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Cardiacin

Cardiacin is used to treat atrial fibrillation and congestive heart failure. Cardiacin is extracted from the foxglove plant, Digitalis lanata. This medication is used to treat various heart conditions (atrial fibrillation, atrial flutter, heart failure).

Other names for this medication:
Agoxin, Cardiacin, Cardiogoxin, Digacin, Digibind, Digitek, Digobal, Digohan, Digoregen, Digosin, Digossina, Digoxen, Digoxin, Digoxine, Digoxinum, Eudigox, Fargoxin, Halfdigoxin, Lanadicor, Lanibos, Lanicor, Lenoxin, Purgoxin, Sigmaxin, Vidaxil

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Also known as: Digoxin

Description

Digoxin injection is given in combination with a diuretic (water pill) and an angiotensin-converting enzyme (ACE) inhibitor to treat heart failure in adults and children. It is also used to treat adults with atrial fibrillation (a heart rhythm problem).

Digoxin belongs to the class of medicines called cardiac glycosides. It is used to improve the strength and efficiency of the heart, or to control the rate and rhythm of the heartbeat. This leads to better blood circulation and reduced swelling of the hands and ankles in patients with heart problems.

This medicine is to be given only by or under the direct supervision of a doctor.

Dosage

Usual Adult Dose of Cardiacin for Congestive Heart Failure:

Rapid Digitalization with a Loading Dose: Peak digoxin body stores of 8 to 12 mcg/kg generally provide a therapeutic effect with minimum risk of toxicity in most patients with heart failure and normal sinus rhythm. The loading dose should be administered in several fractions, with approximately half the total given as the first dose. Additional fractions of the total dose may be given at 6 to 8 hour intervals. Careful assessment of the patient's clinical response should be considered before each additional dose. If the patient's response necessitates a change from the calculated loading dose of digoxin, then calculation of the maintenance dose should be based upon the amount actually given. Tablets: Initial: 500 to 750 mcg usually produces a detectable effect in 0.5 to 2 hours with a maximal effect in 2 to 6 hours. Additional doses of 125 to 375 mcg may be given at 6 to 8 hour intervals until clinical evidence of an adequate effect is noted. The usual amount of digoxin tablets that a 70 kg patient requires to achieve 8 to 12 mcg/kg peak body stores is 750 to 1250 mcg. Injection: Initial: 400 to 600 mcg of digoxin intravenously usually produces a detectable effect in 5 to 30 minutes with a maximal effect in 1 to 4 hours. Additional doses of 100 to 300 mcg may be given cautiously at 6 to 8 hour intervals until clinical evidence of an adequate effect is noted. The usual amount of digoxin injection that a 70 kg patient requires to achieve 8 to 12 mcg/kg peak body stores is 600 to 1000 mcg. The injectable route is frequently used to achieve rapid digitalization, with conversion to digoxin tablets for maintenance therapy. Maintenance Dose: The doses of digoxin tablets used in controlled trials in patients with heart failure have ranged from 125 to 500 mcg once daily. In these studies, the digoxin dose has been generally titrated according to the patient's age, lean body weight, and renal function. Therapy is generally initiated at a dose of 250 mcg once daily in patients under age 70 with good renal function.

Usual Adult Dose for Atrial Fibrillation:

Peak digoxin body stores larger than the 8 to 12 mcg/kg required for most patients with heart failure and normal sinus rhythm have been used for control of ventricular rate in patients with atrial fibrillation. Doses of digoxin used for the treatment of chronic atrial fibrillation should be titrated to the minimum dose that achieves the desired ventricular rate control without causing undesirable side effects.

Detailed Cardiacin dosage information

Overdose

If you overdose Cardiacin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Cardiacin overdosage: confusion, irregular heartbeats, nausea, seizures, vomiting, extremely fast or slow heartbeats, hallucinations, tiredness, problems with vision, diarrhea, lack of appetite.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Cardiacin dosage information

Side effects

The most common side effects associated with Cardiacin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Videotaping of surgical procedures and outcomes following extraperitoneal laparoscopic radical prostatectomy for clinically localized prostate cancer. Before proceeding to national implementation, we expect that this prototype will provide a body of information about what impact these modifications may have on agency operations, notice and other procedures, as well as the resulting quality and timeliness of decisions for the public. High bone mineral density (BMD) has been associated with genetic disorders and a variety of dietary, endocrine, metabolic, infectious and neoplastic diseases that in many cases warrant medical attention. Impact of oxidative stress on the health and immune function of dairy cattle. Saving an access control system when your supplier goes out of business. Early prevention is clearly a better way to improve the prognosis. These limitations must be taken into account in analyses of German hospital discharge data focusing on the hospital level. The back of mice was depilated and the top skin layer was removed either by scratching with the side of a 26 gauge needle, or by abrading with sand paper or a hand held motorized pedicure/manicure instrument. Use of viable intestinal segments for plastic operations on the urinary bladder. Prognostic significance of in vitro marrow culture growth pattern in untreated acute nonlymphocytic leukemia.

