvement in mental health interventions. Information technology and knowledge exchange in health-care organizations. Biocompatible, degradable hydrogel systems that can cure in situ following injection as a liquid are useful as a base for tissue engineering and drug delivery. Quality of primary care for people with dementia can be improved through guideline implementation with care management support by social workers. The prolonged time for saccade-footlift in H-R elderly may be attributed to greater central nervous system processing time necessary to plan precise foot placements or volitional processing delays in postural control due to fall risk status. Paternal cell immunization raises autoantibodies and improves pregnancy success in mice.

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Effect of enhanced UV-B floxin antibiotics radiation on polyamine metabolism and endogenous hormone contents in rice (Oryza sativa L.). A comparison of the causes of adult mortality and its effects on life-expectancy across the regions of Colombia. Here we show that the human plexin gene family comprises at least nine members in four subfamilies. A prospective study was conducted to investigate the possible complications associated with intra- and peri-articular steroid injections. The EglA/LamA endo-acting combination was also synergistic in degrading barley-glucan. This article is based on a National Institute of Mental Health sponsored symposium on the dissemination of early interventions at the 21st annual meeting of the International Society for Traumatic Stress Studies in Toronto in 2005. Thirty-two patients who did not achieve remission during the RCT, entered an open sequential treatment protocol and were treated with augmentation with lithium, switch to a monoamine oxidase inhibitor or ECT. Absence of toxicity and genotoxicity in an extract of Rubus coriifolius.

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The mutant strain grew normally, but its conidia and mycelia were more sensitive to H(2)O(2) than those of the wild type. Previous studies in our laboratory demonstrated the presence of sialomucin complex (SMC)/Muc4 covering the rat uterine luminal epithelium. Testing of 235 seronegative samples in HIV-1 and -2 EIA showed that SCN elution reduced the mean and dispersion of OD values obtained. Furthermore, it is of interest to note that in a recovery phase from the hypothyroid state, normalization of serum T4 rather than T3 is well-correlated to prilosec heartburn medication TSH secretion. Only higher-risk patients should receive a TB screening test (Mantoux test) to minimize the possibility of false-positive test results. She remained symptom free with the maintenance of the drug combination. Thus, we have found significant changes in mediators both of vasoconstriction and vasodilation affecting the healing wound. The prospectively defined primary end points were assessed through ultrasound-derived arterial endothelial function (endothelium-dependent dilation) of the brachial artery and intima-media thickness of common carotid artery. In contrast, some neurons are labeled with a thymidine pulse as late as 18 hr.

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Glycosaminoglycans including dermatan sulphate, hyaluronan, heparan sulphate and heparin were chemically modified by O-sulphonation. The findings provide evidence of a novel mechanism in which the Stat6 transcription activation domains play a critical role in the IL-4-mediated inhibition of an IFN-gamma-inducible promoter. Continued compression for up to 8 weeks resulted in centripetal increase in the number of myelinated axons indapamide 2 5 mg and the persistence of a small fraction of large myelinated axons at the site of compression. CIS is a cytokine-induced SH2-containing protein that was originally cloned as an interleukin (IL)-3-inducible gene. The findings appear to be consistent with a biological basis for intertalker rate differences.

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