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Cardoplus (Losartan)
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Cardoplus

Cardoplus is a hypertension treatment. Research suggests that the medication is safe and effective for most people. People may experience mild side effects, such as dizziness, in the early stages of treatment. People who experience severe or persistent side effects should contact their doctor right away.

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Also known as: Losartan

Description

Cardoplus (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Cardoplus is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Cardoplus is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Cardoplus 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Cardoplus 25 mg, Cardoplus 50 mg, and Cardoplus 100 mg may also contain carnauba wax.

Dosage

Take Cardoplus tablets orally with or without food. Do not crush or chew it. Take Cardoplus once or twice a day at the same time. If you want to achieve most effective results do not stop taking Cardoplus suddenly.

Overdose

If you overdose Cardoplus and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Cardoplus overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Cardoplus are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Cardoplus as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Cardoplus. Correct volume or salt depletion prior to administration of Cardoplus.

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Improving cancer surgery in Ontario: recommendations from a strategic planning retreat. The patient was placed on a beanbag in a right lateral decubitus position. Long-term follow-up studies on the modes of surgical treatment of congenital cataract. Preoperative complaints included metatarsophalangeal pain and especially transfer metatarsalgia. This study estimated the prevalence of problems in current wearers of soft contact lenses and tested the effect of refitting patients with senofilcon A silicone hydrogel lenses (ACUVUE Oasys).

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Molecular mechanism(s) involved in differential expression of vitamin C transporters along the intestinal tract. Physiopathology and evaluation of urinary incontinence in non-institutionalized aged patients. Thirty-eight participants (18 females and 20 males) between 19 and 32 years of age participated in the study. Pathology slide review in gynecologic oncology: routine or selective?. To explore the effects of transforming growth factor beta1 (TGF-beta1) on dendritic cells (DC). We have proposed that MSL recognition of specific entry sites on the X is followed by local targeting of active genes marked by histone H3 trimethylation (H3K36me3). Delta(5)-3-Ketosteroid isomerase from Pseudomonas testosteroni has been intensively studied as a prototype to understand an enzyme-catalyzed allylic isomerization. Decision-makers in other organizations can draw lessons from these findings to enhance the fairness of their priority setting decision-making. Although pulmonary artery pressures and NO were similar in all patients at entry to the study, NO increased in the 12 individuals who survived to complete the study, and correlated with change in pulmonary artery pressures.

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Immunohistochemical detection of p53 phosphorylated at Serine392, p53, CD117, and CD44 suggest targets for design of therapeutic strategies. At 3 and 6 weeks, new bone formation was evaluated by macroscopy, radiography, dual-energy X-ray absorptiometry (DEXA), and quantitative computerized tomography (QCT). A serum-free Vero cell microcarrier culture was also established in the bioreactor, yielding a high-titer of 5.8 x 10(7) TCID50/mL for EV71 production. Recent studies provide evidence that a deficiency in prostaglandins adversely affects membranogenesis and membrane function. One approach to this question has been through the targeted disruption of STAT genes in transgenic mice. Two of them have a quadrupolar order, while the other states show in addition weak orbital magnetism.

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