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Sublethal streptomycin concentrations and lytic bacteriophage together promote resistance evolution. Furthermore, the ethanol-induced form of cytochrome P-450 has a high capacity for the conversion to toxic metabolites of some commonly used drugs, such as acetaminophen, and also carcinogens, such as dimethylnitrosamine which is activated at concentrations much lower than those required for other microsomal inducers. The magnitude of BrdU incorporation was used as the hyperplasia marker, while the proximal tubule protein: DNA ratio was used as the hypertrophy marker. Low prevalence of MYOC mutations in UK primary open-angle glaucoma patients limits the utility of genetic testing. They have shown promising results in terms of cost-effectiveness, and they offer opportunities to reach out on a broad scale to problem drinkers. Its renal toxicity is lower that that of Asarum heterotropoides. The aim of this study was to explore factors affecting efficacy of treatment of common cold symptoms with an over-the-counter ibuprofen/pseudoephedrine combination product.

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The presence of anti-CCP antibodies was determined using 3 synthetic citrullinated peptide variants and 2 commercial kits (Inova Diagnostics and Axis-Shield Diagnostics) optimized for detecting JIA-specific antibodies in serum by an ELISA based assay. calcar demonstrated the same labeling of the hyaline layer for three lectins: Con A, SBA, and WGA. Streptococcus faecalis S-48 produces a broad spectrum antibiotic, active against Gram-positive and Gram-negative bacteria. The HPrH15A and CcpAD297A mutations do not affect complex formation but abolish FBP and Glc-6-P stimulation. Improvement in the treatment of diabetic retinopathy requires a better understanding of the molecular mechanisms that cause neurovascular complications, particularly in type 2 diabetes.

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None of the patients had significant clinical sings of HBV activation. This delayed preconditioning was accompanied by enhanced expression of cardiac muscarinic M(3) receptor and abolished by M(3)-selective antagonist. Single dose pharmacokinetics of 5 formulations of lithium: a controlled comparison in healthy subjects. Although electrical stimulation of vagus nerve is used widely for treatment of epilepsy the electrophysiological properties of human vagus nerve are not well characterized. Perioperative data from the two groups were collected and retrospectively analyzed. Canine ventricular myocyte beta2-adrenoceptors are not functionally coupled to L-type calcium current. Therapeutic hypothermia is being clinically used to reduce neurologic deficits after cardiac arrest (CA). Assessment of the arteries in living kidney donors: correlation of magnetic resonance angiography with intraoperative findings.

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Interleukin-18 mRNA and intracellular protein levels are neither changed in human keratinocytes nor induced in human dermal microvascular endothelial cells, dermal fibroblasts, or melanocytes by exposure to pro-inflammatory stimuli. The measurements of known endocrine regulators of urea synthesis do not explain the phenomenon. Sound nutritional recommendations and regular physical activity are essential components of prevention and treatment plans. The dopamine agonist bromocriptine (2.5 mg twice daily) failed to suppress serum TSH either acutely or over 6 weeks. We conclude that particulate matter air pollution induces the generation of ROS primarily from site III of the mitochondrial electron transport chain and that these ROS activate the intrinsic apoptotic pathway through ASK1, JNK, and p53. Thus, the carbohydrate at Asn(2181) impaired the interaction between FVa and the phospholipid membrane, an interpretation consistent with a structural analysis of a three-dimensional model of the C2 domain and the position of a proposed phospholipid-binding site. Overexpression of CD11b on eosinophils in atopic dermatitis: downregulation by cyclosporin A and upregulation by interleukin 5. trifolius, commonly known as the dwarf ginseng, has a distinctive pollen morphology and exine structure, supporting the hypothesis of its phylogenetically isolated position.

