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Epivir (Lamivudine)
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Epivir

Epivir is a first-choice HIV antiretroviral (ARV) used in combination with other HIV ARVs for the treatment of HIV. It can also be used for the treatment of hepatitis B, but it's not a first-choice option.

Other names for this medication:
Abamune, Combivir, Duovir, Emduo, Emtri, Haptavir, Hepavud, Hepitec, Hepravir, Hivir, Ladiwin, Lamidac, Lamivox, Lamivudine, Lamostad, Lavir, Lazid, Lmivir, Nevilast, Retrolam, Shanvudin, Stadin, Stavex, Tenola, Tenolam, Tenvir, Trimune, Trioday, Viramid, Virolam, Virolis, Zidolam

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Also known as: Lamivudine

Description

{name} HBV is an antiviral medicine that prevents human immunodeficiency virus (HIV) or hepatitis B virus from multiplying in your body.

{name} is for treating HIV in adults and children at least 3 months old. HIV is the virus that can cause acquired immunodeficiency syndrome (AIDS). {name} is not a cure for HIV or AIDS.

{name}-HBV is for treating hepatitis B in adults and children at least 2 years old. {name}-HBV should not be used in people who are infected with both hepatitis B and HIV.

Dosage

Take Epivir exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You should not take Epivir (for treating HIV) together with Epivir-HBV (for treating hepatitis B).

You may take this medicine with or without food.

Lamivudine doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight. Children who weigh more than 30 pounds (14 kilograms) should use the tablet form if possible. The liquid form may not be as effective.

You may need to break a tablet in half when giving this medicine to a child for HIV. Call your doctor if the child has any trouble swallowing the tablet.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

The Epivir brand contains a higher dose of lamivudine than Epivir-HBV brand. Epivir is for treating HIV and Epivir-HBV is for treating hepatitis B. Each time you get a refill of this medication, be sure you have received the correct brand to treat your condition.

You will need frequent medical tests, including frequent HIV testing. If you become infected with HIV while you are taking lamivudine to treat hepatitis B, the HIV could become resistant to antiviral medicines if not treated right away.

The hepatitis B virus can mutate while you are taking Epivir-HBV and may become resistant to treatment. Resistant hepatitis B can lead to worsening liver disease or death. Tell your doctor if you have new or worsening hepatitis symptoms.

Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

If you've ever had hepatitis B, this virus may become active or get worse in the months after you stop using Epivir. You may need frequent liver function tests while using this medicine and for several months after your last dose.

Detailed Epivir dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Epivir are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Chemerin production by human MSCs was investigated under different culture conditions using enzyme-linked immunosorbent assay (ELISA). While the use of many NPS is minimal and transitory, little is known about which products have potential for capturing the attention of significant proportions of the drug consuming market. Influence of moderate Joule heating on electroosmotic flow velocity, retention, and efficiency in capillary electrochromatography. Using self-report to improve substance abuse risk assessment in behavioral health care. The breast cancer cell lines MCF-7 and BT20 were sensitive to the cytotoxic effects of rHuTNF. Importantly, recruitment of endoplasmic reticulum (ER) proteins by vacuoles containing the sidJ mutant was considerably delayed in both mammalian and amoeba cells. Studies designed to prevent or treat acute renal failure often use clinical and physiologic endpoints that are not comparable to other studies making it difficult to compare the results of one study to another. The discriminative effect of a drug in relation to a training drug of the same pharmacological class is not isomorphic with its reinforcing effectiveness. Through analysis of the contrasting relationships of the trait phenotype with haplotypes that carry different allelic combinations from those observed in Caucasians, we demonstrate that (at least) two major intragenic sites within the critical interval and (at least) one minor promoter site are associated with the ACE quantitative trait through additive effects.

