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Axedol (Tramadol)

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Axedol is an opioid (narcotic) pain reliever. It works by binding to mu-opiate receptors in the brain and changes how you feel and respond to pain. Axedol is usually started at 25 mg per day. After slowly raising the dose over several days, a typical dose would be 50 to 100 mg by mouth every 4 to 6 hours as needed for pain.

Other names for this medication:
Accupain, Acuvin, Anatram, Atdol, Bestodol, Bramadol, Cadol, Contramal, Cosdol, Dolotram, Domaspas, Jpdol, Lagesic, Midol, Nictram, Opigesic, Relidol, Tramacip, Tramagesic, Tramex, Trampar, Trandol, Transic, Trasic, Ultracon, Ultrazac, Unidol, Urgendol, Veeradol, Zotadol

Similar Products:
Nimotop, Risperdal, Ultram, Seroquel, Diovan, Epivir

Also known as: Tramadol


{name} (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

{name} is used to treat moderate to severe pain in adults.

The extended-release form of tramadol ({name} ER) is for around-the-clock treatment of pain. {name} ER is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Axedol ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Axedol ER.

Never share Axedol ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Axedol ER.

Axedol ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Axedol ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Axedol ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Axedol ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Axedol ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Axedol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how Axedol ER will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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Cyclosporine (CsA) was previously reported to effectively suppress the induction of experimental autoimmune uveoretinitis (EAU) in rats immunized with S-antigen. The effect of previous exposure to dietary microbial phytase on the endogenous excretions of energy, nitrogen and minerals from turkeys. The production of human leukocyte interferon in a serum-free medium. One function of bone in organism is to mechanically support the body. Hepatic inflow occlusion can be safely employed in a continuous manner for approximately 1 hour, even during resection of chronically diseased liver, particularly when the liver is cooled below 30 degrees C prior to hepatic clamping by our simple in-situ hypothermia technique. Clinical application of genetic testing for posterior uveal melanoma.

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In silico structural analysis of quorum sensing genes inVibriofischeri. In spite of considerable individual differences, the greatest decrease in body weight occurred in mice receiving vitamins E and B complex. Functional parameters and 99mtechnetium-dimercaptosuccinic acid scan in acute pyelonephritis. Modulated fibronectin anchorage at polymer substrates controls angiogenesis. By immunofluorescence and by expressing a green fluorescent (GFP) chimera of cyclin B, we find that cyclin B is present in aggregates in the cytoplasm of immature oocytes. Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: executive summary. The practice of group psychotherapy with adult insulin-dependent diabetics. The mutant plants exhibited relatively normal vascular patterning in leaves and cotyledons.

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Data indicated that videomodeling with graduated guidance and community-based instruction was effective for teaching children with autism how to protect themselves from the lures of strangers. The binding volume for both substrates is likewise pressure dependent falling from 20 ml/mol to 0 ml/mol for Mg-p-nitrophenyl phosphate and rising from 67 ml/mol to 155 ml/mol for calcium. Intestinal perforation and vascular tears are two possible complications to suspect if abdominal pain or systemic arterial to suspect if abdominal pain or systemic arterial urgent surgical repair of such complications. Significant degrees of similarity were also found between sequences of WSCI and of other members of the potato inhibitor I family of the serine proteinase inhibitors. The sombre foetal prognosis, already reported in the literature, requires close supervision and sustained treatment during pregnancy. Karyotyping by ultrasonically-guided withdrawal of fetal blood in an echographic warning sign. In contrast, the receptor subtype(s) involved in mechanisms that underlie mechanical hyperalgesia are at present unknown. These vessels passed through the hole of the hydroxyapatite blocks.

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Recognition of self-pollen during the self-incompatibility response in Brassica oleracea is mediated by the binding of a secreted peptide (the S locus cysteine-rich protein) to the S locus receptor kinase (SRK), a member of the plant receptor kinase (PRK) superfamily. Given such intriguing features, we have analyzed the long-term evolutionary pattern of the H1 multigene family through the evaluation of the relative importance of gene conversion, point mutation, and selection in generating and maintaining the different H1 subtypes. This was a cross-sectional study of 21 children aged 5-10 yr in a clinical research setting. Transgenic analysis of scleroderma: understanding key pathogenic events in vivo. A comparison of photolyase activity in three Australian tree frogs. C3v symmetric receptors show high selectivity and high affinity for phosphate. In contrast, TLR5 and TLR9 mRNA levels were significantly higher in IgAVN patients than in IgAN patients. An Unusual Case of Paraganglioma of the Broad Ligament Presenting as Cystic Mass. Membrane proteins were analyzed by electrophoresis in acrylamide gels containing sodium dodecyl sulfate.

