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Lasix

Lasix is used to reduce extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, and kidney disease. This can lessen symptoms such as shortness of breath and swelling in your arms, legs, and abdomen.This drug is also used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Lasix is a diuretic that causes you to make more urine. This helps your body get rid of extra water and salt.

Other names for this medication:
Aldalix, Anfuramide, Ansemid, Betasemid, Foliront, Frusemide, Frusenex, Furantral, Furesis, Furetic, Furide, Furocot, Furosemide, Furovet, Furoxem, Furozenol, Fursemid, Furtenk, Fusix, Inclens, Intermed, Jufurix, Lasilacton, Lasilactone, Lasiletten, Lasilix, Salix, Vesix

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Also known as: Furosemide

Description

{name} (furosemide) is a loop diuretic (water pill) that prevents your body from absorbing too much salt. This allows the salt to instead be passed in your urine.

{name} is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome.

{name} is also used to treat high blood pressure (hypertension).

Dosage

Adults. The usual initial daily dose is 20 to 80 mg given as a single dose. If the diuretic response to a single dose of 20 to 80 mg is not satisfactory, increase this dose by increments of 20 to 40 mg, not sooner than 6 to 8 hours after the previous dose, until the desired diuretic effect is obtained. This individually determined dose should be given once or twice (e.g. at 8 am and 2 pm) daily. The dose of Lasix may be carefully titrated up to 400 mg/day (except in advanced renal failure) in those patients with severe clinical oedematous states. The mobilisation of oedema may be most efficiently and safely accomplished by giving Lasix on 2 to 4 consecutive days each week.

When doses exceeding 80 mg/day are given for prolonged periods, careful clinical laboratory observations are particularly advisable.

Overdose

In case of a Lasix overdose visit your doctor or health care provider immediately. Symptoms of a Lasix overdose include fainting, tinnitus, confusion, weakness, lightheadedness, lack of appetite.

Storage

Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away unused furosemide solution after 90 days. Throw away any medicine that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medicine.

Side effects

The most common side effects associated with Lasix are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Excessive diuresis may result in dehydration and reduction in blood volume with circulatory collapse and with the possibility of vascular thrombosis and embolism, particularly in elderly patients.

Excessive loss of potassium in patients receiving cardiac glycosides may precipitate digitalis toxicity.

In patients with hepatic cirrhosis and ascites, initiation of therapy with Lasix is best carried out in hospital. Sudden alterations of fluid and electrolyte balance in patients with cirrhosis may precipitate hepatic coma, therefore, strict observation is necessary during the period of diuresis.

Cases of reversible or irreversible tinnitus or hearing impairment have been reported. Usually, reports indicate that Lasix ototoxicity is associated with rapid injection or infusion, severe renal impairment, hypoproteinaemia, doses exceeding several times the usual recommended dose, or concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs. In patients with hypoproteinaemia, e.g. associated with nephrotic syndrome, the effect of Lasix may be weakened and its ototoxicity potentiated. Cautious dose titration is required. If the physician elects to use high dose parenteral therapy, controlled intravenous infusion is advisable (for adults with normal renal function, an infusion rate not exceeding 4 mg Lasix per minute must be used; for adults with impaired renal function, an infusion rate of no greater than 2.5 mg per minute must be used).

Caution should be exercised when administering curare or its derivatives to patients undergoing frusemide therapy. It is also advisable to discontinue frusemide for one week prior to any elective surgery.

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These changes were associated with alterations in the kinetic properties of UDPglucuronyltransferase. Biological principles of individual differences of children in the second half-year of life. Death of a spouse or a child was found to increase the risk of dying directly and indirectly, whereas major financial difficulty during the past 5 years and current financial strain influenced mortality indirectly through their effects on self-rated health disability. To delineate the in vivo cardiac functions requiring normal delta protein kinase C (PKC) activity, we pursued loss-of-function through transgenic expression of a deltaPKC-specific translocation inhibitor protein fragment, deltaV1, in mouse hearts. Effect of grazing by poultry on the numbers of sheep parasitic larvae found on organic grassland. The role of diltiazem is discussed in respect of tissue protection and to the maintenance of the calcium-dependent physiological processes in the inner hair cells during signal transduction. Muscimol, an analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), is a potent agonist at postsynaptic GABA(A) and GABA(C) receptors. Protection against plague following immunisation with microencapsulated V antigen is reduced by co-encapsulation with IFN-gamma or IL-4, but not IL-6. Treatment of mania: a naturalistic study of electroconvulsive therapy versus lithium in 438 patients. The cumulative impact of nonsevere life events predicts depression recurrence during maintenance treatment with interpersonal psychotherapy.

