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Bolodol (Tramadol)

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Bolodol is an inexpensive drug used to treat moderate to severe pain in adults. This drug is more popular than comparable drugs. It is available in generic and brand versions. Bolodol is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

Other names for this medication:
Adamon, Armadol, Bramadol, Cadol, Contramal, Cradol, Damol, Dolex, Dolriz, Ivydol, Medol, Midol, Movon, Muzox, Mydol, Nomadol, Novadol, Orchidol, Pacadon, Pentazen, Radol, Rimol, Sayodol, Sedate, Stemadol, Supridol, Tradol, Traiz, Tramache, Tramaflam, Tramak, Tramospas, Trandol, Trapain, Tremtec, Trofel, Tromfil, Tryme, Ultraspas, Ultrazac, Zotadol

Similar Products:
Priligy, Levothroid, Nuvigil, Sumycin, Trandate, Rhinocort, Exelon, Valium, Benemid

Also known as: Tramadol


{name} (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

{name} is used to treat moderate to severe pain in adults.

The extended-release form of tramadol ({name} ER) is for around-the-clock treatment of pain. {name} ER is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Bolodol ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Bolodol ER.

Never share Bolodol ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Bolodol ER.

Bolodol ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Bolodol ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Bolodol ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Bolodol ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Bolodol ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bolodol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Bolodol if you are allergic to tramadol, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Bolodol should not be given to a child younger than 12 years old. Bolodol ER should not be given to anyone younger than 18 years old.

Do not give Bolodol to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Bolodol. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

To make sure Bolodol is safe for you, tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Using the Diagnostic Interview Schedule, and DSM-III-R criteria we identified 18 individuals with a history of symptoms of hypomania among 56 patients with PD. To find out the frequency of osteopenia and associated risk factors among young female students. However, stents and GP IIb/IIIa receptor inhibitors improved safety of interventional procedures. Therefore, our expression strategy may simplify the production of humanized therapeutic glycoproteins by improving the N-glycosylation pathway in specific insect cells, with an ensemble of exogenous glycosyltransferases in a single recombinant baculovirus. However, in all parameters studied, the magnitude of the response showed clear seasonal variation. IM30/Vipp1 proteins are crucial for thylakoid membrane biogenesis in chloroplasts and cyanobacteria. Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway. Common features before diagnosis include headache, convulsions, and growth or endocrine disorders.

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To investigate causes of death in infants who died after 28 days, beyond the neonatal period but before discharge from the nursery, to establish their clinical courses and causes of death and to attempt to find criteria for earlier identification of these infants. Generally, coagulopathy is a relative contraindication for surgical tracheotomy. Because many antibody-mediated reactions are neutrophil-dependent, the role of this cell population was examined in passive CIA transferred with anti-type II collagen (CII) antibody. The inflammatory mediators bradykinin, prostaglandin E(2) and serotonin interact to excite and sensitize nociceptive neurons. Generally, the sulfur analogues of PAH (SPAH) in bitumen fumes have a higher concentration than the PAH of similar molecular weight, whereas the SPAH in coal-tar fumes have a much lower concentration than the corresponding PAH. Biological effects of bacterial pigment undecylprodigiosin on human blood cells treated with atmospheric gas plasma in vitro.

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The impact of pre-injury anticoagulation therapy in the older adult patient experiencing a traumatic brain injury: A systematic review. Overview of the recent clinical trials in severe head injury and analysis of their therapeutic failure. This study evaluates the effectiveness of two devices, the Hill-Rom Duo mattress and the KCI TheraPulse. Knockdown transgenic mice generated by silencing lentiviral vectors: zona pellucida removal and subzonal injection methods. A new class of promoter mutations in the lactose operon of Escherichia coli. Application of Cerium (IV) as an Oxidimetric Agent for the Determination of Ethionamide in Pharmaceutical Formulations. Western-blot analysis of MoDC after UVB demonstrated a concentration-dependent phosphorylation of p38- and c-JUN N-terminal kinase (JNK)-mitogen-activated protein kinases (MAPK), but not that of extracellular signal-regulated kinases. The extended deltopectoral approach remains the most widely used for this purpose. Publications were grouped by the main symptoms caused by haemophilia and the physiotherapy treatments available.

