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Skelaxin (Metaxalone)

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Skelaxin is a muscle relaxer. It provides relief from the discomfort associated with acute, painful musculoskeletal conditions such as rigidity, tension, stiffness, and muscle spasms.

Other names for this medication:
Fenaplus, Flexura, Metadol, Metaxalone, Mobiswift, Skeltab

Similar Products:
Avapro, Vasotec, Rocaltrol, Cenforce, Feldene, Omnicef

Also known as: Metaxalone


{name} (metaxalone) is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) in the brain.

{name} is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.


Usual Adult Dose for Muscle Spasm:

800 mg orally 3 to 4 times a day.

Usual Pediatric Dose for Muscle Spasm:

>= 12 years: 800 mg orally 3 to 4 times a day.

Detailed Skelaxin dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of metaxalone can be fatal.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Skelaxin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with Skelaxin. Check your food and medicine labels to be sure these products do not contain alcohol.

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Dizziness or drowsiness may be more likely in older adults.

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Blind and bilateral conjunctival biopsy, due to its ease, safety and specificity, could be the first biopsy inpatients with clinical or chest X-ray abnormalities suggesting sarcoidosis. Any mechanism breaking down this harmony by changing the relative levels of these antagonistic proteins could contribute to many diseases, including cancer and neurodegenerative disorders. Data are presented demonstrating the quantitation of fluorescent microspheres. Evaluating the economic consequences of early antidepressant treatment discontinuation: a comparison between controlled-release and immediate-release paroxetine. On the expression of cell cycle regulatory proteins, ferulic acid elevated the protein content of p21(waf1/cip1), decreased expression of cyclin D1 and inhibited phosphorylation of retinoblastoma protein, suggesting that ferulic acid inhibited VSMC proliferation by regulating the cell progression from G1 to S phase. ML-S1 has been purified by chromatography of ribosomes on a poly(U)-Sepharose column and the purified protein has a mobility in sodium dodecyl sulphate/polyacrylamide gels similar to that of ribosomal protein S1 of Escherichia coli (apparent Mr 72,000). Effect of 2,5-anhydro-D-mannitol on membrane potential in rat hepatocyte couplets and hepatocyte monolayer cultures. Editorial overview: newborn screening for cystic fibrosis--benefit or bane?. Whether directives are written or unwritten is of secondary importance. In patients with ileus after colonic surgery, gum chewing in addition to standard treatment significantly reduces the time to first flatus and the time to first passage of feces when compared to standard treatment alone.

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Gene expression of prostanoid forming enzymes along the rat nephron. Goal-oriented emergency sonography for trauma patients (FAST-protocol). From the results, the measured frequency change was about 256 Hz, 160 Hz and 141 Hz, respectively. Among auto-HSCT group, 39 patients received purged autologous bone marrow and 38 received immunotherapy and/or maintenance chemotherapy after transplant. Respiratory infection rates differ between geographically distant paediatric cystic fibrosis cohorts. The proposed cryptosystem is a hierarchical security system that can use multiple phase keys to retrieve different amounts of data. The agglutinating activity of the adhesin was inhibited with N-acetyl-D-glucosamine (GlcNAc), and in a lesser degree with N-acetyl-neuraminic acid (NeuAc). 4D ultrasonography is a powerful tool in the assessment of fetal behavior, and our study showed that there is a continuity from fetal to neonatal behavior, especially in terms of isolated eye blinking movements, mouth and eyelid opening, yawning, tongue expulsion, smiling, scowling and hand movements directed to other parts of the face. Polymerization was induced either by 2 mM MgCl(2) or 150 mM NaCl.

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To assess key environmental, social, and individual correlates of sexual experience, we analyzed data from 4135 American Indian youths who participated in the 1998 and 2001 Minnesota Student Surveys. In vitro, MMP-19 was expressed in cultures of primary human microglia, not in astrocyte cultures. The HuRef Browser is a unique and versatile tool for browsing genome assemblies and studying individual human sequence variation in a diploid context. From May 2002 to December 2006 a psychological questionnaire was sent out to one hundred and six subjects, who freely requested a first genetic informative consultation, and never asked to have a second visit and the family tree drawn up in order to inquire about their eligibility for genetic testing. These data suggest DSG may antagonize the vasodilatory activity of EE and that this effect is further modulated by the EE-to-DSG ratio.

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Influence of oxidative stress on fusion of pre-synaptic plasma membranes of the rat brain with phosphatidyl choline liposomes, and protective effect of vitamin E. Improvements to production in these hosts have focused on novel expression cassettes, cell line modifications, engineering secretion pathways, and media design. In an effort to determine the treatment-independent pregnancy rate, we retrospectively reviewed the first 245 couples enrolled in the IVF-ET program at Duke University Medical Center. Heating in acid or neutral solutions can destroy the capacity of isolated nuclei to form gels. Entrainment of a Bacterial Synthetic Gene Oscillator through Proteolytic Queueing. Both cases responded favorably, clinically and in their EEGs, to continuous therapeutic control with clonazepam, and remained under control with valproic acid. For Bacillus licheniformis SJ4628, an organism widely used in the enzyme industry, methods for determination of cell vitality at a single cell level using 5(6)-carboxyfluorescein diacetate succinimidyl ester in combination with fluorescence ratio imaging microscopy and flow cytometry were developed. In this article we present evidence that the fly homologue of the transitional endoplasmic reticulum ATPase (TER94) is one such protein.

