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Bimode (Glipizide)

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Bimode is in a class of medications called sulfonylureas. Bimode lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently.

Other names for this medication:
Actizide, Bimode, Diabizide, Diacon, Dibimet, Glanase, Glibetic, Glipicon, Glipicontin, Glipid, Glipimet, Glipiriv, Glipized, Glipizide, Glipmet, Gluconil, Glumin, Glunas, Glycind, Glydal, Glylin, Glynase, Glysar, Glysin, Glyson, Glytop, Glyzip, Gpzide, Libiz, Metaglez, Metglib, Tranase

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Also known as: Glipizide


Bimode is a medication consists in a class of drugs called sulfonylureas. Bimode is used to treat type 2 diabetes. Bimode may be used along with diet, exercise and insulin therapy. Bimode is also known as Glipizide, Glytop SR. Bimode works by controlling blood sugar levels in your organism. Generic name of Bimode is Glipizide. Brand names of Bimode are Bimode, Bimode XL.


Usual Adult Dose of Bimode for Diabetes Type 2:

Immediate release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: Up to 40 mg in divided doses 30 minutes before a meal of adequate caloric content. Doses may be increased in intervals of 2.5 to 5 mg a day according to blood glucose response. Maximum single dose: 15 mg Maximum daily dose: 40 mg Comments: -At least several days should elapse between titration steps. -If response to a single dose is not satisfactory, dividing that dose may prove effective. Extended Release: Initial dose: 5 mg orally once a day, 30 minutes before breakfast Maintenance dose: 5 to 10 mg orally once a day Maximum daily dose: 20 mg Patients receiving immediate release may be switched safely to extended release tablets once-a-day at the nearest equivalent total daily dose, or titrate to the appropriate extended release dose starting with 5 mg once daily. Combination use: -When adding other blood-glucose-lowering agents to the extended release tablets, the agent should be initiated at the lowest recommended dose. Observe for hypoglycemia. -When adding extended release tablets to other blood-glucose-lowering agents, Bimode XL extended release can be initiated at 5 mg. Start at a lower dose in patients that are more sensitive to hypoglycemia. When transferring patients from insulin to glipizide, the following general guidelines should be considered: -For patients with daily insulin doses of 20 units or less: Discontinue insulin and begin glipizide at usual dosages. -For patients with daily insulin doses greater than 20 units: Insulin dose should be reduced by 50% and glipizide therapy may begin at usual dosages. Comments: -Several days should elapse between titration steps. -Subsequent reductions in insulin dosage should depend on individual patient response. -During the insulin withdrawal period, the patient should test urine samples for sugar and ketone bodies at least three times daily. -Some patients receiving greater than 40 units of insulin daily may need to consider hospitalization during the transition period. Patients Receiving Other Oral Hypoglycemic Agents: -When transferring from longer half-life sulfonylureas: Observe for 1 to 2 weeks for hypoglycemia. -Bimode XL extended release coadministered with colesevelam: Glipizide should be administered at least 4 hours prior to colesevelam. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose of Bimode for Diabetes Type 2:

Initial dose: 2.5 mg orally once a day 30 minutes before breakfast Comments: -Maintenance dosing should be conservative to avoid hypoglycemic reactions. -Doses can be adjusted with caution taking into account the degree of hepatic, renal, or cardiac function, and the concomitant disease or other drug therapy. Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Detailed Bimode dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glipizide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).


Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bimode are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Bimode if you are allergic to Bimode components. Be careful with Bimode if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Bimode if you have kidney disease, liver disease, thyroid disease, type 1 diabetes, serious infection, illness, or injury. Be careful with Bimode if you take aspirin or another salicylate such as magnesium/choline salicylate (Trilisate), salsalate (Disalcid, others), choline salicylate (Arthropan), magnesium salicylate (Magan) or bismuth subsalicylate (Pepto-Bismol); nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), diclofenac (Voltaren, Cataflam), etodolac (Lodine), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro), naproxen (Anaprox, Naprosyn, Aleve) and others; sulfa-based drug such as sulfamethoxazole-trimethoprim (Bactrim, Septra), sulfisoxazole (Gantrisin), or sulfasalazine (Azulfidine); monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate) or phenelzine (Nardil); beta-blocker such as propranolol (Inderal), atenolol (Tenormin), acebutolol (Sectral), metoprolol (Lopressor) and others; diuretic (water pill) such as hydrochlorothiazide (HCTZ, Hydrodiuril), chlorothiazide (Diuril) and others; steroid medicine such as prednisone (Deltasone, Orasone, others), methylprednisolone (Medrol, others), prednisolone (Prelone, Pediapred, others) and others; phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Prolixin, Permitil), prochlorperazine (Compazine), promethazine (Phenergan) and others; phenytoin (Dilantin); isoniazid (Nydrazid); prescription, over-the-counter, or herbal cough, cold, allergy or weight loss medications. Avoid alcohol. Do not stop taking Bimode suddenly.