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Forty consecutive patients with portal hypertension and 43 patients with non-ulcer dyspepsia (controls) underwent push enteroscopy and jejunal, duodenal and gastric biopsies. Our findings provide the first insight into the Kac events of B. Large seed size is a trait associated with plant species of mature, closed habitats, and is thought to supply an ample nutrient reserve necessary for seedling establishment. A deduced amino acid sequence of the protein was very similar to that of several other Y-box proteins, and we termed the protein rBYB1 (rat brain Y-box protein 1). These methods allow for the characterization of short-term kinetic responses and can be modified for the analysis of roots and seedlings from other species. Optimization of the cryopreservation of dromedary camel semen: Cryoprotectants and their concentration and equilibration times. If distant disease is found, certain sites, such as the CNS or long bones, may warrant aggressive therapy because failure to treat these sites may lead to excessive morbidity. Human immune responses to porcine endogenous retrovirus-derived peptides presented naturally in the context of porcine and human major histocompatibility complex class I molecules: implications in xenotransplantation of porcine organs. A simple model for the mammalian circulatory system is built in entirely physiological terms consisting of a ring shaped, one-dimensional tube which corresponds to the arterial, venular, and pulmonary trees, successively. Constraint based methods, such as Flux Balance Analysis (FBA) and Thermodynamics-based flux analysis (TFA), are commonly used to estimate the flow of metabolites through genome-wide metabolic networks, making it possible to identify the ranges of flux values that are consistent with the studied physiological and thermodynamic conditions.

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The syndrome of hypertension, hyperreninemia and secondary aldosteronism associated with renal juxtaglomerular cell tumor (primary reninism). Co-administration of an equi-molar CNDP with some fluorinated pyrimidine preparations potentiated their antitumor activity. Nevertheless, a direct, quantitative effect of acute smoking on exercise heat tolerance has not been reported. In vivo inhibition of CYP3A-mediated midazolam metabolism by anchusan in rats. Viral-specific protein synthesis in UV light-irradiated, nonsuppressing Bacillus subtilis 60084 was analyzed with exponential acrylamide gels.

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Our results should furthermore be useful to build up an analytic expression for the index of refraction of chromium forsterite. Metabolism of arachidonic acid results in a host of biologically active compounds with profound effects on airway inflammation (1). Since there is no difference in the level of acetylated histone H4 between the intestinal-type and diffuse-type of gastric cancer, histone H4 deacetylation may be involved in both types of gastric cancer. Results indicated that CVIT consists of two major subspecialties: one corresponding to cardiac procedures and one corresponding to procedures involving organ systems other than the heart. Iterative learning-based decentralized adaptive tracker for large-scale systems: a digital redesign approach. A contralateral stenosis is a risk factor for CEA from the hemodynamical point of view, and extreme care should be taken when performing CEA in patients with bilateral stenoses. Seasonal and circadian exacerbations of ischemic heart disease and their prognosis under the regional conditions of Tashkent. On-line sheathless capillary electrophoresis/nanoelectrospray ionization-tandem mass spectrometry for the analysis of glycosaminoglycan oligosaccharides. Anterior gastropexy may reduce the recurrence rate after laparoscopic paraesophageal hernia repair. Thus, such HIV/HBsAg hybrid particles could be a new approach to multivalent vaccination.

