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Eldepryl (Selegiline)
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Eldepryl

Eldepryl works by increasing the amount of dopamine, a chemical messenger that is needed to control movement in the brain. Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.

Other names for this medication:
Elegelin, Emsam, Jumax, Jumex, Selegiline, Selerin, Selgin, Zelapar

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Also known as: Selegiline

Description

Selegiline is used in combination with levodopa or levodopa and carbidopa combination to treat Parkinson's disease (sometimes called "shaking palsy" or "paralysis agitans"). This medicine works to increase and extend the effects of levodopa, and may help to slow the progress of Parkinson's disease.

This medicine is available only with your doctor's prescription.

Dosage

Take Eldepryl orally. Take Eldepryl capsules twice a day, at breakfast and lunch. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Do not drink or eat anything for at least 5 minutes after takink Eldepryl. While using Eldepryl, you must not eat foods that are high in tyramine such as air dried meats, aged or fermented meats, sausage or salami (including cacciatore and mortadella), pickled herring, and any spoiled or improperly stored beef, poultry, fish, or liver; beer from a tap, beer that has not been pasteurized; aged cheeses, including blue, boursault, brick, brie, camembert, cheddar, emmenthaler, gruyere, parmesan, romano, roquefort, stilton, and swiss; sauerkraut, soy beans, soy sauce, tofu, miso soup, bean curd, fava beans; yeast extracts (such as Marmite). Preferable food during Eldepryl usage are fresh meat, poultry, or fish (including lunch meat, hot dogs, breakfast sausage, and cooked sliced ham); any vegetables except broad bean pods (fava beans); processed cheese, mozzarella, ricotta, cottage cheese; pizza made with cheeses low in tyramine; soy milk, yogurt. If you want to achieve most effective results do not stop taking Eldepryl suddenly.

Overdose

If you overdose Eldepryl and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Eldepryl overdosage: severe headache, hallucinations, vision problems, sweating, cool or clammy skin, fast or uneven heart rate, feeling light-headed, fainting, seizure.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Eldepryl are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Eldepryl if you are allergic to selegiline, or if you have taken fluoxetine (Prozac, Sarafem and others) within the past 5 weeks.

Some medicines can cause unwanted or dangerous effects when used with Eldepryl. Your doctor may need to change your treatment plan if you use any of the following drugs:

cough medicine that contains dextromethorphan; cyclobenzaprine (Flexeril); meperidine (Demerol) or other narcotic (opioid) pain medicine; methadone; St. John's wort; tramadol (Ultram, Ultracet); an antidepressant - citalopram, desvenlafaxine, duloxetine, escitalopram, fluvoxamine, levomilnacipran, milnacipran, mirtazapine, nefazodone, paroxetine, venlafaxine, vilazodone, vortioxetine, and others; or p>an MAO inhibitor - isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

After you stop taking Eldepryl, you must wait at least 14 days before taking any of the medications listed above.

To make sure Eldepryl is safe for you, tell your doctor if you have:

liver or kidney disease; high blood pressure; or

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for.

It is not known whether Eldepryl will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether selegiline passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

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alpha-DG was altered in all oral cancer samples and cell lines, despite the persistent presence of DG mRNA in cancer cells. Relationship of fibre number among muscles in the laboratory rat. The proposed method was successfully applied to the determination of superoxide dismutase (SOD) activity in human blood and mouse blood. On the other hand, the clone expressed the receptor only poorly, being stimulated with B cell APC. The early clinical results show encouraging survival rates in patients who do not have chronic systemic disease, especially in association with early stage disease. Six dogs underwent surgical plication of the left half of the aorta. It was demonstrated that during this course of change, ORP and ALK increased, while pH value and the proportion of acetic acid accounting for VFAs decreased significantly, and the type of climax community was changed from stable-type with high COD/SO4(2-) ratio to sub-stable-type with low COD/SO4(2-) ratio, but it was still belonged to typical acetic-acid type climax community. Forty-one military primary care physicians completed a 10-station OSCE. Clinical characteristics of alcoholism in alcohol-dependent subjects with and without a history of alcohol treatment. Next a review of existing data on effects of cytokines, immune regulation, and tumor cytotoxicity is detailed.

