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Trika (Alprazolam)

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Alprazolam, available under the trade name Xanax, is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder, but also in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Trika, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Trika is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aldip, Almac, Alpam, Alpanol, Alpradol, Alprine, Alpronit, Alprop, Altrex, Alzokam, Alzomax, Alzopam, Alzotime, Andep, Anxigon, Ateez, Balmusa, Besquil, Betapax, Copax, Dexolam, Dizeral, Ecsit, Elflu, Endep, Enxolam, Exprex, Fluxin, Hipose, Hiprazole, Oclam, Pecalm, Resolin, Rezolam, Riolam, Samrox, Selam, Tenschem, Tensyn, Viprax, Visram, Welnorm, Wycalm, Xycalm, Zamitol, Ziety, Zolent, Zolorel, Zoltweet, Zopral

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Glucophage, Mobic, Caverta, Cycrin, Zithromax, Paxil, Kemadrin

Also known as: Alprazolam


{name} XR (alprazolam) is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Alprazolam affects chemicals in the brain that may become unbalanced and cause anxiety.

{name} XR is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

{name} XR may also be used for other purposes not listed in this medication guide.


Take Trika XR exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Trika XR may be habit-forming and should be used only by the person it was prescribed for. Trika XR should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Do not crush, chew, or break a Trika extended-release tablet. Swallow the tablet whole. It is specially made to release alprazolam slowly in the body. Breaking the tablet would cause too much alprazolam to be released at one time.

Contact your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms.

Your symptoms may return when you stop using Trika XR after using it over a long period of time. You may also have seizures or withdrawal symptoms when you stop using Trika XR.

Withdrawal symptoms may include blurred vision, trouble concentrating, loss of appetite, diarrhea, muscle twitching, numbness or tingling, or increased sensations.

Do not stop using Trika XR suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. Do not miss any scheduled visits to your doctor.

Store Trika XR at room temperature away from moisture, heat, and light. Remove any cotton from the bottle of disintegrating tablets, and keep the bottle tightly closed.

Keep track of how many pills have been used from each new bottle of this medicine. Benzodiazepines are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Detailed Trika XR dosage information


If you have been prescribed Trika for medical reasons, the best way to avoid a Trika overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Trika consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Trika XR dosage information

Side effects

The most common side effects associated with Trika are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Trika if:

you also take itraconazole or ketoconazole (antifungal medicines); or you have a history of allergic reaction to any benzodiazepine (alprazolam, diazepam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Valium, Versed, and others).

To make sure Trika is safe for you, tell your doctor if you have ever had:

breathing problems such as COPD (chronic obstructive pulmonary disease) or sleep apnea (breathing that stops during sleep); drug or alcohol addiction; depression, mood problems, or suicidal thoughts or behavior; or kidney or liver disease (especially alcoholic liver disease).

Tell your doctor if you are pregnant or plan to become pregnant. Alprazolam may harm an unborn baby. Avoid taking this medicine during the first trimester of pregnancy.

If you use Trika while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

You should not breastfeed while using alprazolam.

Trika is not approved for use by anyone younger than 18 years old.

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Molecular identification of Hemoglobin D Punjab in cases detected in two families. DPC4/Smad4 is a critical tumor suppressor involved in the progression of pancreatic cancer, but few studies have been conducted to determine its relationship with miRNAs. High-resolution mapping of the HyHEL-10 epitope of chicken lysozyme by site-directed mutagenesis. In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. Fetal weight has no effect on expression levels of genes involved in cell cycle progression and DNA content in subcutaneous adipose tissue. Electrocardiograms revealed a transient and complete right bundle branch block with inverted T waves in leads V1, V2, and V3. Serum concentrations of PRL were measured by radioimmunoassay on blood samples collected before and for 90 minutes after drug or saline administration. The risks for husbands when wives were probands were quite similar.

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Long-term follow up of patients with multiple gastric carcinoids associated with type A gastritis. The galactocerebroside content of brain and spinal cord of the affected fetus was essentially identical to that observed in an age-matched control fetus. Thus, a total of 163 patients (81 males, 82 females) qualified for the study. Presumably, fosfomycin stabilises the membranes of lysosomes in tubular cells. A statistically significant association with oral mucosal lesions and OSF was still found in the group of areca/betel quid chewing only.

