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Provigil (Modafinil)
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Provigil

Provigil is used in the treatment of excessive daytime sleepiness (narcolepsy). It improves wakefulness and helps you to stay awake and reduces the tendency to fall asleep during the day, thus restoring the normal sleep cycle.

Other names for this medication:
Alertec, Carim, Dekast, Modafinil, Modafinilo, Modalert, Modapro, Modatec, Modavigil, Modfil, Modiodal, Provake, Renea, Vigia

Similar Products:
Lodine, Omnicef, Sovaldi, Zetia, Moduretic, Nizoral, Precose, Noroxin

Also known as: Modafinil

Description

Provigil is prescribed for people who suffer from sleep disorders or narcolepsy - a pathological sleepiness associated with brain disorders. The active component of Provigil is Modafinil. Researches have shown numerous advantages of using Modafinil as a stimulator in comparison with amphetamines. Provigil doesn't cause addiction syndrome, it almost does not cause euphoria, reduces the peripheral nervous system tension and has very small effect on blood pressure.

Dosage

The Provigil dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Provigil to treat
  • your age
  • other medical conditions you may have
Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Dosage for narcolepsy and sleep apnea

For daytime sleepiness caused by narcolepsy or obstructive sleep apnea, the typical dosage is 200 mg once a day in the morning. Higher doses are sometimes used, up to 400 mg daily. However, these doses may not be any more effective than 200 mg daily.

Dosage for shift work sleep disorder

For excessive sleepiness due to shift work sleep disorder, the typical dosage is 200 mg taken about one hour before the start of your work shift.

Dosage for people with liver problems

If you have severe liver problems, your doctor will likely prescribe a lower dosage. The recommended dosage for people with this condition is typically 100 mg daily.

Dosage for seniors

Seniors may be more sensitive to the effects of Provigil, especially side effects. If you’re over 65 years of age, your doctor may prescribe a lower dosage.

What if I miss a dose?

If you miss a dose, take it as soon as you remember. Remember that Provigil will keep you awake, so don’t take it unless you plan to be awake for several hours. If it’s close to your bedtime, skip the missed dose and take it the next day at the normal time.

Never try to catch up by taking two doses at a time. This can cause dangerous side effects.

Will I need to use this drug long-term?

Yes, Provigil is usually taken long-term by people with narcolepsy or sleep apnea. These are chronic conditions that often require long-term treatment to improve symptoms of daytime sleepiness.

Overdose

If you overdose Provigil and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Provigil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Provigil if you have ever had an allergic reaction or skin rash while taking modafinil or armodafinil (Nuvigil).

To make sure Provigil is safe for you, tell your doctor if you have:

angina (chest pain); cirrhosis or other liver problem; kidney disease; high blood pressure, heart disease, or history of heart attack; a history of mental illness or psychosis; or history of alcoholism or drug addiction.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Provigil can make certain birth control less effective. Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment. Talk with your doctor about the best methods of birth control to use while taking Provigil.

It is not known whether modafinil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Provigil is not approved for use by anyone younger than 17 years old.

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Serum LDH levels at 60 min after start of reperfusion in both SNP groups were significantly lower than in the control group. Micro-morphological analisys of enamel and dentin exposed to picosecond-pulsed Nd: YAG laser. The spleen was inserted in a Vicryl mesh bag and fixed in the left upper quadrant in both cases. Potential answers for both questions will be outlined during the third and fourth sections, respectively, in order to design a framework to study the molecular profile of body embodiment. Twelve healthy volunteers received an oral digoxin loading dose of 1 mg on day 1, followed by 0.125 mg once daily to day 11. Surface-exposed loops on knob contact one face of CAR, forming a high-affinity complex. Under lag phase conditions, 15N resonances of residues that constitute the beta-strands of native CspA are selectively broadened with increasing protein concentration. Leukopenia and changes of differential blood cell count in peripheral blood as an evidence of active focal infection in patients with neurovegetative disturbances.

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The time spent in the mild and moderate disease states (taken together) was considerably longer in patients treated with riluzole than in those treated with placebo (317 days compared with 242 days). Combining a united atom representation for the side chains with the fully atomistic description of the core, we study the effect of side chain substitution on the transition temperatures as well as molecular ordering in the mesophases. Has There Been Adequate Progress in Addressing the NCD Epidemic in LMIC?. It has been assumed that the majority of circulating ApoL1 is produced by the liver, but this has not been shown. Leukocytopenia and anemia (grade 2) were the only observed adverse effects. The mothers with postpartum depression accomplish a childrearing on their children characterized by a lower affection and care. Activation of DeltaRafER by estradiol overrode stromal blockade of megakaryocytic differentiation, implicating the proximal stage of the ERK/MAPK pathway as a relevant control point.

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Perfluorinated compounds in coastal waters of Hong Kong, South China, and Korea. Molecular mechanisms of chemoprevention and therapy of cancer by retinoids. Controlled studies examining the gut microbiome in patients with MS were included for review. To clarify the relationship between these genes in Xenopus laevis, we isolated pMesogenin2, which showed high homology with pMesogenin1. Leaking blebs may be encountered in the early postoperative period, or months to years after filtering surgery. Management of patients who develop NMBD myopathy is supportive, consisting of nutritional support, physical therapy, and daily trials of decreased ventilatory support. Our report suggests that HIV-positive patients with prior cryptococcal systemic infection may present a re-exacerbation of atypical cryptococcosis as a manifestation of immune restoration, even when fluconazole prophylaxis is ongoing. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. A further independent sample extracted by an ongoing cancer clinical trial served as final validation step.