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However, very little is known concerning the acylation/deacylation cycle of the proteins in relation to their activity status. Under these conditions the response to lethal concentrations of E. In the present study, morphological changes of the exocrine pancreas in rats after pancreatic duct ligation were examined with light microscopy (hematoxylin-eosin, TUNEL, and PCNA staining) and scanning electron microscopy in order to elucidate the effects of increased pancreatic duct pressure. Caffeic acid phenethyl ester prevents intestinal reperfusion injury in rats. To our knowledge, 17-allylamino,17-demethoxygeldanamycin (17AAG) is the first inhibitor of heat shock protein 90 (Hsp90) to enter a phase I clinical trial in cancer. The findings related to cancers of the uterus and colorectum as well as the weak association of BMD with breast cancer strengthen the use of BMD as a marker of estrogen exposure and cancer risk. It was found that the goshawk is the host of one of the sarcosporidians inducing muscle sarcocystosis in mice. Quantitative determination of 5-hydroxy-N-methylpyrrolidone in urine for biological monitoring of N-methylpyrrolidone exposure.

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Rank distributions in community ecology from the statistical viewpoint. During the operation, the stimulation was lasted for 30 moduretic tablets weight loss min and ceased for 30 min until the end of operation. Clinical and laboratory data, and complications of the disease and of therapy were ascertained by a chart review. Therefore, before planning any human exploratory mission, the critical issues concerning human health and wellbeing as well as protection of Mars in its pristine condition need to be investigated. Previously, these rare tumors invariably have been fatal and resistant to multimodal therapy.

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The interval between the administration of saline and local anesthetic alters the anesthetic level and quality of epidural analgesia. Comparison of anticancer effects of these compounds with a standard chemotherapeutic agent 5-fluorouracil shows that they are very effective in killing prostate cancer cells with low micromolar cytotoxicity and provide us a new lead for the development of drugs for prostate cancer. burgdorferi sensu stricto were compared with three European isolates, two of species B. The importance of appliance selection is reinforced: dual max dose of ativan iv arch fixed appliances are generally more consistent. Use of a body proportionality index for growth assessment of preterm infants. Building and sustaining community-institutional partnerships for prevention research: findings from a national collaborative. In this paper, a successive parameter estimation algorithm based on the chirplet transform is presented. Reduced DAT- and DBH-immunostaining in the limbic system of Sardinian alcohol-preferring rats. This study documents in vivo the occurrence of wasting of the left ventricle in patients with CHF who demonstrate general body wasting. The efficiency of DNA fixation to the filter, the effect of EDTA and of ultrasonic treatment of the sample were also investigated.

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We investigated the performance of monochromatic computed tomography for the quantification of contrast agent concentrations. Surprisingly, in vitro, Ad-IFNalpha also caused caspase-dependent death of bladder cancer cell lines that were resistant to high concentrations of IFN-alpha protein, including the cell line used in vivo. To determine the expression patterns for these two peroxidases in developing seeds, the abundance and localization of the Ep and Prx2 transcripts were compared by in situ hybridization. Studies of casanova mutants do not support an important role for the forerunner cells in either dorsal axis or tail development, as has been previously proposed. The purpose of this study was to investigate the neural correlates of the neonatal stress axis in response to a stimulus that activates the pituitary-adrenal hormones. We report bacterial ThyX sequences having distinctive ThyX motifs, suggesting a more general ThyX motif, R/THRX7-8S. These results confirm the important role played by LPS in adherence of A.

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Within the promoter region, two betaFTZ-F1 binding sites are present and disruption of these sites reduced the expression level of the reporter gene. Both HCPs and SAs prioritized increased research or public awareness on mental health illness, blood and organ donation, obesity and diet. The need for nutritional support after elective abdominal procedures in 464 patients was analyzed and compared with the experience with needle catheter jejunostomy in 42 patients. Resolution of spinal epidural haematoma without surgery in a haemophilic infant. Our study reveals a crucial condition to induce the desired heterogeneous nucleation process in which the nucleated domain grains grow and merge into a defect-free pattern. To inhibit effector cell functions in a chronic model of experimental asthma by coaggregation of CD300a with CC chemokine receptor 3 (CCR3) using a bispecific antibody fragment (LC1). The last 15 years have seen the development of a large database of mechanistic data implicating both these conditions in the progression of cardiac dysfunction in patients with heart failure. In addition, the activity of this minimal chimera in supporting megakaryocyte development was tested and, remarkably, was observed to approximate that of the endogenous receptor for thrombopoietin.

