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Cytoxan (Cyclophosphamide)
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Cytoxan

Cytoxan is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer. Cytoxan therapy is associated with minor transient serum enzyme elevations and has been linked to rare cases of acute liver injury.

Other names for this medication:
Cyclomet, Cyclophosphamide, Cycloxan, Cycram, Cycrame, Cydoxan, Cyphos, Eldamide, Endoxan, Ledoxan, Neophos, Neosar, Oncomide, Oncophos, Oncoxan

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Differin, Aldactone, Coumadin, Xeloda, Mobic, Artane

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Also known as: Cyclophosphamide

Description

Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Cyclophosphamide is also used for some kinds of kidney disease.

Cyclophosphamide interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by cyclophosphamide, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with cyclophosphamide, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain cyclophosphamide. It may not be specific to Cytoxan. Please read with care.

Take this medicine only as directed by your doctor. Do not take more or less of it, and do not take it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition.

Cyclophosphamide is sometimes given together with certain other medicines. If you are using a combination of medicines, make sure that you take each one at the proper time and do not mix them. Ask your doctor to help you plan a way to remember to take your medicines at the right times.

While you are using cyclophosphamide, it is important that you drink extra fluids so that you will pass more urine. Also, empty your bladder frequently, including at least once during the night. This will help prevent kidney and bladder problems and keep your kidneys working well. Cyclophosphamide passes from the body in the urine. If too much of it appears in the urine or if the urine stays in the bladder too long, it can cause dangerous irritation. Follow your doctor's instructions carefully about how much fluid to drink every day. Some patients may have to drink up to 7 to 12 cups (3 quarts) of fluid a day.

Usually it is best to take cyclophosphamide first thing in the morning, to reduce the risk of bladder problems. However, your doctor may want you to take it with food in smaller doses over the day, to lessen stomach upset or help the medicine work better. Follow your doctor's instructions carefully about when to take cyclophosphamide.

Cyclophosphamide often causes nausea, vomiting, and loss of appetite. However, it is very important that you continue to use the medicine even if you begin to feel ill. Do not stop taking this medicine without first checking with your doctor. Ask your doctor for ways to lessen these effects.

If you vomit shortly after taking a dose of cyclophosphamide, check with your doctor. You will be told whether to take the dose again or to wait until the next scheduled dose.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For the treatment of cancer: Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 milligrams (mg) per kilogram (kg) of body weight per day. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 mg per kg of body weight per day.

Overdose

If you overdose Cytoxan and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Cytoxan Lyophilized dosage information

Side effects

The most common side effects associated with Cytoxan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of cyclophosphamide in the elderly with use in other age groups, it is not expected to cause different side effects or problems in older people than it does in younger adults.

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Considering this form of intrapopulation heterogeneity may improve our understanding of density dependence and population dynamics in general. Activation of transcription can occur by the facilitated recruitment of TFIID to promoters by gene-specific activators. The uptake of iron by mammalian cells is post-transcriptionally regulated by the interaction of iron-response proteins (IRP1 and IRP2) with iron-response elements (IREs) found in the mRNAs of genes of iron metabolism, such as ferritin, the transferrin receptor, erythroid aminolevulinic acid synthase, and mitochondrial aconitase. The etiology of these tumors is uncertain, but resection appears to be curative. The abbreviated injury scale (AIS) is the only dictionary specifically designed as a system to define the severity of injuries throughout the body. The results of testing this new method on multi-class tumor classification problems suggests that the SED-based, normalization-free method of microarray data analysis is feasible and promising.

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Modulation of meiotic homologous recombination by DNA helicases. The heterogeneity of cancer cannot always be recognized by tumor morphology, but may be reflected by the underlying genetic aberrations. Thus we have evaluated the safety and immunogenicity of a 9-valent PnCV (Wyeth Lederle Pediatrics and Vaccines) mixed with diphtheria, tetanus toxoid, cell pertussis and type b (TETRAMUNE). The dietary intake of certain fatty acids might contribute to the development of atopic diseases like allergic rhinitis and asthma. Raf kinase inhibition blocked both VEGF- and EGF-stimulated accumulation of phospho-ERK1/2. Rectal administration of antibiotics in therapy of oral infections.

