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Bactipront (Trimethoprim)
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Bactipront

Bactipront is an effective combination antibiotic; however, it may not be suitable for those with kidney or liver disease or folate deficiency. The risk of side effects may be higher in the elderly.

Other names for this medication:
Actrim, Bactrimel, Bactropin, Baktimol, Berlocid, Bioprim, Biotrim, Bitrim, Chemitrim, Colizole, Ectaprim, Editrim, Escoprim, Eusaprim, Exazol, Fisat, Gantrisin, Groprim, Irgagen, Kemoprim, Linaris, Metrim, Navatrim, Nufaprim, Organosol, Oriprim, Plocanmad, Primadex, Primotren, Sinatrim, Soltrim, Spectrem, Suftrex, Sulfamethoxazolum, Sulfatrim, Sulfoprima, Sulprim, Sumetoprin, Suprim, Tagremin, Trelibec, Trimethazol, Trimethox, Trimosazol, Trimoxsul, Trisolvat, Trisulin, Vanasulf, Wiatrim

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Also known as: Trimethoprim

Description

This medication is used to treat a wide variety of bacterial infections. It is also used to treat a certain type of pneumonia (pneumocystis pneumonia) in patients with a weakened immune system. This medication is a combination of 2 antibiotics: sulfamethoxazole and trimethoprim. It works by stopping the growth of bacteria and the pneumocystis fungus.

Dosage

This section provides information on the proper use of a number of products that contain sulfamethoxazole and trimethoprim. It may not be specific to Bactipront DS. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Sulfamethoxazole and trimethoprim combination is best taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day, unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects (eg, crystals in the urine). .

For patients taking the oral liquid, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (liquid or tablets): For treatment of bacterial infections: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 10 to 14 days. Your doctor may adjust this dose if needed. Children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 40 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 8 milligrams (mg) per kilogram of body weight of trimethoprim, given in two divided doses every 12 hours for 10 days. Weighing 40 kilograms (kg)—4 teaspoonfuls (20 mL) of oral liquid or 2 tablets (or 1 DS tablet) 2 times a day for 10 days. Weighing 30 kg—3 teaspoonfuls (15 mL) of oral liquid or 1 ½ tablet 2 times a day for 10 days. Weighing 20 kg—2 teaspoonfuls (10 mL) of oral liquid or 1 tablet 2 times a day for 10 days. Weighing 10 kg—1 teaspoonful (5 mL) of oral liquid 2 times a day for 10 days. Children younger than 2 months of age—Use is not recommended. For treatment of bronchitis: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 14 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended. For treatment of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults and children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 75 to 100 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 15 to 20 milligrams (mg) per kilogram of body weight of trimethoprim each day, given in equally divided doses every 6 hours for 14 to 21 days. Weighing 80 kilograms (kg)—10 teaspoonfuls (50 milliliters (mL)) or 5 tablets (or 2 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 64 kg—8 teaspoonfuls (40 mL) or 4 tablets (or 2 DS tablets) 4 times a day for 14 to 21 days. Weighing 48 kg—6 teaspoonfuls (30 mL) or 3 tablets (or 1 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 40 kg—5 teaspoonfuls (25 mL) or 2 ½ tablets 4 times a day for 14 to 21 days. Weighing 32 kg—4 teaspoonfuls (20 mL) or 2 tablets (or 1 DS tablet) 4 times a day for 14 to 21 days. Weighing 24 kg—3 teaspoonfuls (15 mL) or 1 ½ tablets 4 times a day for 14 to 21 days. Weighing 16 kg—2 teaspoonfuls (10 mL) or 1 tablet 4 times a day for 14 to 21 days. Weighing 8 kg—1 teaspoonful (5 mL) 4 times a day for 14 to 21 days. Children younger than 2 months of age—Use is not recommended. For prevention of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults—800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim once a day. Children 2 months of age and older—Dose is based on body size and must be determined by your doctor. The usual dose is 750 mg of sulfamethoxazole and 150 mg of trimethoprim per square meter (m[2]) of body surface each day. This is given in equally divided doses two times a day for 3 days a week on consecutive days (eg, Monday, Tuesday, Wednesday). However, the dose is usually not more than 1600 mg of sulfamethoxazole and 320 mg of trimethoprim per day. Children younger than 2 months of age—Use is not recommended. For treatment of traveler's diarrhea: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 5 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe nausea/vomiting/diarrhea, severe dizziness or drowsiness, mental/mood changes.

