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Binoclar (Clarithromycin)

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Binoclar is used to treat bacterial infections in many different parts of the body. It is also used in combination with other medicines to treat duodenal ulcers caused by H. pylori. This medicine is also used to prevent and treat Mycobacterium avium complex (MAC) infection.

Other names for this medication:
Aeroxina, Bacterfin, Bicrolid, Ciclinil, Clacine, Clarithromycin, Claritt, Clariva, Claromycin, Claron, Clarytas, Clasine, Clathrocyn, Cleanomisin, Helimox, Infex, Kalecin, Klarimac, Klarimax, Klarit, Klarithran, Krobicin, Maclar, Macrol, Mononaxy, Preclar, Rocin, Veclam, Vikrol, Xylar

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Also known as: Clarithromycin


Binoclar (generic name: clarithromycin; brand names include: Maclar / Klaricid / Klacid / Clarimac / Claribid) is used to treat many different types of bacterial infections affecting the skin and respiratory system, including: Strep throat, Pneumonia, Sinusitis (inflamed sinuses), Tonsillitis (inflamed tonsils), Acute middle ear infections, Acute flare-ups of chronic bronchitis.

It also is used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus (HIV)]. It is used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers.

It also is used sometimes to treat other types of infections including Lyme disease (an infection that may develop after a person is bitten by a tick), crypotosporidiosis (an infection that causes diarrhea), cat scratch disease (an infection that may develop after a person is bitten or scratched by a cat), Legionnaires' disease (a type of lung infection), and pertussis (whooping cough; a serious infection that can cause severe coughing). It is also sometimes used to prevent heart infection in patients having dental or other procedures.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Binoclar works by stopping the growth of or killing sensitive bacteria by interfering with their protein synthesis.


This section provides information on the proper use of a number of products that contain clarithromycin. It may not be specific to Binoclar Filmtab. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

You may take this medicine with meals or milk or on an empty stomach. However, clarithromycin extended release tablets should be taken with food.

If you are using the extended-release tablets:

Swallow the tablet whole. Do not break, crush, or chew it. While taking the extended-release form of this medicine, a part of the tablet may pass into your stools. This is normal and is nothing to worry about.

Measure the oral liquid with a marked measuring spoon, syringe, or cup. The average household teaspoon may not hold the right amount of liquid. Shake the bottle well before each use.

If you are taking clarithromycin and zidovudine, these medicines should be taken at least 2 hours apart.

Keep using this medicine for the full time of treatment, even if you or your child begin to feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (extended-release tablets): For bacterial infections: Adults—1000 milligrams (mg) once a day for 7 to 14 days. Children—Use and dose must be determined by your doctor. For community-acquired pneumonia: Adults—1000 milligrams (mg) once a day for 7 days. Children—Use and dose must be determined by your doctor. For oral dosage forms (suspension and tablets): For bacterial infections: Adults—250 to 500 milligrams (mg) every 12 hours for 7 to 14 days. Children 6 months of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 7.5 milligrams (mg) per kilogram (kg) of body weight every 12 hours for 10 days. Infants younger than 6 months of age—Use and dose must be determined by your doctor. For community-acquired pneumonia: Adults—250 milligrams (mg) every 12 hours for 7 to 14 days. Children 6 months of age and older—Dose is based on body weight and must be determined by your doctor. Infants younger than 6 months of age—Use and dose must be determined by your doctor. For prevention or treatment of Mycobacterium avium complex (MAC) infection: Adults—500 milligrams (mg) 2 times a day. Children 20 months of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 7.5 milligrams (mg) per kilogram (kg) of body weight, up to 500 mg, 2 times a day. Children younger than 20 months of age—Use and dose must be determined by your doctor. For treatment of ulcers associated with H. pylori: Adults—500 milligrams (mg) every 8 hours for 14 days in combination with omeprazole, 500 mg every 12 hours in combination with amoxicillin and lansoprazole for 10 or 14 days, or 500 mg every 12 hours in combination with amoxicillin and omeprazole for 10 days. Children—Use and dose must be determined by your doctor.