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The extralabel use of drugs can be defined as the use of drugs in a manner inconsistent with their FDA-approved labeling. The use of hybrid diploid strains permits complementation of any spurious recessive mutations in the library strain, facilitating attribution of the observed phenotype to the documented gene deletion and dramatically reducing false positive results commonly obtained in library screens. However, SHIP mRNA also decreased in response to BCR/ABL, suggesting that SHIP protein levels could be affected by more than one mechanism. This rectal biphasic response is reflexogenic in nature as epicardial lignocaine abolished such response. Serum low HDL-C (hypoalphalipoproteinemia) and hyperinsulinemia are independent predictors for CHD, but a strong negative correlation exists between them, as in patients with syndrome X. Analysis of hematologic alterations, immune responses and metallothionein gene expression in Nile tilapia (Oreochromis niloticus) exposed to silver nanoparticles. Ethanol-induced decrease of developmental PKC isoform expression in the embryonic chick brain. This may be due to a feature of the hybrid-lognormal distribution that can be interpreted as maternal constraints on fetal development. While the disease is superficially similar to feline infectious peritonitis (another coronavirus-induced serositis), differences exist between the histopathological findings in these two conditions.

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Alterations in plasma volume and extracellular space as the result of hydration therapy. A neural network model of lexicalization for simulating the anomic naming errors of dementia patients. The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut. Medline, Embase, and reference lists were systematically searched up to November 24, 2015 by two independent review authors. Several factors are important in the etiology of TMA, such as cyclosporin A, GVHD, irradiation, intensive conditioning chemotherapy and infection, which cause damage to vascular endothelial cells leading to activation of these cells. Counsellor behaviours and patient language during brief motivational interventions: a sequential analysis of speech.

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With this aim, we studied its expression in aorta from uraemic rats with calcitriol-induced vascular calcification and in 16-vessel biopsies of uraemic patients undergoing kidney transplantation. Significant differences render the use of most urea kinetic modelling equations problematic. From these strains, only four soil degraders and one strain isolated from the sediment, respectively, were shown to possess a complete chlorobenzoate (CB) pathway. Maternal smoking and childhood leukemia and lymphoma risk among 1,440,542 Swedish children. The properties of ontogene mutations, produced by methods of direct genetics, are described. Male circumcision may reduce the risk of sexually transmitted infection acquisition and transmission by up to one half, suggesting substantial benefits accruing from routine neonatal circumcision. In this study, a novel application of reverse Southern hybridisation was used to screen the RDA library: genomic DNA from each strain was labelled and used to probe the library to identify strain-specific clones. Aspiration biopsy of the kidney in the appraisal of unilateral renal disease with hypertension: report of a case.

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A dense, extensive network of NPY-like immunoreactive nerve fibres was seen between cardiac muscle cells and around blood vessels. Here we describe alterations in the expression of Fas and FasL in the testis after the intimate physical association between Sertoli cells and germ cells is disrupted by exposure to the Sertoli cell toxicant mono-2-(ethylhexyl) phthalate (MEHP). This study was designed to identify and characterize the immune receptors for polysaccharides from Ganoderma lucidum, a Chinese medicinal fungus that exhibits anti-tumor activities via enhancing host immunity. As random shotgun metagenomic projects proliferate and become the dominant source of publicly available sequence data, procedures for the best practices in their execution and analysis become increasingly important. Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. The objective of this work was to develop an in vitro, hepatocellular carcinoma (HCC)-based system supporting HBV full replication and producing mature viral particles. The sources of influence considered to have the greatest importance and legitimacy in influencing medical practice concern the professional medical system (self-defined protocols, discussion with colleagues, etc.). No large-scale studies have examined diagnosis and initial medication management of pediatric hypertension and prehypertension. The aim of the present study is to investigate the effect of VLCSFA accumulation on inflammatory and oxidative responses in VLCSFA-accumulated macrophages derived from X-linked adrenoleukodystrophy (X-ALD) protein (ALDP)-deficient mice.