Storage

Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Bactipront are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sulfamethoxazole and trimethoprim combination in the elderly. However, elderly patients are more likely to have a folate deficiency, age-related kidney or liver problems, and may be more likely to experience unwanted side effects (eg, severe skin rash, increased potassium in the body, or problems with blood clotting or the immune system). There may be an adjustment in the dose for elderly patients receiving sulfamethoxazole and trimethoprim combination.

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Induction of labor with oxytocin is associated with an increased rate of uterine rupture in gravid women with 1 prior uterine scar in comparison with the rate in spontaneously laboring women. When compared to serum ELISA the nested blood- and milk PCRs were equal in identifying DNA from clinically infected animals. To explore the translational potential of these results, we assessed the transcript levels (by quantitative PCR), DNA methylation status (by bisulfite pyrosequencing), and GAL peptide by RIA of the GAL system in postmortem brains from depressed persons who had committed suicide and controls. Sonographic diagnosis of lethal osteogenesis imperfecta in the second trimester: case report and review. However there are a few studies to present negative complications of VAC, especially increase of microorganisms in the wound. The aim of the paper is to demonstrate that the psychometric framework may limit more meaningful educational approaches to performance assessment, because it does not take into account key issues in the mechanics of the assessment process. In spite of complete surgical repair of the cardiac malformation, several episodes of respiratory failure occurred several years after the operation. Ophthalmologists must exercise care when using long-term corticosteroid treatment in this condition. Atherosclerosis is preceded by cholesterol-induced diminution in vascular nitric oxide (NO) production and proatherogenic changes in endothelial cell function.

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Activity in vivo of some antibiotics in mixed infactions caused by M. These interactions and events are facilitated and, in some cases made possible, by the persistent close contacts between platelets that can only occur after the onset of aggregation. A natural source of proline and proline precursors can be obtained from fish protein hydrolysates (FPH), a byproduct of the fishery industry. cholerae O1 El Tor Inaba phage 1d was the predominated biotype with multi-clone coexisting and circulating in Guangdong province in 2007. The use of Schwann cells as stimulators of axon regrowth depends on the neuronal cell type and the appropriate postinjury time point. Measurement of resistant starch by enzymatic digestion in starch and selected plant materials: collaborative study. Heat-shock protein 90, which coprecipitates with M15, might be required in vivo to prevent the degradation of unassembled M15 and to hold it in an interaction-competent conformation. Synthetic RNA substrates were used to determine the substrate specificity of the TCoV nsp15. Use of polydimethylsiloxane in the endoscopic treatment of urinary incontinence of neurologic origin in children. These results suggest that the brain learns multiple internal models to compensate for each transformation and has some ability to combine and decompose these internal models as called for by the occasion.

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As more knowledge on the physiological functions of P-gp has accumulated, the effects of P-gp modulation on the pharmacokinetics and the pharmacodynamics of many drugs have become apparent. A total of 417 female and 466 male fetuses fulfilled our study criteria. Resonant tunneling also leads to a narrowing of the linewidth of the absorption peak to a sublinewidth level. Caring for the uninsured: are not-for-profit hospitals doing their share?. In contrast, thalamic activation increased only when the recognition deficit resulted from impaired memory storage.

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Electron microscope study of thyroid medullary carcinoma with amyloid stroma. New observations, including diffuse white matter and cerebellar insults in some survivors, are being made. Delayed gastric emptying and intolerance to gastric feeding occur frequently in the critically ill. Multislice CT virtual intravascular endoscopy for abdominal aortic aneurysm stent grafts. Children with Pierre Robin sequence can present challenging airway management issues. Emphasis is placed on the diagnostic techniques used in the differential diagnosis. The serum concentration of immunoglobulins of the heavy chain classes IgM, IgG1, IgG2, IgG3 and IgA were determined by single radial immunodiffusion. These measured translations were relatively small and may suggest that the rotational portion of the motion was more dominant than translational and provided sufficient mobility.

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In vitro complement activation after contact with pyrolytic carbon-coated and uncoated polyethylene terephthalate. Simulation results suggest that BTEX mass loss due to biodegradation is greatest under oxygen-reducing conditions, with smaller but similar contributions to mass loss from biodegradation under Fe(III)-reducing, sulfate-reducing, and methanogenic conditions. There was a significant effect of standard length and body mass on the time elapsed until nest completion in the UV experiment. Procedure times are slightly longer, and the ileoscopy rate is lower in this age group. Dysfunction of the microcirculation may correspond to a reduction in the surface of the maximum section of coronary arterioles, which involves multiple mechanisms, although this phenomenon does not appear to play a role in ischaemic heart disease. Anterogradely labeled terminals were present in the ipsilateral area pretectalis pars dorsalis, optic tectum and corpus cerebelli, the bilateral ventromedial thalamic nucleus, lateral valvular nucleus, oculomotor nucleus and inferior olive, and the contralateral periventricular pretectal nucleus.