Overdose symptoms may include severe stomach pain, nausea, vomiting, or diarrhea.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Protect from light. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Binoclar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Concomitant cisapride, pimozide, ergots, HMG-CoA reductase inhibitors extensively metabolized by CYP3A4 (lovastatin or simvastatin). History of QT prolongation or ventricular cardiac arrhythmia (including torsades de pointes). Concomitant colchicine (in renal or hepatic impairment). Cholestatic jaundice/hepatic dysfunction with prior clarithromycin use.

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Exons and exon pairs containing an integer number of triplets are preferred. Two major groups of patients emerged: those consuming adequate protein and calories, yet presenting with hypoalbuminemia, and those suffering from a protein calorie deficit. Images in cardiovascular medicine: Cardiac magnetic resonance imaging and eosinophilic endomyocardial fibrosis. Recombinant activated factor VII (rFVIIa) is infrequently used off-label in infants despite a paucity of data in this population. A 58-year-old man was diagnosed with type 2 diabetes 44 years after having undergone left below knee amputation for congenital AV malformation, at the age of 13. Reengineering respiratory support following extubation: avoidance of critical care unit costs. The oral IL-5 was higher in AD, AR, and asthma in comparison with HCs, whereas the nasal IL-5 concentrations were higher in asthma and AR than in HCs. Rhizobium leguminosarum biovar trifolii strain TA1 polysaccharide synthesis (pss) mutants in the pssD, pssP, pssT and pssO genes and altered in exopolysaccharide (EPS) synthesis were investigated. However, there are advantages to thoracoscopic ITA mobilization in MIDCAB that could also be realized in the redo situation.

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To characterize the extent of PSA screening among elderly men, including those with limited life expectancies. Our understanding has been constrained for various reasons, perhaps including a quest by researchers to denote 2- or even 3-dimensional tree distribution limits to a single line on a map. However, four genes were pinpointed to be required for the quercetin derived lifespan extension, namely age-1, daf-2, unc-43 and sek-1. Beraprost sodium improves pulmonary hemodynamics in patients with pulmonary arterial hypertension. Threadlike micelles long enough to be entangled with each other were formed in a clear aqueous solution of two anionic surfactants, sodium hexadecyl sulfate and sodium tetradecyl sulfate. Direct implantation of the graft was performed in type A and was possible in type B after simple plasty of the ostia to create a single orifice. Strains of Lactobacillus plantarum, Weissella cibaria/confusa, Lactobacillus brevis, Pediococcus pentosaceous, Lactobacillus sp. coli C175-94 and type 1 fimbrial expression was determined directly by two independent methods at 2 h, 1 d and 3 d after infection. This suggests a mechanism whereby gallbladder epithelial cells in vivo may mediate gallbladder secretory function, inflammation and diseases in an autocrine/paracrine fashion by producing and secreting cytokines and/or chemokines during sepsis.

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Clearance kinetics of solutes used to measure glomerular filtration rate. The results of this study suggest that among patients with periodontal disease the serum folic acid concentration is lower in smokers compared with non-smokers. Perinatal ischemic stroke has become recognized as a not-rare adverse outcome of pregnancy and a common cause of chronic neurologic disability in children. The use of best practices across a range of health and social services, combined with an effective process that facilitates the exchange of knowledge between sectors, establishes an important mechanism by which shared care, education, and program and systems development can be achieved. Conversely, enforced Pax5 re-expression in macrophage-like Myc5 cells led to down-regulation of the M-CSF receptor and re-acquisition of some B-cell surface markers (e.g., CD79a) and lineage-specific transcription factors (e.g., IRF4 and Blimp). However, many viruses are known to encode viral products that inhibit IFN-beta production.

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Appropriate antihypertensive drugs are used to manage hypertension, to control associated cardiovascular symptoms, and to prepare patients for operation. MatrixExplorer provides several novel features to support the exploration of social networks with a matrix-based representation, in addition to the standard interactive filtering and clustering functions. a 5-year-old female child with an oronasal foreign body which created an oronasal fistula that was closed with local palatal mucoperiosteal-lined flaps. In this case report, we present the use of percutaneous tracheostomy on a patient with mandibulo-maxillary interfixation. The implications of these findings with respect to the replacement of sigma 43 by the 28-kDa peptide and the mechanism of promoter search by B. To determine the association between the patient-to-nurse ratio and patient mortality, failure-to-rescue (deaths following complications) among surgical patients, and factors related to nurse retention.