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Feedback was positive, learning objectives appeared to be achieved and the plan is to continue to develop the PGY1 curriculum in the same format. The surface morphology was examined on the base of scanning electronmicroscopic and optical microscopic studies. Cardiac output and coronary blood flow during steady state recumbent exercise. To test this hypothesis, we measured IP-10 by specific ELISA in whole lung homogenates in either bleomycin-treated or control mice and correlated these levels with lung hydroxyproline. A very similar protein of unknown function is encoded by a fungal and an animal genome. MEGF markedly reduced the viability of HepG2 cells and induced the G2/M arrest of the cell cycle in a concentration dependent manner.

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A number of square pyramidal o-semiquinonic nickel complexes with 2,6-bis(diphenylphosphinomethyl)phenyl were investigated by EPR spectroscopy in solution. Consistent with our previous reports on renal tubular epithelium, apoptosis is involved in the Stx-mediated cytotoxicity of these lines. Human corticotropin-releasing hormone in man: dose-response of minute ventilation and end-tidal partial pressures of carbon dioxide and oxygen. This phase III, randomized, open-label, multicenter study compared the overall survival associated with irinotecan plus gemcitabine (IRINOGEM) versus gemcitabine monotherapy (GEM) in patients with chemotherapy-naive, locally advanced or metastatic pancreatic cancer. Recently, intensive laboratory and preclinical studies have identified and validated therapeutic molecular targets in MM. Identification of thiol-disulfide exchange reaction products of captopril and thiurams. This indicates that continuous oxidative stress to the cells and the matrix is one major underlying pathogenetic mechanism in OA.

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Acute abdomen in pediatric patients admitted to the pediatric emergency department. After elimination of chloroform by vacuum evaporation, dense compacts were obtained by cold or hot pressing. Requirements of an NCI contract examining a novel treatment for leukoplakia were to compare standard bi-dimensional measurement of oral lesions to examine for correlation with Response Evaluation Criteria in Solid Tumors (RECIST) criteria, and to examine the feasibility of digital image analysis for automated measurements. Inferences about the gene-specific amplitude parameters allow us to examine differential gene expression. Luminescent logic function of a surfactant-encapsulated polyoxometalate complex. Erythrocyte membrane lipid composition in exogenous and endogenous hypertriglyceridemia.

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Transesophageal echocardiography showed an intramural aortic hematoma with cardiac tamponade. A total of 160 cases of chronic gastralgia we treated in recent years were reviewed. Their concentration in cells is highly regulated, interconversion with corresponding acylcarnitines being the most important mechanism involved. Extracellular accumulation of proline, serine and trehalose in the haemolymph of osmoconforming brackish-water mosquitoes. In culture cells, where the genes are inactive, there is a chromatin configuration similar to that of prepupal salivary glands. Dominant American values of individualism, competition, and inequality shape American health care policy. Role of the sulphate assimilation pathway in utilization of glutathione as a sulphur source by Saccharomyces cerevisiae.

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Gender differences in the historical trauma response among the Lakota. The purified VP2 also had a strong affinity for binding to glycophorin A, a sialoglycoprotein component of erythrocytes, indicating that VP2 may be responsible for BTV transmission by the Culicoides vector to vertebrate hosts during blood feeding. Although the size of the remaining polyp in patient No I was greatly reduced after H pylori acquisition, it became enlarged again after eradication. Psychopathology in adolescents presenting for laparoscopic banding. He had also been taking naproxen for 2 years for the treatment of chronic back pain.