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All children received 4 g/kg/day of protein and 150 kcal/kg/day of energy from a milk-based recovery formula, providing 130-140 mg/kg/day of calcium (Ca). The island factor in the cities of Las Palmas de Gran Canaria and Santa Cruz de Tenerife, their meteorology and the proximity to the African Continent that originates the natural particulate matter transport over the islands, cause some specific features in their air quality. This new flap has been used successfully in seven cases for reconstructing composite defects of the nasal tip and ala. Controlled reproducible alignment of cone targets and mitigation of preplasma in high intensity laser interactions. To describe the level of experiential and educational preparation of emergency nurses responsible for pediatric triage decisions in pediatric and adult and pediatric population EDs. Forty-three clinical questions, for four categories-epidemiology and pathogenesis, diagnosis, treatments, and prognosis and complications-were selected, and a literature search was performed for the clinical questions with use of the MEDLINE, Cochrane, and Igaku Chuo Zasshi databases for the period between 1983 and June 2012. To investigate the correlation of perihematomal free radical level and neuronal apoptosis following the intracerebral hemorrhage (ICH). Incomplete seating of an acetabular metal wire retaining ring during total hip arthroplasty.

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Thus, the response of tumor cells to PGE2, rather than simply their production of PGE2, appears to be important in regulating tumor dissemination. Chiral separation of N-imidazole derivatives, aromatase inhibitors, by cyclodextrin-capillary zone electrophoresis. Optical difference spectroscopy was used to identify and quantify human adrenal microsomal and mitochondrial cytochrome P450 enzyme interactions with the histamine H(3) receptor antagonists thioperamide, clobenpropit and ciproxifan. Cryoinjury was applied over an experimental model of local, controlled freezing of different intensity for certain experimental groups. Homologous facial representations reside in the human brain based on observations following cortical stimulation, functional neuroimaging, and localized surgical resection. Social capital, political trust and self-reported psychological health: a population-based study.

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Phylogenetic conservation of disulfide-linked, dimeric acetylcholine receptor pentamers in southern ocean electric rays. Whether the red wine polyphenols quercetin and resveratrol affect thrombin-dependent adenosine nucleotide, metabolism and thrombin-induced signaling is unknown. Subunit ESSS has a cleaved mitochondrial import sequence and one potential transmembrane helix. The authors report a new murine model for myotonia congenita designated as B6MT. Mitochondrial gene rearrangements and partial genome duplications detected by multigene asymmetric compositional bias analysis. In humans, the interaction between animal and bacterial cells is especially important in the gastrointestinal tract. The ovariectomized (OVX) monkey is an accepted model of human postmenopausal bone loss and was used to study the effects of PTH treatment at clinically relevant skeletal sites. Follicular fluid LDH level has shown association with patient age and the follicle size, however, no significant association was found with other parameters studied.

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The morphologic features of bone bark, a structure surrounding the distal and proximal ends of long bones, were studied in the distal femur, proximal tibia, and proximal fibula of 77 spontaneously aborted human fetuses varying in gestational age from 10 to 20 weeks. To assess safety and effectiveness of excision of small renal cancer. The depolarization due to 50-100 micro m lamotrigine reduces additionally the critical frequency of back-propagating spikes necessary to elicit a dendritic calcium action potential. A sterile polyethylene device was introduced in the milk cistern of two mammary quarters of forty dairy cows. Using auditory evoked potentials to obtain pure-tone thresholds and cochleograms to quantify sensory cell losses, the issue of priming-induced protective effects was examined in the chinchilla. Detection and management of alcohol misuse by general practitioners. The blood pressure-lowering dose-response relationship for angiotensin converting enzyme (ACE) inhibitors is assumed to flatten at doses higher than those conventionally used in clinical practice.

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The model provides data on lumbar segmental and intersegmental motion patterns that are otherwise difficult to obtain experimentally. AP-1 and CyclinD1 activation were analyzed by promoter luciferase reporter system. We built a laboratory protocol measuring the effects of population density and feeding patterns on the growth of R. On the basis of phylogenetic and phenotypic evidence, it is proposed that the unknown bacterium be classified as Gemella palaticanis sp. Model building by comparison at CASP3: using expert knowledge and computer automation. We reported a case of an 86-year old woman with pure agraphia due to the left parietal lobe infarction. Can mastication in children with cerebral palsy be analyzed by clinical observation, dynamic ultrasound and 3D kinematics?.

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But, more recently, excitement is growing around an emerging alternative to the cell-based approach - here nanotechnology for targeted delivery of growth factor aims to support and expand resident central nervous system (CNS) stem cells for endogenous repair. A positive effect on tumor control and survival is achieved with preoperative irradiation with the doses used in this study, with moderate side effects. This modeling framework could be a first step toward more sophisticated cough models as well as in developing ideas for new bench-top experiments. The characteristics of this sequence suggest a functional role involving the specific organization of large regions of chromosomes. In this work, we present a facile strategy for the formation of glycopolymer tethered on polypropylene microporous membrane surface. Recurrent syncope represents a debilitating disorder and quality of life deteriorates as a function of recurrence of symptoms. In order to identify research priorities in oncology care in Switzerland, a systematic review of literature was conducted.

