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Caltop (Calcitriol)
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Caltop

Caltop is a hormonally-active, synthetic vitamin D analog prescribed to treat hypocalcemia, osteoporosis, and the prevention of corticosteroid-induced osteoporosis. Systemic Caltop is FDA indicated to control hypocalcemia in patients on chronic renal dialysis, secondary hyperparathyroidism in those with chronic kidney disease not yet on dialysis, and hypocalcemia in patients with hypoparathyroidism and pseudohypoparathyroidism.

Other names for this medication:
Actical, Admax, Alfacal, Alfarich, Alphadol, Aristrol, Biocal, Biocitral, Bonestat, Calasto, Calbec, Calbory, Calbovic, Calcibest, Calcicare, Calcigra, Calcimet, Calcitriol, Calcor, Caldix, Calfa, Calotec, Calsonic, Calsure, Caltin, Calvical, Calzem, Carcal, Cholical, Denscal, Duracal, Kurecal, Laretol, Minroset, Nutribone, Ostonex, Politrol, Qpcal, Refirm, Rical, Ritoca, Rockbon, Roical, Rolsical, Romical, Statbone, Sunmic, Tobalt, Vezocal, Zaxial

Similar Products:
Glucophage, Adipex, Duphaston, Glucotrol, Zyvox, Famvir, Aricept

Also known as: Calcitriol

Description

Generic Caltop is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Caltop are intestine and bone. Generic Caltop receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Caltop may also act on the kidney and the parathyroid glands. Generic Caltop is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Caltop has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Caltop, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Caltop in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Caltop produces other independent beneficial effects. Caltop is also known as Calcitriol. Generic Caltop treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Caltop is Calcitriol. Brand name of Generic Caltop is Caltop.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Caltop. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Caltop and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Caltop are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Caltop if you are allergic to Generic Caltop components. Do not take Generic Caltop if you are pregnant, planning to become pregnant, or are breast-feeding. It is not known if this medication appears in breast milk. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Be careful with Generic Caltop if you have heart disease, kidney disease or kidney stones, coronary artery disease (hardening of the arteries). Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. It can be dangerous to stop Generic Caltop taking suddenly.

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The present study demonstrates that the alpha beta gamma heterotrimer and beta gamma heterodimer complexes of IL-2 receptor reconstituted on murine fibroblast L929 cells can transduce IL-2-mediated signals for activation of tyrosine kinase and for induction of c-myc, c-fos, and c-jun expression. VEGF immunoreactivity was concentrated in clusters of tumor cells and patches of stromal matrix. Patients with diabetes were older, more often women, with a greater prevalence of comorbidities, and they were less likely to be treated with effective cardiac therapies than nondiabetic patients. The methodology determines protein impurities by mass spectrometry and separation difficulty from the product based on adsorption properties deduced from a single set of experiments. Activation differences in the orbitofrontal cortex (BA11) and anterior cingulate cortex (BA24) underlie these modulations. Evidence was found for the specificity of pain responses to homographic pain stimuli as the chronic pain group produced more of these responses than the two comparison groups. Laparoscopic ports closed with OCT had fewer early complications, such as wound erythema, tenderness, and drainage. Binding of streptococcal competence factor by the spheroplast membrane of a group H streptococcus. All participants completed a standard neuropsychological evaluation and completed VR services (i.e., were followed from enrollment to case closure). Experimental conditions are described for simultaneous purification of three forms of lipocortin (lipocortin I, lipocortin II and lipocortin-85) from bovine lung.

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While it is clear that some behavioural methods, alarms and desmopressin can be effective interventions, the evidence for other treatments is not so definitive. The intrinsic determinants that direct this process are not well defined. CA IX is a stable marker of current or previous chronic hypoxia but influenced by nonhypoxic stimuli. Are cytokines linked to collagen breakdown during periodontal disease progression?. In this article, we discuss the risk factors, strategies for prevention, approaches to diagnosis and management plan for the patient with VAP. To investigate the therapeutic value of liver transplantation for advanced hepatocellular carcinoma (HCC). Glycine is used as a transmitter by decrementing expiratory neurons of the ventrolateral medulla in the rat. There were significant differences in motility between refrigerated and nonrefrigerated larvae immediately after baseline until day 8. These results suggest that there is an inhibitory rectovesical reflex in the lumbosacral cord of rats with spinal cord injury, which modulates the spinal micturition reflex via glycinergic or GABAergic mechanisms. The superior imaging features of ECG-gated CT have enabled preoperative identification of coronary grafts, preventing injury to these important structures during reoperative surgery.

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This method allows one to dissociate modulations of the event-related brain potentials (ERPs) associated with cognitive control from modulations of the ERPs associated with conflict processing that are temporally confounded in the standard Stroop task. Reactogenicity was higher for concomitant vaccines administration, but no safety concerns were identified. Secondly, international consensus was reached on the content of the website. Interestingly, the TCR-V beta repertoire of the tumor-infiltrating lymphocytes and tumor-rejecting lymphocytes were identical with V beta 1 and V beta 8 being predominant at both sites. A critical step of the protocol is the choice of detergents to prevent aggregation and/or precipitation of proteins particularly associated with cellular membranes such as MxA, without interfering with its enzymatic activity. Two cases are described of percutaneous removal of trapped, broken steerable PTCA guidewire. The economical and evolutionary aspects of the optimal catch of the fish population.