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Visual figure discrimination and the mediation of equivalence responses. All other parameters remained within or close to physiological limits without significant changes from pre-CRI values. We performed ex vivo experiments with Plasmodium falciparum-infected human placentas from primi- and multigravida women from Cameroon. Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of vitamins. The influence of a macrolide antibiotic, roxithromycin (RXM), on co-stimulatory molecule expression was examined in vitro and in vivo. Environmental monitoring and assessment of short-term exposures to hazardous chemicals of a sterilization process in hospital working environments. Most of the age- and gender-related variance in activity levels could be explained by differences in available resources. Organizational structure was assessed for the similarity judgment task using multidimensional scaling and additive similarity tree analyses. CAG repeat length does not associate with the rate of cerebellar degeneration in spinocerebellar ataxia type 3. Mechanisms of action proposed to explain the antimanic activity of lamotrigine include inhibition of voltage-sensitive and use-dependent sodium channels, inhibition of glutamate release and calcium channel blockade.

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Plasma and urine samples were collected before and up to 24 h after administration on days 14, 15 and 21 for the determination of the maximum concentration (C(max)), time to reach C(max)(t(max)), the area under the concentration-time curve (AUC) of S-warfarin and the cumulative urinary excretion of warfarin and its metabolites. Significant correlations were found between test performance and fractional anisotropy in areas of the frontal white matter. SDS-PAGE, in combination with Coomassie Brilliant Blue (CBB) staining, revealed up to 20 bands and the patterns were characterised by major protein constituents of Mr 105000, 51000, 47000, 33000, 22000 and 16 400 common to all samples from all animals. We determine if intravesical bacillus Calmette-Guerin (BCG) reduces the risk of progression after transurethral resection to stage T2 disease or higher in patients with superficial (stage Ta, T1 or carcinoma in situ) bladder cancer. One of them, at 13q33, was defined by LOH at markers D13S158 and D13S280.

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On the basis of these results, it proposes a typology of the networks from which the activities are built, then analyses the conditions necessary in order that health education be implemented within a framework of partnership established on the competencies, differences and contributions of each partner. Widely available methods based on the culture of spirochetes from tissues do not provide quantitative information. Amino PAC PA-10 (2 x 250 mm) column with a pulse amperometric detector with an Au working electrode and an Ag/AgCl reference electrode was applied to determine the monosaccharides. This synthesis is provided by the special organization of brain processes which includes circulation of nerve impulses in the brain structures. AFM-IR works by using the tip of an AFM probe to locally detect thermal expansion in a sample resulting from absorption of infrared radiation. Mutations in SHR3 specifically impede the transport of all 18 members of the amino acid permease (aap) gene family away from the ER. In study two, anti-TNF attenuated the hypothermic response induced by 10 mg/kg CHP but had no effect on the magnitude of the delayed fever. The mRNA expression analysis revealed that OseIF1A-2 mRNA was much more accumulated than OseIF1A-1 in all tissues but each gene is expressed in root, stem, leaf and flowering spike in high and nearly equal level, and in immature spike in lower level. Human serum DDT concentration related to environmental DDT exposure.

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The composition, physical condition, and the amount of SBH introduced have significant effects on the filtration of the immune globulin and the log removal values obtained. Decreased lysosomal membrane stability coincided with increased size of lysosomes and increased lipid content during the progression toward degeneration. The globular region forms a five-stranded anti-parallel beta-barrel. The results of numerical simulation reveal that, due to the effect of shear thinning, the electrophoretic mobility for the case of a Carreau fluid is greater than for that of a Newtonian fluid. Efficacy of nephron-sparing surgery for renal cell carcinoma: analysis based on the new 1997 tumor-node-metastasis staging system. Advantages and disadvantages of the surveyed methods are pointed out, and an assessment with respect to practical potential is provided. A review of TIA and minor stroke patients evaluated at Veterans Affairs hospitals was conducted with regard to medical history, use of diagnostic imaging within 2 days of presentation, and in-hospital care variables.

