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Imdur (Isosorbide)
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Imdur

Imdur reduces your risk of getting heart-related chest pain (angina attack). It does not treat an angina attack that has already begun and should not be used for this purpose. It works by relaxing and widening blood vessels in the heart.

Other names for this medication:
Aspitrate, Dilatrate, Ecosmin, Ismorin, Ismotic, Isoditrate, Isoloprin, Isordil, Isosorbide, Monit, Monoket, Monosprin, Nitren, Nitrofix, Nitroprin, Solosprin, Vasoprin

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Also known as: Isosorbide

Description

{name} (isosorbide mononitrate) is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

{name} is an extended release tablet used to prevent angina attacks (chest pain).

{name} will not treat an angina attack that has already begun.

Dosage

This section provides information on the proper use of a number of products that contain isosorbide mononitrate. It may not be specific to Imdur ER. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This form of nitrate is used to reduce the number of angina attacks over a long time. It will not relieve an attack that has already started because it works too slowly. The extended-release form gradually releases medicine to provide its effect for 8 to 10 hours. Check with your doctor if you also need a fast-acting medicine to relieve the pain of an angina attack.

You should take this medicine first thing in the morning and follow the same schedule each day. This medicine works best if you have a "drug-free" period of time every day when you do not take it. Your doctor will schedule your doses during the day to allow for a drug-free time. Follow the schedule of dosing carefully so the medicine will work properly.

Swallow the extended-release tablet whole with a half glass of water. Do not split, crush, or chew it.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For prevention of angina: For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Take the dose in the morning right after you wake up. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—20 milligrams (mg) two times a day. Take the first dose in the morning right after you wake up, and the second dose 7 hours later. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of isosorbide mononitrate can be fatal.

Overdose symptoms may include a severe throbbing headache, fever, confusion, severe dizziness, fast or pounding heartbeats, vision problems, nausea, vomiting, stomach pain, bloody diarrhea, trouble breathing, sweating, cold or clammy skin, fainting, and seizure (convulsions).

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Imdur are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Early Responsive to Dehydration (ERD) genes are described as rapid response mediators of dehydration stress. Health, Aging, and Body Composition Study--Dual-Energy X-ray Absorptiometry and Body Composition Working Group. In the present study we analyzed the effect of continuous intraventricular infusion of the histamine H(1) receptor antagonist d-chlorpheniramine on the performance of 32-month-old Fischer 344/Brown Norway F1 hybrid rats in the place version of the Morris water maze and in two different tests of anxiety (open field and black-and-white exploration). The results indicate that patients with ILOCA exhibit slowing of cognitive information processing and suggest that its cognitive slowing may be due to a disruption of neural circuits between the cerebellum and the frontal cortex. Periodontitis is a chronic inflammatory disease that is caused by a bacterial infection in the periodontal region. A consideration of the mechanism of reticulocytosis: an experimental study in the duck. Medico-genetic and cytogenetic investigation in family with high predisposition to diffuse intestine polyposis. HapCUT2: robust and accurate haplotype assembly for diverse sequencing technologies. An improvement of clinical symptoms was observed in patients operated with a v.-p. Therapeutic efficacy of guided tissue regeneration and connective tissue autotransplants with periosteum in the management of gingival recession.

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A deletion in the Drosophila Adar gene generated by transposon remobilization prevents this modification, proving that the ADAR enzyme is responsible for the pre-mRNA editing described here. Although high-density lipoprotein (HDL) metabolism is a crucial process for cholesterol homeostasis and coronary heart disease, therapeutic approaches for selective modification of plasma HDL levels are not currently available. The three image aspects of difficulty, masculinity and heteronomy predicted explicit attitudes. In patients whose disease was at this more advanced phase, losartan or irbesartan led to lower levels of proteinuria, lower rates of decline in the glomerular filtration rate, and later onset of end-stage renal disease than the control medications, amlodipine and a mixture of drugs. The MESP values at the critical points (CPs) indicate overall lowering of aromaticity in these annelated systems. At the completion of the chemoradiation, patients without disease progression were given gemcitabine (1000 mg/m2) weekly for five cycles.

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We analyzed retrospectively the diagnostic accuracy of these two methods. Programs and policies to discourage the use of tobacco products. Imaging following allograft reconstruction in children with malignant bone tumours. In this paper we present an improved model for line and edge detection in cortical area V1. Widely used in hospitals it has now been adopted for use in hospices. Arterial spin labeling (ASL) is a developing magnetic resonance imaging (MRI) method for noninvasive measurement of cerebral blood flow (CBF). Expression of TGFbeta3 RNA during chick embryogenesis: a possible important role in cardiovascular development. This is the first report of a traumatic 3-column injury occurring through an asymptomatic pseudarthrosis site.

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Complete resection of macroscopic colorectal peritoneal carcinomatosis (PC), followed by intraoperative intraperitoneal chemohyperthermia (IPCH) to treat residual microscopic disease achieves cure in some patients. Here, we studied angiopoietin-like protein 4 (ANGPTL4), an upcoming cardiovascular marker, in stable COPD, and its relationship to cardiovascular function with respect to well-known CVD risk factors. The problem with any attempt to feed patients in multiple organ failure is that, because of an ongoing inflammatory process, the conventional techniques of supplying energy and protein do not maintain lean tissue mass. Soluble lignins were found as the key composition which promoted sugars utilization and cell viability without nutrient supplementary. Introduction to special issue on betrayal and recovery: understanding the trauma of clergy sexual abuse. This new elasticity imaging technique is based on remotely creating shear sources using an acoustic radiation force at different locations in the medium. Further randomized studies are needed to assess the benefit of simple or complex strategy in the treatment of specific subsets of bifurcated lesions. Seasonal variation in the Q-T interval, with reference to its variable part according to Gross.

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Determination of the severity of endogenous intoxication at the level of average molecular peptides. Patients with triple-negative breast cancer, when considered as a group, have a worse outcome after chemotherapy than patients with breast cancers of other subtypes, a finding that reflects the intrinsically adverse prognosis associated with the disease. The inhibition by EB-382 was equipotent to that of indomethacin on carrageenin-induced rat pleurisy and the zymosan air pouch, and it demonstrated a strong inhibition on the kallikrein and zymosan-induced intensive guinea-pig skin vascular permeability. These were measurement of detection threshold of CO2 mixed with air, measurement of the threshold concentration of CO2 that causes a transient reflex apnea, and measurement of the suprathreshold perceived strength of five levels of CO2 by the method of magnitude matching. Monocyte-macrophage mediated suppression is depo provera safe to take while breastfeeding of erythropoiesis in renal anaemia.

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