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The purpose of the present article is to review comfort studies on hearing protector devices. This was possible by first generating boranephosphoroamidate morpholino internucleotide linkages followed by oxidative substitution with four different amines: N,N-dimethylamine, N-methylamine, ammonia, and morpholine. UDP-glucose was found to be the most important sugar nucleotide isolated from both cambial and young xylem tissue. Neuroendocrine activation in heart failure is modified by endurance exercise training. Constituents of Musa x paradisiaca cultivar with the potential to induce the phase II enzyme, quinone reductase. This result is consistent with other SFE methods for determining pesticides from various environmental matrices. Understanding and quantifying the global dynamics and sinks of persistent organic pollutants (POPs) is important to assess their environmental impact and fate. The lipoxins were found to be a mixture of four lipoxin A isomers and two lipoxin B isomers.

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Subjective quality of life in schizophrenic patients living in the community. To evaluate discrepancies between flow cytometry (FCM) and image cytometry (ICM), ploidy incidence and relation between DNA ploidies and survival in distal bile duct carcinomas (DBDCs). Moreover, equine dominant follicular fluid was able to induce proteolysis of exogenous recombinant bovine (rb)IGFBP-2, this degradation being dose-dependently enhanced by IGFs. Reactivity of the nitrogen-centered tryptophanyl radical in the catalysis by the radical SAM enzyme NosL. Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes.

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Carers who are spouses have a better perception of QoL-p than do carers who are sons or daughters. The Rockall risk scoring system uses clinical criteria and endoscopy to identify patients at risk of adverse outcomes after acute upper gastrointestinal haemorrhage. One of the hallmarks of human immunodeficiency virus type I (HIV-1) infection is the rapid removal of the viral receptor CD4 from the cell surface. Immunohistochemistry showed that the sprouting of sympathetic nerves into DRG by neuropathic surgery was markedly inhibited by TFV. Transient focal ischemia affects the cAMP second messenger system and coupled dopamine D1 and 5-HT1A receptors in the living monkey brain: a positron emission tomography study using microdialysis. The output from the workshop was a set of recommendations which NIHR is now considering to shape future support. Systematic review and meta-analysis of corticosteroids for the resolution of malignant bowel obstruction in advanced gynaecological and gastrointestinal cancers. Clinical and experimental studies on sex hormones and tuberculosis.

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Additionally, we describe a genetic interaction between RPT4 and the naturally polymorphic gene SSD1, which in wild-type form modifies the rpt4-145 phenotype such that cells arrest in G2 of the first cycle with complete bipolar spindles. Data from the national and international literature were collected using the PubMed, Medline, Drugs and Pharmacology, ISI, and Cochrane databanks. Protein O-GlcNAcylation is proceeded by O-linked GlcNAc transferase (OGT) in nucleocytoplasm and is involved in many biological processes although its physiological role is not clearly defined. Microcalorimetric measurements on tissue cells attached to microcarriers in stirred suspension. Early death was defined as death on discharge from the acute hospital. Due to the presence of a potential transcription factor binding site in the 18mer element of the VNTR, the variation in the number of tandem repeats of the 18mer element might be causal for the variability in the transcription level of the DGAT1 gene. The objectives of the Edifice study were to analyze a large cohort of patients and doctors in order to further characterize these parameters. While standard HTML-based web pages offer significant advantage over paper compilations, employing emerging computer science tools offers even greater promise. The aim of this study was to identify the dysfunction of lncRNA in OSCC.

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Demographics, prodromal signs and symptoms, initial medical treatment and outcomes were assessed. Orientation Selectivity from Very Sparse LGN Inputs in a Comprehensive Model of Macaque V1 Cortex. Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique. Recreation of normal subtalar kinematics is an important goal in these patients as well, and may have long term implications. CII degradation is an early event following ACL injury and is unlikely to be a direct result of mechanical loading, since it was observed in cartilage obtained from a low-weight-bearing site. This has enabled SRS research to move from its original domain, of probing bulk media, to imaging biological tissues and single cells at the micro scale, and, ultimately, to characterizing samples with subdiffraction resolution at the nanoscale. To our knowledge, this is the first case of follicular dendritic cell sarcoma occurring in the dura mater of the spine. Fever can be defined as a specific model of body temperature control, modified by action of humoral substances released due to bacterial infection. Altered BChE activity was correlated with trauma severity, resulting in systemic inflammation.

