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Glyburide (Glibenclamide)

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Glyburide is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
Afdiex, Aviglen, Benformin, Betanase, Betrol, Bionil, Codica, Combidos, Daonil, Diabetnil, Diabetrol, Diabnil, Diolin, Dutrol, Eumet, Glibet, Glibson, Glime, Glimsug, Glinil, Glitrac, Glucomin, Glucored, Glucosafe, Glucosil, Glucotrac, Glunil, Glutowin, Glybenclamide, Glybid, Glybonil, Glyboral, Glybovin, Glybovine, Glycurb, Glycurub, Iscept, Melitus, Metclam, Metica, Monomet, Pionorm, Secrin, Sugatrol, Sugnil, Sugnl, Sugronil, Triglucored

Similar Products:
Myambutol, Colcrys, Fasigyn, Precose, Panadol, Fosamax

Also known as: Glibenclamide


Glyburide comes as a tablet to take by mouth. It is usually taken once a day with breakfast or the first main meal of the day. However, in some cases your doctor may tell you to take glyburide twice a day. To help you remember to take glyburide, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take glyburide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of glyburide and gradually increase your dose if needed. After you have taken glyburide for some time, glyburide may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.

Glyburide helps control blood sugar but does not cure diabetes. Continue to take glyburide even if you feel well. Do not stop taking glyburide without talking to your doctor.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For type 2 diabetes:
    • For oral dosage form (tablets):
      • Adults—At first, 2.5 to 5 milligrams (mg) once a day taken with breakfast or the first main meal. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
      • Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Glyburide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


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The mechanism of sudden stripe formation during dorso-ventral patterning in Drosophila. A 5.4-kb fragment of the glycine receptor (GlyR) alpha1 subunit gene was cloned and used to drive the expression of a construct encoding for the enhanced green fluorescent protein (EGFP). The protein was revealed to be identical to hGCMa, a mammalian homologue of the Drosophila GCM (glia cells missing) protein. Relationship between tissue factor activity and prostacyclin release. UvrB, the central component of this system, is responsible for the ultimate DNA damage recognition and participates in the incision of the damaged DNA strand. Are we underestimating the clinical efficacy of botulinum toxin (type A)?.

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Cost effectiveness of colony lysis and colony PCR methods for screening of recombinant Escherichia coli colonies--a comparative study. Trypanosomes genetically inactivated in the RAD51 gene were shown to be viable, and had phenotypes consistent with lacking functional expression of an enzyme of homologous recombination. Patients who engaged in some heavy drinking during treatment had better long-term outcomes than persistent heavy drinkers. Since oncological patients are also treated with rhuEPO it is interesting to know whether this side effect could be observed in the patients with solid tumors as well. The findings of this study suggest that further research is needed to investigate the effects of body size on wideband energy reflectance. Therapeutic effect of mitomycin C in the immediate postoperative period in patients with intermediate-risk non-muscle-invasive bladder tumors. Our results showed differences in cytosine methylation levels in the FMV promoter and cry2Ab2 transgene of the four Bt-expressing hybrid varieties. We investigated the role of PCNA ubiquitination in variants of the DT40 B cell line that are mutant in K164 of PCNA or in Rad18, which is involved in klonopin generic vs brand PCNA ubiquitination. High plasma levels of pro-inflammatory cytokines play an important role in the pathophysiology of congestive heart failure (CHF). Shared decision making is a process in which clinicians and patients make health care decisions in a collaborative manner using the most up-to-date evidence, while considering patient values and preferences.

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Bilateral cerebellar infarction: a rare complication of scorpion sting. Finally, controversial issues with regard to benzodiazepines are discussed. It appears that this technique can be effective in knees with collapse of the femoral condyle, and it may delay the need for a total knee arthroplasty. Controlled molecular organization of surface macromolecular assemblies based on stimuli-responsive polypeptide brushes. Pruritus is a distressing symptom in a considerable proportion of cholestatic patients and a few of them do not respond to conventional treatment. The challenge is compounded because there is limited literature concerning development of interventions and their evidence base. IL-1 beta levels in peritoneal fluid were substantially lower after laparoscopic adnexal surgery than after laparotomy.