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Bacteria are considered as the major mediators of chitin degradation in nature. A 43-year-old otherwise healthy female patient presented with mild pancreatitis. The mechanism of reaction of Cys- 149 of D-glyceraldehyde-3-phosphate dehydrogenase with p-hydroxy-mercuribenzoate. The genes encoding the flagellum are expressed under cell cycle control predominantly in the predivisional cell type. Presence and distribution of immunoreactive FMRFamide- and bovine pancreatic polypeptide-like peptides in a protochordate ascidian. Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures. Despite a radical surgery of the sinuses and early treatment with Amphotericin B, the disease progressed rapidly and was fatal.

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Early Experience With a Partial Stapled Hemorrhoidopexy for Treating Patients With Grades III-IV Prolapsing Hemorrhoids. To identify critical features of the virus infection process in Dengue serotype 2 (DENV2)-infected Ae. While Rituximab is not considered a broad immunosuppressant, our results indicate a role for B cells as a therapeutic cellular target in regulating encephalitogenic T cell responses in specific tissues. The patients were classified according to the Blaivas-Groutz nomogram. A multispeciality team approach is advisable in such cases if radical excision is to be achieved. Relative effectiveness of various promoters from Escherichia coli and phage lambda. Because of recent improvements in pharmacologic therapy and medical interventions, the criteria used to select patients for CABG surgery has changed secondary to the clinical characteristics of the patient population. Interestingly, hypoxia, even hypoxia-induced oxidative stress, coagulation and inflammation can all induce release of endothelial microparticles (EMPs).

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This membrane glycoprotein is structurally and antigenically distinct from decay accelerating factor (DAF), a complement regulatory protein previously identified on human platelet membranes. Further studies concerning the role of nitric oxide in LTP induction and maintenance. The analysis suggests that a chief contributor to the observed enthalpic destabilization is the differential hydration, of protein and ligand atoms, by light and heavy water. Association of this complex with the polyA polymerase can modulate mitochondrial polyA tails. Enabling Chemistry Technologies and Parallel Synthesis-Accelerators of Drug Discovery Programmes. The present paper deals with a succession of two epidemics caused by two different viruses. Upon hospitalization, anorexia nervosa patients are often markedly bradycardic, which may be an adaptive response to progressive weight loss and negative energy balance. Diagnosis of high-grade prostatic intraepithelial neoplasia: the impact of the number of biopsy cores at initial sampling on cancer detection after a saturation re-biopsy.

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The structure was obtained through Rietveld refinements and the minimization of crystalline energy for the localization of the H atoms of the hydroxyl groups. The location of the other epitope was determined by immunoprecipitation of actin fragments synthesized in vitro. Antigenic diversity in flagellar epitopes among Bacillus piliformis isolates. Serum concentrations of Lp(a) were measured by enzyme linked immunosorbent assay. Apathy was significantly elevated among HIV-infected individuals compared to healthy comparison subjects. Plasma concentrations of ir-inhibin did not change significantly during the ovulatory cycle. Role of ovary and adrenal glands in hyperandrogenemia in patients with polycystic ovary syndrome. Treatment of severe perianal cutaneous lesions in hospitalized neonates: Orabase ointment interest.

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Light-induced reactions and biological functions of c-type cytochromes in relation to P-870. Overall survival (OS) was determined for each treatment modality. ICAM-1-dependent pathway is not critically involved in the inflammatory process of autoimmune encephalomyelitis or in cytokine-induced inflammation of the central nervous system. Role of 256-slice MDCT in the evaluation of coronary artery fistula: A case series with review of literature. This diabetic late complication comprises a number of mono- and polyneuropathies, plexopathies, radiculopathies and autonomic neuropathy. Mice infected with Trypanosoma cruzi exhibit an early and profound suppression of parasite-specific and nonspecific immune responses.