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These data support further evaluation of PEP005 as an anticancer agent and may help to optimise clinical trials with PEP005-based combinations in patients with solid tumours. These ranged from tens of days for the lower molecular weight congeners to tens of years for the higher molecular weight PCBs. Left ventricular systolic time intervals as indices of postural circulatory stress in man. A complete 2(3) factorial design was used to determine influential factors and interactions among these factors. The pyrimidines uracil and thymine, but not cytosine, were also degraded to serve as a source of nitrogen. Gross cumulative event rates at 5 years per 100 women were pregnancy 1.0, expulsion 5.9, removal for bleeding problems 16.7, removal for pain 4.3, and removal for pelvic inflammatory disease (PID) 1.2. Previous studies have shown that increased mRNA and protein levels of MIOX in the cortex of the kidney in diabetic mice. On excitation at 417 nm, a weak emission from the ground-state anion species was observed at 483 nm, whereas excitation at absorption maxima (345 nm) gives the usual intense fluorescence of the phototautomeric emission at 530 nm.

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In both rat strains the activity of glycogen phosphorylase in liver extracts was enhanced by pretreatment of the animals with Na2SO4, but in phosphorylase kinase-deficient livers the enhancement was solely in phosphorylase b activity, whereas both the a and b forms of the enzyme were activated in normal livers. Eruption times of permanent teeth in children and adolescents in the German state of Saarland. Extinction antagonizes olfactory memory at the subcellular level. To determine whether the incidence of multiple primary malignancies in this series was higher than expected, we calculated the expected numbers of carcinoma occurrences and evaluated these findings by exact binomial test. A survey of the main medical causes of rejection for national service.

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Birth after the injection of sperm and the cytoplasm of tripronucleate zygotes into metaphase II oocytes in patients with repeated implantation failure after assisted fertilization procedures. We hypothesized that transferrin plays a critical role both in iron transport and in regulating hepcidin expression in zebrafish embryos. Further investigations with larger sample sizes and using brain imaging should strengthen these findings. With the help of random mutational effects of nucleotides on protein function, I have derived the distribution of selection coefficient among sites, called the S-distribution whose parameters have clear biological interpretations. Our data provide evidence that Gas1 acts to maintain high levels of FGF10 at the tip mesenchyme and support the proposal that Fgf10 expression in this region is crucial for maintaining Fgf8 expression in the AER. Acute infusion reactions whose clinical features are somewhat similar have been variably described with many mAbs.

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In Northern Ireland there is no database designed to cover all the major clinical aspects of obstetrics and gynaecology. Here we report an asymmetric complex of the Type IIP restriction enzyme MspI in complex with its cognate recognition sequence. Systems-level approach to uncovering diffusive states and their transitions from single-particle trajectories. Although it is not clear at present whether HHARI and H7-AP1 serve, for instance, as substrates for UbcH7 or represent proteins with E3 activity, our data suggests that a subset of RING finger/IBR proteins are functionally linked to the ubiquitin/proteasome pathway. Treatment with oral TRH for 30 days decreased body weight and increased food intake in sham-operated rats.

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Providing the missing link between atomic and nanoparticle behavior in noble metals, these emissive, water-soluble Au nanoclusters open new opportunities for biological labels, energy-transfer pairs, and light-emitting sources in nanoscale optoelectronics. Loss of differentiation of 4NQO-induced rat malignant oral keratinocytes correlates with metastatic dissemination and is associated with a reduced cellular response to TGF-beta1 and an altered receptor profile. In head and neck cancer, we have found that gemcitabine doses far below the maximum tolerated dose for the drug when used alone significantly potentiate the toxicity of treatment. We conducted a population-based cohort study to compare mortality among 238,292 persons who purchased a handgun in California in 1991 with that in the general adult population of the state. Deletions in the proximity of the break were due to a non-homologous end-joining pathway, while larger deletions were processed via a SSA pathway. Circadian variations of the acetylcholine muscarinic receptor and some glycosyltransferases were studied in brain using multivariate analysis.

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Poly(ethylene glycol) hydrogel-encapsulated fluorophore-enzyme conjugates for direct detection of organophosphorus neurotoxins. We used expressed sequence tag, reverse transcription PCR and RNAse protection assay analysis of synaptotagmin messenger RNAs to demonstrate the occurrence of alternative splicing events involving a number of exons. Emergency department (ED) chief-complaint (CC) data increasingly are important for clinical-care and secondary uses such as syndromic surveillance. Thus, this work represents a step toward the development of a practical subunit smallpox vaccine. Cryptococcal infection uncommonly presents with pulmonary manifestations and even more rarely so as massive bilateral effusions.