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Inappropriate handling of the missing data in the analysis can result in misleading conclusions. Considering the data published on the intramolecular chaperone-like propeptide function within other protease classes as well, our data suggest that intrinsically structured propeptides are more selective than intrinsically unstructured propeptides, i.e., those adopting tertiary structure elements only in complex with their maternal enzyme. Neuropsychic and ophthalmic manifestations in the coup-de-sabre syndrome. We investigated the effect of ethnicity and gender on optic nerve head morphology in healthy subjects using spectral-domain optical coherence tomography (SD-OCT). NS1 protein of A/Anhui/1/2005 (H5N1) can down-regulate the expression level of IP-10, but this may not clarify its relationship with the virulence of AIV. Eighty-two patients with mid rectal adenocarcinoma stage II and III who underwent low anterior resection from January 1980 to December 1995, were retrospectively analyzed. This study characterises the features, surgical outcome, and incidence of bilateral involvement of detachment associated with round retinal holes. Intensive glucose control increased mortality and did not prevent cardiovascular events in type 2 diabetes.

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We describe here a patient with right putamen-centred hemorrhage who exhibited a consistent counterclockwise rotation of approximately 90 degrees when drawing and writing from memory. Astroglial differentiation of cortical precursor cells triggered by activation of the cAMP-dependent signaling pathway. Following a 7-day withdrawal period rats received a second cocaine challenge. Hence, impairment of renal function during therapy with dihydrotachysterol should be considered as being due to hypercalcemia and hypercalciuria. Elevated amniotic fluid ferritin levels are associated with inflammation-related pregnancy loss following mid-trimester amniocentesis. This device might allow the surgeon to ablate tissue in regions not accessible to other devices during atrial fibrillation surgery. The first child had a varus ankle deformity at the age of 4 months.

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The focus of the review is to delineate protocols for catheter removal, catheter replacement and duration of therapy when a catheter-related infection occurs, and to demonstrate possible means of preventing such infections. Anatomy online: presentation of a detailed WWW atlas of noroxin dose human gross anatomy--reference for medical education. This article reports on the development of an Interprofessional Capability Framework that articulates the learning outcomes that students need to achieve and continue to develop in order to become capable interprofessional workers. coli to inhibit virus infection and induce the neutralizing antibody. Signal intensity increased significantly with oblique sesamoidean desmitis compared with the controls. Studies on flavonoids extraction technology from Glycyrrhiza inflata and their bacteriostatic activities. The buprenorphine-containing matrix patch was effective and well tolerated in patients with moderate to severe chronic cancer and noncancer pain. Colloidal drops-suspensions, dispersions, emulsions-are widespread in the process industry but are difficult to characterize by size, velocity, and concentration of particulate matter in the drop.

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The role of 68Ga-DOTA-NOC PET/CT in evaluating neuroendocrine tumors: real-world experience from two large neuroendocrine tumor centers. We detected significantly greater levels of the Th2 cytokines IL-6 and IL-10 in normal pregnancy compared to unexplained RSA and significantly higher levels of the Th1 cytokine IFN-gamma in RSA compared to normal pregnancy. Modulation of oxytocin secretion by ascending noradrenergic pathways: sexual dimorphism in rats. In contrast, chemical respiratory allergens are found to induce the appearance of preferential type 2 immune responses characterized by IL-4 and IL-10 production, but comparatively low levels of IFN-gamma. Clozapine is often effective in the treatment of a great proportion of previously neuroleptic refractory patients. Abnormalities related primarily to time-distance parameters (reduced speed of progression, shorter strides, prolonged double support phase) and muscular function (premature recruitment of gastrocnemius and late relaxation of tibialis anterior during stance phase) were identified regardless the severity of the clinical score.

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In CHO cells, beta-carotene inhibited the clastogenic and micronucleus-forming effect of methyl methanesulfonate (MMS) and 4-nitroquinoline-1-oxide (4NQO), but had no protective action against gallic acid, tannic acid, and aqueous extract of areca nut or H2O2. Our study suggests that leptin action could be inhibited at a step downstream of STAT3 phosphorylation and nuclear translocation, and provides a potential mechanism of leptin resistance in which an increased FoxO1 antagonizes STAT3-mediated leptin signaling. Pharmacokinetic-pharmacodynamic modeling in phase II of drug development. Cross-sectional studies have shown associations between BMD and indirect measures of physical activity, such as muscle strength and a self-reported degree of physical activity and functional capacity. The study shows that walking in the streets or driving with open windows benemid can be dangerous in Iran during Charshanbe suri. Implementation of maskless laser lithography using a Raman spectroscopy microprobe. The features of severe clinical disease may include bleeding and/or central nervous system manifestations.

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