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To study the effect on tumor control probability of selectively boosting the dose to hypoxic subvolumes. MSC viability was detected by MTT and flow cytometry following culture in serum-free medium for 24 h with or without EPO. Purification and characterization of rat sterol 14-demethylase P450 (CYP51) expressed in Escherichia coli. At all times, HF rats also displayed hepatic insulin resistance. Here, we address two outstanding problems in bacterial cell division by developing a generally applicable, standardized, and modular software suite termed Projected System of Internal Coordinates from Interpolated Contours (PSICIC) that solves common problems in image quantitation. Intention-to-treat analyses were used to assess the effectiveness of the intervention overall and according to ER intervention attendance. The general physical principle underlying the watertightness of integuments consist in a effect of surface tension arresting the water penetration deep into the coats soon as meniscus of a liquid has attend the widening section of intraintegumental capillary.

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Preliminary biological studies using short-term cell growth inhibition assays show that some of the ligands have cancer cell selectivity, although they appear to have low potency for intracellular telomeric G-quadruplex structures, suggesting that their cellular targets may be other, possibly oncogene-related quadruplexes. One-step transepithelial PRK was performed with an aberration-free aspheric optimized profile and the Amaris 500 laser. The optimum pH for enzymatic activity of hog kidney acylase was 7.5 and a Km value of 8.2 mM for N-(methoxycarbonyl)-DL-alanine was determined. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Professional staff, or non-academic staff who do administrative work in medical schools, are often the first to be approached by students, yet there is little research on how they manage student issues. Tyrosine aminopeptidase activities were measured fluorimetrically using tyrosine-beta-naphthylamide as substrate and puromycin as selective inhibitor of one of the membrane-enzymes. Collateral artery growth was assessed by the use of a model of acute femoral artery ligation. Establishment and characterization of cytopathogenic and noncytopathogenic pestivirus replicons.

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We report a 58-year-old patient who, after having colon cancer, had PRP with biopsies showing acantholytic lesions and a heavy lichenoid lymphocytic infiltration. This review is divided into the following sections: biological nitrogen and phosphorus removal, wastewater treatment for organic conversion, industrial wastewater treatment, anaerobic digestion of sewage sludge and solid waste, sludge biochar preparation and application, pyrolysis of sewage sludge, reduction heavy metal in sewage sludge and soil, and other issues of wastewater and sludge treatment. In addition, the origin of some supply houses is discussed and the role of the instrument companies in the dissemination of technical information is emphasized. An F (5) generation of an advanced inter-cross between red junglefowl (wild-type) and White Leghorn (domesticated) was used to investigate earlier findings suggesting that a mutation in the plumage color gene PMEL17 protects against victimization to feather pecking (FP). The early Pe promoter was found to be much stronger than the Pc promoter. Combined effects of lead and humic acid on growth and lead uptake of Duckweed, Lemna minor. Genetic analysis of a canine calicivirus: evidence for a new clade of animal caliciviruses.

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Gene-physical activity interactions in the etiology of obesity: behavioral considerations. The diminished role of folk psychiatry among Los Angeles Mexican-Americans. Results of the GnRH-TRH and arginine-GnRH-TRH test in females with hyperprolactinemic galactorrhea. After a 1-month run-in period, patients were treated with levetiracetam at a dosage of 1000 mg/d for 6 months. Mass spectrometry (matrix-assisted laser desorption ionization-time of flight and MS/MS) identified these spots as heat shock protein 60 (HSP60), alpha-synuclein (alpha-syn), and 14-3-3 protein zeta/delta.

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Application of histopathologic classification schemes developed for nodal lymphomas, i.e. The protease constitutes one functional domain of the bifunctional HCV NS3 (non-structural protein 3). We tested whether phosphorylation-mediated inactivation of FoxO3a by TGF-beta can mediate MC survival and oxidative stress. After the animal became neurontin gabapentina 300 mg para que sirve clinically normal, siderocytes disappeared from peripheral blood but intraerythrocytic crystals and reticulocytosis persisted. Human immunodeficiency virus (HIV) infection is associated with a high risk of cardiovascular disease and increased arterial inflammation. Puromycin and low doses of cycloheximide (50 mug/kg per hr) did not significantly affect RNA synthesis as measured by orotic acid incorporation, but RNA synthesis was clearly reduced by administration of cycloheximide at 200 mug/kg per hr.6.