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Between-group comparisons did not demonstrate significant effects with respect to the processing time and free recall of nonactivated items. Probiotics have potential to reduce colonization of pathogenic bacteria, representing a promising alternative for S. Membrane potential and endocytic activity control disintegration of cell-cell adhesion and cell fusion in vinculin-injected MDBK cells. Urea and creatinine were significantly higher in the hypertension and glomerulonephritis groups than in the controls and also higher in the glomerulonephritis group than the hypertension group. Zero-current potentials in a large membrane channel: a simple theory accounts for complex behavior. Laser Doppler flowmetry was used to study nasal mucosal microcirculation in seven asymptomatic patients with allergic rhinitis. De novo cancer and mortality rates after organ transplantation were evaluated using standardized incidence ratios, excess absolute risks of cancer, and standardized mortality ratios in recipients were compared with those in the general population.

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White blood cells, isolated from EDTA-blood by centrifugation after cell fixation with paraformaldehyde, were labelled with FITC-conjugated CD16 (FcgammaRIII), CD32 (FcgammaRII), CD64 (FcgammaRI), CD11b (CR3) and CD35 (CR1) monoclonal antibodies and analysed by flow cytometry. Impact of aortic encroachment to left atrium on non-pulmonary vein triggers of atrial fibrillation. There is considerable variability in the manner in which prescriptions are written by physicians and transcribed by pharmacists, resulting in patient misunderstanding of label instructions. Furthermore, the augmented ADP-induced secondary aggregation of platelets on G-CSF receptors was completely abrogated in the presence of anti-G-CSF polyclonal antibodies. However, West syndrome remains to be one of the most challenging epilepsies to treat. Predation on artificial, solitary and aggregated wader nests on farmland.

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It has been shown that the most stable electronic structure for a pi-acceptor ligand correlates with a maximum charge transfer from the metal center to the C-C bond of the unsaturated hydrocarbons, resulting in the formation of two new basins located on the carbon atoms (away from hydrogen atoms) and the reduction of the number of attractors of the C-C basin. The pure electrostatic component of the intermolecular potential functional representation is as usual expressed in terms of a set of punctual charges distributed over the molecular frames, consistently with the permanent molecular dipole values. Orally active CCR5 antagonists as anti-HIV-1 agents 2: synthesis and biological activities of anilide derivatives containing a pyridine N-oxide moiety. From 1975 to 1993, 11 of 375 patients treated for soft tissue sarcoma presented with post-irradiation sarcoma. Kinetic studies on the inhibition of nucleoside diphosphate kinase by desdanine. The frequency of direct cannulation to the coronary sinus for retrograde cardioplegia was significantly higher in group A. Animals from the TBI plus 6-OHDA group displayed significant motor and neurological impairments that were improved by acute l-DOPA administration (25mg/kg, i.p.). It is possible that the basis for some of the anticancer action of antiestrogens is that the induction of NQO1 inhibits the genotoxic effects induced by the oxidative metabolism of estrogens.

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Surgical repair of complete atrioventricular canal defects in infancy. Inhibitors of tetrahydrobiopterin biosynthesis could provide a novel approach for therapy of pathological conditions mediated by nitric oxide, such as septic shock. Further, pneumothorax itself recurs frequently, and acute exacerbation of IPF may develop after a surgical intervention. Complication rates remained stable or decreased over the 5 years studied. Parasitism in skeletal muscles and myositis are commonly observed during experimental Trypanosoma cruzi infection. The aim of conducting this study was to investigate whether childhood asthma was associated with the ratio of omega 6 (n-6) to omega 3 (n-3) fatty acids in the diet (n-6:n-3). The results indicate that persistent PI-PLC activation is insufficient to sustain the stimulation of a cytoplasmic serine/threonine protein kinase regulated by Gq-coupled receptor signal-transduction pathways. The immediate morbidity and mortality is high, and long-term sequelae in terms of lung structure, and thus function, are common, particularly in premature infants. Clinical research in the ICU is thus a discipline in its own right that still requires tailored approaches. The range of TENA flex features will be discussed in this article.