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Advantages of this technology are the high efficiency and specificity of the resulting esiRNA and its usefulness for not only small-scale applications, but also high-throughput loss-of-function analyses. Regardless of the degree of recurrent risk and availability or not of prenatal diagnosis, couples were several fold more likely to reproduce again when the affected child was the 1st rather than later born. A better understanding of the host response at a molecular level also allows for estimating individual risk. Inhibition of either Raf-1 or ALG-2 (apoptosis-linked gene 2) expression results in apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase (ASK1/JNK) signaling activation, and cell sensitivity to chemotherapeutic reagents, indicating that inhibition of ASK1/JNK apoptotic signaling by Raf-1 is mediated by ALG-2. The mercury intoxication was caused by the application of an over-the-counter metallic mercury ointment. The most frequent causes are tuberculous pleuritis and pleurel effusion secondary to rheumatoid arthritis. The adaptive value of cyclomorphic spine production in Brachionus calyciflorus pallas (rotatoria) : I. Selected were only those studies that describe upper limb posture during experiments clearly enough so that it could be transferred according to the Seven Degrees of Freedom Model, which unambiguously defines upper limb posture with values of seven angles. Immunization is considered one of the most cost effective public health interventions for reducing child morbidity, mortality and disability.

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Therapeutic vaccination with Ad26/MVA resulted in a marked increase in the magnitude and breadth of SIV-specific cellular immune responses in virologically suppressed, SIV-infected monkeys. Odds ratio (OR) and adjusted hazard ratio (HR) for short-term prognosis were calculated for PE patients with or without hyponatremia. The Syrian hamster (Mesocricetus auratus) is the best animal model for human leishmaniosis, an emergent disease that causes 400,000 new cases every year moduretic tablets weight loss . A comparison of the leachability in FA treated by several methods showed a difference in the reduction efficiency of leachability, depending on the adsorption of SAAs by each treated FA. Patients aged 6 months to 12 years, having fever of more than four days duration with clinical suspicion of typhoid fever were enrolled. Patients and controls executed a motor task with two sequences (a simple and a more difficult one) of consecutive button presses. The difference in maternal serum and cord blood hCG levels in correlation with the fetal gender is not associated with cytotrophoblast cell activity in the human term placenta. Moreover, indications of lysosomal rupture, including release of lysosomal enzymes, were apparent 1 h after addition of 10 mM of hydrogen peroxide.

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Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes. Genotyping was performed in 110 dizygotic white twin pairs from Flanders, Belgium. We assessed the number of tumor cells 24 h later and the outcome of metastases of the target organ. There was no significant change in GM-CSF and grey WM-CSF ratios. Epidemiological association between chlorinated water and overall risk of cancer: A systematic review. The measured UV irradiance was weighted using action spectra to calculate the biologically effective UV irradiances that cause non-melanoma (UVBEnon-mel) skin cancer. Etiology was retrieved in subsets of this cohort by discharge codes and by linkage to a microbiological database.

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Computer simulations demonstrate that (1) it can learn categories to reduce reaction time without a decrease in performance, (2) the model reveals a performance similar to that of humans in feature and conjunction search, and (3) its learning dynamics are comparable with those of humans. Long-term results after primary restoration of the orbital floor. The epidemiology of Clostridium difficile infection in a national kidney transplant center. This study was carried out in May 2004 at the Department of Anatomy, Hacettepe University, Ankara, Turkey. Except for the morphological changes in minimal medium and slightly reduced colonization capacity, mutant strain IEM101-T maintained most of the desirable features as the wild-type strain IEM101 in terms of growth rate and immunogenicity. An inexpensive, simple, and manual method of CD4 T-cell quantitation in HIV-infected individuals for use in developing countries. Similarly, molecular genetics researchers have drawn attention to the importance of the enzymatic systems that metabolize ethanol and acetaldehyde in the study of alcoholism.