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While correlation in severity between parent and child is poor, siblings do resemble each other in terms of severity, supporting the findings of segregation studies indicating significant genetic dominance in the heritable component of disease activity. A pharmacological treatment algorithm for localised neuropathic pain. A cardinal process in bacterial endocarditis (BE) is the activation of the clotting system and the formation of a fibrin clot on the inner surface of the heart, the so-called endocardial vegetation. ELISA kit for detection of biliary vesicular protein and its preliminary clinical application. The basic building block of the extra-cellular matrix in native tissue is collagen.

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Upper eyelid ptosis, measured by margin reflex distances, was improved. However, we show that some features of taxonomic interest are not correlated with total body length. Incubation of striatal slices with DL-2,4-dihydroxyphenylalanine (2,4-DOPA) resulted in biosynthesis and accumulation of 2,4-dihydroxyphenylethylamine, which was completely blocked by carbidopa. MRCP combined with dynamic contrast-enhanced MRI can be useful for detecting early bile duct cancers. Given the high rate of recurrent coronary events despite current antiplatelet therapies, agents with potentially greater efficacy are under investigation. This review brings together important issues concerning the spinal technique, anaesthetic agents and benefits as well as the disadvantages of spinal anaesthesia in outpatients.

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Insects have developed a mechanism different from that known for all other eukaryotes investigated so far. A Revised Approach for the Detection of Sight-Threatening Diabetic Macular Edema. The majority of newly generated cells in extrahippocampal areas proliferated in situ, and differentiated mainly into astrocytes or oligodendrocytes. The unusual nonlinear pharmacokinetics of mibefradil originates from the heterogeneous conditions in the reaction space of the enzymatic reaction. Long-term treatment of chronic hepatitis C with ursodeoxycholic acid: influence of HCV genotypes and severity of liver disease. The corresponding domain of the yeast Kluyveromyces lactis Mig1 conferred glucose-regulated Msn5-dependent protein export from the nucleus in S.

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Evolutionary analysis of 11beta-hydroxysteroid dehydrogenase-type 1, -type 2, -type 3 and 17beta-hydroxysteroid dehydrogenase-type 2 in fish. Three-dimensional ultrasound imaging provides reproducible, affordable and clinically relevant information in the assessment of urethral bulking agent therapy with collagen. To examine the population-based survival rates of patients with metastatic renal cell carcinoma (RCC) treated with cytoreductive nephrectomy (CNT) and compare them with those of patients treated without surgery. Spheroid model for functional osteogenic evaluation of human adipose derived stem cells. Clinical findings in patients with orofacial discomfort complaints. To date, the mechanisms of nAChR-mediated angiogenesis and their relationship to angiogenic factors, eg, VEGF and bFGF, are unknown. Lennox-Gastaut syndrome: potential mechanisms of cognitive regression.

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The distal end of the graft is beveled superiorly, to spare the origins of brachiocephalic vessels as in the standard bevel technique, but the incision line is curvilinear to form a concave cut end. Energy density analysis of cluster size dependence of surface-molecule interactions: H2, C2H2, C2H4, and CO adsorption onto Si(100)-(2x1) surface. Relation between Natural and Practical Ligand Binding Constants: Strong Implications for Extraction of Molecular-Level Information from the Temperature Dependence of Ligand Binding Equilibria. Self-prescription of medicines are common especially in low income countries.Paracetamol is a common medicine that is self-prescribed also among university students. However, in clinical studies, the relationship between hypertension and progression is difficult to demonstrate owing to confounding factors such as age, gender, race, difficulty in identifying blood pressure (BP) parameters that correlate with progression, abnormal circadian BP pattern, and many non-haemodynamic factors of progression.

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The A1 allele of the ANKK1 TaqIA polymorphism (previously reported as located in the D2 dopamine receptor (DRD2) gene) is associated with reduced DRD2 density in the striatum and with clinical disorders, particularly addiction. A novel, rapid and sensitive heterotypic cell adhesion assay for CD2-CD58 interaction, and its application for testing inhibitory peptides. The postoperative survival of 650 patients with gastric cancer who underwent D2 curative gastrectomy was analyzed with regard to the RML. A frequent mutation in the lipoprotein lipase gene (D9N) deteriorates the biochemical and clinical phenotype of familial hypercholesterolemia. Hybrid central giant cell granuloma and central odontogenic fibroma-like lesion of the mandible.