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On evaluation, a papillary pedunculated tumor was detected in the left wall of the urinary bladder. The role of alpha1- and beta-adrenoceptors in initiation and development of thermoregulatory reactions during fast and slow cooling. Effects of 4-methylcatechol (4MC), a known potent stimulator of nerve growth factor (NGF) synthesis, on expression of brain-derived neurotrophic factor (BDNF) mRNA and BDNF-like immunoreactivity (BDNF-LI) was investigated in infant rat brains. In many cases, the diagnosis of different hepatic affections can be established or confirmed through the usage of some approaches to the hepatic circulation, approaches that can point out the intrahepatic morphopathological processes that in fact explain the functional state as well. This technique does not assign individual scores to raters, but computes a single agreement score from the concordance of their check mark configurations. During this period several parameters of child health have been monitored, such as mortality rates, nutritional status and immunization status.

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Contrary to the common misperception that BMD measurement and interpretation is a simple procedure requiring no special expertise, densitometer maintenance/operation, data acquisition, and interpretation/reporting of the results are skills that must be acquired and maintained. The head shake reflex is a rapid rhythmic shaking of the head in a radial motion and is a prominent part of the behavior of most mammalian species. Human umbilical vein endothelial cells (HUVECs) were stimulated with proinflammatory cytokines and lipopolysaccharide extracted from Porphyromonas gingivalis and it induced iNOS expression, whereas it reduced VE-cadherin expression, compared with negative controls. These include activation of the Jak-STAT (signal transducers and activators of transcription) pathway, mitogen-activated protein kinase (MAPK), Tec, and phospatidylinositol (PI) 3-kinase and phosphorylation of Shc and Vav. Aortic valve stenosis (AVS) usually results from three distinct processes (degenerative-calcific, rheumatic, and congenital), with a final common pathway of significant aortic outflow tract obstruction. The disease severity was assessed in all patients using POSSUM score. Growth-factor-like activities were found in less-hydrolyzed fractions. Primary, press fit, hemispherical metal-on-polyethylene THA performed between 2003 and 2011 were analyzed. High-resolution computed tomographic angiography/computed tomographic cholangiography image fusion of the hepatobiliary system.

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Although the most apparent clinical finding in aniridia is the absence of iris tissue, additional ocular structures are often affected. Presenilin-1 (PS-1) is the most causative Alzheimer gene product, and its function is not well understood. Body temperatures of white-footed mice (Peromyscus sp.) furing daily torpor. Each sub group reported back and presented evidence to the main working party. Intraocular glucophage metformin hcl 500 mg pressure variations after diode laser photocoagulation for threshold retinopathy of prematurity. To determine whether nitric oxide (NO) might modulate ventilator-induced lung injury. In a 16-week, double-blind, placebo-controlled study 211 patients using insulin glargine with or without oral antidiabetes agents were randomized to addition of pramlintide or placebo. We then discuss some recent advances in predicting hot spots and communication pathway analysis in terms of amino acid networks. The mature soluble form of GPV was produced by an enzymatic cleavage which was not affected by inhibitors of proteasome, calpain or metalloproteinases.

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Chlorinated tap water filtrate (0.2 and 0.1 microm) still harbours opportunistic micro-organisms that can pose some health threat. In this paper we review alternative non pharmacological treatments for patients with epilepsy, both focal and generalized, which are resistant ticlid medication administration to the pharmacological treatment normally used. Until few years ago benzodiazepines were the only drugs effective in the treatment of insomnia. The answer to this question is found in his political usefulness. When faced with competing gradients of end target and intermediary chemoattractants, Akt activation was significantly reduced within neutrophils, and the cells migrated preferentially toward end target chemoattractants even at 1/1,000th that of intermediary chemoattractants. There are conflicting reports concerning a diurnal variation in serum DHEAS. These observations support the notion that by removing aldehydic products of lipid peroxidation, AR decreases ischemia-reperfusion injury by diminishing ER stress. Among other types of mutualistic interactions, the formation of ectomycorrhizas, a symbiosis between tree roots and certain soil fungi, is a way to overcome nutrient and carbohydrate limitations typical for many forest ecosystems. Survival benefit in patients after palliative resection vs non-resection colon cancer surgery. By determining the sedimentation coefficient, we have calculated the partial specific volume, diffusion coefficient and frictional coefficient of the protein.

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