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Some individuals with developmental disabilities develop inappropriate sexual behaviors such as public masturbation, disrobing, and touching others in an unwanted sexual manner. Considerable knowledge has been gained from successful and unsuccessful vaccine development efforts, and large gains in knowledge relevant to vaccine development have resulted from studies of basic immunology and microbial pathogenesis. Due to this major problem, a new generation of anticoagulants must be developed to limit this risk. Here, synchrotron X-ray total scattering and pair distribution function analysis methods provide insight into the nature of atomistic disorder in a synthetic bone mineral analogue, chemically substituted hydroxyapatite. One-year outcome in multivessel coronary disease patients undergoing coronary stenting. Phase II/pharmacodynamic trial of dose-intensive, weekly parenteral hydroxyurea and fluorouracil administered with interferon alfa-2a in patients with refractory malignancies of the gastrointestinal tract.

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There was a significant difference in the death of IRF-1-/- mice when infected with B. This work proposes a method to infer anxiety states of caregivers when caring for people with dementia, by using physiological data. The protocol for piracanjuba semen cryopreservation can use solutions including either DMSO or methanol as intracellular cryoprotectant and egg yolk or lactose as extracellular cryoprotectants. There is concern that tongue protrusion may be maladaptive in individuals with Down syndrome (DS). The hallmark of CCl(4) hepatotoxicity, zone 3 necrosis, was observed 24 h after CCl(4) administration and immuno-positive hepatocytes were observed in zone 2 as well as zone 3. This was reflected by a higher abundance of growth essential and growth contributing genes of which many locate near the origin of replication. In the presence of the analog, the wild-type Synechocystis strain was protected against fructose. The new instrument has been named the Utility Based Quality of life--Heart questionnaire, or UBQ-H. However, null mutations of the fz gene have little effect on Wg signal transduction and the lack of mutations in the fz2 gene has thus far prevented a rigorous examination of its role in vivo.

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We report a patient with chronic Sweet syndrome (SS) treated by anti-Tumor Necrosis Factor (TNF) therapy, who presented with a severe bilateral chemosis. Cellular and molecular effects of n-3 polyunsaturated fatty acids on adipose tissue biology and metabolism. Considerations in microscope design to avoid cumulative trauma disorder in clinical laboratory applications. False negative result for amphetamines on the Triage Drug of Abuse panel?. Cartilage and bone neoformation in rabbit carotid bifurcation aneurysms after endovascular coil embolization. Finally, this study concluded that internal health locus of control had a moderating effect on the relationship between uncertainty and appraisal of danger. The effect of lithium on platelet count was studied by examining 12 patients treated with lithium carbonate without any additional acticin medication, 13 patients treated with lithium carbonate with additional psychotropic medication, 25 patients with major affective disorder prior to any treatment, 25 patients with panic disorder prior to any treatment and 25 healthy controls. These data suggest that recovery from hepatic ATP depletion becomes progressively less efficient as body mass increases in healthy controls and is severely impaired in patients with obesity-related nonalcoholic steatohepatitis.

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Articular cartilage proteoglycans immunoreactive with an antibody to skin proteodermatan sulfate core protein. Environment- and gene-dependent human ontogenesis, sociogenesis and phylogenesis (eco-geno-onto-socio-phylogenesis). Evidence-based medicine, opinion-based medicine, and real-world medicine. The strong parallelism to the experimental data obtained in the stroke-prone animal model provides assurance for the relevance of our observation. These actions are partially reversible with local anti-oxidants. The fabricated high-performance SR-MSCs offer new opportunities for intuitively observing the working state of energy devices without the aid of extra equipment and techniques. Treatment consisted of 12 sessions of a biofeedback-based behavioral intervention over a 3-month period.

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The role of the pharmacy committee in drug evaluation, selection and utilization and its importance to the accreditation of the hospital. Termination rates after prenatal diagnosis of Down syndrome, spina bifida, anencephaly, and Turner and Klinefelter syndromes: a systematic literature review. Sex ratio of early embryos fertilized in vitro with spermatozoa separated by percoll. Prolonged survival of endocrine allografts with preoperative cyclosporine A. This ectoparasite has been hypothesized to rely on its hosts for dispersal due to its low inherent dispersal potential. It is shown that diamond nanocrystal morphology is markedly different from silicon and germanium. Spinal subdural hematoma is a rare clinical entity marked by the onset of pain and paralysis, which is usually associated with hemorrhagic disorders, trauma, and iatrogenic causes such as lumbar puncture or epidural anesthesia. A number of sociodemographic and clinical factors significantly associated with this tendency to underreport community service utilization were identified. To investigate long-term sick leave among primary care patients with musculoskeletal disorders and the predictive value of health-status and sense-of-coherence measures.