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Three different cases of acute pancreatitis and of a false cyst of the pancreas seen in Tongking within the period of four months. Polyphosphate and orthophosphate content of Nitrosomonas europaea as a function of growth. Pollination Flow in Hybrid Formation between Orchis morio and Orchis papilionacea (Orchidaceae) in Two Different Habitats. In silico analysis was done to identify conserved DNA sequence in the HMG box region of the sex-determining region of the Y-chromosome (SRY gene) across the bovids. Addition of graded doses of IL-12 with anti-CD3 resulted in a significant increase in both IFN-gamma and TNF-alpha.

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This study aimed to analyze hypotensive anesthesia (MAP less than 65 mm Hg) at incision for its effect on blood loss. Support and development of more pharmacist-directed anticoagulation, hyperlipidemia, and hypertension clinics are also needed. Epileptic spasms preceded by partial seizures with a close temporal association. The Woodcock-Johnson Test of Concentration showed better performance by the fourth grades and within Grade 4 in favor of the physical activity group. The number and intensity of immunostained cells increased over 2 hr after hCG injection. The more deprived area had a greater proportion of low birth weight and very low birth weight babies and more mothers who were in their teens and early teens. The 6-minute withdrawal time for colonoscopy, widely considered the standard of care, is controversial. There is overwhelming evidence that invasion of the central nervous system (CNS) by HIV-1 takes place at an early stage of the infection.

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For all other behavioral health disorders, pediatricians reported variability in both comfort and practice. Our study sought to understand the opinions Mexicans hold about abortion and sexuality and to learn about their fears and hopes about more liberalized abortion laws in Mexico. Noncatalytic Organic Synthesis Using Supercritical Water: The Peculiarity Near the Critical Point. Efforts to model pancreatic cancer in mice have focused on mimicking genetic changes found in the human disease, particularly the activating KRAS mutations that occur in pancreatic tumors and their putative precursors, pancreatic intraepithelial neoplasia (PanIN). Simplified tests for some amino acid decarboxylases and for the arginine dihydrolase system. Convincing reliability was found in the evaluation of disc- and muscle-related MRI variables. Currently it is known that a tumor response to trastuzumab strongly correlates with the level of HER2 expression evaluated by the Hercep Test, thus, it seems desirable to evaluate the status of expression of this receptor using the FDA-approved Hercep Test and grading system to gain insight in the feasibility of using trastuzumab in cervical cancer patients. Other closely related sites do not compete for this binding, implying a restriction enzyme-like binding specificity. Risk model for severe anemia requiring red blood cell transfusion after cytotoxic conventional chemotherapy regimens.

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Acquired pure red cell aplasia associated with malignant B cell lymphoma. However, immune-related adverse events are common and can be severe. In addition, a cell culture derived from a nonneurofibromatosis human malignant astrocytoma showed apolipoprotein E expression. To identify which factors influence the plavix dose range final visual acuity in children with anisometropic amblyopia. This paper aims to study the detection of individuals malingering posttraumatic stress disorder (PTSD) in criminal and civil situations. Liver, distal kidney and muscle transcriptomes of salmon exposed to the extreme dose of GLs were profiled by microarray, while qPCR analysis followed up selected hepatic and renal responses under the extreme and moderate GLs dose during the L. The advantages and limitations are discussed and recent developments such as MR-coil designs and MR-sequences are presented. Accordingly, inhibition of fatty acid oxidation, or stimulation of CrAT, may be a novel approach to treatment of insulin resistance.

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Fear of cancer recurrence and physical well-being among Chinese cancer survivors: the role of conscientiousness, positive reappraisal and hopelessness. Irreversible binding and metabolism of propranolol by human liver microsomes--relationship to polymorphic oxidation. These results should be considered as a useful benchmark for future studies, until further data is reported in the form of randomized trials. Stereotactic radiosurgery with low radiation dose under the guidance of PET provides a safe, effective and minimally invasive surgical approach for patients with intractable epilepsy, and peripheral radiation doses of 9 to 11 Gy for the epileptic foci localized by PET is sufficient to ensure good clinical outcome. Postnatal development and regulation of proteins secreted in the boar epididymis. Although rat is a critical model organism in preclinical medications development, its use in systems genetics studies remains sparse. Four mutants were unable to produce hydroxamate, six were hydroxamate positive, one was temperature sensitive for pyoverdin production, and another was unable to synthesize pyoverdin on succinate minimal medium but was capable of synthesizing pyoverdin when grown on Casamino Acids medium (Difco Laboratories, Detroit, Mich.). Both AG1478 and ZD1839 inhibited expression of Cox-2 protein, whereas celecoxib mainly blocked the production of prostaglandin E(2). This limitation impedes the widespread use of EEG in assessing real-time brain function in critically ill patients.

