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Azulfidine

Azulfidine is used to treat bowel inflammation, diarrhea (stool frequency), rectal bleeding, and abdominal pain in patients with ulcerative colitis, a condition in which the bowel is inflamed. Azulfidine is used to treat rheumatoid arthritis in adults and children whose disease has not responded well to other medications. Azulfidine is in a class of medications called anti-inflammatory drugs. It works by reducing inflammation (swelling) inside the body.

Other names for this medication:
Iwata, Rhemosaz, Salazar, Sulfasalazine

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Also known as: Sulfasalazine

Description

Generic Azulfidine is used for the treatment of mild to moderate ulcerative colitis, as adjunctive therapy (with other medications) in the treatment of severe ulcerative colitis, for the treatment of Crohn's disease, for the treatment of rheumatoid arthritis or ankylosing spondylitis. Generic Azulfidine is a sulfonamide that decreases inflammation and help regulate the immune system in various areas of the body. Azulfidine is also known as Sulfasalazine. Generic name of Generic Azulfidine is Sulfasalazine. Brand name of Generic Azulfidine is Azulfidine.

Dosage

This section provides information on the proper use of a number of products that contain salicylate. It may not be specific to Azulfidine. Please read with care.

Take this medicine after meals or with food (except for enteric-coated capsules or tablets and aspirin suppositories) to lessen stomach irritation.

Take tablet or capsule forms of this medicine with a full glass (8 ounces) of water. Also, do not lie down for about 15 to 30 minutes after swallowing the medicine. This helps to prevent irritation that may lead to trouble in swallowing.

For patients taking aspirin (including buffered aspirin and/or products containing caffeine):

Do not use any product that contains aspirin if it has a strong, vinegar-like odor. This odor means the medicine is breaking down. If you have any questions about this, check with your health care professional. If you are to take any medicine that contains aspirin within 7 days after having your tonsils removed, a tooth pulled, or other dental or mouth surgery, be sure to swallow the aspirin whole. Do not chew aspirin during this time. Do not place any medicine that contains aspirin directly on a tooth or gum surface. This may cause a burn. There are several different forms of aspirin or buffered aspirin tablets. If you are using: chewable aspirin tablets, they may be chewed, dissolved in liquid, crushed, or swallowed whole. delayed-release (enteric-coated) aspirin tablets, they must be swallowed whole. Do not crush them or break them up before taking. extended-release (long-acting) aspirin tablets, check with your pharmacist as to how they should be taken. Some may be broken up (but must not be crushed) before swallowing if you cannot swallow them whole. Others should not be broken up and must be swallowed whole.

To use aspirin suppositories:

If the suppository is too soft to insert, chill it in the refrigerator for 30 minutes or run cold water over it before removing the foil wrapper. To insert the suppository: First remove the foil wrapper and moisten the suppository with cold water. Lie down on your side and use your finger to push the suppository well up into the rectum.

To take choline and magnesium salicylates (e.g., Trilisate) oral solution:

The liquid may be mixed with fruit juice just before taking. Drink a full glass (8 ounces) of water after taking the medicine.

To take enteric-coated sodium salicylate tablets:

The tablets must be swallowed whole. Do not crush them or break them up before taking.

Unless otherwise directed by your medical doctor or dentist:

Do not take more of this medicine than recommended on the label, to lessen the chance of side effects. Children up to 12 years of age should not take this medicine more than 5 times a day.

