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Lunesta (Eszopiclone)

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EsLunesta, marketed by Sunovion under the brand-name Lunesta, is a nonbenzodiazepine hypnotic agent used in the treatment of insomnia. It is slightly effective for this use. Lunesta is the active dextrorotatory stereoisomer of Lunesta, and belongs to the class of drugs known as cyclopyrrolones. It is also classified as a therapeutic sedative hypnotic and pharmacological cyclopyrrolone.

Other names for this medication:
Bexomer, Eszopiclone, Fulnite, Zolnite, Zopimin, Zopipure

Similar Products:
Aurogra, Parlodel, Dostinex, Benicar, Cenforce, Alprostadil, Priligy, Zyvox

Also known as: Eszopiclone


{name} (eszopiclone) is a sedative, also called a hypnotic. It affects chemicals in your brain that may be unbalanced in people with sleep problems (insomnia).

{name} is used to treat insomnia.

{name} causes relaxation to help you fall asleep and stay asleep.


Read the Medication Guide provided by your pharmacist before you start using Lunesta and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually just before you get into bed. Do not take it with or right after a high-fat or heavy meal since it may not work as well. The dosage is based on your medical condition, age, liver function, other medications you may be taking, and response to treatment. Do not take more of this medication than prescribed because your risk of side effects will increase. The starting dose is 1 milligram at bedtime as directed. That dosage lessens the risk of having trouble safely doing activities requiring alertness the next day (such as driving or operating machinery). Also, you may not be fully alert the next day, yet you think you are fully alert. If you are prescribed the 3 milligram dosage of Lunesta, you should not do activities the next day that require alertness. Ask your doctor or pharmacist for more details.

If you are an older adult or you have liver disease, a low dose will usually be prescribed to lessen the risk of being impaired the next day. Do not stop your medication without talking to your doctor or pharmacist.


According to the U.S. Prescribing Information, overdoses of Lunesta up to 90 times the recommended dose have been reported in which the patient fully recovered. According to the May 2014 edition of the official U.S. Prescribing Information, fatalities have been reported only in cases in which eszopliclone was combined with other drugs or alcohol.

Texas poison control centers reported that during 2005–2006 there were 525 total Lunesta overdoses recorded in the state of Texas, the majority of which were intentional suicide attempts.

If consumed within the last hour, Lunesta overdose can be treated with the administration of activated charcoal or via gastric lavage.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Do not share this medication with others. It is against the law.

Side effects

The most common side effects associated with Lunesta are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There is an increased risk of increased central nervous system depression when it is used with eszopicolone including anti-psychotics, sedative/hypnotics, antihistamines, opioids, and antidepressants. There is also increased risk of increased risk of central nervous system depression with other medications that inhibit the metabolic activities of the CYP3A4 enzyme system of the liver. Medications that inhibit this enzyme system include nelfinavir, ritonavir, ketoconazole, itraconazole and clarithromycin. Alcohol also has an additive effect when used concurrently with eszopicolone. Eszopicolone is most effective if it is not taken after a heavy meal with high fat content.

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Visual perception has hindered the development of blinded, placebo-controlled ultraviolet light exposure conditions in humans. The aim of our study was to investigate whether ocular saccades also evoke movement related EEG changes. Outcome following initial external beam radiotherapy in patients with Reese-Ellsworth group Vb retinoblastoma. The pattern of infertility diagnoses in women of advanced reproductive age. The synergistic effect of co-administration of ezetimibe with statins seemingly offers a new approach in reaching the therapeutic goals. Representing nursing judgements in the electronic health record.

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A specific inhibitor of JNK, SP600125, abolished paclitaxel-induced HO-1 mRNA expression, whereas PD98059, a specific inhibitor of ERK, and SB203580, a specific inhibitor of p38, had no significant effect. Formalin-embedded tissues of cardiac myxomas were obtained by surgical resection from 15 patients and analyzed by immunostaining of bFGF and FGFR-1. We report 13 cases of locking screw migration from tibial component after Duracon posterior stabilized primary total knee arthroplasty. The exceptionally high stereoselectivity of this allylation in the presence of an acid-scavenger, 2,6-DTBMP, can be attributed to the allylsilyl ether 16 behaving as the allylating agent. The antidiabetic agents, incretins, have been used successfully to treat psoriasis - a disease also associated with metabolic syndrome. Controversy in heart failure management: Digoxin use in the elderly. Beta testing of a network-based health literacy program tailored for older adults with hypertension. We examined the effect of locally administered theophylline on active hyperemia and myocardial adenosine production during intracoronary isoproterenol infusion in the dog heart. Regardless of the presence of TBI, the classification of hypovolemic shock based on the SI enables a fast and reliable assessment of hypovolemic shock in the emergency department. There is a growing appreciation that the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway is organized to form transduction units that function to deliver specific messages.

