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Azpax (Clonazepam)
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Azpax

Clonazepam, sold under the brand name Klonopin among others, is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Azpax was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Adnil, Calmnir, Cloam, Clonapax, Clonark, Clonasig, Clonax, Clonopam, Deptune, Easyfeel, Epitril, Escitacalm, Esitor, Lonazep, Lozep, Melzap, Nexclo, Onapil, Ozepam, Prasilex, Prasilife, Repam, Somnolex, Somnotril, Xitzen, Zepam

Similar Products:
Lioresal, Altace, Cardura, Alprostadil, Prometrium, Silagra, Aurogra, Kamagra

Also known as: Clonazepam

Description

Azpax results in a depression of the activities of the central nervous system. This depression is not meant to designate a feeling of depressed mood, although some people may experience depressed mood as a side effect of Azpax use. It instead relates to a reduction in the rate of activity of the cells in the brain. This reduction in the rate of brain activity affects several cognitive functions, most notably the ability to form new memories. Memories are formed in the brain as a result of increased activity of neurons, and a person using a benzodiazepine like Azpax will experience a dampening of these processes that can interfere with the ability to form new memories while one is taking the drug.

There is some evidence that cognitive abilities, such as memory, attention, visual spatial skills, and even intellect, might be affected as a result of long-term benzodiazepine abuse; however, the research in this area is limited due to many of the subjects in the studies having a history of abusing benzodiazepines and other substances, such as alcohol.

Dosage

Your doctor will probably start you on a low dose of Azpax and gradually increase your dose, not more often than once every 3 days.

Azpax can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer period of time or in a different way than prescribed by your doctor. Take Azpax exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Azpax may help control your condition, but will not cure it. It may take a few weeks or longer before you feel the full benefit of Azpax. Continue to take Azpax even if you feel well. Do not stop taking Azpax without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood, If you suddenly stop taking Azpax, you may experience withdrawal symptoms such as new or worsening seizures, hallucinating (seeing things or hearing voices that do not exist), changes in behavior, sweating, uncontrollable shaking of a part of your body, stomach or muscle cramps, anxiety, or difficulty falling asleep or staying asleep. Your doctor will probably decrease your dose gradually.

Overdose

Benzodiazepines like Azpax became popular prescription medications, as alternatives to another class of anti-anxiety medications called barbiturates. Barbiturates were once very popular in the treatment of anxiety; however, they were highly addictive, carried a high risk for overdose, and were frequently abused. Benzodiazepines also carry a significant risk for the development of physical dependence and abuse (see below); however, they do not appear to carry the same risk of overdose that is associated with barbiturates (although overdose on benzodiazepines can occur).

Many of the cases of overdose that include benzodiazepines also include the co-occurring use of other drugs, such as alcohol, narcotic pain medications, or antidepressants. Using these drugs and benzodiazepines like Azpax together enhances the effects of all drugs as well as increases the risk for overdose and potential fatalities due to drug interactions and drug overdose.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Side effects

The most common side effects associated with Azpax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Male Noble rats were exposed from conception until 200 days of age to diets containing an adequate (0.33-0.45 mg/kg diet) or high (3.33-3.45 mg/kg) concentration of selenium as Se-methylselenocysteine and a low (10 mg/kg) or high (600 mg/kg) level of isoflavones in a 2 x 2 factorial design. Transient rheological properties and mucoadhesion of hydrogels composed of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO, or Pluronic) block copolymers and poly(acrylic acid) were explored. Our intensive screening under standardized conditions provides the opportunity to compare cellular uptake of CPPs, an important step for the use of CPPs as peptidic vectors in the medical field. The child with the more proficient speech production and perception skills showed consistent and significant reductions in Po, F0, and intensity in the OFF condition. The partial 16S rDNA and ribonuclease P RNA (RNase P) genes were amplified, cloned, and sequenced in blood samples obtained from H canis-infected dogs and M haemofelis-infected cats. Phylogenetic analysis of CbbQ and NirQ/NorQ indicated that CbbQ-m from Hv.

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The slopes of the relationship between delta13Cresid and delta18Oresid differ insignificantly. Diabetes alters drug metabolism--in vivo studies in a streptozotozin-diabetic rat model. The ability of hormones (insulin, insulin-like growth factor I, glucocorticoids) or cytokines (tumor necrosis factor, interleukin-1) to act as mediators or modulators of protein catabolism is also examined. Small non-coding microRNAs (miRNAs) can modulate the outcome of virus infection. Needle-catheter jejunostomy for postoperative nutritional support. Therefore, although protein stability can be altered by single amino acid substitution, evolution for optimal function may require more subtle and delocalized mechanisms. Clinical outcome of patients with head and neck squamous cell carcinoma (SCCHN) depends on several risk factors like the presence of locoregional lymph node or distant metastases, stage, localisation and histologic differentiation of the tumour. These findings suggest that the primary activation function of the C-terminal activation domain is different from the function of the N-terminal activation domain and that it is required for derepression of the chromatin-repressed MMTV promoter. A transparently scalable visualization architecture for exploring the universe. The changes probably represent the toxicity of intraarterial methotrexate possibly potentiated by mannitol-induced opening of the blood-retinal barrier.

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Hh signaling stabilizes and activates the full-length Ci protein leading to strong activation of downstream target genes including patched and decapentaplegic. The authors reviewed the software application design aspects responsible for these usability problems. In contrast, thalidomide-treated rats experienced comparable arthritis severity to placebo-treated animals. In vitro absorption studies with carvedilol using a new model with porcine intestine called BM-RIMO (Boehringer-Mannheim ring model). A mathematical model describing HIV transmission among homosexual men was developed.

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Thymic localization of gallium-67 in pediatric patients with lymphoid and nonlymphoid tumors. Stenting-related myocardial injury has been recognized as a frequent and prognostically important event, the extent of which depends on microcirculatory impairment in association with platelet aggregation, inflammation, and increased oxidative stress. The Effects of a Community-Based Sodium Reduction Program in Rural China - A Cluster-Randomized Trial. However, when number and length were presented sequentially (Experiment 2), the differences in discrimination performance between time, number, and length disappeared. The infection is shown as a secondary phenomenon in lithiasic acute cholecystitis.

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Abstracts of the American Society for Histocompatibility and Immunogenetics 28th Annual Meeting. Twenty-two normal pregnant women were compared with 22 women diagnosed with gestational diabetes mellitus (GDM). The size of the probe/pilot hole had a nonlinear, parabolic effect on pullout strength. A prospectively collected consecutive series of meniscal repairs performed with the FasT-Fix device was studied. Implantation of spheroids into a gel matrix of collagen type I was associated with measurable invasion of the surrounding gel by individual tumor cells. Alternative splicing of Staufen2 creates the nuclear export signal for CRM1 (Exportin 1). Academic performance and comparative effectiveness of computer- and textbook-based self-instruction.

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