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Coaggregation reactions were common between these oral bacteria and both the mucoid and nonmucoid variants of P. We therefore have evaluated the general muscle and bone reaction to porous nickel-titanium. The cytoskeleton is characterized by a subpellicular corset of microtubules that are cross-linked to each other and to the plasma membrane. tuberculosis organisms while T cells from normal mice did not respond. It also seems likely that future studies will demonstrate that the specific chemical messenger and the mechanism by which it reaches its target cells are far more important factors in the understanding of gastrointestinal and endocrine pancreatic function, than whether or not these signals are neural or endocrine in origin. Since histological criteria are the same, a pulmonary neoplasm has to be excluded in every case. In hepatocellular carcinoma concurrent with cirrhosis, neoplastic cells were shown to react with this antibody as well. For some subgroups these were offset by increases in employer coverage, but not for Mexicans, resulting in a four-percentage-point increase in their uninsured population.

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The MHC class I-like Fc receptor FcRn plays an essential role in extending the half-life (t(1/2)) of IgG antibodies and IgG-Fc-based therapeutics in the circulation. coli bacteria for 5 days showed foci of uniformly acute inflammation in the glandular lumen and a persistent inflammation at 12 weeks post-inoculation in the stroma. In this retrospective cohort study that used the disease management database from a specialized downtown Toronto tuberculosis clinic, patients with latent tuberculosis infection were included if they had risk factors for periactin max daily dose progression of disease and were excluded if they had contraindications to treatment. Angiographic adverse events during percutaneous coronary intervention fail to predict creatine kinase-MB elevation. These results provide a potential new strategy to prevent endotoxin-mediated complications in cholestatic patients undergoing major surgery.

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Tissue-engineered oral mucosa was applied successfully in all four surgical methods. To evaluate the effect of carbohydrate supplementation upon some aspects of the immune function in athletes during intense indoor cycling. Twenty-two women in the third trimester of pregnancy with pre-eclampsia, IUGR, or both, entered the study. Evaluate real-life experience with eslicarbazepine acetate (ESL) after first monotherapy failure in a large series of patients with focal epilepsy. At the same time amaryl 1mg tablet , their faculty may be engaged in nursing education research in order to facilitate student learning. The parenchymal transit time is a good indicator of ischemic damage. These structures, which may be either muscular or fibrotic, attach to the globe and produce a mechanical restriction resulting in incomitant strabismus.

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The two steroid UDP-glucuronosyltransferases were shown to exhibit strict stereospecificity with respect to the conjugation of steroids and bile acids. Clinicians and researchers might consider illness-specific features when evaluating the risk of stress reactions among mothers of children with life-threatening illnesses. The success of MST in engaging challenging families in treatment is due to programmatic commitments to family collaboration and partnership as well as to a conceptual process that delineates barriers to family engagement, develops and implements strategies to overcome these barriers, and evaluates the success of these strategies. Mechanistic and structural studies have been carried out to investigate the molecular basis for the irreversible inhibition of human MAO-B by mofegiline. Explication of these findings provides a research base to inform recommendations relating to improving the practice milieu of the critical care environment. These observations suggest to us that there was an orientation toward a passive consuming of information by these participants. Using a physiological anatomical hip joint simulator, five different bearing systems involving three thick (8-12 microm) coatings, TiN, CrN and CrCN, and one thin (2 microm) coating diamond like carbon (DLC) were evaluated and compared to a clinically used MOM cobalt chrome alloy bearing couple. Hypermethylation of TNFRSF10C promoter CpG island (CGI) had been reported in many tumors including PCa. Our study demonstrates that whole genome tiling arrays are a powerful platform for dissecting natural transcriptome variation at multi-dimension and high resolution.

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However, we cannot judge whether a high CL-Gap indicates VA dysfunction immediately because it is necessary to consider not only VA dysfunction, but also the effect of other factors on the CL-Gap. One signal caused the mobilization of calcium and the other signal circumvented the need for macrophages or macrophage products possibly by mimicking diacylglycerol, the activator of protein kinase C. Nineteen individuals with alpha(1)-AT deficiency, 22 healthy controls, and 12 patients with non-alpha(1)-AT-deficient chronic obstructive pulmonary disease (COPD) had NO, CO, CO(2), and O(2) measured in exhaled breath. The aim was to answer a fundamental question: Do the chemical properties of titanium implants influence osseointegration?. For the cine scans, optimal times were a 9-sec delay time post IV injection in the arterial phase, and an 18-sec delay time post IV injection in the venous phase.

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