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Fasigyn (Tinidazole)
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Fasigyn

Fasigyn is an antibiotic, which belongs to a group of medicines called nitroimidazoles. Fasigyn works by killing or stopping the growth of bacteria causing your infection. Fasigyn will not work against viral infections such as colds or flu.

Other names for this medication:
Simplotan, Tindamax, Tinidazole

Similar Products:
Micardis, Motilium, Viramune, Catapres, Astelin, Imuran, Duphaston, Diflucan, Suprax, Skelaxin

Also known as: Tinidazole

Description

Fasigyn 500mg film-coated tablets contain 500mg of the active substance tinidazole. This medicine is an anti-infective agent. It is used to treat a variety of bacterial infections including: infections of the skin, blood, chest, lung, genitals or womb lining, an infection associated with stomach ulcers in combination with other drugs, infections caused by organisms called protozoa, such as amoebiasis and giardiasis (stomach infections) and trichomoniasis (a genital infection), vaginal infections (vaginitis) and gum infections (gingivitis).

It is also used before certain surgical operations to prevent bacterial infections developing.

You should ask your doctor if you are unsure why you have been given this medicine.

Dosage

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

Take Fasigyn with a glass of water during or after a meal. Swallow the tablets whole. It is best to take the medicine at the same time each day.

For bacterial infections, this medicine is not recommended for use in children less than 12 years as it has not been tested in this age group.

For protozoal infections, Fasigyn 500mg film-coated tablets can be used in children and has not been shown to cause any different side effects or more problems than it does in adults.

The dose and length of treatment depends upon the infection being treated. If you are on dialysis, your doctor may prescribe a different dose.

The doses most commonly used for the different infections are shown in the table below:

For treating the infection associated with stomach ulcers. The usual dose is 1 tablet (500mg) taken twice a day. Your doctor will probably prescribe two other medicines to be taken with Fasigyn 500mg film-coated tablets. Treatment with the three medicines together will usually be for 1 week.

For treating most bacterial infections. The usual dose is 4 tablets (2g) on the first day then 2 tablets (1g) once a day or 1 tablet (500mg) twice a day. The usual length of treatment is 5 to 6 days.

For treating bacterial vaginitis (a vaginal infection) and acute ulcerative gingivitis (a gum infection). The usual dose is 4 tablets (2g) given as a single dose. For vaginitis you may be given 4 tablets (2g) on two consecutive days.

For preventing bacterial infections after surgery. Usually 4 tablets (2g) are given as a single dose about 12 hours before surgery.

For treating protozoal infections. For treating intestinal amoebiasis (a stomach infection). Adult: The usual dose is 4 tablets (2g) once a day for 2 to 3 days. Child: The usual dose is 50 to 60mg/kg of body weight once a day for 3 days.

For treating amoebic involvement of the liver (a liver infection). Adult: The usual dose is 3 to 4 tablets (1.5 to 2g) once a day for 3 to 6 days. Child: The usual dose is 50 to 60mg/kg of body weight once a day for 5 days.

For treating giardiasis (an abdominal infection) and trichomoniasis (an infection of the sex organs in males and females). Adult: The usual dose is 4 tablets (2g) given as a single dose. Child: The usual dose is 50 to-75mg/kg of body weight given as a single dose.

Your doctor will calculate the dose required for a child and may repeat the dose once if the infection has not cleared up completely.

Overdose

Immediately telephone your doctor or go to Accident and Emergency (Casualty) at your nearest hospital if you think you or anyone else may have taken too much Fasigyn. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Keep telephone numbers of these places handy.

If you take too many tablets, you may get an upset stomach, diarrhoea or skin rashes.

Storage

Keep Fasigyn in its original packaging until it is time to use it. If you take Fasigyn out of its packaging, it may not keep as well.

Keep your Fasigyn in a cool, dry place where it stays below 25 degrees C.

Do not store Fasigyn or any other medicine in the bathroom or near a sink. Do not leave it in the car or on a window sill. Heat and dampness can destroy some medicines.