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It could completely degrade 100 mg L(-1) ONBA at a range of pH 6-8 in 48 h at 30 degrees C, and up to 400 mg L(-1) after 288 h. Complete and reproducible separation of feeder and embryonic stem cells was accomplished by adaptation of an automated cell selection system that resulted in the aspiration of distinct cell colonies or fraction of colonies according to predefined physical parameters. Primary polyuric kidney failure and acute yellow liver dystrophy following infusion of glucose substitutes in children. Other aspects of NET discussed in this short review include the regulation of the transporter and how novel protein-protein interactions between NET and structures such as syntaxin 1A may hold the key to innovative ways to increase the therapeutic value of 131I-MIBG. In 10 subjects of a particular inbred strain of rats (WAG/Rij), two types of spike-wave complexes were detected in the cortical electroencephalogram (EEG) during the two recording hours. A 21 year old female presented with congenital vaginal agenesis combined with cervical atresia. In this study, we investigated the potential role of kallistatin in angiogenesis in vitro and in vivo.

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The system is designed as a distributed three tier model and implemented in Java (Sun Microsystems). Traumatic Pseudoaneurysm of Superior Rectal Artery - an Unusual Cause of Massive Lower Gastrointestinal Bleed: A Case Report. In order to examine the putative three-dimensional structure of S3(C) and to illustrate the residues required for Hanatoxin binding, molecular simulation and docking were performed, based on the solution structure of Hanatoxin and the structural information from lysine-scanning results for S3(C) fragment. The production of reactive oxygen species (ROS), as well as apoptosis-related genes, play a critical role. Laparotomy revealed a right ovarian cystic mass and the cystic mass was found on the sigmoid colon. We report the cases of two elderly patients with serology, in one case positive biaxin antibiotic for hepatitis C, and in the other with anti-DNA antibodies, and discuss the part these might play in causing progressive multifocal leukoencephalopathy.

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Radiographic and laboratory evaluations are often routinely used in the initial work-up for melanoma. This review will largely focus on our current understanding of the structure of CRP, its ligands, the effector molecules with which it interacts, and its apparent functions. Terminal restriction fragment length polymorphism (TRFLP) analysis protonix pantoprazole dosage revealed that lime and nitrogen addition altered soil bacterial community structure, while plant species had little effect. Investigate the radical extent of lymphadenectomy of right colon cancer. Forty-four Swiss outbred mice were divided into control and treatment groups. Thus, the World Health Organization (WHO) Classification of haematopoietic malignancies not only incorporates morphology, immunophenotype, cytogenetic and molecular features, but also ensures to be clinically useful. Compared with inmates, probationers and parolees have substantially greater opportunities to engage in HIV risk behaviors. To assess the validity of a clinical diagnosis of parkinsonism in the general population according to strict published criteria. The N-terminal domain required for control of DNA synthesis maps to residues 186-212 that are also critical for binding Orc5 of the origin recognition complex. Novel CC2D2A compound heterozygous mutations cause Joubert syndrome.

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Influence of plastic deformation and prolonged ageing time on microstructure of a Haynes 242 alloy. The inverse dynamic analysis of complex lifting tasks involving significant lower limb displacements requires the use of upper body linked models. Variants of rhythmic auricular tachysystole concomitant with total atrioventricular block. In the bone marrow, where neutrophils mature, certain components of the stromal microenvironment, e.g. Flocculation analysis of growth hormone distribution by fractions of the Reben human pituitary extract. This pathogen should be suspected in immunosuppressed patients who experience gastrointestinal symptoms and should not be precluded by the absence of fever, especially if steroids such as dexamethasone are being given. We have used the hyperglycemic glucose clamp technique to investigate the initial hormonal and metabolic responses of the septic patient to glucose under controlled conditions. 14-3-3 proteins are highly conserved and have been found in all eukaryotic organisms investigated. The use of chemokines as footprints of rejection may be of considerable value as noninvasive biomarkers in transplantation.