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Histochemical studies on functional groups of proteins in abnormal forms of glial cells. This change is exactly opposite to that expected if overall PFK activity was regulated by changes in cellular pH since PFK is less active at lower pH values in vitro. We describe two children with Melkersson-Rosenthal syndrome in whom combination treatment with prednisone and minocycline proved effective and well tolerated. The key findings of this study open the possibility to apply scientific information obtained from the studies with simple surfaces such as HOPG diflucan fluconazole 150 mg cara kerja under ideal conditions (UHV) to industrial sorbents under realistic process conditions. Location, resource loss (especially personal characteristic resources) and social support accounted for a significant portion of psychological distress variance. It is essential that the full spectrum of options remain treated equally.

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Structure elucidation of Coumarin-500 Laser-dye in cyclohexane at room temperature has been studied by UV-Vis, Raman, and FTIR spectroscopic techniques. Monocytes did not produce interleukin 12p40 upon stimulation with various TLR stimuli and nuclear translocation of NF-kappaB was impaired. Swelling and indapamide medicine contraction of heart mitochondria suspended in ammonium chloride. Moreover, inhibition of p38 activity and thus of Stat3 serine phosphorylation results in suppression of transformation by v-Src but not v-Ras, consistent with a requirement for Stat3 serine phosphorylation in Src transformation. The extant research on animal hoarding has a dearth of information on animal hoarding tendencies in adults diagnosed with hoarding disorder (HD). Gingival tissue samples and block biopsies were obtained from all experimental and control sites for LM and TEM evaluation at 7 days.

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The purpose of this study was to compare and contrast linear cardiac lesions produced with sequential applications using a novel cryoablation system to those produced using radiofrequency (RF) energy. While hypophysectomy can alter the increase in striatal dopamine (DA) receptor density observed after estrogen, haloperidol or prolactin treatments, it does not alter the increase in density found after 6-hydroxydopamine lesions of the DA neurons in male rats. Monoamines and monoamine oxidase in denervated sympathetic ganglia of the cat. Such responses can lead to injury, especially if significant ventricular cardiac dysrhythmias occur, or if a person is working at some height above ground and falls as a result of a musculoskeletal response. A systematic approach is recommended for diagnosis of a posterior tongue mass, with neoplastic, infectious, and congenital categories. In endothelial cells, the expression of VEGFR1 and P-STAT5 closely correlated with each other, as well as VEGFR2 and P-STAT3.

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Using migration chambers we found that the trophoblast cells migrated towards vitronectin but not towards bovine serum albumin. Protective equipment usage was measured by a primary data collector at each training and game session during the 2001 playing season. It is unlikely that the protective effect of pioglitazone against endotoxin-induced decreases in the hepatic drug-metabolizing enzyme activity and protein levels of CYP3A2 in the liver is due to the inhibition of the overproduction of NO. The histologic characteristics of 29 recurrent glottic carcinomas after radiation failures, initially classified as T1 and T2, were analyzed on whole-organ slices. A transient increase in p27(Kip1) in cdk2 immunoprecipitates, without changes in total cellular p27(Kip1) levels, correlates with the delay in cdk2 activation caused by cGMP. Tissues from cows, goats, and mice inoculated with B periactin abortus strain 2308 were examined, using rabbit antiserum to Brucella cell surface protein as primary antibody.

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EBI3 is an EBV-induced cytokine homologous to the interleukin (IL)-12 p40 subunit and can heterodimerize with IL-12 p35. Mass spectra of various proteins with molecular weights as large as that of myoglobin monomer and dimer were obtained. In elderly patients, the plasma concentration of fentanyl was higher but plasma levels of oxycodone were at a similar level compared with middle-aged patients. This paper explores the concept of diversity at the level of the system and organisation, in essence, at the level of Faculty, School or Department of Nursing. Migrating a lecture in nursing informatics to a blended learning format--A bottom-up approach to implement an open-source web-based learning management system. The resolution of the current OCT system is 10-20 microm, which is approximately ten-times higher than that of intravascular ultrasound. Preoperative utilization of this method simplifies the planning of endoscopy by visualization of anatomical structures. Anticancer effects were reported for 14 of 27 herbal substances searched for, 8 of which had reported effects specifically in gynecological cancer models. Increased availability of nitric oxide leads to enhanced nitric oxide dependency of tubuloglomerular feedback in the contralateral kidney of rats with 2-kidney, 1-clip Goldblatt hypertension.

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