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Pragmatic randomised controlled trial of local corticosteroid injection and naproxen for treatment of lateral epicondylitis of elbow in primary care. The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin. The similarities between the implant incorporation process found in the experiment and its simulation with the computer model demonstrate that our hypothesis is viable from a regulatory point of view. The activation of IR was analyzed using specific antibodies against phosphotyrosine. A small but significant (P less than 0.05) reduction in PaCO2 occurred when the RFG was moved to the distal end of the tracheal tube. albicans may compensate for the deletion of certain SAP genes by upregulation of alternative SAP genes. Since circulating proteasome 20S has recently emerged as an important marker of tumor progression, the possibility of proteasomes controlling the production of angiostatic endostatin may inspire the development of new anticancer therapies. Considering the standards of diagnosis, treatment, and results assessment, a high quality of palliative treatment can be assumed.

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Intermolecular N-H...N hydrogen bonds between tetrazole moieties were observed in all four structures and are compared with the analogous interactions observed in tetrazole derivatives deposited in the Cambridge Structural Database (CSD). Integrin structures have been solved by X-ray crystallography, revealing unexpected data about the activation mechanism of integrins in cells. This study investigated this topic in otherwise healthy patients receiving buffy coat-depleted or WBC-filtered RBCs and undergoing standardized perioperative management. Because the mitochondrial membrane potential (MMP) reflects the functional status of mitochondria and metastasis is the principal cause of death due to cancer, the relationship between MMP and metastasis was evaluated. monocytogenes resulted in diminished development of T-cell reactivity to this organism. We compared the CSF proteomes from patients with neoplastic and reactive/inflammatory CNS diseases to identify seroquel medication classification benzo potential biomarkers. The IFN-beta-induced cell cycle effect has been implicated in the antitumor effect of combinations of IFN-beta and chemotherapeutic drugs.

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After subdividing the rectangular piston into smaller rectangles, the pressure produced by each of the smaller rectangles is calculated using the uniformly excited FNM expression for a rectangular piston, and the total pressure generated by an apodized rectangular piston is the superposition of the pressures produced by all of the subdivided rectangles. To explore this approach, we used a viability test, an immunofluorescence microscopy to detect Histone phosphorylation and mitotic spindle aberrations. The results of the current study suggest that p53 mutations, loss of bcl-2 expression, and tumor angiogenesis are events linked to the processes of metastases and local invasion in patients with colorectal carcinoma. The result of processing experimental data shows that the uncertainty of determining the period with this method has been improved about twofolds than traditional correlation method, which is significant for the determination of gravitational constant with time-of-swing method. Upon pretreatment with GdA and lipitor 60 mg subsequent maturation with tumor necrosis factor-alpha and interleukin (IL)-1beta, moDC displayed a reduced expression of costimulatory molecules, an unchanged major histocompatibility complex-II expression and persistence of DC-SIGN positive cells. Despite the limitations of these tests in predicting carcinogenicity, the genotoxicity of mycotoxins as shown by the results of a battery of genotoxicity tests indicates that mycotoxins are indeed a class of significant naturally occurring environmental carcinogens which warrant rigorous regulatory actions. The vascular stiffening mechanism in the tongue of the echidna (Tachyglossus aculeatus). All inoculated sheep remained clinically normal except for mild pyrexia between PID 12 and 18. Differential diagnosis of chronic fatigue syndrome and major depressive disorder.

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Pimavanserin tartrate: a 5-HT2A inverse agonist with potential for treating various neuropsychiatric disorders. Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4). Microbial diversity and activity through a permafrost/ground ice core profile from the Canadian high Arctic. Interestingly, due to the presence of a redox sensitive TEMPO moiety, an enhancement in the intracellular fluorescence of TEMPO-functionalized Ru(ii) complexes was observed during photodynamic treatment in both confocal microscopy and flow cytometry. A mixed culture containing methane-utilizing bacteria was obtained by methane enrichment of a sediment sample. Our findings demonstrate that sex influences the chondrogenic differentiation and articular cartilage regeneration potential of MDSCs. Late radiation-induced skin effects were studied in a multicenter project using our new sensitive noninvasive viscoelasticity skin analyzer (VESA). This bipartite transcription factor is targeted to the upstream regulatory regions of Tcf target genes including Siamois and Nodal related gene-3 in Xenopus, engrailed and Ultrabithorax in Drosophila via the sequence-specific HMG box, and mediates their transcriptional activation by virtue of transactivation domains contributed by beta-catenin/Armadillo.

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Detoxification of LysoPC by reacylation occurred in both the H99 wild-type and the Deltaplb1 strains in the presence of glucose, but PLB1 was required when LysoPC was the sole carbon source. Application of low tension Roux-y sigmoid neobladder in urine diversion. Idiopathic thrombocytopenic purpura in a newly diagnosed pancreatic adenocarcinoma. A case series of 68 patients with extraperitoneal rectal cancer treated with neoadjuvant chemoradiation and surgery (including total mesorectal excision) were investigated for presence of neoplastic MMF. Because a large number of studies, however, have focused on two-state proteins with single well-defined folding pathways and without detectable intermediates, the extent to which free energy landscapes are shaped up by the native topology at the early stages of the folding process has not been fully characterized experimentally.

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A biometric study based on 20 human scapulae made it possible to specify the variations in the gap of the coraco-acromial arch in relation to its depth and height. Spirolactams as conformationally restricted pseudopeptides: synthesis and conformational analysis. However, calcification and degeneration are common following their implantation. Taking estimates from previous studies often leads to a misspecification of the true value of the variance. Congenital afibrinogenaemia is a rare autosomal recessive disorder, characterized by the complete absence or extremely reduced level of fibrinogen (Fg). To increase the accumulation of mitoxantrone in solid tumor by synthesis and characterization of N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer-mitoxantrone conjugate (p-DHAQ). Poor conductivity materials, like PU foam, make better molds for the characterization of bone cement thermal behavior.

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