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Wellbutrin (Bupropion)

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Wellbutrin works in depression by increasing the levels of chemical messengers in the brain that helps in regulating mood. The mechanism underlying its use in smoking addiction are not fully understood.

Other names for this medication:
Aplenzin, Budeprion, Bupdep, Bupraset, Bupron, Bupropion, Ession, Nicotex, Smoquit, Unidep, Zyban

Similar Products:
Allegra, Ovral, Floxin, Naprosyn, Cycrin, Alprostadil, Silagra, Xanax, Mysoline

Also known as: Bupropion


{name} (bupropion) is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Too much of this medicine can increase your risk of a seizure.

You may take Wellbutrin SR with or without food.

Swallow the extended-release tablet whole and do not crush, chew, or break it.

You should not change your dose or stop using Wellbutrin SR suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

If you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the first 2 weeks of treatment. Talk to your doctor if you have trouble quitting after taking Zyban for 7 to 12 weeks.

Your doctor may prescribe a nicotine replacement product (such as patches or gum) to help you stop smoking. Start using the nicotine replacement product on the same day you stop (quit) smoking or using tobacco products.

Some people taking Wellbutrin SR (Wellbutrin or Zyban) have had high blood pressure that is severe, especially when also using a nicotine replacement product (patch or gum). Your blood pressure may need to be checked before and during treatment with this medicine.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

You may have nicotine withdrawal symptoms when you stop smoking, including: increased appetite, weight gain, trouble sleeping, trouble concentrating, slower heart rate, having the urge to smoke, and feeling anxious, restless, depressed, angry, frustrated, or irritated. These symptoms may occur with or without using medication such as Zyban.

Smoking cessation may also cause new or worsening mental health problems, such as depression.

This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use Wellbutrin SR.

Store at room temperature away from moisture, heat, and light.

Detailed Wellbutrin SR dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Wellbutrin XL can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting.


Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Wellbutrin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Drinking alcohol with bupropion may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. Bupropion can also cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication.

Bupropion may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

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Species accumulation provided a set of simple curve-parameters that captured the net result of numerous local effects of treatments on plant species and, in some instances, the balance between grass and broadleaf types. Topological properties of DNA influence its structure and biochemical interactions. This study contrasts the relative buffering power of bicarbonate-based and tromethamine-based hyperkalemic crystalloid cardioplegic solution with histidine protein-type buffer (Bretschneider) solution. However, the correlation between OGM and spontaneous brain activity in depression remains unclear. A mutant p300 that lacks histone acetyltransferase (HAT) activity did not reverse E1A-mediated inhibition. In the light of our experience and a review of the literature, it is difficult to distinguish secondary tumours of the right atrium from myxomas especially when the tumours are mobile and when it is impossible to visualise a pedicle inserted on the interatrial septum or tumoral invasion of the inferior vena cava. The observed absence of cox3 and rps13 RNA editing in Iridaceae and Amaryllidaceae and the striking RNA editing reduction of ccb2 in the latter family is likely generated by recombination and reverse transcription mediated events involving edited mitochondrial transcripts. According to scientific literature nontoxigenic diphtheroids cause different nosocomial infections of immunocompromised patients.

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Spontaneous rupture of the normal esophagus: report of a case with an unusual clinical course and pathologic findings. The hypervariable loops are all visible in the electron density map with the exception of three residues in the first hypervariable loop of the light chain. Large multicenter studies that include all children with perinatal stroke are needed to determine further the risk factors and outcome of perinatal stroke. On the other hand, AT2 receptor stimulation induced apoptosis myofibroblasts associated with reduced interstitial fibrosis. Botulinum neurotoxin is the most potent naturally occurring toxin known to inhibit various neurotransmitters. A redescription of Protospirura muricola Gedoelst, 1916 (Nematoda: Spiruridae), a parasite of murid rodents.

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This pattern of association between socio-economic status and obesity may reflect a late socio-economic transition of Portugal, compared to that of other high-income countries. This induces an increase in the price of the branded good produced by this firm, which in turn implies a welfare reduction. To assess the incidence and severity of PONV after balanced desflurane-N(2)O-anaesthesia and to compare the antiemetic efficacy of dolasetron or metoclopramide versus placebo. The human genome is estimated to contain 700 zinc-finger genes, which perform many key functions, including regulating transcription. Endothelial damage and intimal proliferation occur in vasospastic cerebral arteries after subarachnoid hemorrhage (SAH). The discovered antimutagenic activity of aspartame was manifested more when it was injected for 5 days before the administration of a mutagen, whereas in joint administration of aspartame with the mutagens, the substitute for sugar did not change the clastogenic effect of dioxydin and cyclophosphan. Members of the LIM homeodomain family of transcription factors have been implicated in specifying cell identity in a range of species. In TPA-treated samples no difference between the relative content of type I and III collagen was observed, whereas the content of type V was significantly increased. The functions of E6 necessary for viral replication have not been determined, and to address this question we used a recently developed transfection system based on HPV31.