When used for arthritis (rheumatism), this medicine must be taken regularly as ordered by your doctor in order for it to help you. Up to 2 to 3 weeks or longer may pass before you feel the full effects of this medicine.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For aspirin For oral dosage forms (short-acting tablets, chewable tablets, and delayed-release [enteric-coated] tablets): For pain or fever: Adults and teenagers—325 to 500 milligrams (mg) every three or four hours, 650 mg every four to six hours, or 1000 mg every six hours as needed. Children 11 to 12 years of age—320 to 480 mg every four hours as needed. Children 9 to 11 years of age—320 to 400 mg every four hours as needed. Children 6 to 9 years of age—320 to 325 mg every four hours as needed. Children 4 to 6 years of age—240 mg every four hours as needed. Children 2 to 4 years of age—160 mg every four hours as needed. Children up to 2 years of age—Dose must be determined by your doctor. For arthritis: Adults and teenagers—A total of 3600 to 5400 mg a day, divided into several smaller doses. Children—A total of 80 to 100 mg per kilogram (kg) (32 to 40 mg per pound) of body weight a day, divided into several smaller doses. For preventing a heart attack, stroke, or other problems caused by blood clots: Adults—Most people will take 81, 162.5, or 325 mg a day or 325 mg every other day. Some people taking aspirin to prevent a stroke may need as much as 1000 mg a day. Children—Use and dose must be determined by your doctor. For oral dosage form (chewing gum): For pain: Adults and teenagers—2 tablets every four hours as needed. Children 6 to 12 years of age—1 or 2 tablets (227 mg each) up to four times a day. Children 3 to 6 years of age—1 tablet (227 mg) up to three times a day. Children up to 3 years of age—Dose must be determined by your doctor. For long-acting oral dosage form (extended-release tablets): For pain: Adults and teenagers—1 or 2 tablets twice a day. Children—The long-acting aspirin tablets are too strong for use in children. For arthritis: Adults and teenagers—1 or 2 tablets twice a day, at first. Your doctor will then adjust your dose as needed. Children—The long-acting aspirin tablets are too strong for use in children. For rectal dosage form (suppositories): For pain or fever: Adults and teenagers—325 to 650 mg every four hours as needed. Children 11 to 12 years of age—325 to 480 mg every four hours as needed. Children 9 to 11 years of age—325 to 400 mg every four hours as needed. Children 6 to 9 years of age—325 mg every four hours as needed. Children 4 to 6 years of age—240 mg every four hours as needed. Children 2 to 4 years of age—160 mg every four hours as needed. Children up to 2 years of age—Dose must be determined by your doctor. For arthritis: Adults and teenagers—A total of 3600 to 5400 mg a day, divided into several smaller doses. Children—A total of 80 to 100 mg per kilogram (kg) (32 to 40 mg per pound) of body weight a day, divided into several smaller doses.

For aspirin and caffeine For oral dosage forms (capsule): For pain or fever: Adults and teenagers—325 to 500 milligrams (mg) of aspirin every three or four hours, 650 mg of aspirin every four to six hours, or 1000 mg of aspirin every six hours as needed. Children 9 to 12 years of age—325 to 400 mg every four hours as needed. Children 6 to 9 years of age—325 mg every four hours as needed. Children up to 6 years of age—Aspirin and caffeine capsules are too strong for use in children up to 6 years of age For preventing a heart attack, stroke, or other problems caused by blood clots: Adults—325 mg a day or every other day. People who take smaller doses of aspirin will have to use a different product. Some people taking aspirin to prevent a stroke may need as much as 1000 mg a day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): For pain or fever: Adults and teenagers—325 to 500 mg of aspirin every three or four hours, 650 mg of aspirin every four to six hours, or 1000 mg of aspirin every six hours as needed. Children 9 to 12 years of age—325 to 400 mg every four hours as needed. Children up to 9 years of age—Aspirin and caffeine tablets are too strong for use in children up to 9 years of age. For arthritis: Adults and teenagers—A total of 3600 to 5400 mg of aspirin a day, divided into several smaller doses. Children—A total of 80 to 100 mg per kg (32 to 40 mg per pound) of body weight a day, divided into several smaller doses. For preventing a heart attack, stroke, or other problems caused by blood clots: Adults—325 mg a day or every other day. People who take smaller doses of aspirin will have to use a different product. Some people taking aspirin to prevent a stroke may need as much as 1000 mg a day. Children—Use and dose must be determined by your doctor.

For buffered aspirin For oral dosage forms (tablets): For pain or fever: Adults and teenagers—325 to 500 milligrams (mg) of aspirin every three or four hours, 650 mg of aspirin every four to six hours, or 1000 mg of aspirin every six hours as needed. Children 11 to 12 years of age—One or one and one-half 325-mg tablets every four hours as needed. Children 9 to 11 years of age—One or one and one-fourth 325-mg tablets every four hours as needed. Children 6 to 9 years of age—One 325-mg tablet every four hours as needed. Children 4 to 6 years of age—Three-fourths of a 325-mg tablet every four hours as needed. Children 2 to 4 years of age—One-half of a 325-mg tablet every four hours as needed. Children up to 2 years of age—Dose must be determined by your doctor. For arthritis: Adults and teenagers—A total of 3600 to 5400 mg of aspirin a day, divided into several smaller doses. Children—A total of 80 to 100 mg per kilogram (kg) (32 to 40 mg per pound) of body weight a day, divided into several smaller doses. For preventing a heart attack, stroke, or other problems caused by blood clots: Adults—325 mg a day or every other day. People who take smaller doses of aspirin will have to use a different product. Some people taking aspirin to prevent a stroke may need as much as 1000 mg a day. Children—Use and dose must be determined by your doctor.