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We demonstrate that this new antibody can be used in several avian species to study FOS expression induced by a variety of pharmacological, physiological and behavioral stimuli. However, its diagnostic value has been considered to be limited in patients with chronic renal failure (CRF) because renal dysfunction itself may affect BNP levels. These immature secretion variants provide an important tool for studying the regulation of HBV virion assembly and secretion. Although there has been a large number of trials on pharmacist care, often demonstrating clinically significant benefits, the trials generally have not changed practice or healthcare policy. However, even if health financing is still insufficient, better health care in these countries could be produced with their present resources. As for reproduction, the mean number of eggs per mass was described as a linear function of feeding quantity. Variations in the plasma fibrinogen during the course of multiple sclerosis. Furthermore, this mutation was not found in a series of 20 alleles of normal individuals. Isolated rat adipocytes were incubated with adrenaline, adrenaline plus insulin, alloxan or alloxan plus insulin.

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Based on the positive data emerging from the public awareness campaign in different Countries of the world, we strongly encourage an accurate training for doctors and midwives and the implementation of adequate facilities in order to support breastfeeding. We investigated the role of tumor suppressor p53 and Fas (CD95/APO-1), a member of the tumor necrosis factor receptor family, in neural progenitors response to gamma-irradiation exposure. The outcome of 16 patients with esophageal varices who underwent endoscopic therapy plus all interventional radiologic procedures (transportal vein obliteration, partial splenic adalat 40 mg embolization, and left gastric arterial embolization) were compared with those of 23 who underwent esophageal transection. However, relapse after SCT remains the major cause of treatment failure. Further, grafting of the thymus from 42-day PNU-treated rats into thymectomized rats resulted in T-lymphomas of donor origin without additional PNU treatment. The TCAN and 1,1,1-TCP degradation rates, however, tended to decrease with increasing aging time. The variation of the solvent composition during gelation was determined from a simple weighting, and the ionisation state of the polymer at the gel point, by pH titrations. A search of the literature yielded 15 instances of severe antithyroid-drug-induced granulocytopenia (ATDIA) (granulocyte count of less than 0.1 x 10(9)/L) treated with G-CSF. Effectiveness of nimesulide has been demonstrated by numerous clinical studies in various inflammatory diseases of upper airways. Determination of manganese and chromium in atmospheric air in a single sample.

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Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipid metabolites. Excavation of the water system uncovered a direct cross connection between the potable water system and a sewage generic version of lipitor atorvastatin -effluent irrigation system. It was found that, in nonengineered vein grafts, the density of activated monocytes and granulocytes increased significantly compared to that in normal jugular veins at day 1, 5, 10 and 20. The purpose of the present article is to bring together the evidence indicating that, at minimum, postischemic PSI should be conceptualized as consisting of two components: an acute, transient component mediated by unfolded protein response-induced eIF2alpha phosphorylation and a longer term component that correlates with neuronal death. In normal mucosa, combined pools of tetrahydrofolate and 5,10-methylenetetra-hydrofolate were significantly elevated at all FA dose levels compared with untreated controls. A virulent isolate of yellow head nidovirus contains a deformed envelope glycoprotein gp116. Evaluation of Mannose-Binding Lectin is a Useful Approach to Predict the Risk of Infectious Complications Following Autologous Hematopoietic Stem Cell Transplantation.

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On neurological examinations, he was noticed an intermittent claudication, spastic paraparesis and stocking type sensory loss in his lower extremities. Mutational inactivation of BRCA1 confers increased risk for breast cancer. Postnatal maturation of mouse medullo-spinal cerebrospinal fluid-contacting neurons. The regulation of renin and renin messenger RNA (mRNA) in the rat ovary was examined to test the hypothesis that the expression of what drugs interact with klonopin renin gene and the secretion of renin in the ovary is the estrogen-mediated process that responds to follicle-stimulating hormone (FSH). Nuclear magnetic resonance analysis allowed the identification of galactosylisomaltol and pyrraline. Ovarian tissue from adult female rhesus macaques was transplanted into sc abdominal pouches of 4 male rhesus macaques that had been castrated after reaching sexual maturity.