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The contribution of adjuvant therapies, both irradiation and chemotherapy, in the context of gross total resection is unclear, but where such resection is not possible there may be a role for adjuvant therapy to permit more nearly complete resection. Chilling of newborn infants: its relation to circumcision immediately following birth. Then it was well up to 51 years old when he began to suffer shortness of breath with minimal exertion. The data are from a survey of 1,580 students in an urban public school system located in the mid-Atlantic region of the United States. Using auto- and cross-correlation techniques, CC-potentials were characterized with parameters amplitude (A), duration (D), dominant frequency (DF), maximum cross-correlation coefficient of longitudinal and bilateral CC-potential pairs (Rmax-lon. In a sphere-plane geometry, routinely used in atomic force microscope and surface force apparatus, it can form a bridge connecting the surfaces. However, if free air is not detected on an erect X-ray or not demonstrated over the anterior surface of the liver by US, the diagnosis of perforation of the hollow organ will be difficult. A retrospective chart review was performed of children with FC (according to the Rome III criteria) who underwent ileostomy, colostomy or (sub)total colectomy at a tertiary hospital. We report that trichostatin A (TSA), an inhibitor of histone deacetylases (HDACs), abrogates the ability of p53 to repress the transcription of two genes that it negatively regulates, Map4 and stathmin.

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occipitalis major showed a high correlation between measured values. In captopril treatment the survival rate among rats with ischemia of the brain increased. The size and configuration of the artifacts caused by instruments and implants is predictable. Gap junction alterations recently have been implicated in chronic heart failure, but direct evidence between gap junction manifestation in nonischemic dilated cardiomyopathy (DCM) is lacking. The significance of antioxidant enzymes in asbestos related diseases has, however, remained unclear. A computer program was developed that provides point and interval estimates of the percentile rank corresponding to raw scores on the various self-report scales. Data collected included demographic characteristics, occupational clinical history, hazardous occupational exposures, use of personal protection equipment, and knowledge about occupational risks and habits. Flow cytometric analysis is a sensitive method to assess the presence and magnitude of in vivo inflammation. Rats treated with or without LPS were administered intra-peritoneally simvastatin (5 and 20 mg/kg) for 4 days. Rates of hospital-associated methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) colonization or infection were the primary end point.

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Prediction of the development of sigmoid ischemia on the day of aortic operations. Right lobe living donor liver transplantation poses challenges that require a meticulous surgical technique to minimize morbidity in the recipient. Oxazepamum (7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-onum). During brake engagement, trunk flexion angle, task completion time, and questionnaires were used to quantify postural comfort and usability. The introduction into clinical practice of novel immunosuppressive mometasone furoate nasal spray generic name agents with no or lower nephrotoxicity, like mycophenolate mofetile, rapamycin and everolimus, will make therapeutic strategies aimed at decreasing the incidence of CAD feasible.

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Effect of Brassinolide on Growth and Shikonin Formation in Cultured Onosma paniculatum Cells. Prasugrel appears to be a promising antiplatelet agent, with emerging clinical data in direct comparison with clopidogrel supporting its role in reducing recurrent ischemic events. pRb(-/-) mice show abnormal neuronal cell death in the developing brain. Leadership in academic medicine: reflections from administrative exile. Some transplant centers have begun offering living donor liver transplantation (LDLT) for selected patients whose HCC exceeds Milan criteria by a small margin. In this study among perimenopausal women a significant effect of 17betaE-D and CEE-N on common carotid intima-media thickness and lumen diameter could not be demonstrated. The mutations we studied are associated with clinically distinct forms of TNF receptor-associated periodic syndrome (TRAPS). Structure-based comparisons of YPD1 to other proteins having a similar function, such as the Escherichia coli ArcB histidine-containing phosphotransfer (HPt) domain and the P1 domain of the CheA kinase, revealed that the helical bundle and several structural features around the active-site histidine residue are conserved between the prokaryotic and eukaryotic kingdoms.

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Insulin resistance seems to be associated with increased oxidative stress in H pylori infection. Change in physician knowledge and attitudes after implementation of a pneumonia practice guideline. If such a diversity in protein and lipid polar headgroup structures may easily be related to a large panel of functions, the wide dispersion in acyl chain length and structure which the lipids display what drug class is allegra is more difficult to understand. A third advantage is that the clip applier is used as a clip remover should adjustment or reapplication of the clip be necessary. Medicinal chemistry of nicotinamide in the treatment of ischemia and reperfusion. However, these promising efficacy results are overshadowed by safety problems, such as reversion of the vaccine strain to a pathogenic virus encoding full-length nef or residual virulence of multiply deleted vaccine strains.

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