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Fourteen proteins increased in biofilms, whereas three decreased. To determine the effect of Propionibacterium acidipropionici, alone or in combination with Lactobacillus plantarum, on the fermentation and aerobic stability of wheat, sorghum and maize silages. In this study, we identified a transmembrane form of HAI-1 integrated in the plasma membrane of cultured cells using a monoclonal antibody against HAI-1. the calcium chelating properties and physical obstacle of microtubules in the space between the sarcolemma and the SR. Preillumination with a higher light intensity resulted in a further shift of the fluence-rate response curve. Background and bleaching equivalence in steady-state adaptation of vertebrate rods. Imaging studies suggest that brain regions engaged by rewarding and punishing stimuli in lower mammals are also implicated in mood disorders.

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35 Labrador Retrievers with genetic epilepsy (20 male and 15 female), 94 non-Labrador Retrievers with idiopathic epilepsy (71 male and 23 female), and 20 control dogs (10 male and 10 female). Nevertheless, one in three biopsies done at our institution is excisional. Pancreatoduodenectomy (PD) may be followed by serious complications chiefly associated with exocrine pancreatic secretion. Autumn vegetation growth was mainly dependent on the vegetation growth in summer. Subsequently, vestibuloplasty was performed and implants were inserted. Psychotherapy with HIV-infected clients: factors influencing notification of third parties. In skeletal muscle, CLC-1 is associated with maintaining normal sarcolemmal excitability, and a number of myotonic mutants were reported to modify the channel gating of CLC-1.

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Sex-specific effects of altered competition on nestling growth and survival: an experimental manipulation of brood size and sex ratio. All femoral heads tested were 28 mm diameter and included: Biolox Forte alumina, CoCr, arc evaporative physical vapour deposition (AEPVD) chromium nitride (CrN) coated CoCr, plasma-assisted chemical vapour deposition (PACVD) amorphous diamond-like carbon (aDLC) coated CoCr, sputter CrN coated CoCr, reactive gas controlled arc (RGCA) AEPVD titanium nitride (TiN) coated CoCr, and Graphit-iC coated CoCr. This approach may help to evaluate the effects of treatment of human schistosomiasis where the detection of low egg counts is problematic. Polyferrocenylsilane microspheres: synthesis, mechanism of formation, size and charge tunability, electrostatic self-assembly, and pyrolysis to spherical magnetic ceramic particles. In summary, high glucose and insulin peaks upregulate GDF15 transcription and release. We have investigated the morphogenetic basis for formation of specific hypaxial muscles within the zebrafish embryo and larvae. By breaking the rotational symmetry of a WGM microcavity and introducing chaotic behaviors, we show that the ringing phenomenon in chaotic WGM microcavities extends over both the positive and the negative frequency detune, allowing the ringing phenomenon to interact with analytes over a much broader bandwidth with a reduced dead time. In one half of the jaw, between the exit of the nerve-vessel bundle and the midline, one type of implant was placed and in the remaining half the other type.

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This effect of knowledge on decisional conflict is indirect, however, through an association with greater perceived risk and lower decisional anxiety. This study was carried out to clarify the localization of bikunin, a Kunitz-type protease inhibitor, and relation between expression of individual bikunin protein and ovarian cancer progression. Skeletal resistance to PTH was initially recognized as a blunted calcaemic action of PTH, which has been considered another stimulus for PTH secretion. Furthermore, there is evidence for compositional related non-linearity in the dissolution of the glasses with time. Monoclonal antibodies (mAbs) were obtained from hybridoma clones established by cell fusion between mouse myeloma cells and spleen cells from a mouse immunized against an affinity-purified 40-kDa component of rat 125-kDa glycoprotein (GP125). Causes of the release of titanium in the group (1) include that in the groups (2) and (3). The neuronal labeling was high in the neocortex, striatum, hippocampus, brain stem nuclei, deep cerebellar nuclei, catecholaminergic neurons, and reticular nuclei, and particularly high in neurons of the mesencephalic trigeminal nucleus and medial habenular nucleus. There was no evidence of impaired concanavalin A-inducible T-suppressor cell activity.

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Tentative method for preparation of carbon monoxide standard mixtures. Clinical outreach to Rarotonga provided a broad case mix of patients and a change in student perceptions of preparedness to practice with children, which was positively affected by the total number of children managed and the number of children managed who were under 10 years of age. Here we show that Aire-regulated single positive thymocyte trafficking in neonatal period is critical for thymic egress. Quantitative image quality parameters, such as the signal-to-noise and contrast-to-noise ratios obtained using 1D, 2D, and 3D motion tracking algorithms, are compared to evaluate the performance with the 3D strain imaging system. Two schemes are proposed to design the new FOCI pulses with dramatically reduced peak RF power requirements. Alpha-interferons in the treatment of patients with chronic myeloid leukemia. Intramuscular rapacuronium in infants and children: dose-ranging and tracheal intubating conditions.