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Intestinal microflora in breastfed colicky and non-colicky infants. The strains from abroad present heterogeneous profiles, with the Bolivian strain and the Colombian strains related to one of the Peruvian population. While sibutramine and topiramate have both been associated with weight loss in controlled trials, the former appears to be fairly well-tolerated and the latter appears to be responsible for the emergence of significant cognitive and peripheral nervous system side effects in some patients. The effects of high-diversity plant species mixtures on weed suppression differed between sites. The route was readily adapted to the synthesis of the three other stereoisomers of natural cytoxazone. Their derivation is carried out rigorously by taking into account the scale of variation of the solution correctly. These RNAs are precipitated by antibodies directed against the trimethylguanosine cap structure, characteristic for small nuclear RNAs (snRNAs) of the U type. The selective adsorption of p-chloronitrobenzene (p-CNB) using zeolite as the adsorbent from an aqueous mixture containing p-CNB and o-chloronitrobenzene (o-CNB) was investigated. To analyze corneal topographic data by Fourier analysis to determine differences in irregular astigmatism following tenormin tablet price in pakistan spherical hyperopic correction by photorefractive keratectomy (PRK) or laser in situ keratomileusis (LASIK). All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationship were established.

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Since HC3 is a potent and relatively selective inhibitor of high affinity choline uptake (HACU), the results indicate that the toxic effects of AF64A in the neonatal rat are dependent upon its uptake via the HACU site. It is therefore proposed that both of these interactions play a role in stabilizing the inactive state of the receptor. Eye protection is available for most sports and should be worn in accordance with the standards of regional authorities. The attachment and outgrowth on fibronectin were significantly inhibited in the presence of synthetic peptides containing the Arg-Gly-Asp (RGD) sequence, which interacts with the fibronectin receptor (integrin alpha5beta1), but were not inhibited by the control peptides containing the Arg-Gly-Glu (RGE) sequence. There were three cases of osteopetrosis with intracranial calcifications: one had calcifications in the peritentorial region and two in the junction regions between the grey and white matters with basal ganglia. Development of a novel surface modification for improved bonding to zirconia. Recurrent squamous cell carcinoma of the cervix with pulmonary lymphangitic metastasis. The effects of an intranasal administration of synthetic alpha-human natriuretic polypeptide (alpha-hANP) were studied in 8 healthy male volunteers.

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Here, we show that deoxyadenosine itself is also a potent activator of dCK if its deamination was prevented by the adenosine deaminase inhibitor deoxycoformycin. The thrombus solidifies significantly during the process of remodeling, thereby changing elasticity, while the tissues located around the vessel remain unchanged. Improved image quality for epifluorescence microscopes through adapting confocal techniques. This study examined the relationship between psychological mood, stress and oral hygiene behaviour in a group of 51 regular dental attenders. Additionally, some Myb genes with similar functions were clustered in the same subgroups. In part 1 (quantitative longitudinal study), the relevance of IAM items was measured. Fifty two children who had had cancer and been treated with chemotherapy, and who were long term event free, were examined for caries prevalence, gingival health, and oral hygiene and compared with a control group. This analysis was based on the Beijing multidimensional longitudinal study of aging (BLSA), which included 2,090 subjects over 55 years old and was followed-up from 1992 to 2012. Using transcranial magnetic stimulation (TMS), we demonstrate the role of human PMd in specific stages of learning of a novel conditional visuomotor task that required subjects to identify object center of mass using a color cue and to apply appropriate torque on the object at lift onset to minimize tilt. Cemented total hip arthroplasty (THA) is a safe and common procedure.