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The phosphatidylglycerol lipid was deuterated at all three segments of the glycerol headgroup. One such strong RMA derivative of FK-506 (SDZ neurontin gabapentin 300 mg obat apa 280-629) was further shown able to restore completely daunomycin retention by highly resistant MDR P388 tumor cells. All proband groups showed significantly increased brain signal randomness in dorsal and ventral prefrontal cortex (PFC), and unaffected relatives showed no complexity differences in PFC regions. Difference in size (temporal separation) was important to the co-existence of I. In this model the D1/D2 agonist apomorphine, the D1 agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrochloride and the D2 agonists N-n-propyl-N-phenylethyl-P-(3-hydroxyphenyl) ethylamine hydrochloride, trans-(-)-4aR,4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrazolo-(3, 4-g) quinolino monohydrochloride and lisuride evoked a characteristic spectrum of motor responses when administered systemically. Pathological changes based on degeneration of epithelial structures predominantly with preserved typical cell differentiation, but with unstable epithelial secretory function were detected in biopsy specimens of gastroduodenal mucosa from patients with psoriasis associated with chronic opisthorchiasis. Electrolytic lesion or pharmacological inactivation of the ipsilateral A5 neurons altered both the phrenic burst frequency and occurrence after the stimulation. The spinal reflex potential was recorded from the L5 ventral root following stimulation of the L5 dorsal root, and the effects of electrical stimulation of the LC and the NRM were tested in anesthetized rats. Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study. Percutaneous transluminal coronary angioplasty: an evaluation of sustained clinical efficacy.

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The present study investigated the effects of reducing serotonin function, using acute tryptophan depletion, on the recognition of basic facial expressions of emotions in healthy male and female volunteers. The results of clinical treatment of a non-typical and specific skin disease are presented. Insulin resistance, fibrosis, and genotype are independent predictors of the response to antiviral therapy in chronic hepatitis C patients treated with peginterferon plus ribavirin. These results are congruent with a conceptualization of adolescent MDD and adult MDD as having very similar etiologic determinants. The incidence of this subset of CSCC continues to rise in the US, as does the confusion surrounding exactly how it should be managed.

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We also demonstrate that the E3/E4 ubiquitin-protein ligase proteins RSP5 and BUL1/2 are required for GLN3 activation under poor nitrogen conditions. Recently, a novel histamine receptor termed type 4 (H4) has been identified and shown to be selectively expressed by eosinophils and mast cells. Two kinds of monochromators covering the energy ranges 100-150 keV and approximately 300 keV have been designed for inelastic (Compton) scattering experiments at the elliptical multipole wiggler beamline, BL08W, of SPring-8. Methods of detecting potential causes of vascular cognitive impairment after coronary artery bypass grafting. The present study clearly shows that glucocorticoids, androgens and thyroid hormones directly stimulate synthesis of ANP by atrial myocytes and suggests that ANP may play a potential role in mediating and/or modulating the biological effects by these hormones in the cardiovascular system. These mutant strains, Delta Ylmnn9, Delta Ylanl1, Delta Yloch1, Delta Ylanl1 Delta Ylmnn9 and Delta Ylmnn9 Delta Yloch1 may thus be used to establish a model for plavix brand name the Y. Serum zinc levels in patients with the acquired immunodeficiency syndrome. Our objective has been to analyse the mortality, survival and disease-free survival lung metastasis surgery by studying the different variables that determine them. These results show that the adjusted glycopeptide DIA workflow using soft collision-induced fragmentation of glycopeptides is suitable for site-specific analysis of protein glycosylation in complex mixtures of analytes without glycopeptide enrichment. The national strategy instaured since September 2000 has been respected.

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In the context of medicine, lifelong learning has always been formally considered an ethical obligation of doctors although the term Continuing Medical Education (CME) is more commonly used than Continuous Professional Development (CPD). Dehydration processes for lanthanoid(III) chrolanilate complexes studied by EXAFS. The aim of this study was to evaluate the development in aerobic power in elite as well as non-elite soccer players during the years of puberty and to relate it to maturation as well as hemoglobin and hematocrit. The bifurcation beyond the circle of Willis (that is, the MCA) closely approximated optimality principles, whereas the bifurcations within the circle of Willis (that is, the distal ICA and BA) did not. Despite its clinical significance, relatively little is known about the components of Helicobacter pylori that allow it to colonize, persist, and elicit an inflammatory response within the host. One factor that has been stressed in the literature is the lack of standardized outcome measures that can be used in all countries. The projections of the nucleus of Bellonci into the primordial hippocamp were compared to the limbic thalamo-hippocampal pathways of other vertebrates. In chemical fertilizer plots treated with AN or CU, NO(3)-N concentrations in soil water at 1-m depth increased markedly in the summer of the second year and fluctuated between 30 and 60 mg l(-1). Mobility and interactions of coronavirus nonstructural protein 4. The present article reviews the use of psychologic measures in guiding a functional restoration treatment program with chronic low-back pain patients.