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Stable expression of COX-2 increased anchorage-dependent and -independent cell growth, which was accompanied by elevated PGE2 production. Monitoring Countries in a Changing World: A New Look at DIF in International Surveys. Revised Chapman-Enskog analysis for a class of forcing schemes in the lattice Boltzmann where to buy nolvadex and clomid method. Quantitative modelling of legume root nodule primordium induction by a diffusive signal of epidermal origin that inhibits auxin efflux. vivax isolates obtained from 591 symptomatic patients from 1997 to 2013. Previous research has implicated oligopeptides derived from SCO-spondin TSRs in in-vitro development of various neuronal cell types. This experimental study showed no statistically significant differences in biomechanical performance between 1.8-mm ASAs and 2.9-mm SAs. Despite vigorous antibiotic treatment and physiotherapy, the pneumonitis persisted with clinical and radiologic deterioration. Morphogenesis during division and griseofulvin-induced changes of the microtubular cytoskeleton in the parasitic protist, Trichomonas vaginalis.

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Preparation of liposome containing bacteriorhodopsin with natural preferred orientation of its transient photoresponse. To investigate if neurodynamic treatment is more effective than advice to remain active in patients with nerve-related leg pain. Although it cannot be predicted which girls will become infertile or develop premature ovarian insufficiency (POI) following intensive chemotherapy or irradiation, patients who are at high risk of POI should be offered ovarian tissue cryopreservation (OTC). The control group outperformed their counterparts on the control and interference conditions of the Stroop test, suggesting ADHD-specific executive and reading deficits. Until recently, the prognosis of patients with melanoma brain metastases (MBM) was poor.

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Increasing utilization more broadly could result in better overall treatment effectiveness for all intervention modalities. Six cases of diffuse large cell lymphoma (DLCL) of the liver were studied with immunohistochemistry for common leukocyte antigen (CLA), lysozyme, alpha-1-antitrypsin (AAT), and kappa and lambda light chains on paraffin-embedded tissues. Effect of defoliation upon root growth, phosphate absorption and respiration in nutrient-limited tundra graminoids. A significant relationship between the daily dose and the mean creatinine-corrected concentration of buprenorphine in the urine was observed, together with a relatively stable relationship between the ratio of the urinary concentrations of norbuprenorphine to buprenorphine across the dose range studied. Clinically nonfunctioning pituitary adenomas are one of the most common types of pituitary tumors. The main limitations of this study were the size of the sample and in particular its cross-sectional design which only allows predictive associations to be made.

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Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. This study was aimed at the isolation of active amber tRNA(Asn). Capillary electrophoresis-mass spectrometry in impurity profiling of pharmaceutical products. A dual fluorescent multiprobe assay for prion protein genotyping in sheep. Agglutination activity of Limulus polyphemus coagulogen following limited proteolysis. Comparison among resins revealed that for MW7, the roughness flagyl side effects yeast infection of A was significantly lower than that of L. Adenylate cyclase activity is decreased in chick embryo fibroblasts transformed by wild type and temperature sensitive Schmidt-Ruppin Rous sarcoma virus. They were judged to be mild in 8 patients, moderate in 5 and severe in 8.

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In cDNA-amplified fragment length polymorphism (cDNA-AFLP) analysis, it is critical to choose a suitable pair of restriction enzymes for tagging sites in bystolic 2 mg cDNA for amplification. Synthesis and characterization of two quaternary thorium chalcophosphates: Cs4Th2P6S18 and Rb7Th2P6Se21. The results are discussed in terms of masker envelope fluctuations. Feeding Moringa oleifera fresh or ensiled to dairy cows--effects on milk yield and milk flavor. The target population consisted of lower-class Brazilians, many living in poor social conditions. Inhibition of platelet aggregation can reduce the risk for acute atherothrombosis. Additionally, biochemical investigations demonstrated the very good preservation of collagen and glycosaminoglycans of the dermal extracellular matrix.

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The application of vegetable extracts or dietary supplementation with selenium or antioxidant vitamins results in positive benefits on immunity and other phenomena associated with chronic diseases, ageing and cancer. Use and limitations of imatinib mesylate (Glivec), a selective inhibitor of the tyrosine kinase Abl transcript in the treatment of chronic myeloid leukaemia. Cytokinins are important purine derivatives that serve as hormones that control many processes in plants. In addition to increasing cell number, the period of culture may also permit genetic manipulation to define mechanisms of neuronal function and to enhance the therapeutic utility of transplanted cells. We report the incidence of port-site metastases and causative factors associated with this condition. A decrease in GAT-1 and GAT-3 immunostaining but no change in GAT-2 staining was observed in the degenerating CA subfields. Our results indicate that these basic peptides can constitute effective components of synthetic gene-transfer complexes, as long as sufficient copies are displayed on the outer surface of the complex. Epilepsy surgery for magnetic resonance imaging (MRI)-negative patients has a less favorable outcome. Although not yet curable in humans, pain related to SCD can be effectively managed in most patients by using a comprehensive approach that incorporates pharmacologic, psychologic, behavioral, and physical pain management strategies. This article will examine the ethical, social, legal, political, and economic impact of physician-assisted suicide.

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Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine. Determinants and Duration of Impact of Early Gut Bacterial Colonization. Intradural lumbar disc herniations: the role of MRI in preoperative diagnosis and review of the literature. International experience has demonstrated the clinical value dogs tramadol dosage and the technical feasibility of telemedicine-based patient care and service collaboration in primary care. Given the increased incidence of venous thromboembolism (VTE) in pediatric patients, which has been associated with increased survival of medically complex patients and increased use of invasive supportive measures, it is important to understand treatment options and unique aspects of anticoagulant use in children. Fetal hydrops, mostly associated with late referral, decreases the chance of survival.

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