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PD98059 also ameliorated pancreatitis over a 6-hour cerulein time course. Within the classical framework, it is shown that the doubling of the p-value results from a discontinuity due to testing a point null hypothesis. Microwave-assisted synthesis of sensitive silver substrate for surface-enhanced Raman scattering spectroscopy. The structure of the ligand-binding domain of neurexin Ibeta: regulation of LNS domain function by alternative splicing. A mutation in the mPer2 gene leads to a gradual loss of circadian rhythmicity in mice kept in constant darkness (DD). Arthroereisis is a rare and disputed procedure, where an implant screw is inserted into the sinus tarsi to treat flatfoot deformity. We suggest that for some types of objects, dynamic information may be weighted differently by pigeons and humans. Methodologic difficulties and personality approach in the psychological study of the aged.

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Although cyclin D1 immunohistochemistry does not stain as intensely as p53 stain, similar conclusions can be derived from those data. As Macleaya cordata contains diverse types of benzylisoquinoline alkaloids (BIAs), the alkaloid metabolite profiling was carried out on various tissues of the root. Targeted therapies have revolutionized the treatment of cancer in recent years. However, data subsequently derived from work on a model of diffuse lung disease indicates that the external shape of the lobes and lungs may be the most significant contributor to the optimal views of the lungs. Clinical presentation on-admission has a strong impact on in-hospital prognosis.

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The aim of this study was to evaluate plasma lipid levels in sibling pairs with gallstones and to assess their correlation with common gene polymorphisms in the ABCG5/ABCG8 genes. Thirty-three gate power m-mode transcranial Doppler (pmTCD) was evaluated for its accuracy in diagnosis of PFO and utility in evaluating residual intracardiac right-to-left shunt (RLS) following transcatheter closure. Role of carbon dioxide in the maintenance of positive changes in myocardial metabolism and the mechanisms of cardiac regulation after physical exercise training. The equilibrium and kinetic drug binding properties of the mouse P-gp1a and P-gp1b P-glycoproteins are similar. Chronic urticaria is not significantly associated with hepatitis C or hepatitis G infection: a case-control study. Transient modulation and internalization of T4 antigen induced by phorbol esters. These data were consistent with the N-terminus of SCP2 providing a membrane interaction domain that preferentially bound to membranes rich in anionic phospholipid and cholesterol. Micrometastases do not provide prognostic information on survival.

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The membrane receptors reported to bind directly to Dab2 include LDL receptor and its family members LRP1 and LRP2 (megalin), growth factor receptors EGFR and FGFR, and the cell adhesion receptor beta1 integrin. In patients with cholestatic liver disease, the extent of hepatocyte damage caused by intracellular accumulation of bile acids appears to be delayed by ingesting a hydrophilic bile acid. Effect of anti-Ia antibodies, culture, and cyclosporin on prolongation of canine islet allograft survival. There is a subgroup of nulliparous patients that will probably be candidates to induction of labour. Enzymatic activity was appraised in vivo by serotonin (5-HT) accumulation or 5-hydroxyindole acetic acid (5-HIAA) disappearance with time after systemic administration of MAO inhibitors. Nineteen SSc patients, 22 patients affected by SSc associated with autoimmune thyroiditis, and 100 healthy controls were analyzed.

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Developing, delivering, and evaluating cancer nursing services: searching for a United Kingdom evidence base for practice. The APOE polymorphism was not associated with the risk of cognitive impairment in MS patients. Microtubular protein (tubulin) isolated from porcine brain was subjected to selected oxidative stresses, including incubation with the neurotoxin 6-hydroxydopamine (6-OHDA) under aerobic and anaerobic conditions. The form of expression, the goals as well as the sources of these aggressive behaviors are examined. Surviving the butterfly and the wolf: mortality trends in systemic lupus erythematosus.

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