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Cost-effectiveness of inhaled nitric oxide in near-term and term infants with respiratory failure: eighteen- to 24-month follow-up for Canadian patients. Some rats were naive at the start of spatial training, whereas other rats received water maze strategies pretraining prior to spatial training to familiarize them with the general behavioral strategies required in the task. In addition, the greatly elevated content of thiobarbituric acid reactive substances (TBARS) and carbonylated protein in diabetic rats were reduced by P55A treatment. NHE) was measured for MP8, which was almost identical to that reported for N-acetyl-MP8 in aqueous solution. Pharmacological inactivation of the EGFR and ERK kinase activities, by use of specific inhibitors AG1478 and PD98059 respectively, blocked PV-IgG-induced phosphorylation of EGFR, ERK and c-Jun and cellular apoptosis, measured by flow cytometry and caspase 3 activity. Dual PPARalpha/gamma ligand TZD18 either alone or in combination with imatinib inhibits proliferation and induces apoptosis of human CML cell lines. Childbirth-related perineal trauma: clinical significance and prevention. In neurons of mutant animals, PI(4,5)P2 levels are increased, and clathrin-coated vesicles accumulate in the cytomatrix-rich area that surrounds the synaptic vesicle cluster in nerve endings. The clinical prediction rules are helpful for improved clinical decision making for bacteremia patients.

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Analysis of HtrA1 serine protease expression in human lung cancer. The radical SAM tryptophan (Trp) lyase NosL involved in nosiheptide biosynthesis catalyzes two parallel reactions, converting l-Trp to 3-methyl-2-indolic acid (MIA) and to dehydroglycine and 3-methylindole, respectively. About 49,000 miners are defined as exposed (underground or processing), while the internal control group (surface only) consists of 15,000 workers. In mice with VM, the activities of myocardial MMP-2 and MMP-9 at acute stage increased significantly, then myocardial collagen amount elevated in recovery stage. The youth/adolescent questionnaire has low validity and modest reliability among low-income African-American and Hispanic seventh- and eighth-grade youth. Autonomic activation was investigated in response to facial expressions of emotion in adolescents and adults with WS, compared to age-matched normal controls and to age-, IQ- and language-matched individuals with learning or intellectual disabilities (LID).

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The cytoplasmic domain of human FcgammaRIa alters the functional properties of the FcgammaRI.gamma-chain receptor complex. Simultaneous detection of co-segregating missense mutations of the Toll-like receptor 4. Nations face numerous challenges in providing high-quality end-of-life care for their citizens, and an aging population that has a prolonged trajectory of decline and substantial needs for care magnifies these challenges. Genetic architecture of resistance to aphids and mites in a willow hybrid system. Eight male beagle dogs with moderate periodontitis were enrolled in this split-mouth, double-blind randomized trial with ethical approval.

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In some cases, these structures imitate the region of protein binding to rRNA. Physicians take lead in the integration of medication and disease management. A significant change in attitudes was evident, with the students feeling more comfortable interacting with people with disabilities after the session than before. None of the tested sorbents reduced the mercury concentration to less than the existing 12 ng/l NPDES limit. Each collagen type isolated from the treated tissue preparations displayed properties consistent with those exhibited by its counterpart obtained from fresh tissue which was directly processed. We used our recently published and experimentally validated L3-S1 finite element model for the present study. However, the physical nature of this DFT estimate of electron correlation energy is not well understood and, in fact, most current DFT methods do not describe dispersion energy at all.

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A reversed graft may ensure that regenerating nerve fibers are not lost at branching points, however this may not translate into improved function. In agreement with these changes, analysis of a major substrate of cyclin-activated cdks, retinoblastoma protein (Rb), showed an increase in the level of phosphorylated forms within 1 hr of KCl withdrawal. Mice bearing a luciferase reporter gene for mPer2 were subjected to a 6-h advance of the light cycle and molecular rhythms in suprachiasmatic nuclei (SCN), thymus, spleen, lung and esophagus were measured periodically for 2 weeks following the shift. These findings in pediatric encephalitis are suggestive of influenza A infection and may guide investigation and early diagnosis. Developmental indicators, established by measuring the length of florets and panicles, indicate that the critical stage for sex determination occurs when floret and panicle lengths are 1-2 mm and 3 cm, respectively. Percutaneous endovascular techniques are used increasingly in the vascular armamentarium. The fate of free cholesterol released after endocytosis of low-density lipoproteins remains obscure. Control patients were patients with CF not B cepacia complex colonized during the study period.