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The instruments used for data collection in this ethnographic qualitative study were interviews, field reports and analysis of documents. Altered expression and activity of G-proteins, mitogen activated protein kinases, and tyrosine kinases in aging kidney cortex. One patient had a self-limiting asthma attack during peplomycin sulfate treatment, and another had transient partial hair loss. Fine needle aspiration cytology of hyalinizing trabecular adenoma of the thyroid. It was found that cisplatin treatment activated the AKT signaling pathway and promoted cell proliferation in cisplatin-resistant EOC cells. The aim of this study was to analyze the utility of preoperative thin cut (2.5 mm) computed tomography (CT) in patients with primary hyperparathyroidism (PHPT) and negative sestamibi scans. Treatment of polypoidal choroidal vasculopathy with transpupillary thermotherapy: an interventional case report. The only exception was PGE2 which showed a significantly lower concentration in umbilical veins of smoking mothers. Indirect immunohistochemistry with different mouse monoclonal antibodies was used on frozen and acetone-fixed sections.

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Maternity health care: The experiences of Sub-Saharan African women in Sub-Saharan Africa and Australia. MTB optical density (OD) values increased to a maximum level of 3.5 to 4.0, with both increasing numbers of acid-fast bacilli and CFU. 4-Methylumbelliferone and p-nitrophenol xeloda pill picture were used as representative substrates for one functional form of UDP-glucuronyltransferase (GT1) and testosterone for the second functional form (GT2) of the enzyme. Moreover, the results for EC(50) at various intervals were in accordance with degradation processes of the initial compounds, in which rapid formation of DP was attributed to an increasing toxicity of DM. Behavior of protein level and fractions in blood in various diseases. The dual technique described is likely to be useful in selected cases with small residual AVMs and AVMs near eloquent areas of the brain, where the extent of surgical dissection and postoperative morbidity can be minimized by the precise localization of the AVM. These include the effects of these agents in malnourished patients, the influence of nutritional deficiencies on anabolic effects, the effect of inflammation on growth factor-stimulated protein synthesis, and concerns with safety and cost. Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services (HHS).

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24 patients with a proven rheumatoid arthritis and affected knee joints were recruited for the study. New approaches to the problem could be of great help for plant biotechnologists. Esterified maxalt 10 mg propoxylated glycerol soyate, a fat substitute model compound, and soy oil after heating. Injected ovaries were excised 56 hrs after injection and examined histologically. In SART-stressed mice treated with 6-hydroxydopamine, gastric and dermal blood flows tended to show a further decrease and increase, respectively, over and above the changes caused by SART stress.

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SPECT and PET images, the former reconstructed with(out) attenuation correction, were corecorded and reoriented along the short axis. This implies a more stable tear film, reflected in subjective improvement in ocular comfort. It occurs in women of childbearing age, as episodes of pain in the distribution of the sciatic nerve, which present in a cyclic manner and coincide with menstruation. Beta-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanisms. Altogether, our findings anticipate that GB exerts a cardioprotective effect through possible regulation of the ROS, Akt and calcium pathways. Often, a delay in diagnosis may contribute to a more advanced stage at presentation. In the setting of transplantation, this will allow monitoring of inflammatory responses, as well as the state of the graft. Emerging evidence has identified mitochondrial biogenesis and oxidative phosphorylation as potential targets for the prevention and treatment of metabolic syndrome. Outcome and management of blunt liver injuries in multiple trauma patients. The results indicate that the intravesical instillation of MMC promotes 2-stage bladder carcinogenesis, whereas CA does not.

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Combined sewer overflow (CSO) structures are constructed to effectively discharge excess water during heavy rainfall, to protect the urban drainage system from hydraulic overload. Evidence for apoptosis in the telomerase-inhibited cells was provided by flow cytometric analysis with APO2.7 monoclonal antibody. GlycCompSoft: Software for Automated Comparison of Low Molecular Weight Heparins Using Top-Down LC/MS Data. The phenylazomethine dendrimer (DPA) has a layer-by-layer electron density gradient that is an analog of the Bohr atom (atom mimicry). The biochemical and genetic basis of microbial degradation has received considerable attention. Our simulations have shown that a charge reversal after each deposition step is critical for steady multilayer growth and that there is a linear increase in polymer surface coverage after the first few deposition steps. These facilitative glucose transporter proteins are expressed in a tissue and cell-specific manner, exhibit distinct kinetic properties, and are developmentally regulated. POC and reference glucose calibration should be harmonized and standardized.

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