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Tectal gliomas appear to be very slow growing tumours that can be managed conservatively in adults as well as children. To our knowledge, there have been no reports of TTP occurring as a complication of ATRA therapy. We found this device to be efficient, simple to use, and suitable for all varieties of perimetry. Randomized clinical trial of antibiotic and prostaglandin treatments for uterine health and reproductive performance in dairy cows. One-time urine samples were collected during a routine prenatal visit to measure the level of 15-isoprostane F2t and cotinine as biomarkers of oxidative stress and tobacco smoking, respectively. This in turn spares non-responders from chemotherapeutic side effects and financial costs. The Anticoagulation Management Service at the University of Alberta Hospital in Edmonton. VWF seemed to play some role in hearing deterioration and possibly in genesis of balance disorder.

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SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis. The article summarizes the role of bacteria in the mosquito nutrition, the midgut bacterial flora in anopheline mosquitoes and their application in disease control, transstadial transfer of bacteria within mosquitoes, the molecular immune responses of the mosquito to bacteria and the feasibility of applying bacteria to control malaria. RHAMM is expressed as a 58-kDa protein and is distributed primarily as patches over lamellae. This is a vast improvement over manual methods of knowledge and data recording and greatly increases the efficiency of the biomedical researcher. Both family-based linkage analyses and population-based association studies have failed to identify disease-regulatory non-human leucocyte antigen genes of importance in multiple sclerosis (MS). The present study is a critical review of the role of computed tomography (CT) and magnetic resonance imaging (MRI) in the diagnosis and therapy of nasopharyngeal cancer.

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We also demonstrated that this technique is a valuable tool in the study of transcriptional regulation in the developing endoderm. This case once again demonstrates possible difficulties in obtaining a correct diagnosis, especially when imaging techniques reach their limits. A study on the levels of nucleic acids, protein and phosphatases in normal and X-irradiated guinea pigs. banksiana feeders regurgitated greater volumes of fluid and were less likely to be disabled or killed by ants in one-on-one interactions than were larvae fed on P. In this study, naprosyn dosing adults we have examined the influence of different lipids on the solubility of the xanthophyll cycle pigments diadinoxanthin (Ddx) and violaxanthin (Vx) and on the efficiency of Ddx and Vx de-epoxidation by the enzymes Vx de-epoxidase (VDE) from wheat and Ddx de-epoxidase (DDE) from the diatom Cyclotella meneghiniana, respectively.

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The genome organization of the pufferfish is clearly different from that observed in humans, where repeated sequences make up an important fraction of euchromatic DNA, and is more similar to that observed in the fruit fly Drosophila melanogaster. It is assumed that the patient motion is known or can be measured separately, and that the head is rigid. Evidence has accumulated that dysregulation of growth factors such as TPO and/or impaired expression of its receptor may be leukemogenic and myelofibrogenic, and will be reviewed. Intracellular-messenger-mediated cation channels in cultured olfactory receptor neurons. This study deals with the ingrowth behaviour of biomaterials (hydroxyapatite, cp-titanium, cobalt-chromium-molybdenum and PAEK) in relationship to the immunological competence in an animal model. Particularly high local concentrations were observed in the protoderm of the seed cotyledonary axis. There is also a pressing need for additional information on the long-term efficacy and safety of each second-generation antipsychotic agent during maintenance therapy for bipolar disorders. A roentgen study on the anatomic basis of left subphrenic abscess: emphasis placed on the anatomic features of the left triangular ligament of the liver (LTLL). Intravenous administration of physostigmine, an acetylcholinesterase inhibitor, evoked a spatial frequency-dependent change in VEP amplitude.

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It is also recommended that the peer-review of the validation study be accessible to the interested public. The GLP-1 agonist exenatide was administered twice daily to a murine model of dilated cardiomyopathy (TG9) starting at 56 days of life. Interestingly, reconstitution of p32 in an in vitro transcription reaction demonstrated that p32 specifically inhibits CBF-mediated transcription activation. The major barrier to their implementation was related to the time taken to develop and present these measures. pylori infection in CRF leads to decreased acidity and, consequently, to fasting hypergastrinaemia via a feedback mechanism. The results suggest caution in using such self-report measures as an ecological extension of objective testing, but suggest a role in assessing self-appraisal of deficits. Sarcoidosis: an update on current pharmacotherapy options and future directions.