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The Fluoropen is a device consisting of a light source fitted with color filters to create the required emission and visualization wavelengths. Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?. Subsequent to concentration of Fcepsilon receptor I, the mast cell receptor for IgE, and colocalized tyrosine phosphorylation activity, Lyn kinase and other proteins anchored to the inner leaflet of the plasma membrane redistribute selectively with the receptor clusters in a process that depends on actin polymerization. We report the use of costochondral autograft as an interposition material in revision of trapeziectomy in trapeziometacarpal osteoarthritis and to study its usefulness. Selective regulation of integrin--cytoskeleton interactions by the tyrosine kinase Src. The following two groups were assessed: (1) an early relapse (ER) group of patients who experienced recurrence during AED withdrawal and (2) a late relapse (LR) group of patients who experienced recurrence after completion of the AED discontinuation process. However, four cages inserted through posterior exposure during an interbody lumbar fusion procedure had to be removed because of migration into the spinal canal.

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The modeling revealed that the intermolecular contacts of chymosin in crystal have negligible influence on the energy stabilization of its self-inhibited conformation. Physical Activity Contributes to Several Sleep-Cardiometabolic Health Relationships. Two independent assessments of ego level were related to IQ and defense mechanism use in a sample of 89 young adults. The maximum tolerable dose (MTD) of CDDP suppressed early-stage c26 and c38 tumor growth when treatment was started after the tumor volume (TV) reached 0.2-0.5 cm3, but it showed reduced activity against the same tumors at an advanced growth stage when TV exceeded 2 cm3. The first formant was very stable in every child and showed only discrete deviations from the normal range. Absolute left ventricular volume changes after sublingual nitroglycerine and nifedipine intervention.

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A dose-response curve was achieved for all three cyclooxygenase products with the zebeta medication cost calcium ionophore A23187. The data are presented in the context of key stakeholder perspectives on the current use and purpose of CTOs. To delineate the role of IL-6 in this process, we treated IL-6-deficient mice with CCl4 in a similar manner for 12 weeks, after which fibrotic changes were less evident and serum albumin levels were lower in IL-6-deficient than wild-type mice. Characterization of benzaldehyde lyase from Pseudomonas fluorescens: A versatile enzyme for asymmetric C-C bond formation. Compounds were detected with a Waters Micromass Quattro Premier mass spectrometer operating in positive electrospray ionization using the compound-specific MRM methods. The objective of this study is to assess the relevance of the concept of virtue and vice to patients with chronic arthritis. The interrelations between neurons of the amygdala and hypothalamus during conditioning with selection of food reinforcement quality in cats. Use of autologous transfusion in the management of acute traumatic haemothorax in the accident and emergency department. This report evaluates the dynamics of nucleotide incorporation opposite an abasic site, a commonly formed DNA lesion, by using two fluorescent nucleotide analogues, 2-aminopurine deoxyribose triphosphate (2-APTP) and 5-phenylindole deoxyribose triphosphate (5-PhITP).

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The characteristics and performance of FLURBIPROFEN 8.75 mg SPRAY were compared with 12 other sprays. Use of macrolides as part of an initial therapeutic regimen appears to be associated with shorter LOS. Cyclin A correlates with carcinogenesis and metastasis, and p27(kip1) correlates with lymphatic invasion, in colorectal neoplasms. Hepatocelluar norethindrone 5 mg coupon carcinoma is one of the commonest cancers in Nigeria. Using such an allelic series and a novel thermotolerance assay for Drosophila embryos, we investigated the role of the 70 kD heat-shock protein, Hsp 70, in thermotolerance.

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In total 70 patients, 53 men and 17 women, who were recruited into the study, were indicated for primary laparoscopic resection for colorectal carcinoma, with laparoscopic intra-operative ulrasonographic examination of the liver (L-IOUS) being used during the initial part of the operation. Fatty acid biomarkers of symbionts and unusual inhibition of tetracosapolyenoic acid biosynthesis in corals (octocorallia). Nasal carriage of methicillin-resistant staphylococcus aureus in vascular surgery. Functionalized oxepines via fragmentation of highly strained epoxides. The aim of this article is to provide a systematic review of the literature concerned, and to present a case series with representative defects from various zones.