For buffered aspirin and caffeine For oral dosage form (tablets): For pain or fever: Adults and teenagers—325 or 421 milligrams (mg) of aspirin every three or four hours, 650 mg of aspirin every four to six hours, or 842 mg of aspirin every six hours as needed. Children 11 to 12 years of age—One or one and one-half 325-mg tablets, or one 421-mg tablet, every four hours as needed. Children 9 to 11 years of age—One or one and one-fourth 325-mg tablets every four hours as needed. Children 6 to 9 years of age—One 325-mg or 421-mg tablet every four hours as needed. Children 4 to 6 years of age—Three-fourths of a 325-mg tablet every four hours as needed. Children 2 to 4 years of age—One-half of a 325-mg tablet every four hours as needed. Children up to 2 years of age—Dose must be determined by your doctor. For arthritis: Adults and teenagers—A total of 3600 to 5400 mg of aspirin a day, divided into several smaller doses. Children—A total of 80 to 100 mg per kilogram (kg) (32 to 40 mg per pound) of body weight a day, divided into several smaller doses. For preventing a heart attack, stroke, or other problems caused by blood clots: Adults—162.5 or 325 mg (one-half or one 325-mg tablet) a day or 325 mg every other day. People who need smaller doses of aspirin will have to use a different product. Some people taking aspirin to prevent a stroke may need as much as 1000 mg a day. Children—Use and dose must be determined by your doctor.

For choline salicylate For oral dosage form (oral solution): For pain or fever: Adults and teenagers—One-half or three-fourths of a teaspoonful every three hours, one-half or one teaspoonful every four hours, or one or one and one-half teaspoonfuls every six hours as needed. Children 11 to 12 years of age—2.5 to 3.75 mL (one-half to three-fourths of a teaspoonful) every four hours as needed. This amount should be measured by a special measuring spoon. Children 6 to 11 years of age—2.5 mL (one-half of a teaspoonful) every four hours as needed. This amount should be measured by a special measuring spoon. Children 4 to 6 years of age—1.66 mL every four hours as needed. This amount should be measured by a special dropper or measuring spoon. Children 2 to 4 years of age—1.25 milliliters (mL) (one-fourth of a teaspoonful) every four hours as needed. This amount should be measured by a special dropper or measuring spoon. Children up to 2 years of age—Dose must be determined by your doctor. For arthritis: Adults—A total of five and one-half to eight teaspoonfuls a day, divided into several smaller doses. Children—A total of 0.6 to 0.7 mL per kilogram (kg) (0.25 to 0.28 mL per pound) of body weight a day, divided into several smaller doses.

For choline and magnesium salicylates For oral dosage forms (oral solution or tablets): For pain or fever: Adults and teenagers—A total of 2000 to 3000 milligrams (mg) a day, divided into two or three doses. Children weighing more than 37 kg (90 pounds or more)—2200 mg a day, divided into two doses. Children weighing up to 37 kilograms (kg) (about 89 pounds)—A total of 50 mg per kg (20 mg per pound) of body weight a day, divided into two doses.

For magnesium salicylate For oral dosage form (tablets): For pain: Adults and teenagers—2 regular-strength tablets every four hours, up to a maximum of 12 tablets a day, or 2 extra-strength tablets every eight hours, up to a maximum of 8 tablets a day. Children—Dose must be determined by your doctor.

For salsalate For oral dosage forms (capsules or tablets): For arthritis: Adults and teenagers—500 to 1000 milligrams (mg) two or three times a day, to start. Your doctor will then adjust your dose as needed. Children—Dose must be determined by your doctor.

For sodium salicylate For oral dosage forms (tablets or delayed-release [enteric-coated] tablets): For pain or fever: Adults and teenagers—325 or 650 milligrams (mg) every four hours as needed. Children 6 years of age and older—325 mg every four hours as needed. Children up to 6 years of age—This medicine is too strong for use in children younger than 6 years of age. For arthritis: Adults and teenagers—A total of 3600 to 5400 mg a day, divided into several smaller doses. Children—A total of 80 to 100 mg per kilogram (kg) (32 to 40 mg per pound) of body weight a day, divided into several smaller doses.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include vomiting, stomach pain, drowsiness, or seizure.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Azulfidine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Elderly people are especially sensitive to the effects of salicylates. This may increase the chance of side effects during treatment.

