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Provigil (Modafinil)

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Provigil is used in the treatment of excessive daytime sleepiness (narcolepsy). It improves wakefulness and helps you to stay awake and reduces the tendency to fall asleep during the day, thus restoring the normal sleep cycle.

Other names for this medication:
Alertec, Carim, Dekast, Modafinil, Modafinilo, Modalert, Modapro, Modatec, Modavigil, Modfil, Modiodal, Provake, Renea, Vigia

Similar Products:
Lodine, Omnicef, Sovaldi, Zetia, Moduretic, Nizoral, Precose, Noroxin

Also known as: Modafinil


Provigil is prescribed for people who suffer from sleep disorders or narcolepsy - a pathological sleepiness associated with brain disorders. The active component of Provigil is Modafinil. Researches have shown numerous advantages of using Modafinil as a stimulator in comparison with amphetamines. Provigil doesn't cause addiction syndrome, it almost does not cause euphoria, reduces the peripheral nervous system tension and has very small effect on blood pressure.


The Provigil dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Provigil to treat
  • your age
  • other medical conditions you may have
Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Dosage for narcolepsy and sleep apnea

For daytime sleepiness caused by narcolepsy or obstructive sleep apnea, the typical dosage is 200 mg once a day in the morning. Higher doses are sometimes used, up to 400 mg daily. However, these doses may not be any more effective than 200 mg daily.

Dosage for shift work sleep disorder

For excessive sleepiness due to shift work sleep disorder, the typical dosage is 200 mg taken about one hour before the start of your work shift.

Dosage for people with liver problems

If you have severe liver problems, your doctor will likely prescribe a lower dosage. The recommended dosage for people with this condition is typically 100 mg daily.

Dosage for seniors

Seniors may be more sensitive to the effects of Provigil, especially side effects. If you’re over 65 years of age, your doctor may prescribe a lower dosage.

What if I miss a dose?

If you miss a dose, take it as soon as you remember. Remember that Provigil will keep you awake, so don’t take it unless you plan to be awake for several hours. If it’s close to your bedtime, skip the missed dose and take it the next day at the normal time.

Never try to catch up by taking two doses at a time. This can cause dangerous side effects.

Will I need to use this drug long-term?

Yes, Provigil is usually taken long-term by people with narcolepsy or sleep apnea. These are chronic conditions that often require long-term treatment to improve symptoms of daytime sleepiness.


If you overdose Provigil and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Provigil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Provigil if you have ever had an allergic reaction or skin rash while taking modafinil or armodafinil (Nuvigil).

To make sure Provigil is safe for you, tell your doctor if you have:

angina (chest pain); cirrhosis or other liver problem; kidney disease; high blood pressure, heart disease, or history of heart attack; a history of mental illness or psychosis; or history of alcoholism or drug addiction.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Provigil can make certain birth control less effective. Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment. Talk with your doctor about the best methods of birth control to use while taking Provigil.

It is not known whether modafinil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Provigil is not approved for use by anyone younger than 17 years old.

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Perfluorinated compounds in coastal waters of Hong Kong, South China, and Korea. Molecular mechanisms of chemoprevention and therapy of cancer by retinoids. Controlled studies examining the gut microbiome in patients with MS were included for review. To clarify the relationship between these genes in Xenopus laevis, we isolated pMesogenin2, which showed high homology with pMesogenin1. Leaking blebs may be encountered in the early postoperative period, or months to years after filtering surgery. Management of patients who develop NMBD myopathy is supportive, consisting of nutritional support, physical therapy, and daily trials of decreased ventilatory support. Our report suggests that HIV-positive patients with prior cryptococcal systemic infection may present a re-exacerbation of atypical cryptococcosis as a manifestation of immune restoration, even when fluconazole prophylaxis is ongoing. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. A further independent sample extracted by an ongoing cancer clinical trial served as final validation step.

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Pragmatic randomised controlled trial of local corticosteroid injection and naproxen for treatment of lateral epicondylitis of elbow in primary care. The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin. The similarities between the implant incorporation process found in the experiment and its simulation with the computer model demonstrate that our hypothesis is viable from a regulatory point of view. The activation of IR was analyzed using specific antibodies against phosphotyrosine. A small but significant (P less than 0.05) reduction in PaCO2 occurred when the RFG was moved to the distal end of the tracheal tube. albicans may compensate for the deletion of certain SAP genes by upregulation of alternative SAP genes. Since circulating proteasome 20S has recently emerged as an important marker of tumor progression, the possibility of proteasomes controlling the production of angiostatic endostatin may inspire the development of new anticancer therapies. Considering the standards of diagnosis, treatment, and results assessment, a high quality of palliative treatment can be assumed.

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Intermolecular N-H...N hydrogen bonds between tetrazole moieties were observed in all four structures and are compared with the analogous interactions observed in tetrazole derivatives deposited in the Cambridge Structural Database (CSD). Integrin structures have been solved by X-ray crystallography, revealing unexpected data about the activation mechanism of integrins in cells. This study investigated this topic in otherwise healthy patients receiving buffy coat-depleted or WBC-filtered RBCs and undergoing standardized perioperative management. Because the mitochondrial membrane potential (MMP) reflects the functional status of mitochondria and metastasis is the principal cause of death due to cancer, the relationship between MMP and metastasis was evaluated. monocytogenes resulted in diminished development of T-cell reactivity to this organism. We compared the CSF proteomes from patients with neoplastic and reactive/inflammatory CNS diseases to identify seroquel medication classification benzo potential biomarkers. The IFN-beta-induced cell cycle effect has been implicated in the antitumor effect of combinations of IFN-beta and chemotherapeutic drugs.

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Pimavanserin tartrate: a 5-HT2A inverse agonist with potential for treating various neuropsychiatric disorders. Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4). Microbial diversity and activity through a permafrost/ground ice core profile from the Canadian high Arctic. Interestingly, due to the presence of a redox sensitive TEMPO moiety, an enhancement in the intracellular fluorescence of TEMPO-functionalized Ru(ii) complexes was observed during photodynamic treatment in both confocal microscopy and flow cytometry. A mixed culture containing methane-utilizing bacteria was obtained by methane enrichment of a sediment sample. Our findings demonstrate that sex influences the chondrogenic differentiation and articular cartilage regeneration potential of MDSCs. Late radiation-induced skin effects were studied in a multicenter project using our new sensitive noninvasive viscoelasticity skin analyzer (VESA). This bipartite transcription factor is targeted to the upstream regulatory regions of Tcf target genes including Siamois and Nodal related gene-3 in Xenopus, engrailed and Ultrabithorax in Drosophila via the sequence-specific HMG box, and mediates their transcriptional activation by virtue of transactivation domains contributed by beta-catenin/Armadillo.

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