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Advances in the study on chemical constituents of Chrysanthemum morifolium Ramat. Monolithic polymer containing ZIF-8 coating was implemented as a microreactor catalyzing the Knoevenagel condensation reaction and also in extraction column format enabling the preconcentration of trace levels of toxic chlorophenols in environmental waters. An electrochemical study of the factors responsible for modulating the reduction potential of putidaredoxin. We also use the dual-binding assay as an internal control to identify substances which inhibit SH3 and SH2 binding via nonspecific mechanisms. These observations indicate that MP60 is expressed both in vitro and in vivo, but to a different degree in the different cell wall layers. A decision model was used to compare the costs and effects of two different treatment strategies. The estimation of the cutaneous blood flow with an optoelectric method. Characterization of detection efficiency as function of energy for soft x-ray detectors. Hemodynamic and electrophysiological study of the role of the anterior cingulate in target-related processing and selection for action.

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The present study also included the dicationic 5,10-diphenyl-15,20-di(1-methylpyridinium-4-yl)porphyrin (14b), which has previously shown promising results on a psoriasis-like in vivo model. Data were extracted from included articles using the standardized data extraction tool from JBI-QARI or JBI-MAStARI. Observations of GUV formation dynamics elucidate parametric effects of charge, ionic strength, pH, and osmolarity, demonstrating the versatility of this biomimetic platform. Recognition of the dermatologic manifestations associated how to use albendazole suspension with nutritional disorders is important for early diagnosis and management. Although that FHO does not seem to influence the adherence to dietary patterns, results of this study suggest that anthropometric, lifestyle and sociodemographic variables associated with dietary patterns differ according to FHO and gender. A case of deferred death from drowning of a man found dead in bed at home.

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PPI medication is effective in the treatment of laryngeal contact granuloma, even in the absence of identifiable symptoms of gastroesophageal reflux. Elucidation of polysaccharide origin in Ramalina peruviana symbiosis. All cases demonstrated common magnetic resonance imaging findings of a well-defined, heterogeneous mass, slightly or clearly hypo-intense to subcutaneous fat on T1-weighted spin-echo images, with prominent thin low signal bands throughout the tumour. Previous efforts have been largely focused on 5mC, providing invaluable insights into epigenetic regulation through DNA methylation. It appears that, for the visualizations selected for this study, the relative comparison between designs is generally consistent between display sizes. This release may account for the reported efficacy of amantadine hydrochloride in the treatment of human parkinsonism. Chondrocyte recovery in cryopreserved porcine articular cartilage after bone carrier alteration. Mitogen activated protein kinases are a family of kinases of different lineages that are thought to be important in tumor growth and metastasis. NP recording using a Holter system is an efficient and easy-to-use tool for screening for sleep-disordered breathing in routine cardiology practice. The simultaneous treatment with L-ascorbic acid or alpha-tocopherol appears to be beneficial for regulating glucose homeostasis in rats.

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The designs are meant to yield a physiological load sharing between the trabecular and the cortical bone in the proximal tibia, and to minimize anterior lift-off of the tibial base plate. Groups were cohort-matched based on age, paying particular attention to the number of catheter migrations. Summarizing magnetic resonance imaging and positron emission tomography findings on the effects of MBCT and the neurobiology of drug addiction, this article outlines directions for further research on potential benefits of MBCT for the recovering individual. We studied risk factors, vascular lesions, symptoms, signs, and outcomes in patients with bilateral ICVA disease among 430 patients can you drink alcohol with tamoxifen in the New England Medical Center Posterior Circulation Registry. Here, we show how information about the binding of proteins to conjugated gold nanospheres can be obtained using straightforward experimental techniques. Experiments were carried out to determine whether proinsulin is converted to intermediate forms or insulin as a requisite to its biological activity.

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The positive opinion about TPN is strongly supported by the experience in surgical patients with GI disorders. In liver transplantation, understanding the altered anatomical features unique to the reduced-size hepatic allografts commonly used in children is crucial in assessment of the post-surgical imaging findings. The choice of the lipids allowed us to make several direct comparisons concerning the effect of the nature of the lipid head group on the activity of the enzyme. CSD was induced by topical application of KCl and monitored using electrophysiological methods. Development of a simple multiplex polymerase chain reaction for the simultaneous detection of factor V Leiden and prothrombin 20210A mutations. Substitution of the highly conserved residue alphaLeu(64) seems to be most important for allowing access of the neurontin medication class inhibitor to the binding site.