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Automated affinity chromatography measurements of compound mixtures using a lab-on-valve apparatus coupled to electrospray ionization mass spectrometry. To improve our understanding of this tumor and define outcomes with current management, we performed a retrospective review of these cases. Serial assays of thyroid and pituitary hormones were done, and magnetic resonance imaging of the pituitary was performed before and 16 weeks after initiation of cabergoline therapy. Uncoupling of oxidative phosphorylation and Smac/DIABLO release are not sufficient to account for induction of apoptosis by sulindac sulfide in human colorectal cancer cells. Within community programs, presence of a relevant goal was positively related to change in independent living skills, and clients with musculoskeletal impairments tended to regress in motor and eating skills. Symptoms of the antiphospholipid syndrome determined the outcome.

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These results were further synthesized with the relational cultural theory (RCT). Early onset (less than 25 years of age) was associated with a high frequency of A1, B17, B37, and Cw6 antigens, whereas patients with late onset (greater than 25 years of age) had a significantly lower incidence of A1, B17, and Cw6, which did not differ from that of the control subjects. We report four children from four inbred Arab families with varying manifestations of max dose of klonopin per day Hennekam syndrome and additional features that have not been previously reported. Nevertheless, moderate levels of sodium chloride improved bacteriocin activity because they increased the biomass concentration at which bacteriocin production was switched off. Greater efforts are warranted to prevent injuries associated with other nursery products, especially baby carriers, cribs, and strollers. Adherent omentum was reduced from the sac and a wide flap of peritoneum extending 5 cm on all sides of the fascial defect was raised. In addition, we present the result of a simulation comparing our methods to well-known statistics and multiple testing adjustments.

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A combination of physicochemical methods was applied including surface tension measurements on adsorbed and spread monolayers at the air-water interface, Fourier transform infrared, circular dichroism, and atomic force microscopy on Langmuir-Blodgett monolayers. Patients undergoing stent placement as treatment for severe stenosis of the internal carotid artery (ICA) were assessed with MR imaging in a combined MR-radiographic (XMR) angiography suite. The prevalence of BL in a Sicilian population of CRF patients was higher than in the general population, but lower than in patients with CRF on chronic HD. To gain clarity about the institutional changes necessary to limit the scale of economic activity, it is essential that ecological economics understands the limitations of its neoclassical roots and expands its theoretical framework to include how markets are embedded in social and institutional structures. The contrasting low versus high diversity in the two sub-populations (K1 and K2) infers that a combination of local transmission and cross-border malaria from higher transmission regions shape the genetic make-up of the P. The nuclear bile acid receptor FXR as a novel therapeutic target in cholestatic liver diseases: hype or hope?. Expression and regulation of Groucho-related genes in the embryonic chicken feather bud. In contrast MOR-IR was present only in supporting cells at P0-P16. Direct observation by cryoEM reveals that this occupancy-enhancing N-terminal domain is partially ordered. Phosphoketolases catalyze an energy- and redox-independent cleavage of certain sugar phosphates.

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Ultrastructure of Goussia cruciata (Apicomplexa: Coccidia) infecting the liver of horse mackerel, Trachurus trachurus (L.), from Ibero-Atlantic waters. Electrochemical detection of DNA hybridization using a change in flexibility. HIV may be one of the major causative agents of multiple benign giant esophageal ulcers in AIDS patients. Production and characterization of monoclonal antibodies to the extracellular domain of P0. Electromechanical Conditioning of Adult Progenitor Cells Improves Recovery of Cardiac Function After Myocardial Infarction. Pathologic findings, surgical approach, extent of tumor resection, rate of facial nerve mobilization and ear canal closure, facial and lower cranial nerve outcomes, and hearing preservation.

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