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Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) have emerged as major infection control problems worldwide. In addition, the function and the underlining mechanism of glucose transporters, phosphate transporters and water channels in PKD is 80 mg of lipitor a high dose are also discussed. CVID is a combination of humoral and cell-mediated deficiency, which explains not only why so many systems are affected but also why standard therapy in the form of intravenous immunoglobulin is not always effective. Simple detection of small amounts of Pseudomonas cells in milk by using a microfluidic device. It contains many different epithelial cell types arranged in precise patterns along the proximodistal axis. Re: Enigmatic morphological traits in human teeth from early bronze age. A novel compound heterozygous mutation in the steroidogenic acute regulatory protein gene in a patient with congenital lipoid adrenal hyperplasia.

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WHO or RECIST criteria did not provide a reliable evaluation of disease evolution or recurrence. A population-based transverse study was carried out on the Island of La Palma (population: 81,507), from 1995 to 1998. Using C-PCR, infectious enterovirus presence was confirmed in 3 d and adenovirus presence in 5 d, compared with up to 10 d required by conventional cell culture methods. Tetrasulfonated aluminum phthalocyanine (AlPcS4) was covalently coupled diovan dosage size to the various capsid proteins via one or two caproic acid spacer chains (A1 or A2) in 7:1 up to 66:1 molar ratios. The Nature of the Structural Changes in Nerve Endings in Starvation and in Beri-beri. Twenty-three formalin-fixed paraffin-embedded lymph nodes from 16 patients and two skin biopsies from two patients suspected of having CSD were included in this study.

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Interrelationship of acute alkalosis and potassium metabolism: a clinical study. To study the association between birth weight and blood pressure in children from multiple pregnancies (multiplets), mostly twins, to determine whether floxin otic drops dosing maternal or genetic factors are responsible for the association. In this study, we demonstrated the difference between activations detected from low-resolution EPI data, which were covering whole brain, and high-resolution segmented EPI data covering partial brain by volume- and surface-based analysis methods. Since their preparation by direct N-acylation of expensive, enantiopure, alpha-aminophosphonic acids proceeds in low yields, we devised and evaluated a stereoselective and straightforward method of synthesis that avoids the unfavourable step of N-acylation. Recent evidence demonstrates that they can disrupt quorum sensing, a cell-to-cell signaling process linked to the formation of biofilms. In the first experiment, five pigeons were trained to discriminate among 3.2 mg/kg morphine, 5.6 mg/kg nalbuphine, and saline. Type II cell phenotype was best maintained over eight days when densely packed cells were plated out on a commercially available extracellular matrix.

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Moreover, the status of macrophage activation was compared in these animals by analyzing the inducible nitric oxide synthase-arginase balance, tumor necrosis factor secretion, and expression of the FIZZ1 and YM genes. We demonstrate that the selective caspase-8 inhibitor IETD-fmk blocks neuronal death induced by beta-amyloid. Smoking status was recorded yearly, including dates of quitting and restarting. Periodic schizophrenias as based on the psychiatric school of the USSR Academy of Sciences in comparison with cycloid psychoses. The occurrence of bundles of cytoplasmic microfilaments, not observed before treatment and the reduced number of D cells may also be signs of inactivity. The levels of sFas and sFasL were normalized 6 months after successful treatment. We review the presentation and treatment of a patient with an unusual appearing postauricular sebaceous nevus that was raised in a cerebriform appearing fashion, and discuss the related literature. A prospective, uncontrolled, consecutive case series of patients with symptomatic CCH that were treated using the standard PDT protocol was evaluated periodically with ophthalmic exams and echography.

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The paper reviews operating tables made in foreign countries, some joint ventures and enterprises of CIS countries. The differential regulation of mPer1 and mPer2 by light in Cry double mutants reveals a surprising complexity in the role of cryptochromes in mammals. Effects of smoking on the pharmacokinetics and pharmacodynamics of a nicotine patch. All the strains produced clinical disease with typical symptoms and lesions of acute theileriosis. The k2 and t1/2 values were of comparable magnitude for each organisms, but k1 values, calculated for polychaetes on the basis of PCB concentrations in whole sediment, were considerably lower, as were the KB values similarly determined. Immunohistochemistry with antibodies against the mismatch repair genes MLH1, MSH2, MSH6, and PMS2 were used to stain the tissue microarray. These data indicate that RARgamma, but not RXR, plays an important role in the improvement of the signs of photoaging, and so a specific RARgamma agonist might be superior to an RAR pan-agonist for clinical treatment. Our aim was to reassess kidney graft biopsies and study the impact of histopathologic lesions, both those graded in the Banff classification and those related to inflammation, on the graft function and evolution. The surgical resection and overall survival rates of these patients were better than the published retin results. In Group D, changes in structural chromosomal aberrations after Hp eradication as compared to the pre-eradication structures were also analyzed.

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