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Bionil (Glibenclamide)

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Bionil belongs to a class of drugs known as sulfonylureas. These drugs act by closing ATP-sensitive potassium channels on pancreatic beta cells. The ATP-sensitive potassium channels on beta cells are known as sulfonylurea receptor 1 (SUR1).

Other names for this medication:
Afdiex, Benclamet, Betrol, Bionil, Codica, Comdiab, Daocon, Diabetrol, Dutrol, Giclamide, Glibenclamide, Glibet, Glibson, Glimsug, Glinil, Glucomin, Glucosafe, Glybenclamide, Glybid, Glybonil, Glyboral, Glycurb, Glycurub, Glymep, Iscept, Monomet, Sugatrol, Triglycomet

Similar Products:
Rogaine, Xanax, Casodex, Combivent, Ilosone, Flomax, Zantac, Robaxin, Duricef

Also known as: Glibenclamide


Bionil is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future.

Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Bionil belongs to a class of medicines called sulfonylureas. It causes your pancreas to release more insulin into the blood stream. This medicine may be used alone or with another oral medicine such as metformin.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet


Take Bionil, micronized exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Carefully follow the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

Do not change to another brand without checking with your doctor. The number of tablets that you take depends on the brand and strength of the medicine. If you refill your medicine and it looks different, check with your pharmacist.

The dose of Bionil, micronized will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Bionil, micronized. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For type 2 diabetes: For oral dosage form (micronized tablets): Adults—At first, 1.5 to 3 milligrams (mg) once a day taken with breakfast or the first main meal. Some patients may start at 0.75 mg per day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 12 mg per day. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Bionil overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Bionil dosage information

Side effects

The most common side effects associated with Bionil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to Bionil, micronized or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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