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To explore range of motion in children with cystic fibrosis (CF) compared to children developing typically. Testing the Vascular Invasive Ability of Cancer Cells in Zebrafish (Danio Rerio). Assessing cardiac autonomic function through HRV is of pivotal prognostic significance for this patient population. The tick-borne encephalitis virus, strain Absettarov, was used as positive control. The divergence of protein sequences, the phylogenetic distribution, and the expression of COMT and COMT-like genes suggest that they have evolved different functions or tissue specificities following duplications.

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These results indicate that glgBII is regulated (directly or indirectly) by whiG, and not by any of the other whi genes tested, and that the aerial hyphae of a whiG mutant are atypical in being physiologically similar to the substrate hyphae from which they emerge. It is important that cultural norms not be used as an excuse for inaction or substandard delivery of services. Accurate measurement of a health problem is crucial in defining its burden. Enzyme immunometric assay for endothelin using tandem monoclonal antibodies. There is limited data on the effect of corticosteroid therapy in lipitor tablets patients with cardiac sarcoidosis (CS). This report describes the morphology, surface markers, growth requirements, and functional activity of the M1-A5 cell line, which was established by the limiting dilution of spleen cells from a mouse bearing a large methylcholanthrene-induced fibrosarcoma. Isolating Staphylococcus aureus from children with suspected Staphylococcal scalded skin syndrome is not clinically useful. Half of the patients (nine patients) were fed intraoperatively, whereas in the other nine patients feeding was suspended beginning 1h prior to surgery until 6h after surgery. Crustaceans, insects and to a lesser degree arachnids have been employed in regeneration studies.

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Laparoscopic placement of prolene mesh in the rectovaginal septum and veslcovaginal septum of 42 women with uterine prolapse with bladder and rectum prolapse. In addition, anti-mu stimulation of antisense-treated cells failed to induce any detectable increase in kinase activity of p55blk, a result suggesting the uncoupling of blk proteins from normal signal pathways that are essential for growth inhibition. Inhibitory effects of formaldehyde on the reproductive system of male rats. An association between diabetes mellitus and HCV has been recognized previously. There is a pressure to both identify and expand the evidence base with regard to the treatment of speech and language disorders in children, as there is in other areas of speech and language therapy. INTRODUCTIONThis protocol describes a method for inducing ovulation in Xenopus laevis for the purpose of in vitro fertilization. The spontaneous blink rate (SBR) is believed to reflect a complex interaction between peripheral influences mediated by the eye surface and the central dopaminergic activity. The modification of the stylus provided the mechanical advantage to simulate surface stiffness values that are beyond the original capability of the haptic device. Modeling anorexia nervosa: transcriptional insights from human iPSC-derived neurons. A novel type of applicator for the treatment of intra-ocular tumors has been developed, based on the two radionuclides 106Ru/106Rh and 125I.

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Surprisingly, expression of VCAM-1 on lymph node endothelium was not found even in mice which had been treated systemically with high doses of TNF-alpha or LPS, although VCAM-1 expression was strongly induced on endothelial of all other organs that were analyzed.(ABSTRACT TRUNCATED AT 250 WORDS). Mechanisms by which sugars may signal regulatory systems for food intake need to be considered when evaluating both study designs and conclusions. Current and emerging treatment options for venous thrombosis: a case discussion. Effects of mast cell growth factor, interleukin-3, and interleukin-6 on human primitive hematopoietic progenitors from bone marrow and cord blood. Chronic is generic zyrtec as good as brand name Heart Failure With Preserved Systolic Function and Reversible Dilatation of Cardiac Chambers. The rate of infection therefore depends on the fraction of infectious virions that are sufficiently saturated with CCR5 to undergo this conformational change and on the magnitude of the activation energy barrier. Regulation of butyrate uptake in Caco-2 cells by phorbol 12-myristate 13-acetate. Such an increase in the intensity might be easily achieved with a superconducting cyclotron. morbidity, mortality etc.) are crucial for rapid assessment of disease burden and mortality trends in the population. The effects of diet mixing on consumer fitness: macroalgae, epiphytes, and animal matter as food for marine amphipods.

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