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A three-step search strategy was devised which consisted of using high-precision MeSH terminology and keywords to ensure that all material relevant to the review was captured. In this paper, we will focus what is the highest dose of methotrexate on transgenic plants as a promising large scale production and processing system. To report a case of mediastinal paraganglioma in the setting of the Carney triad (gastric leiomyosarcoma, extra-adrenal paraganglioma, and pulmonary chondroma). We detected nNOS in the sarcolemma of some but not all striated fibers, where nNOS seems to be concentrated at the neuromuscular junction. The pilot study of the SAED system showed that a mobile health technology can significantly improve the HbA1C levels among Saudi diabetic and improve their disease management plans. Viruses employ a variety of strategies to hijack cellular activities through the orchestrated recruitment of macromolecules to specific virus-induced cellular micro-environments.

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Adaptation of reach-to-grasp movement in response to force perturbations. Type I IGF receptors of Leydig cells are upregulated by human chorionic gonadotropin. They also raise further doubt that these MRI changes should be used as an indicator of clinical symptoms or of surgical outcome. Within the hematopoietic lineage, specific cell types display characteristic structural forms of the molecule on their surface. Assessment of blood flow in the bactrim antibiotics side effects left ventricle using four-dimensional flow MRI requires accurate left ventricle segmentation that is often hampered by the low contrast between blood and the myocardium. This prospective cohort study compares coronary calcification, assessed by computed tomography, in postmenopausal black women and white women. Differential expression of bovine MHC class II antigens identified by monoclonal antibodies. Depletion of E6/E7 proteins, concomitant upregulation of p53, p21WAF1, and hypophosphorylated Rb, and downregulation of E2F1, c-Myc, and hTERT were achieved in HeLa cells through SV40-mediated E2 transduction.

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Hemiballismus is a rare movement disorder characterized by involuntary, large amplitude movements of the limbs of 1 side of the body. However, there is not sufficient data about their usefulness in elderly patients with acute septic pathology. Recombinant Activated Factor VIIa (rFVIIa) Treatment in Very-Low-Birth-Weight (VLBW) Premature Infants with Acute Pulmonary Hemorrhage: A Single-Center, Retrospective Study. This review should help to illustrate some of the possible repair strategies for these difficult surgical problems. These parallel arrays, spontaneously formed, are based on HA tertiary structures (beta sheet-like) which are stabilized by hydrophobic and hydrogen bonds. 15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression. Expression and effects of inhibition of type I insulin-like growth factor receptor tyrosine kinase in mantle cell lymphoma.

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From October 1990 through June 1993, the Florida pouch, a continent urinary reservoir using the ascending colon and the dexter half of the transverse colon was constructed in 7 patients after cystectomy for invasive tumor. These compounds are slightly more potent, and they have a significantly higher log P value. Effects of habitat fragmentation on the insect community of stinging nettle (Urtica dioica L.) were studied, using 32 natural nettle patches of different area and degree of isolation in an agricultural landscape. Molecular weight determination of Sendai RNA by dimethyl sulfoxide gradient sedimentation. Evaluation of the efficacy of treating the lumbosacral pain syndrome according to the degree of respiratory rhythm irregularity upon inclining the body forward. simplex was estimated in 135 consecutive CU patients and the result was compared with known data about sensitization in a healthy population. Western policy initiatives prioritize early diagnosis of dementia, but minority ethnic (ME) people currently present later to dementia specialist care than their indigenous counterparts.