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Alzet miniosmotic pumps were implanted SC to administer saline or three different concentrations of nicotine to female Sprague-Dawley rats for 17 days. The objective of this study was to evaluate a novel personal bioaerosol sampler designed to collect the inhalable dust fraction and further subdivide the sample into thoracic and respirable fractions. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. However, the observed CTL lysis was low and cofeeding of biaxin xl filmtab encapsulated peptide with cholera toxin as a mucosal adjuvant did not result in any significant enhancement of the observed CTL responses. Seizures with identical onset were precipitated predictably by two independent triggers, micturition and immersion of the feet in tepid or hot water. Cyclic GMP and cyclic AMP induced changes in control and hypertrophic cardiac myocyte function interact through cyclic GMP affected cyclic-AMP phosphodiesterases. Midterm Results of Renal Transplantation From Controlled Cardiac Death Donors Are Similar to Those From Brain Death Donors. We evaluated the involvement of IAR3 genes in defense responses by using virus-induced gene silencing. to examine mortality, mobility, pain, institutionalization rates six month after hip fractures. The devised multilevel mediation analysis of the temporal characteristics of EEG microstates during ITI provides a new window into the neurobiology of decision making by bringing the spontaneous brain activity to the forefront of the analysis.

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Strains cured of the 110 MDa or the 60 MDa plasmid were more than 100-fold less virulent to mice than were the parental strains harbouring these plasmids. Eating infected wild birds may put wild carnivores at high risk for infection with highly pathogenic avian influenza (HPAI) virus (H5N1). The significance and management of meconium in the liquor amnii during labor. Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights can you buy prilosec 40 mg over the counter into the metabolism of small branched-chain fatty acids and macrolide antibiotic production. Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity. Combining radiation with mitomycin and cisplatin in patients with locally advanced anal cancer is feasible. TH was lower in the substantia nigra of dystonic than in inbred controls. The few tests of this prediction often neglect the fact that sexual selection acts through multiple mechanisms, both before and after mating.

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Awareness about morphologic differences between the 2 types of LPGs could help to avoid a potential diagnostic pitfall of misinterpreting SVED epithelium for adenocarcinoma. A novel, high stringency selection system allows screening of few clones for high protein expression. Effects of peripheral administration of 5-hydroxytryptamine (5-HT ) on 2-deoxy-D-glucose-induced hyperphagia in rats. Efficacy and safety of photodynamic therapy versus Nd-YAG laser resection in NSCLC with airway obstruction. Mixtures of amorphous (high-energy) and crystalline (lower energy) lactose particles were prepared and tested using IGC with nonpolar probes. This study provides this step for further evaluation of this arthroscopic training device.

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Unequal access to cadaveric kidney transplantation in California based on insurance status. Among several candidate genes that promote peritoneal dissemination extracted by comprehensive expression analysis of both in vivo selected metastatic cell lines and patients with gastric cancer, we focused on the chemokine (C-X-C motif) receptor (CXCR7) and explored its clinicopathological significance in gastric cancer. A 71-year-old woman complained of a sudden onset of right upper abdominal pain with development of peritoneal signs at 21 days after coronary artery bypass grafting. A common functional ENPP1 K121Q polymorphism has been suggested to contribute to insulin resistance, obesity and type 2 diabetes (T2D) in various ethnic groups. Survival analysis of APD patients, especially in cohorts in which icodextrin has been used, would suggest that high transport status is not a risk factor, although some of these data are only preliminary. The Council is of the opinion that an OEL should prevent against allergic sensitization, as sensitization plays a crucial biological role and is a prerequisite for the development of allergy. It was found that 107 genes were associated with liver regeneration. To experimentally verify the suggestion of Gullstrand (1909), i.e., that the equivalent refractive index of the human lens increases with accommodation.

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Leukocyte oxidative metabolism was measured by means of luminol-enhanced chemiluminescence and superoxide generation after stimulation with Staphylococcus aureus or phorbol myristate acetate. Relationship between availability of NMDA receptor subunits and their expression at the synapse. Recently accepted codes in the Current Procedural Terminology system permit licensed pediatric psychologists to deliver psychological services utilizing billing codes that focus on improving medical and physical health. Therefore, the predialysis period is the ideal time to start therapeutic interventions. The eNOS gene polymorphisms side effects of prometrium 200 mg may contribute to the development of macular edema by impairing basal eNOS expression and resulting in the breakdown of the blood-retina barrier. Dysaesthesia in the palmar region and loss of grip strength prevented performing normal daily activities. Interleukin-10 is localized to and released by human lung mast cells. We found that serum-starved NHERF1 knockdown cells had a faster G1-to-S transition after serum re-stimulation than the control cells.

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