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The LI of C38 and C26a decreased upon all treatments, which was statistically significant in the combination treatment of C38. Resulting gamma-amino alpha-dehydroaminophosphonates can be used for the preparation of phosphorylated pyrimidine derivatives. The effect of lethal mutations and deletions within the bithorax complex upon the identity of caudal metameres in the Drosophila embryo. The carboxyl terminal region of MobA did not share homology with other mobilization proteins, but may be involved in promoting efficient transfer of pSJ7.4. In this work, we show that inducible NDRG1 expression can drive leukemic U937 cells to undergo differentiation, while the knock-down of NDRG1 expression by specific small interfering RNA significantly antagonizes ATRA-induced differentiation of leukemic cells, proposing the role of NDRG1 in leukemic cell differentiation. The usefulness of handheld computers in a surgical group practice.

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Mining activities in the former German Democratic Republic were documented as early as 1168 in the ore mountains (Erzgebirge) of Saxony. Relaxation of a simulated lipid bilayer vesicle compressed by an atomic force microscope. In cultured cells, MYPT1 and PP1cdelta colocalized with synaptophysin. The frequency of recombination in the experimental males was two to three times that in the control. Previous research has failed to establish the role of parental individual differences in the reported use of different coping strategies. This study suggests that clinical hemostasis laboratories might consider replacing the platelet aggregation test with the carbon 14-serotonin release assay or should use another functional assay such as the flow cytometric assay for the diagnosis and care of patients with suspected HIT. 3,3-diphenyl-4-methylazetidin-2-one and 3,3-diphenyl-1,4-dimethylazetidin-2-one. These results show a close temporal correlation between the onset of neuronal degeneration and the beginning of astrogliosis in this neurodegenerative disease and reveal a novel spatial relationship that is consistent with the view that astrocytes play an active role in the neuronal degeneration process.

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Twelve cases of tuberculosis of the upper extremity over a 5-year period are presented. Results from this study determined that there were significant differences among student life stressors and physical and psychological health status between first-year on-campus and first-year off-campus college students. The change in visual acuity (LogMAR), the grade of inflammatory activity, therapeutic concentration of CsA in the blood and systemic and renal toxicity were determined after comparing two groups, one treated with CsA and diltiazem (treatment group), and the other without diltiazem (control group). The behavior below and above resonance is qualitatively different and is qualitatively material dependent. We show that these spectral observables obey universal expressions, which hold for a broad class of oriented random matrices.

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Pravastatin therapy in normocholesterolemic patients with coronary sclerosis seems to have an excellent pharmacoeconomic profile. The mRNA region where these mutations are located shares primary and secondary structure homologies with specific parts of several isoacceptor tRNAThr species. However, current diagnostic algorithms involve confirmation of HCV infection by RT-PCR. Good to excellent chemoselectivity was observed for competitive protection of hydroxyl groups in favor of sterically less hindered alcohols. Our findings indicate that MFAP4 has two binding specificities, one for collagen and one for carbohydrate, and we suggest that MFAP4 may fix the collectins in the extracellular compartment during inflammation. This led us to consider the microvascular network not only as one of the putative factors responsible for increased pressure but also as a key target of hypertension.

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Role of renal nerve activity, plasma catecholamines and plasma vasopressin in cardiovascular responses to intracisternal neurotoxins in the rabbit. Lymphocytes from individuals sensitized against the Rh-D antigen were found to lyse O,Rh-positive erythrocytes. New method for the preparation of nonuniform distributed Co/SiO2 catalysts. Physicians should be aware of the associations between obesity, negative body image tenormin medicine side effects and psychiatric morbidity. As dimethylsulphoxide (DMSO) induces apoptosis in the RPMI-8402 human pre-T cell line, the present study analysed the involvement of the c-myc proto-oncogene and polyamine pathway as mediators of apoptosis. We studied the relationship between selenium concentrations in whole blood and the activities of glutathione peroxidase and glutathione reductase in plasma.

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