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Public health advocates also need to be willing to take prompt action to defend these programmes and hold public officials who attack tobacco control programmes accountable for their actions. Although many instruments are sensitive to the amplitude and frequency (or wavelength) of these oscillations, they cannot access the light field itself. SH-SY5Y cells transfected with plasmid DNA containing the neuroglobin or cytoglobin sequence showed enhanced survival after exposure to 300 microM H(2)O(2) for 24h as compared to untransfected controls. We further assume that partial removal of the fibrotic ventricular wall may lead to a particularly inhomogeneous pattern of wall stress, giving rise to the potential of a paradoxical increase in wall stress and the creation of arrhythmogenic foci. hDelGEF2 is derived from the same DELGEF gene by alternative splicing. NAT at blood donation could reduce the HIV-1 window period to a minimal value of 8 days without pooling the blood samples, but the yield of NAT would be close to that of combined HIV antibody and p24 antigen tests for high values of the detection threshold and the pool size. A 36-year-old man was admitted to our clinic with the complaint of right flank pain. To help make this sometimes difficult determination, we have constructed a benefit equation that calculates the benefit to society (either positive or negative) of any proposed living-related transplant. Grading articular cartilage of the knee using fast spin-echo proton density-weighted MR imaging without fat suppression. Conversely, expression of many Amy3 subfamily genes was up-regulated and prolonged in embryo tissues under anoxic conditions.

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Medical records of 208 consecutive cirrhotic critically ill patients were reviewed. It is recommended to use only one method for choosing the region of background activity. Changes in blood glucose, liver glycogen, ketone bodies and plasma insulin in suckling rats treated with a single high cortisol dose one day after birth. Effects of different thermal treatments and storage on the proximate composition and protein quality in canned tuna. To confirm antifungal effect of DMHF, we investigated the effect on dimorphism of Candida albicans induced by FBS, which plays a key role for pathogenesis in host invasion. The postmortem stability of the structural properties of myosin makes immunocytochemical fibre typing suitable for the study of preserved cadavers. A drug discrimination procedure was used to determine whether the administration of an SSRI was associated with a specific interoceptive stimulus cue and to what extent that cue was related to activation of the 5-HT(1A) receptor. Autoimmune diseases developed in athymic nude mice grafted with embryonic thymus of xenogeneic origin. These results suggest that representations of the target are substituted in consciousness by that of the interruption mask when visual attention is preoccupied.

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Compounds 3 and 4 were identified by characterization of their respective peracetyl derivatives 5 and 6. 196 staff participated in the survey and 13 participated in follow up in telephone interviews between August and vasotec 10 mg November 2015. A Contribution to the Study of the Comparative Histology and Physiology of the Spleen, with reference chiefly to its Cellular Constituents: I. HIV infection is characterized by progressive immunodeficiency: HIV-infected peripheral blood mononuclear cells (PBMCs) cannot properly react to stimulation with allo-antigens and mitogens. Unusual diagnosis of ascending aorta dissection with left ventricular angiogram. The bands preferentially involved were 1p32, 1p36, 1q32, 3p21, 6p21, 7p13, 7q11, 7q32, 19p13, 19q13, and 22q13. (3) To determine measurement precision in three successively more exacting trial protocols on the same set of subjects.

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These findings demonstrate for the first time that freshly fractured silica induces AP-1 activation, which may be mediated through p38 MAPK and ERK pathways. This step initiates the synthesis of all the glycerolipids and evidence from gain-of-function and loss-of-function studies in mice and in cell culture strongly suggests that each isoform contributes to the synthesis of triacylglycerol. Thus, there is a pressing need for a careful consideration of the benefits and side effects to the use of nanoparticles in medicine and cosmetics. Patient-Practitioner-Remedy (PPR) Entanglement, Part 7: a gyroscopic metaphor for the vital force and its use to illustrate some of the empirical laws of homeopathy. Regulation of CAS and KKS protein expression has a profound influence zyrtec allergy tablets 10mg on thrombosis-generating mechanisms in the intravascular compartment. The UV-vis spectra and chemical analysis (acidic hydrolysis) of the degradation products suggest that they resulted from the condensation of caffeic acid and Cy 3-glc. To introduce into the clinical nomenclature a sign frequently observed in our patients with persistent corneal inflammation associated with herpetic stromal keratitis.

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