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A 46-year-old Chinese woman presented with nausea, recurrent vomiting, and abdominal pain. The present results suggest that changes in reproductive functions and sex steroid secretion in male HDC-KO mice are not due to altered hypothalamic GnRH expression but are probably related to definite modifications during fetal development of KO mice reinforced later by the lack of the effect of peripheral histamine. Ribosomal frameshift is used by HIV-1 to synthesize the precursor of its enzymes. For all 3 groups, the direction in which the target traveled had no influence, but the size of the forward displacement increased as target speed increased. Small GTPases of the Rab family play a key role in controlling vesicular transport, and the Rab GDP-dissociation inhibitor (GDI) is a regulatory protein for the Rab proteins. The 2 suture loops are twirled twice around the corresponding haptics of a standard 3-piece PMMA IOL, and the IOL is placed in the sulcus. To elucidate the mechanism of the type 2 carbohydrate chain accompanying the development of endometrial cancer, we studied the expression of beta-1,4-galactosyltransferase (beta-1,4GT) in normal endometrial and endometrial cancer tissues. A total number of 104 patients with ingested foreign body admitted in our hospital are reviewed. Individuals with specific reading disability (SRD) may exhibit visual psychophysical abnormalities that include prolonged visual persistence, decreased luminance contrast sensitivity, lower flicker fusion thresholds, abnormal metacontrast masking, and lower motion detection sensitivity.

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The concept can be compared to that of the global positioning system (GPS) that is used by motorists. Although the lesion was initially mistaken for metastasis, at surgery an intramedullary abscess was discovered, from which group F Streptococcus was isolated. Descriptive and inferential statistics (chi square and t test) were used for data analysis. In this paper, we describe our approach to placement of peritoneal access and report our experience with 304 embedded catheters placed between January 2000 and December 2003. To investigate the feasibility of applying isokinetic dynamometry for identifying submaximal grip strength. For many years the complexity of the structures required sophisticated analytical techniques only available to a few specialist laboratories. GPI anchors are widely represented among organisms and have several cellular functions. Stellate and pyramidal neurons in goldfish telencephalon respond differently to anoxia and GABA receptor inhibition. Idazoxan does not prevent but worsens focal hypoxic-ischemic brain damage in neonatal Wistar rats. Involvement of cAMP and protein kinase A in conidial differentiation by Erysiphe graminis f.

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Ciliostasis is a key early event during colonization of canine tracheal tissue by Bordetella bronchiseptica. After applying the Fourier transform to the intensity time curves (ITC) of an angiographic sequence, we are able to produce both morphological and functional images. It will be necessary to investigate the optimal radiation dose and target of GKS diflucan dosage medscape for achieving long-term pain relief in GPN. Additionally, previous research found a higher risk for late HIV-testing for migrants. Using a computer-based program, the total surface area of each premolar and molar, the outer enamel ridge perimeter distance, infundibular surface areas and perimeter distances were measured. The capacity of RAW 264.7 mouse macrophages exposed to polymer particles to produce factors affecting bone metabolism was also studied. Programmed cell death (PCD) is one possible mechanism that myeloid cells may use to prevent excessive inflammation.

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We therefore screened esophageal tumor cell lines and tumor tissues to detect tumor specific mutations of the LATS2 gene. SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine in a murine model of bone cancer pain. This fraction is absent in A 23187- or 4-O-methyl-TPA-treated dermis. Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Developing an interaction-centered evaluation tool for distance education. The choice between irinotecan- or oxaliplatin-based cytotoxic chemotherapy regimen is primarily based on differential toxicity profile because they have similar efficacy. One hundred seventy patients completed the study by undergoing either subtotal or total gastrectomy with D2 lymph node dissection. The desired beta-allyl-C-mannosyl products 42 and 43 were obtained, albeit in low yield, when bulky ethyl and isopropyl groups were employed at the silyl ether tether.

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We studied 514 male and 965 female African-Americans 51 to 70 years old, in whom echocardiographic left ventricular mass measurements were collected for the ARIC Study. In this review we describe our initial studies and the results of more recent investigations into the effects of the gastric hormone ghrelin and the intestinal hormones peptide YY, pancreatic polypeptide, glucagon-like peptide-1, and oxyntomodulin on energy homeostasis. The selection of device size is determined by the placement of the left disc. The data reveal a correlation between electrocardiographic changes and hemostasis in patients with ACS. Sphingosine contributes to glucocorticoid-induced apoptosis of thymocytes independently of the mitochondrial pathway.

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