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We formulated a prognostic index according to SPF and tumor stage that has discriminatory capacity for biologic behavior in colorectal tumors. In a study of 39 subjects, blood pressure was measured using two indirect methods (two-stage and one-stage approaches). This review focuses on the aims, results, advantages, and possible disadvantages of preoperative chemotherapy and endocrine therapy. Usefulness of an inexpensive, Paracheck test in detecting asymptomatic infectious reservoir of plasmodium falciparum during dry season in an inaccessible terrain in central India. Caricatures of faces of famous people and photographs of non-famous faces yielded higher percent signal changes in the OFA and FFA compared to photographs of famous faces. We highlight and discuss the different topological patterns recovered by concatenated and coalescent species tree methods for these closely related lineages.

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A lack of eNOS accelerates both glomerular and tubulointerstitial injury with a loss of glomerular capillaries and peritubular capillaries. Two separate control cat groups were evaluated at 8 months and 16 months of age. Furthermore, lay approaches such as aromatherapy were also commonly used. Recombinant GH replacement in hypopituitary adults improves endothelial cell function and reduces calculated absolute and relative coronary risk. Identification of t-PA as the major active plasminogen activator in human milk. The men were divided into four groups, determined by their sperm densities and hormonal parameters. It has been defined, that other fragments of fibrin (D and DD) are not capable to induce amydolytic activity of prothrombin. Although major progress has recently been achieved through ex situ methods, there is still a lack of understanding of the behavior of the active center in non-precious metal Fe-N/C catalysts under operating conditions. Maintenance of the stationary phase growth state has been proposed to be critical for the virulence is lipitor generic or brand of several mammalian pathogens, but analysis of this relationship for the brucellae has not been undertaken. It also showed antifungal activity against certain fungal pathogens such as Rhizoctonia solani, Phytophthora cinnamomi and Fusarium oxysporum.

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In correlation, experiments with dichlorofluorescein demonstrated increased formation of ROS upon treatment with fly ash. BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3. Our results duphaston 10 mg mims suggest that the L-arginine/NO pathway is not altered in SIOD. There were significant differences between either two groups about the expressions of IL-3. Three children, two girls aged 9 and 13 years and a boy aged 9 years, and a man aged 22, presented with headache of migrainoid character. Phase II study of interferon-enhanced 131I-labeled high affinity CC49 monoclonal antibody therapy in patients with metastatic prostate cancer. However, combined treatment of MDMA and music stimulation did not fully restore normal sexual behavior as the animals reaching ejaculation still showed a marked reduction of copulatory efficiency. Structured feedback of information can produce change in physician behaviour. The clearest sign of the transition from the vegetative state to the tassel is the scale leaf, which is intermediate in form between a vegetative leaf and a lateral tassel primordium.

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However, combination of an appropriate enrichment condition with advanced detection techniques may enable a 24h detection of L. However, the intermediate steps linking activated receptor tyrosine kinase to ERKs during ulcer healing are as yet unknown. Characterization of ribosomes from the phycomycetes, Rhizopus arrhizus and Pythium debaryanum. Free NAPL removal can improve the removal efficiency for moderately low solubility chemicals like benzene, but cleanup times even after free NAPL removal can be prolonged for very low solubility chemicals like cyclohexane and styrene. The stress and coping of Israeli emergency room social workers following terrorist attacks. The improvements are such that it is possible to optically section thick specimens with little degradation in the image quality of interior sections. Effects of the inhalable particle (PM10) on secretion of inflammatory factors in human lung fibroblasts and tenormin medication mouse alveolar macrophage cell. Characterization of macrolide-resistant Campylobacter coli isolates from food-producing animals on farms across Japan during 2004. EUS-FNA technology can also be applied to the evaluation of non-GI disorders.

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Quantification of stress sensitive markers in single fecal samples do not accurately predict excretion of these in the pig. This study is important for verification of the reference range recommended by the manufacturer. Patients with a history of ileal resection had the length of small bowel removed determined by review of their pathology report. These results provide, for the first time, a potential mechanism of action for the anorectic effects of metformin, a widely used drug that could represent a valuable adjunct to novel therapies aimed at modulating central feeding pathways. Diabetes is associated with a high incidence of ischaemic disease and impaired nitric oxide responses. These results raise questions about the use of currently available anti-HBc reagents as a surrogate test for non-A, non-B hepatitis.

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