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The protective effect of Cu/Zn-SOD against oxidative stress after PTEN deletion. New triterpenoids from the tubers of Corydalis ternata: structural elucidation and bioactivity evaluation. Protection of mice with a divalent tuberculosis DNA vaccine encoding antigens Ag85B and MPT64. Stanniocalcin (STC)-1 is a recently discovered human gene that has been implicated in cellular calcium homeostasis and resistance to hypoxia and is located on chromosome 8p in a region associated with amplification in breast cancer. Nutritional therapy for ulcerative colitis (UC) is controversial. Given the paucity of inpatient-specific evidence for croup care, we hypothesized that there would be marked variability in the use of not routinely indicated resources (NRIRs). An 83-year-old woman was transferred to our hospital because of pacing failure and suspected ventricular perforation by a permanent pacing lead. Increase in trimethoprim-sulphamethoxazole (co-trimoxazole) resistance at Chris Hani Baragwanath Hospital, Soweto, in the AIDS era. These findings suggest that the concentration of the substrate dopamine may determine the alkaloid level during in vivo formation. To investigate interaction between the intermediate cover and the MSW, five sets of columns were set up, one packed with refuse only, and four with a soil-refuse mixture (a clay loam, an organic-rich peaty soil, a well limed sandy soil and a chalky soil).

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Effectiveness of two-liquid silane primers on bonding sintered feldspathic porcelain with a dual-cured composite luting agent. These investigations have demonstrated an abnormal 24-hour pH score in about half of the patients with GERD-associated respiratory complications, and indicated that short reflux events are characteristic of the reflux activity in one third of this population. A number of workers have tried to formulate various conventional and nonconventional dosage forms of AD. ROS and ET can serve as a unifying framework for both transmission and toxicity, with ROS concentration being a crucial issue. Determining standards for assessing clinical performance is a controversial issue. Evaluation of changes in the visual field in glaucoma during examination with white and colored stimuli. Perceived physical appearance, issues related to sexuality, stress, anxiety, and even guilt complicate the emotional and psychological landscape after transplantation. The goal of the present study was to investigate the transcriptional response of the obscurin gene cluster to the initiation of myocardial hypertrophy induced in mice by aortic constriction. Contribution of Doppler ultrasound flowmetry in the evaluation of intracranial albenza cost impedance. Sensitivity and specificity of manual measurement of hippocampus was higher compared to visual rating scores for MTL in patients with AD.

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The enzyme was stable in a pH range of 5.5-9.0 and below 40 degrees C. Arguably the most prolific and powerful of these reactions, the copper-catalysed alkyne-azide reaction (CuAAC) is highly efficient and ubiquitous in an ever increasing number of synthetic methodologies and applications, including bioconjugation, labelling, surface functionalization, dendrimer synthesis, polymer synthesis and polymer modification. In addition, the mercury-NADPH complex, once formed, could limit the utilization of reduced pyridine nucleotides by NADPH-dependent enzymes such as NADPH oxidase, thereby inhibiting the PMN respiratory burst. Multi-herb therapy has been widely used in Traditional Chinese medicine and tailored to meet the specific needs of each individual. To understand the molecular mechanism of cell death in lesion mimic mutants, we isolated a lesion initiation 1 (len1) mutant by a T-DNA tagging method. The quaternary antagonist N-methylnaltrexone (1 mg/kg) failed to block the fentanyl-induced increase of ANF, suggesting that opiates bring about their action on ANF via a central mechanism. The data raise the possibility of a role of octopamine-sensitive adenylate cyclase in the physiology of synaptic transmission. Hybrid hamstring grafts are a cost-effective treatment option because of a reduced rate of graft failure. Risks and benefits of rate control versus maintenance of sinus rhythm.

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Trypanosoma cruzi: inhibition of alpha-hydroxyacid dehydrogenase isozyme II by N-allyl and N-propyl oxamates and their effects on intact epimastigotes. One of the most effective and reliable methods of controlling the disease has been the use of resistant cultivars worldwide. The two bicyclic fragments of the title compound, C(22)H(20)N(4)O(4), are individually planar and are turned with respect to each other by 77.8 (2) degrees. Current Practices in Lumbar Surgery Perioperative Rehabilitation: A Scoping Review. Of note, one patient showed an intermediate multiplex ligation-dependent probe amplification (MLPA) result with an abnormal FISH result, which is consistent with mosaicism. The selected compounds were tested against Her2, a client protein of Hsp90, and showed significant reduction in Her2 protein expression. One year later, a good functional result concerning the mother was shown.

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