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Zofran (Ondansetron)

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Zofran is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.

Other names for this medication:
Domar, Donrid, Emitus, Lupisetron, Naucid, Odanse, Omcet, Ondansetron, Ondar, Ondet, Ontron, Osetron, Pantorex, Periset, Rancet, Ranidom, Ranon, Renty, Tiron, Vomicare, Vomigo, Vomikind, Vomipra, Vomiven, Vomiz, Vomizen, Vorast, Voset, Xondmet, Zonda, Zondan, Zonde

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Also known as: Ondansetron


{name} ODT blocks the actions of chemicals in the body that can trigger nausea and vomiting.

{name} ODT is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.

{name} ODT may be used for purposes not listed in this medication guide.


Ondansetron is injected into a vein through an IV. A healthcare provider will give you this injection.

Ondansetron is usually given just before your surgery begins, or within 2 hours after surgery.

To prevent nausea and vomiting caused by chemotherapy, ondansetron is given 30 minutes before the start of chemotherapy. A second and third dose of ondansetron are sometimes given 4 hours and 8 hours after the first dose.

Detailed Zofran dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.


Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the unused soluble film in the foil pouch until you ready to use it.

Detailed Zofran ODT dosage information

Side effects

The most common side effects associated with Zofran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Zofran ODT if:

you are also using apomorphine (Apokyn); or you are allergic to Zofran ODT or similar medicines (dolasetron, granisetron, palonosetron).

To make sure Zofran ODT is safe for you, tell your doctor if you have:

liver disease; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); congestive heart failure, slow heartbeats; a personal or family history of long QT syndrome; or a blockage in your digestive tract (stomach or intestines).

Zofran ODT is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Zofran ODT is not approved for use by anyone younger than 4 years old.

Zofran ODTly disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

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