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Daple (Adapalene)

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Daple is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Daple belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.

Other names for this medication:
Aclene, Acneril, Acniriv, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Rozac, Zolvee

Similar Products:
Tricor, Lioresal, Omnicef, Cozaar, Zovirax, Celebrex, Actos, Prilosec, Antivert, Bactrim

Also known as: Adapalene


{name} (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

{name} is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


Usual Adult Dose for Acne:

Daple 0.1% cream, 0.1% gel, 0.3% gel: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Lotion: Apply a thin film of lotion to the entire face and other affected areas of the skin once daily, after washing gently with a mild soapless cleanser. Dispense a nickel size amount of lotion (3 to 4 actuations of the pump) to cover the entire face. Avoid application to the areas of skin around eyes, lips and mucous membranes.

Usual Pediatric Dose for Acne:

Daple 0.1% cream, 0.1% gel, 0.3% gel: 11 years or less: Safety and efficacy have not been established. 12 to 18 years: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Safety and effectiveness of the lotion formulation in pediatric patients under the age of 12 have not been established.

Detailed Daple dosage information


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Daple are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Studies of this medicine have been done only in adult patients, and there is no specific information comparing use of adapalene in children up to 12 years of age with use in other age groups. In teenagers, adapalene is not expected to cause different side effects or problems than it does in adults.

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Capillary electrophoretic determination of cathepsin D activity using Oregon Green-labeled hemoglobin. This study shows a good adhesion of screening procedures for GP and patients, shows that screening is improved by general screening policy in colorectal cancer, but that prostate cancer screening practices exceed what is recommended according to evidence based medicine. Calculations showed that oxalate is 23 times more potent than calcium in its effect on the supersaturation of calcium oxalate. Synthesis of ribooligonucleotides using aromatic phosphoramidates as a protecting group. Presenting symptoms of the neonate were fully improved with balloon dilation. Our preliminary experience suggests that the most frequent gastrointestinal complaints can be prevented with ramosetron. Gastric cancer cells (AGS) were incubated with two highly specific PKC inhibitors (RO-31-8220 and chelerythrine).

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Treatment with Li2CO3 caused a significant change of some haematological parameters including red blood cells (RBC), white blood cells (WBC), haemoglobin content (Hb), haematocrit (Ht) and mean corpuscular volume (VCM) compared to the control group. Difluoromethylornithine treatment was associated with clearing of parasites from blood within one to four days, a trend towards normalization of all altered biologic values associated with the disease, and marked amelioration of clinical symptoms. Protective effect of sodium-2-mercaptoethanesulfonate on the gastrointestinal toxicity and lethality of cis-diamminedichloroplatinum. Assessment of sexual dysfunction in male patients with Ankylosing Spondylitis. We describe a six-compartment kinetic and dynamic physiological model of induction of anaesthesia with thiopental.

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To evaluate the effectiveness and safety of nucleoside antiviral drugs for the treatment of recurrent herpes labialis. The induction of the immediate-early-genes Egr-1, PAI-1 and PRL-1 during liver regeneration in surgical models is related to increased portal flow. Pathogenesis appears to be related to either recipient seeding in one elderly immunocompromised patient or a previously contaminated donor valve implanted in an otherwise healthy recipient. These subjects rated the match between stimulus pairs as more sound than did control subjects. Effective doses of both compounds caused hypercalcemia and a significant increase in mortality. Procoagulant activity was detectable in cell supernatants, thus suggesting that the central portion present in the FVIII protein (domain B) is not required for FVIII function. Balanced complex chromosomal rearrangements (BCCR) with at least three chromosomes and three or more breakpoints: report of three new cases. In the present work, the effect of human recombinant HARP on the expression of the vascular endothelial growth factor (VEGF) receptors KDR, Flt-1 and neuropilin-1 was studied in cultured human umbilical vein endothelial cells (HUVEC).

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Empirical amide I vibrational frequency map: application to 2D-IR line shapes for isotope-edited membrane peptide bundles. Fermentations with a sudden temperature increase or lowered pH were carried out as well to try to avoid EPS degradation upon prolonged fermentation. The cellular response to magnetic fields is activated by unusually weak stimuli, and involves pathways only partially associated with heat shock stress. Compared with the healthy guinea pigs, the activity of nuclear transcription factor p65 in guinea pigs of chronic asthma is much higher than that of control groups. A diagnosis of sarcoidosis was made based on bilateral hilar lymphadenopathy, gallium uptake, elevated serum angiotensin-converting enzyme levels, as well as non-caseating granulomatous lymphadenitis in a prescalenic node. The effects of CO2 and fixed acid on the O2-Hb affinity of rabbit and cat blood. Such a list highlights the unavoidable necessity of developing valid assessment methods, the use of specific measurement tools and more rigorous guidelines in the treatment and rehabilitation.

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Develop and test a short-form comprehensive outcome measure for back pain. Long-term follow-up of children with neurogenic bladder and artificial urinary sphincter. Enhanced performance of blue polymer light-emitting diodes by a self-assembled thin interlayer. Our analysis reveals a highly dynamic process in which Ngn2 and the Isl1/Lhx3 pair initially engage distinct regulatory regions. In contrast, the Lv, which is directly related to the length of the sinusoids, and the Vv did not vary significantly in the same groups. The aim of this review is to describe recent observations regarding the immunologic pathogenesis of MS. This finding suggests that the technology should have an impact on disease treatment and in functional genomics where proteins of unknown function are predicted from genomic sequences. The primary outcome measure was the 6-month change in prostate tissue androgen levels (testosterone and dihydrotestosterone). However, no studies have explored the prevalence of dyspraxia in a large sample of individuals with and without ASC or associations between dyspraxia and autistic traits in these individuals.

