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Glucotrol (Glipizide)
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Glucotrol

Glucotrol is a medicine used to treat type 2 diabetes mellitus in adults. It belongs to a group of medicines called sulfonylureas and helps control blood sugar levels in people with diabetes. This helps to prevent serious complications of diabetes like kidney damage and blindness.

Other names for this medication:
Actizide, Bimode, Diabizide, Diacon, Diaglip, Dibimet, Dibizide, Glanase, Glibetic, Glicept, Glimet, Glipicon, Glipicontin, Glipid, Glipimet, Glipiriv, Glipitis, Glipixor, Glipized, Glipizide, Glipmet, Glucolip, Gluconil, Glumin, Glunas, Glycind, Glydal, Glylin, Glynase, Glysar, Glysin, Glyson, Glytop, Glyzip, Gpzide, Libiz, Metaglez, Metglib, Swiglip, Tranase, Zidmin

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Also known as: Glipizide

Description

Glucotrol is a medication consists in a class of drugs called sulfonylureas. Glucotrol is used to treat type 2 diabetes. Glucotrol may be used along with diet, exercise and insulin therapy. Glucotrol is also known as Glipizide, Glytop SR. Glucotrol works by controlling blood sugar levels in your organism. Generic name of Glucotrol is Glipizide. Brand names of Glucotrol are Glucotrol, Glucotrol XL.

Dosage

This section provides information on the proper use of a number of products that contain glipizide. It may not be specific to Glucotrol XL. Please read with care.

Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Swallow the extended release tablet whole. Do not split, crush, or chew it.

If you are taking the extended release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For type 2 diabetes: For oral dosage form (extended-release tablets): Adults—At first, 5 milligrams (mg) once a day taken with breakfast. Your doctor may adjust your dose if needed. The dose is usually not more than 20 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 5 milligrams (mg) once a day taken at least 30 minutes before breakfast. Your doctor may adjust your dose if needed. The dose is usually not more than 40 mg per day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Glucotrol and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Glucotrol overdosage: hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, coma.

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Glucotrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid drinking alcohol. It lowers blood sugar and can cause side effects.

Avoid driving or operating machinery until you know how glipizide will affect you.

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By using standardized cognitive, academic, and behavioral assessments performed at 3, 8, and 18 years of age, we compared groups after adjusting for intervention status, birth weight, gestational age, sex, severity of neonatal course, race, maternal education, and maternal preconception weight. Investigation on the spontaneous combustion of refuse-derived fuels during storage using a chemiluminescence technique. All patients underwent pre- and postoperative manometry, 24-hour pH-metry and laparoscopic anti-reflux surgery. The purpose of this study was to identify the risk factors for development of acute compartment syndrome resulting from this type of leg positioning. BEC were collected periodically from 17 volunteers of undergraduate programs, who had participated in practical anatomy classes, before and after FA exposure. In this relatively small data set, the percentage of normal glomeruli, the crescent score, and interstitial fibrosis as a percentage of cortical surface area correlated with renal function at both baseline and 1 year of follow-up. Congenital nystagmus (CN) is characterized by conjugated, spontaneous, and involuntary ocular oscillations.

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Patterns in the development of the plasma cell reaction and smallpox immunity in irradiated animals. 3-Sulfanyl-4-methylpentan-1-ol in Dry-Hopped Beers: First Evidence of Glutathione S-Conjugates in Hop (Humulus lupulus L.). Haplotype analysis showed that all of them were haplotype III like the american patients indicating that the american and german kindreds have a genetic linkage and common familial roots. This finding correlated significantly with a low antioxidative capacity and the presence of antibodies against hsp70. Herein, we review the current evidence on metabolic abnormalities in inflammatory arthritis.

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Transgenic plants exhibited lower LT50 values and improved survival when exposed to freezing stress compared to the control plants. In particular, compounds 4a, 5a, 7a, 13a,b, and 16a,b showed higher activity than the lead compound on human monocytes, compound 7a being 2.5 times more active than DMXAA, which is the most potent compound synthesized so far. Cromolyn reduced the magnitude of early and late responses and abolished the increase in methacholine responsiveness. On the other hand, stroma-free hemoglobin induced significant adverse effects on liver as shown by elevation in alanine aminotransferase and aspartate aminotransferase throughout the 21 days. During the corresponding period, the expression rate of undifferentiated cell marker CD133 and nestin in BTSCs kept decreasing, but 1 week later, they regained ascending tendency. Deterministic models based on ordinary differential equations can capture essential relationships among virus constituents. Mature teratoma represented the adult pattern of somatic repression. Although late neonatal mortality rates remained low in the country, a significant decrease was seen in districts without ORI.

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These findings support the hypothesis that circulating factors in the plasma of women with preeclampsia activate endothelial cell monocyte chemoattractant protein-1 and interleukin-8 production, and although not directly examined in this study, may increase monocyte adherence to the vascular endothelium. The results support the view that there is a causal relationship between the thiamine status of the yolk-sac fry and M74 mortality. Airway mechanics and methods used to visualize smooth muscle dynamics in vitro. During the first acute study, ISDN 5 mg s.l., led to a significant reduction in systolic BP, a reflex increase in heart rate and a further improvement in exercise tolerance, whether patients were on placebo or TTS.(ABSTRACT TRUNCATED AT 250 WORDS). Alpha-fetoprotein (AFP) promoter-driven target gene could be specifically expressed in AFP-positive hepatoma. Since autophagy is well recognized as a survival mechanism, autophagic smooth muscle cells in the fibrous cap may reflect an important feature underlying plaque stability.

