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Differin (Adapalene)

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Differin is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Differin belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Cozaar, Addyi, Skelaxin, Plaquenil, Aygestin

Also known as: Adapalene


Adapalene is used to treat acne. It works partly by keeping skin pores clear.

Adapalene is available only with your doctor's prescription.


Follow the directions for using this medicine provided by your doctor. Use Differin exactly as directed. Differin is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Differin. Differin should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Differin. Continue using Differin until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Differin promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


If you overdose Differin and you don't feel good you should visit your doctor or health care provider immediately.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Differin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Differin if you are allergic to Differin components. It is not known whether Differin will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. Do not get Differin in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time. Do not use other medicines on your skin without first discussing it with your doctor. While you are using Differin, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Differin. Use a sunscreen if you must be outside. Do not apply it to sunburned skin. Do not stop taking Differin suddenly.

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Efficacy and tolerance of tocainide during long-term treatment of malignant ventricular arrhythmias. Clinical experience with biliopancreatic bypass and gastrectomy or selective vagotomy for morbid obesity. A protocol for high throughput methods for the expression and purification of inner membrane proteins. Findings from this study reveal widespread nuclear contamination of gorilla HV1 GenBank databases and underline the importance of recognizing not only Numts but also PCR recombinant artifacts as potential sources of data contamination. Severe gout: Strategies and innovations for effective management. Evaluating geometric accuracy of multi-platform stereotactic neuroimaging in radiosurgery. This increase in survival, however, has been accompanied by the occurrence of metabolic and morphologic changes known collectively as HIV-associated lipodystrophy. However, clinical studies are required to provide evidence of its ability to reduce vascular events. Descriptive anatomic study of the fourth perforating artery of the femoral system. The discovery of 2-methylene-19-nor-1alpha,25-dihydroxyvitamin D3 (2MD) as a bone selective and bone anabolic form of vitamin D has stimulated an investigation of structure/function of bone selectivity.

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American Society of Animal Science 2004 sectional meeting abstracts. Outcome of patients with systemic lupus erythematosus in intensive care unit. Patients were 425 men with pathologically advanced prostate cancer who had undergone radical prostatectomy. There has been an increase in nonsurgical interventions for facial rejuvenation since 2001, which can be attributed to an increase in the use of injectable fillers, volumizers, and biostimulators for soft tissue augmentation. Comparison of Reversed, Nonreversed Translocated, and In Situ Vein Grafts in Arterial Revascularization: Techniques, Cumulative Patency, Versatility, and Durability. No mutations were found, making it unlikely that any of these genes represent a major cause of dystocia in man. The strengths and weaknesses of each treatment are reviewed, and a model for treatment selection is provided. Injection of colored silicone into the vascular tree can enhance the educational value of cadaveric head dissections. Although two-pulse echoes decay faster as optical density increases for a Bloch model, we find that systems with memory exhibit the opposite trend.

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