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Capxcel (Capecitabine)
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Capxcel

Capxcel is in a class of medications called antimetabolites. It works by stopping or slowing the growth of cancer cells. Capxcel is used in combination with other medications to treat breast cancer that has come back after treatment with other medications.

Other names for this medication:
Capecitabine, Capegard, Capehope, Capget, Capiibine, Capres, Capscare, Captabin, Capxcel, Distamine, Naprocap, Xabine, Xelocel

Similar Products:
Prograf, Lanoxin, Cenforce, Mellaril, Levitra, Arimidex, Sovaldi

Also known as: Capecitabine

Description

{name} (capecitabine) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

{name} is used alone or in combination chemotherapy to treat colon cancer, breast cancer, or colorectal cancer.

{name} is sometimes used when cancer has spread to other parts of the body (metastatic).

Dosage

Usual Adult Dose of Capxcel for Colorectal Cancer:

MONOTHERAPY: For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles ADJUVANT TREATMENT IN PATIENTS WITH DUKES' C COLON CANCER: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles for a total of 8 cycles (24 weeks) Comments: -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Colorectal Cancer: -As monotherapy for adjuvant treatment in patients with Dukes' C colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferred; this drug was non-inferior to 5-fluorouracil and leucovorin (5-FU/LV) for disease-free survival (DFS); physicians should consider results of combination chemotherapy trials, which have shown improvement in DFS and OS, when prescribing this drug as a single-agent in the adjuvant treatment of Dukes' C colon cancer -As first-line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone is preferred; combination chemotherapy has shown a survival benefit compared to 5-FU/LV alone; survival benefit over 5-FU/LV has not been demonstrated with this drug as monotherapy; use of this drug instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage

Usual Adult Dose of Capxcel for Breast Cancer:

MONOTHERAPY: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period combined with docetaxel 75 mg/m2 as a 1 hour IV infusion, every 3 weeks IN COMBINATION WITH DOCETAXEL: -RECOMMENDED DOSE: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles Comments: -The manufacturer prescribing information for docetaxel should be consulted for premedication advice. -The tablets should be swallowed whole with water within 30 minutes after a meal. Use: Breast Cancer: -In combination with docetaxel for the treatment of patients with metastatic breast cancer after failure of prior anthracycline-containing chemotherapy -As monotherapy for the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen or resistant to paclitaxel and for whom further anthracycline therapy is not indicated (e.g., patients who have received cumulative doses of 400 mg/m2 of doxorubicin or doxorubicin equivalents); resistance is defined as progressive disease while on treatment, with or without an initial response, or relapse within 6 months of completing treatment with an anthracycline-containing adjuvant regimen

Detailed Capxcel dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at a room temperature between 4 and 30 degrees C (39 and 86 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Capxcel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Capxcel if you are allergic to capecitabine or fluorouracil, or if you have:

severe kidney disease.

To make sure Capxcel is safe for you, tell your doctor if you have ever had:

a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency; liver or kidney disease; heart problems; or if you use a blood thinner and you have routine "INR" or prothrombin time tests.

Capecitabine can harm an unborn baby if the mother or the father is using Capxcel .

If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using Capxcel and for at least 6 months after your last dose. If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Tell your doctor right away if a pregnancy occurs.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

Do not breastfeed while using Capxcel, and for at least 2 weeks after your last dose.

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JMJD5 Functions in concert with TOC1 in the arabidopsis circadian system. Plants carrying mutations in the NEVERSHED (NEV) gene, which encodes an ADP-ribosylation factor GTPase-activating protein, retain their outer floral organs after fertilization. These results likely reflect limited heme synthesis for cytochrome assembly in the absence of oxygen and represent a discrete and reversible blockage of full mitochondrial biogenesis in this anoxia-tolerant species. Comparison of hapten-specific cytotoxic and suppressor T cells by a split culture approach. Sentinel surveillance is advised to monitor impact post-vaccine introduction and to document changes in genotype distribution. Preservation of left ventricular systolic function is an important goal of treatment. Isolation and characterization of fourteen novel putative and nine known target genes of the p53 family. Moreover, a mutant lacking the Ptk2 kinase, necessary for positively regulating polyamine transport, was defective in fluoro-BLM-A5 uptake and exhibited extreme resistance to the drug. Fundus flourescein angiography showed early and late hyperflourescence with late pooling in serous detachments.

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Inhibitory actions of salmeterol on human airway macrophages and blood monocytes. Binding and internalization of Helicobacter pylori VacA via cellular lipid rafts in epithelial cells. Multidisciplinary teams and childhood visual impairment: a study of two teams. Kawasaki disease (KD) is an acute, self-limiting vasculitis of unknown etiology. Body surface mapping for the assessment of left ventricular hypertrophy in patients with essential hypertension. public clinics compared elavil 10 mg douleur with women who obtained combined oral contraceptives over the counter (OTC) in Mexican pharmacies. In this paper, a method of rapid and undamaged identification of wild and cultivated Gastrodia elata Blume, and one of its fakes by Fourier transform infrared spectroscopy (FTIR) is reported. In addition to anti-desmoglein 3 antibodies, these patients had anti-DP autoantibodies, demonstrable by immunofluorescence (IF), immunoprecipitation (IP), and indirect immunoelectromicroscopy (IIEM). Predictors of therapeutic benefit from amitriptyline in mild depression: a general practice placebo-controlled trial. However, the possibility of a conditioned cytokine response has not been assessed.

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To systematically review and quantitatively synthesize the long-term effects of inhaled corticosteroids, long-acting beta2 agonists, leukotriene pathway modifiers/receptor antagonists, and anti-IgE therapies on clinical outcomes and particular clinically relevant exacerbations in adult patients with chronic asthma. Simulations demonstrate that SPURS outperforms other reconstruction methods while maintaining a similar computational complexity over a range of sampling densities and trajectories as well as various input SNR levels. Addition of the EP1/EP2/EP3 receptor antagonist AH6809 inhibited this contraction and facilitated further relaxation through concentrations above 1 microM of PGE1. Immunofluorescent localization of collagen types I, III is neurontin a safe drug and IV, fibronectin, laminin, and basement membrane proteoglycan in developing mouse skin. By such an analysis, nickel had no relative effect on the ability of competition to reduce plant size in two experiments, and caused a small reduction in competition in another. Impact of chitosan and polyacrylamide on formation of carbonaceous and nitrogenous disinfection by-products.

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Expression of p185(BCR-ABL) causes factor independence, signifying a conversion toward a transformed phenotype in hematopoietic precursors. Diagnosis and pathogenesis of abortion in women with adrenal hyperandrogenism. Mutation analysis and haplotype correlation for 139 cystic fibrosis patients from the Nebraska Regional Cystic Fibrosis Center. Five affected males were identified in previously unknown families and 17 new pedigrees were diagnosed. However, PN soft-tissue stranding was shown to be the only significant factor for predicting PNF invasion, which showed good accuracy with high sensitivity and high specificity in tumors 4 cm or less. In addition, there was no evidence of passive gene-environment correlation, what medication should not be used in combination with amiodarone suggesting that the link between lower levels of maternal mutuality and higher levels of child behavior problems is not only reflecting overlapping genetic influences on parent and child behavior. Despite the different approaches available and the improvements achieved, a gold standard for fully functional tissue engineered oesophageal constructs has not been defined yet.

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