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Clinical ophthalmological evaluations including visual evoked potentials (VEPs) were carried out. Phycoremediation of heavy metals by the three-color forms of Kappaphycus alvarezii. The significance (or the insignificance) of wide pulse pressure. The formulation of stopping distance treats each variable as a probability density function for implementing Monte Carlo simulations. The creation of necessary, efficient forms at the lowest possible cost is possible. Analysis by reverse transcription-polymerase chain reaction and RNase protection assays revealed that LR11 transcript levels rise in rabbit aortas displaying atheromatous lesions after the rabbits have been fed a high-cholesterol diet. Data from 339 consecutive liver transplant recipients were analyzed with attention to the time period as a proxy for leukoreduction, the number of transfusions, the wait list status, the hepatitis B or C status, the recipient age, and the type of immunosuppression. Selected cultures were also supplemented with hemin modeling bleedings. aeruginosa acyl-HSL synthesis mutant by using a transposon containing a promoterless lacZ.

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Because of irritation of the canaliculus it had to be pulled out after 2 months. We discuss the implications of this study, particularly the possibility of early detection and intervention in patients at risk. After seeking numerous consultations around the Southeast, the patient came to our facility, 6 months after the initial laser treatment, with exuberant granulation tissue of the forehead and temples and a painful wound. Both methods have been reported in literature before, but have hitherto not been combined and evaluated systematically. Health-related quality of life of pediatric renal transplant recipientsand their parents: the role of associated factors and clinical counseling. Retrospective file review was carried out of all patients with proven diagnosis of sarcoidosis in a general hospital in Western Saudi Arabia over a period of 11 years (1985-1996). To evaluate the adequacy of the MEDLINE instruction routinely given to all entering medical students at the University of Miami School of Medicine and the ability of students to search effectively for and retrieve evidence-based information for clinical decision making by the end of their third-year.

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Next, we analyzed the expression mRNA level of Beclin 1, LC3B, and p62/STSQM1 and the relative expression of LC3B protein under combined treatment. The spectra were taken from 177 to 890 nm with a wavelength resolution of 1.3 nm. Individual ASF profiles, once established, were highly stable over time in the absence of environmental perturbation. These contemporary data highlight the multiple challenges of preventing and managing an increasing and complex burden of HF in urban Africa. We used a femoral artery wire injury mouse model, rodent models with insulin resistance and diabetes, and patients with type 2 diabetes. Do plasma concentrations obtained from early arterial blood sampling improve pharmacokinetic/pharmacodynamic modeling?. Molecular cloning of cDNA for human poly(ADP-ribose) polymerase and expression of its gene during HL-60 cell differentiation. In this study, we fabricated radio frequency identification (RFID)-based wireless sensor systems using carboxyl group functionalized polypyrrole (C-PPy) nanoparticles (NPs).

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Management of chronic daily headache in children and adolescents. The metal wear particles isolated were an order of magnitude smaller than polyethylene particles, at 60-90 nm, and consequently, 100-fold more particles were produced per unit volume of wear compared to polyethylene. We then demonstrated that 9-cis-RA was capable of exerting the same neurotrophic and chemotropic effects on cultured neurons as atRA. Nature uses dioxygen as a key oxidant in the transformation of biomolecules. Additionally, the SiLTP promoter drove GUS expression in root tips, stems, leaves, flowers, and siliques of transgenic Arabidopsis. We performed a systematic search of the literature in addressing factors influencing parental attitudes to and beliefs about HPV vaccine and its acceptability for use. To review the use of preoperative screening for Staphylococcus aureus for all pediatric spine procedures that was instituted at our facility in a multimodal approach to decrease the frequency of postoperative wound infections. The influence of HLA phenotypes on the response to parenteral gold in rheumatoid arthritis.

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Identifying alternative exercise modalities in an effort to stimulate and promote participation in physical activity, especially among older adults, is a critical health consideration. Furthermore, the maxilla was found to be the most commonly involved bone in both monostotic and polyostotic CFD. Furthermore, novel developments and future perspectives regarding the identification of novel antifolate target proteins and mechanisms of action, as well as rationally designed emerging drug combinations containing antifolates along with receptor tyrosine kinase inhibitors are being discussed. In Escherichia coli, there are two membrane-bound, differentially regulated nitrate reductases. Interestingly, GR induces hyperacetylation of histones H3 and H4, but this is not sufficient either for remodeling or for transcriptional activation. Indeed, abnormalities of the how to take suprax 400 mg transcription factor Pit-1 are responsible for combined deficiencies affecting thyrotroph, somatotroph and lactotroph cell lineages both in dwarf mouse strains (Snell, Jackson) and in human patients.

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In further tandem mass spectrometric experiments of different rutin-metal complexes, product fragments came from the neutral loss of the external rhamnose and the internal glucose unit, oligosaccharide chain, aglycone, and small organic molecules. Glucose tolerance in adult life was assessed by a 75-g oral glucose tolerance test. The effect of Arg in treating many developmental and health problems is unique among AAs, and offers great promise for improved health and wellbeing of humans and animals. Ambient pressure upregulates nitric oxide synthase in a phosphorylated-extracellular regulated kinase- and protein kinase C-dependent manner. Considering the new incentives and the promising pre-clinical results, compstatin seems to be well equipped for the challenges on its way to a clinical therapeutic. We confirm previous experiments that suggested a decrease in the conversion rate above about 0.5 GPa. Human urine gas change measurement and its application in acute renal failure. Gonadal and gonadotropic function of late middle-aged men and women with sequelae of ischemic stroke. Three patients had chronic inflammation confirmed by both methods. Bladder cancer is one of the most common cancers diagnosed in the world and leads to significant mortality and morbidity among affected patients.

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