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Is cisplatin still the best platinum compound in non-small-cell lung cancer?. However, grip strength measurement is not routinely used in clinical practice. The effects of spiders demonstrated in the field experiment support this result. Four patients with operated cleft palate with a speech prosthesis. A lack of innovative therapies and the appearance of drug-resistant pathogens are becoming increasingly serious problems. A comparison between a rebeccamycin derivative and camptothecin. We tested the diagnostic value of cTnT for left ventricular hypertrophy (LVH) and LV systolic dysfunction in a large group of clinically stable hemodialysis patients without heart failure.

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Prevalence and susceptibility testing of new species of pseudallescheria and scedosporium in a collection of clinical mold isolates. Extracted human molars were cut into enamel and dentin with both systems. The reaction proceeded with the disappearance of NADPH in the presence of the nucleotides, GTP and ATP, in a Tris-HCl buffer (pH 7.5) at 37 degrees C. These data favour a new scheme of gastric secretion regulation where gastrin would be the last step for stimulating parietal and chief cells. In a randomized study of envelope and ink color, colored ink was found to increase the response rate to a postal questionnaire. To investigate the possible influence of the impairment of lymph fluid on the metabolism of hyaluronic acid (HA) in the lymphedematous skin tissue. To maintain the quality of care and to comply with legal requirements related to dental patients with LEP, additional funding sources might be required to recruit multilingual staff, support language services in dental clinics, and provide language skills training for practicing dentists. OIE philosophy, policy and procedures for the development of food safety standards. Considerably less is known about the persistence and repair of DNA adducts in mouse liver.

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This report briefly discusses a successful lung transplantation case for severe lung GVHD after allograft for acute lymphoblastic leukemia. Osteonectin has been suggested to be important in the progression of pancreatic cancer but has not been correlated with survival. The kinetic equations are solved by incorporating memory effects to account for anomalous diffusion and, consequently, non-Debye relaxations. In this article, a semi-analytical method that is based on weighted mean-value theorem for obtaining solutions for a wide class of Fredholm integral equations of the second kind is introduced. It is also to provide a method capable of suggesting cross-disciplinary connections via the pairs derived from all of MEDLINE. Based on this review, we conclude that though there is literature contributing to the knowledge of the pathology and pathogenesis of tissue burn, there is scant quantitative information regarding changes in tissue properties including mechanical, thermal, electrical and optical properties as a result of burns that are linked to altered tissue morphology. In addition, our findings indicate that endogenous production of MuIFN-gamma in vivo plays a role in development of the full antibody response to SRBC surface antigens. Enantioseparation of benzoxazolinone aminoalcohols and their aminoketone precursors, potential adrenergic ligands, by analytical and preparative liquid chromatography on amylose chiral stationary phases and characterization of the enantiomers.

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Pesticide pollution in water systems in a small rural community in Southeast Brazil. We develop a multicolor fluorescent nanoprobe for assessing cellular migration and invasion by simultaneously imaging miRNA-221, PTEN mRNA and MMP-9 involved in the PI3K/AKT pathway which can regulate cellular mobility and invasiveness. There were no significant differences in mood, sleep interference, or activities of daily living, but a type II error cannot be excluded for these variables. Principles of physiotherapeutic management of shoulder impingement syndrome. A new and sensitive quantification method based on the derivatisation of protamine with ortho-phthaldialdehyde (OPA) in the presents of 2-mercaptoethanol (ME) or N-acetyl-L-cysteine (NAC) in basic aqueous solution using 96-well microtiter plates are introduced in this report. argued that rational self-interest varies across individuals and negatively relates to other orientation (OO). The authors describe a case of a cutaneous sinus at the umbilical port site following spillage of gallstones during laparoscopic cholecystectomy. A retrospective single-center chart review of all patients in whom nontraumatic primary convexity SAH was diagnosed between 2002 and 2007 was performed. Women with chronic pelvic pain thought to be due to endometriosis. Activation of defence reactions in Solanaceae: where is the specificity?.

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Male rats subjected to trauma (laparotomy) plus hemorrhagic shock (mean arterial pressure, 30 mm Hgx90 min) (T/HS) or trauma plus sham shock (T/SS) and treated with amiloride or its vehicle had their mesenteric lymph duct catheterized. The present study was undertaken to develop binding assays suitable for measuring the rat ICAM-1/LFA-1 interaction in vitro. Intrinsic characteristics of the prefabs (being constructed with synthetic materials, combustion sources, poor ventilation and insulation) and psychosocial factors e. Control group rats were received an equivalent volume of saline. Samples were collected every hour, and the reaction was monitored by measuring the pH, the optical density at 420 nm, and the relative antioxidative efficiency (RAE).

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Assessing satisfaction with pain medication in primary care patients: development and psychometric validation of a new measure. Moreover, inhibition of ERS activation blocked TTF1-NP-induced apoptosis in HepG2 cells. The ventral tegmental area (VTA) is the presumed source of dopamine in the dorsal hippocampus. Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury. More recently, advances have been made in gynecological applications, with promise demonstrated in pelvic floor and lower urinary tract imaging. We present an 18-month-old female with thoracic spinal intramedullary ependymal cyst that was diagnosed pathologically. vasotec 20 mg tablet

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