Keep your Fasigyn where young children cannot reach it. A locked cupboard at least one and a half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Fasigyn are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Pregnancy: Fertility studies in rats receiving 100mg and 300mg tinidazole/kg had no effect on fertility, adult and pup weights, gestation, viability or lactation. There was a slight, not significant, increase in resorption rate at the 300mg/kg dose. Tinidazole crosses the placental barrier. Since the effects of compounds of this class on foetal development are unknown, the use of tinidazole during the first trimester is contraindicated. There is no evidence that Fasigyn is harmful during the latter stages of pregnancy, but its use during the second and third trimesters requires that the potential benefits be weighed against possible hazards to mother or foetus.

Breast-feeding: Tinidazole is excreted in breast milk. Tinidazole may continue to appear in breast milk for more than 72 hours after administration. Women should not nurse until at least 3 days after having discontinued taking Fasigyn.

No special precautions should be necessary. However, drugs of similar chemical structure, including Fasigyn, have been associated with various neurological disturbances such as dizziness, vertigo, ataxia, peripheral neuropathy (paraesthesia, sensory disturbances, hypoaesthesia) and rarely convulsions. If any abnormal neurological signs develop during Fasigyn therapy, the drug should be discontinued.

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Angiostatin induces intracellular acidosis and anoikis in endothelial cells at a tumor-like low pH. A set of criteria is proposed for reliable scientifically sound differential diagnosis between the causes of death from these pathologies. Development of an ultra-high-temperature process for the enzymatic hydrolysis of lactose. To evaluate the influences of CO(2) insufflation on changes in blood gas analysis and end tidal CO(2) tension (PetCO(2)) during posterior retroperitoneoscopic adrenalectomy in the prone position. Identification and quantification of proteins differentially secreted by a pair of normal and malignant breast-cancer cell lines. Prohormone convertase (PC) 1 and 2 represent major secretory granule proteolytic processing activities capable of converting neuroendocrine and neurotransmitter peptide (dynorphin) precursor intermediates to their mature, biologically active products. Immunohistochemical characterization of the basement membrane epitopes in bis(2-chloroethyl) sulfide-induced toxicity in mouse ear skin. Data and model predictions with a simplified model of the auditory system indicate an independent and serial processing of binaural cues and monaural across-frequency cues, maximizing the benefits from the envelope comparison across frequency and the comparison of fine structure across ears. The instability of the hypervariable region II of the mitochondrial genome was investigated in radiation-associated thyroid tumours, which were diagnosed in children from Belarus after the accident at the Chernobyl nuclear power plant, and from 40 sporadic thyroid tumours from Munich. Several different hypothesis has been put forward in order to explain the mechanism of tolerance.

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Psychological evaluation and support is important before and after amputation since it is a traumatic step for patients. This study provides preliminary proof of principle for using modified PEI for targeted gene delivery and PDT. Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation. Levels of mRNA for a fumarate reductase gene, frdA, quantified by real-time reverse transcription-PCR were directly correlated with fumarate reduction rates. There is considerable variation in current approaches to defining treatment resistance in schizophrenia. After immunosuppressive treatment for a colitis ulcerosa, a 49-yr-old man developed signs of systemic aspergillosis with subsequent septic shock and encephalitis. Moreover, most of the IgG tests ignore early convalescence as well as past exposure. The levels of total hexachlorocyclohexane in water varied from 31.95 to 129.8 ng/l (mean 62.51 ng/l), and those of total DDTs were in the range 19.24-96.64 ng/l (mean 48.69 ng/l). Identifying relevant epigenetic changes could lead to interventional strategies in ND.

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Primary care physician supply, physician compensation, and Medicare fees: what is the connection?. Current development of diagnostic irradiation in digestive tract radiology. Furthermore, our computations reveal that the rigidity of a given DNA sequence is controlled by its ability to form cross-strand bifurcated hydrogen bonds between the successive base pairs. Effect of sodium hyaluronate administered at the end of penetrating keratoplasty on reepithelialization of the graft. To do so, we used a multi-species microarray to measure gene expression levels in livers, kidneys, and hearts from six humans, chimpanzees, and rhesus macaques. TF and TFPI are measured by enzyme-linked immunosorbent assay in cell lysates. Such a mixture model accommodates correlated and overdispersed data through the incorporation of random effects. and subsequent restriction endonuclease digestion, was performed in agarose blocks/plugs thus minimizing shearing and loss of DNA, problems commonly associated with liquid phase phenol extraction.

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