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Bicofen (Roxithromycin)
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Bicofen

Bicofen is indicated for the treatment of the following mild to moderately severe infections in children caused by or likely to be caused by susceptible micro-organisms: acute pharyngitis, acute tonsillitis and impetigo.

Other names for this medication:
Acevor, Aristomycin, Asmetic, Azuril, Biaxsig, Biostatik, Cadithro, Claramid, Crolix, Erybros, Floxid, Macrosil, Makrodex, Nirox, Overal, Pedilid, Pedrox, Redotrin, Renicin, Ritosin, Roksimin, Roksolit, Rolexit, Romac, Romyk, Rotramin, Roxacine, Roxithromycin, Roxithromycine, Roxithromycinum

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Also known as: Roxithromycin

Description

Each Bicofen tablet contains either 150mg or 300mg of the active ingredient roxithromycin. Each tablet also contains: hydroxypropylcellulose, poloxamer, povidone, colloidal anhydrous silica, magnesium stearate (470), purified talc (553), maize starch, hypromellose, anhydrous glucose, titanium dioxide (171), propylene glycol (1520). Bicofen does not contain gluten, sucrose, lactose, tartrazine or any other azo dyes.

Dosage

Take Generic Bicofen by mouth with food. If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water. Swallow Generic Bicofen tablets whole with a glass of water. Generic Bicofen should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). Generic Bicofen works best if you take it on an empty stomach. For treating bacterial infections, Generic Bicofen is usually taken for 5 to 10 days. If you want to achieve most effective results do not stop taking Generic Bicofen suddenly.

Overdose

If you overdose Generic Bicofen and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep the medicine in a cool, dry place where the temperature stays below 25 degrees C.

Do not store it or any other medicine in the bathroom, near a sink or on windowsill.

Do not leave it in the car. Heat and damp can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Bicofen are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Specifically, it has been suggested that ethanol effects are mediated by changes in the endogenous opioid peptides derived from the proopiomelanocortin (POMC) precursor. The polysubstituted tetrahydrobenzimidazole core of the pyrrole-imidazole alkaloid ageliferin can be constructed through the use of pseudo dimeric 4-vinylimidazoles. Analysis of the epigenetic characteristics of the region demonstrated a significant increase in replication asynchrony in the patient compared to controls, with the inverted chromosome showing delayed replication timing across at least a 500-kb interval. It seemed feasible that HFESCs were gene transfected with liposome or adeno-associated virus as the vector. Our technique provides a new platform for MALDI-MS analysis in single or several cells to get a wide information from one sample. Between 2003 and 2015, 31 patients underwent double stenting due to oesophago-respiratory fistulas. In addition, severe SCI induced reactive microglia and astrogliosis in all dentate gyrus sub-regions. We validated our algorithm using standard protein mixture experiments.

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Approximately one quarter of persons exposed to hepatitis C virus (HCV) will spontaneously clear infection. Comparison of functional outcomes and patient-reported satisfaction between titanium and absorbable plates and screws for fixation of mandibular fractures: A one-year prospective study. Antioxidant and Anticholinesterase Activities of Some Dialkylamino Substituted 3-Hydroxyflavone Derivatives. Breast cancer in sub-Saharan Africa: how does it relate to breast cancer in African-American women?. Seven candidate gli binding sites were identified in the bcl-2 promoter. ACDD4 score: A simple tool for assessing risk of pneumonia after stroke. Also in laboratory experiments at the highest densities encountered in the field, larvae and nymphs of each species attached and engorged equally well whether alone or mixed with the other species.

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